• Korean Chemical Engineering Research
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• v.59 no.3
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• pp.366-372
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• 2021

Cadherin-Catenin complex is thought to play an essential role in the transmission of force at adherens junction. Due to the lack of proper tools to visualize and detect mechanical force signals, the underlying mechanism by which the cadherin-catenin complex regulates force transmission at intercellular junctions remains elusive. In this study, we visualize cadherin-mediated force transmission using an engineered α-Catenin sensor based on fluorescence resonance energy transfer. Our results reveal that α-catenin is a key force transducer in cadherin-mediated mechanotransduction at cell-cell junctions. Thus, our finding will provide important insights for studying the effects of chemical and physical signals on cell-cell communication and the relationship between physiological and pathological phenomena.

• Journal of Ocean Engineering and Technology
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• v.10 no.3
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• pp.138-152
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• 1996

Many studies of heat transfer on the swirling flow or unswirled flow in a abrupt pipe expansion are widely carried out. The mechanism is not fully found evidently due to the instabilities of flow in a sudden change of the shape and appearance of turbulent shear layers in a recirculation region and secondary vortex near the corner. The purpose of this study is to obtain data through an experimental study of the swirling flow and heat transfer downstream of an abrupt expansion in a circular pipe with uniform heat flux. Experiments were carried out for the turbulent flow nd heat transfer downstream of an abrupt circular pipe expansion. The uniform heat flux condition was imposed to the downstream of the abrupt expansion by using an electrically heated pipe. Experimental data are presented for local heat transfer rates and local axial velocities in the tube downstream of an abrupt 3:1 & 2:1 expansion. Air was used as the working fluid in the upstream tube, the Reynolds number was varied from 60, 00 to 120, 000 and the swirl number range (based on the swirl chamber geometry, i.e. L/d ratio) in which the experiments were conducted were L/d=0, 8 and 16. Axial velocity increased rapidly at r/R=0.35 in the abrupt concentric expansion turbulent flow through the test tube in unswirled flow. It showed that with increasing axial distance the highest axial velocities move toward the tube wall in the case of the swirling flow abrupt expansion. A uniform wall heat flux boundary condition was employed, which resulted in wall-to-bulk temperatures ranging from 24.deg. C to 71.deg. C. In swirling flow, the wall temperature showed a greater increase at L/d=16 than any other L/d. The bulk temperature showed a minimum value at the pipe inlet, it also exhibited a linear increase with axial distance along the pipe. As swirl intensity increased, the location of peak Nu numbers was observed to shift from 4 to 1 step heights downstream of the expansion. This upstream movement of the maximum Nusselt number was accompanied by an increase in its magnitude from 2.2 to 8.8 times larger than fully developed tube flow values.

• Journal of the Korean GEO-environmental Society
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• v.8 no.1
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• pp.33-40
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• 2007

Engineering behaviour of uplift-resisting ground anchors constructed in weathered rocks has been investigated by carrying out a series of full scale pull-out tests. The anchor was to resist uplift forces (buoyancy) associated with high groundwater table acting on the basement of a rail way station. The study has included the ultimate pull-out capacity of the anchors and shear stress transfer mechanism at the anchor-ground interface. The pull-out tests were conducted by changing bonded lengths of the anchor (2~7 m) and diameter of drilled borehole (108~165 mm) to investigate their effects on the behaviour of the anchor. The measured results showed that the ultimate capacity of the anchors was increased with an increase in the bonded length, diameter of drilled borehole as expected. The ultimate capacity of the anchors deduced from the pull-out tests ranged from 392 to 1,569 kN, depending on the above-mentioned factors. This corresponds to the interface shear strength of about 227~505 kPa. Interface shear stresses deduced from the pull-out test showed that the larger the pull-out force, the larger the mobilisation of the interface shear strength. The failure mode of the anchors heavily depended on the bonded lengths of the anchors. When the bonded length was short (2~3 m), a cone-type failure was observed, whereas when the bonded length increased (5~7 m), failure developed at the grout-ground interface.

• Journal of the Korean GEO-environmental Society
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• v.16 no.6
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• pp.13-22
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• 2015

In the current work, a series of three-dimensional (3D) numerical modelling has been performed in order to study the effects of the relative locations of tunnels with respect to the position of pile tips which governs the behaviour of pre-existing, adjacent single piles. In the numerical analyses, several governing factors, such as tunnelling-induced pile head settlements, relative displacements, volume losses, axial pile forces, interface shear stresses and apparent factors of safety have been analysed. When the pile tips are inside the tunnelling influence zone, of which the pile tip location is considered with respect to the tunnel position, tunnelling-induced pile head settlements are larger than the ground surface settlements, resulting in tunnelling-induced tensile pile forces. On the contrary, when the pile tips are outside the influence zone, compressive pile forces associated with downward shear stresses at the upper part of the piles are developed. Based on computed load and displacement relation of the pile, the apparent factors of safety of the piles inside the tunnelling influence zone have been reduced by 36% in average. The shear transfer mechanism based on the relative tunnel locations has been analysed in great detail by considering tunnelling-induced pile forces, interface shear stresses and the apparent factors of safety.

• Journal of Korean Tunnelling and Underground Space Association
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• v.8 no.3
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• pp.273-287
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• 2006

This study investigates the failure mechanism and load-carrying capacity of a single-shell lining which has no disturbance in transfer of shear force, with respect to a conventional double-shell lining which has separation between layers of shotcrete lining and secondary concrete lining by water-proof membrane. In order to evaluate the capacity, a 2-D numerical investigation is preliminarily carried out and then real-scale loading tests with tunnel lining section specimens are performed on the condition given by the numerical investigation. In the test, a concentrated load is applied for considering a released ground load or rock wedge load. Through this study, it appears that the single-shell lining takes the load-bearing capacity 20% higher than in case of the double-shell lining. In addition, a possibility of a composite single-shell shotcrete layer composed by multiple bonded layers partly involving different contents of high-capacity additives is shown thereby leading to use of less amount of the high-capacity additives on the condition of taking a similar load-bearing capacity.

• Journal of Korean Tunnelling and Underground Space Association
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• v.14 no.5
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• pp.529-545
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• 2012

Three-dimensional (3D) finite element analyses have been performed to study the behaviour of a single pile to open face tunnelling in stiff clay. Several key factors such as tunnelling-induced ground and pile settlement, and shear transfer mechanism have been studied in detail. Tunnelling resulted in the development of pile settlement larger than the Greenfield soil surface settlement. In addition, due to changes in the shear transfer between the pile and the soil next to the pile with tunnel advancement, axial force distributions along the pile change drastically. The apparent allowable pile capacity was reduced up to about 30% due to the development of tunnelling-induced pile head settlement. The skin friction on the pile was increased with tunnel advancement associated with the changes of soil stresses and ground deformation and hence axial pile force distribution was reduced. Maximum tunnelling-induced tensile force on the pile was about 21% of the designed pile capacity. The zone of influence on the pile behaviour in the longitudinal direction may be identified as ${\pm}1$-2D (D: tunnel diameter) from the pile centre (behind and ahead of the pile axis in the longitudinal direction) based on the analysis conditions assumed in the current study. Negative excess pore pressure was mobilised near the pile tip, while positive excess pore pressure was computed at the upper part of the pile. It has been found that the serviceability of a pile experiencing adjacent tunnelling is more affected by pile settlement than axial pile force changes.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.14 no.1
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• pp.171-178
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• 1994

The skin friction on single piles was investigated by using an analytical study and a numerical analysis. The emphasis was given to the variation of skin friction on piles based on the load transfer mechanism developed for the consolidation of a surrounding soft clay. Local yield or slip at the pile-soil interface was taken into account by specifying a limiting value of shear stress. The response of a single pile was analyzed and compared to the results of field case study. Based on the results obtained, it is shown that the skin friction on a pile increases as the degree of consolidation increases and the ultimate axial forces result from the long term behavior of clay corresponding to the end of the consolidation. It is also found that the analysis using one-dimensional consolidation theory as well as two or three-dimensional non-linear analysis gives relatively reasonable results.

• Journal of the Korea Concrete Institute
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• v.24 no.6
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• pp.737-744
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• 2012

Hysteretic steel damper has been applied mainly to steel buildings. However, the usage in RC buildings is rapidly increasing recently. In order to apply the steel hysteretic damper in RC buildings, supporting elements of the damper should have sufficient strength and stiffness suitable for transferring damper forces to beams and walls. But due to the inevitable damage in reinforced concrete elements due to cracking, identification of the load transfer mechanism from damper to supporting element and hysteretic characteristics of the supporting element are extremely important in evaluating the damper behavior. Experiments were carried out on connection details between RC walls and supporting elements of the steel plate typed damper such as EaSy damper. The test results showed that fracture patterns of all specimens were almost identical except in the crack number and pattern associated with shear loading condition. Among the specimens, HD-3 shoed a well distributed cracks patterns along with good performance with respect to energy dissipation capacity, stiffness deterioration, and strength degradation.

• Journal of the Korean Geotechnical Society
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• v.32 no.7
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• pp.35-45
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• 2016

Estimation of vertical bearing capacity is critical in the design of bucket foundation used to support offshore structure. Empirical formula and closed form solutions for bucket foundations in uniform sand or clay profiles have been extensively studied. However, the vertical bearing capacity of bucket foundations in alternating layers of sand overlying clay is not well defined. We performed a series of two-dimensional axisymmetric finite element analyses on bucket foundations in sand overlying clay soil, using elasto-plastic soil model. The load transfer mechanism is investigated for various conditions. Performing the parametric study for the friction angles, undrained shear strengths, thickness of sand layer, and aspect ratios of foundation, we present the predictive charts for determining the vertical bearing capacities of bucket foundations in sand overlying clay layer. In addition, after comparing with the finite element analysis results, it is found that linear interpolation between the design charts give acceptable values in these ranges of parameters.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.4
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• pp.605-615
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• 2016

It is difficult to form a rational strut-tie model that represents a true load transfer mechanism of structural concrete with disturbed stressed region(s). To overcome the difficulty and handle numerous load cases with just one strut-tie model, a two-dimensional grid strut-tie model method was proposed previously. However, the validity of the method was not fully examined, although the incorporated basic concepts and new methods regarding the effective strength of concrete strut, load carrying capacity of struts and ties, and geometrical compatibility of grid strut-tie model were explained in detail. In this study, for accurate strength analysis and reliable design of reinforced concrete deep beams, the appropriateness of the two-dimensional grid strut-tie model method is verified. For this, the failure strength of 237 reinforced concrete deep beams, tested to shear failure, is predicted by the two-dimensional grid strut-tie model method, and the results are compared with those obtained by the sectional shear design methods and conventional strut-tie model methods of current design codes.