• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1404-1408
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• 2008

The migration and proliferation of vascular endothelial cells (VEC), which play an important role in vascular remodeling, are known to be regulated by hemodynamic forces in the blood vessels. When shear stresses of 2, 6, 15 dynes/$cm^2$ are applied on mouse micro-VEC in vitro, cells surprisingly migrate against the flow direction at all conditions. While higher flow rate imposes more resistance against the cells, reducing their migration speed, the horizontal component of the velocity parallel to the flow increases with the flow rate, indicating the higher alignment of cells in the direction parallel to the flow at a higher shear stress. In addition, cells exhibit substrate stiffness and calcium dependent migration behavior, which can be explained by polarized remodeling in the mechanosensitive pathway under shear stress.

• Journal of Biomedical Engineering Research
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• v.13 no.3
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• pp.253-262
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• 1992

The wall shear stress in the vicinity of end-to end anastomoses under steady flow condi- tions was measured using a flush-mounted hot-film anemometer(FMHFA) probe. The experi- mental measurements were in good agreement lith numerical results except In flow with low Reynolds numbers. The wall shear stress increased proximal to the anastomosis in flow from the Penrose tubing (simulating an artery) to the PTFE graft. In flow from the PTFE graft to the Penrose tubing, low wall shear stress was observed distal to the anastomosis. Abnormal distributions of wall shear stress in the vicinity of the anastomosis, resulting from the compli- ance mismatch between the graft and the host artery, might be an important factor of ANFH formation and the graft failure. The present study suggests a correlation between regions of the low wall shear stress and the development of anastomotic neointimal fibrous hyperplasia (ANFH) in end-to-end anastomoses.

• 한국신재생에너지학회:학술대회논문집
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• 2007.11a
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• pp.387-390
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• 2007

Recently the diameter of the 5MW wind turbine reaches 126m, and the tower height is nearly the same with the wind turbine diameter. The blade will experience periodic inflow oscillation due to blade rotation inside the ground shear flow region, that is, the inflow velocity is maximum at uppermost position and minimum at lowermost position. In this study we compare the aerodynamic data between two inflow conditions, i.e, uniform flow and normal wind profile. From the computed results all of the relative errors for oscillating amplitudes increased due to the ground shear flow effect. Especially My at hub and $F_x$, $M_y$, $M_z$ at LSS increased enormously. It turns out that the aerodynamic analysis including the ground shear flow effect must be considered for fatigue load analysis.

• Journal of Advanced Marine Engineering and Technology
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• v.24 no.6
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• pp.120-127
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• 2000

This study is concerned with evaluating the effects of acoustic excitation on the development of two stream mixing layer generated by split plate. The ratios of two velocities U1 and U2 either side of the splitter plate were such that $U_1/U_2$=1.0 (uniform flow) or $U_1/U_2$<1.0(shear flow). The mixing layers were disturbed acoustically through the edge of split plate. Quantitative data were obtained with hot-wire anemometry. Flow visualization with smoke-wire was also employed for qualitative study. the results show that the large scale structures of mixing layers are strongly affected by excitation frequency and amplitude in both uniform and shear flows. The maximum streamwise and vertical turbulent intensities of the excited flow fields are apt to be decreased as compared with those of without excitation. The flow characteristics of uniform flow are more influenced by acoustic excitation than those of shear flow.

• Bulletin of the Korean Chemical Society
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• v.17 no.3
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• pp.262-268
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• 1996

Flow properties of all suspensions are controlled by their flow units. The factors effecting on the flow units are the characteristics of the particle itself (surface properties, particle sizes, particle shapes and etc.), the electrostatic interactions among the particles and the influences of the medium in the suspensions. Here, we studied the transition between the flow units with shear rate which can be added to the above factors. For the concentrated starch-water suspensions, by using the Couette type rotational viscometer, we confirmed that at low shear rate, dilatancy is appeared, but it is transformed to thixotropy with increasing shear rate. In order to explain this fact, we derived the following flow equation, representing the transition from dilatancy to thixotropy with shear rate, by assuming the equilibrium between the flow units. f = X1β1s./α1 + 1/(1+Kexp(c0s.2/RT))((1-X1)/α2)sinh-1{(β2)0 s. exp(c2s.2/RT)} + K exp(c0s.2/RT)/(1+K exp(c0s.2/RT))((1-X1)/α3)sinh-1{(β3)0 s. exp(-c3s.2/RT)} By applying this flow equation to the experimental flow curves for the concentrated starch-water suspensions, the flow parameters were obtained. And, by substituting the obtained flow parameters to the flow equation, the theoretical flow curves were reproduced. Also, Ostwald curve was represented by applying the flow equation, and the applicability for stress relaxation was discussed.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.12
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• pp.1567-1572
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• 2004

Although accurate measurement of velocity profiles, multiple velocity vectors, and shear stress in arteries is important, there is still no easy method to obtain such information in vivo. This study shows the utility of combining ultrasound contrast imaging with particle image velocimetry (PIV) for non-invasive measurement of velocity vectors. The steady flow analytical solution and optical PIV measurements (for pulsatile flow) were used for comparison. When compared to the analytical solution, both echo PIV and optical PIV resolved the steady velocity profile well. Error in shear rate as measured by echo PIV (8%) was comparable to the error of optical PIV (6.5%). In pulsatile flow, echo PIV velocity profiles agreed well with optical PIV profiles. Echo PIV followed the general profile of pulsatile shear stress across the artery but underestimated wall shear at certain time points. These studies indicate that echo PIV is a promising technique for the non-invasive measurement of velocity profiles and shear stress.

• Journal of the Korean Society of Visualization
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• v.20 no.1
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• pp.52-63
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• 2022

Direct numerical simulation of blood flow in a stenosed, patient-specific carotid artery was conducted to explore the transient behavior of blood flow with special emphasis on the wall-shear stress distribution over the transition region. We assumed the blood as an incompressible Newtonian fluid, and the vessel was treated as a solid wall. The pulsatile boundary condition was applied at the inlet of the carotid. The Reynolds number is 884 based on the inlet diameter, and the maximum flow rate and the corresponding Womersley number is approximately 5.9. We found the transitional behavior during the acceleration and deceleration phases. In order to quantitatively examine the wall-shear stress distribution over the transition region, the probability density function of the wall-shear stress was computed. It showed that the negative wall-shear stress events frequently occur near peak systole. In addition, the oscillatory shear stress index was used to further analyze the relationship with the negative wall-shear stress appearing in the systolic phase.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.7
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• pp.920-928
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• 2003

The objective of the present study was to investigate the characteristics of flow and wall shear stress under steady and pulsatile flow in the aneurysm. The numerical simulation using the software were carried out for the diameter ratios ranging from 1.5 to 3.0, Reynolds number ranging from 900 to 1800 and Womersley number, 15.47. For steady flow, it was shown that a recirculating vortex occupied the entire bulge with its core located closer to the distal end of the bulge and the strength of vortex increased with increase of the Reynolds number and diameter ratio. The position of a maximum wall shear stress was the distal end of the aneurysm regardless of the Reynolds number and diameter ratios. For the pulsatile flow, a recirculating flow at the bulge was developed and disappeared for one period and the strength of vortex increased with the diameter ratio. The maximum values of the wall shear stress increased in proportion to the diameter ratio. However, the position of a maximum wall shear stress was the distal end of the aneurysm regardless of the diameter ratios.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.318-323
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• 2001

Characteristics of the pulsatile flow in a 3-dimensional elastic blood vessel are investigated to understand the blood flow phenomena in the human body arteries. In this study, a model for the elastic blood vessel is proposed. The finite volume prediction is used to analyse the pulsatile flow in the elastic blood vessel. Variations of the pressure, velocity and wall shear stress of the pulsatile flow in the elastic blood vessel are obtained. The magnitudes of the velocity waveforms in the elastic blood vessel model are larger than those in the rigid blood vessel model. The wall shear stresses on the elastic vessel vary with the blood vessel motions. Amplitude indices of the wall shear stress for blood in the elastic blood vessel are $4\sim5$ times larger than those of the Newtonian fluid. As the phase angle increased, point of the phase angle is are moved forward and the wall shear stresses are increased for blood and the Newtonian fluid.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.13 no.2
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• pp.177-188
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• 2001

The paper presents the method to estimate the bottom shear stress driven by waves and current on rough turbulent flow. Parameter adjusting technique is suggested for the computation of bed shear stress driven by uni-directional flow, and the value ofpararneter is determined by comparing the computational results against Bijker's laboratory data. For the computation of combined flow bottom shear stress, two methods are presented; one is the modified Bijker approach (BYO Model) and the other is the modified Fredsoe approach (FY Model), both of which are refined by the present writers. BYO model is again refined in the computation of maximum shear stress, and the final version is tested against Bijkcr's laboratory data.