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Reproductive and Developmental Toxicity Study of 1,4-Dichlorobutane (1,4-Dichlorobutane 생식능 및 차세대영향시험)

  • Chung, Yong Hyun;Kim, Jong Kyu;Yu, Wook Joon
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.23 no.3
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    • pp.273-286
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    • 2013
  • Objectives: The present study was conducted in order to investigate the reproductive toxicity in rats exposed to 1,4-dichlorobutane. Methods: The test chemical was administered orally at 0, 8.3, 50 and 300 mg/kg/day. Males were administered daily for 10 weeks prior to the mating period. Females were administered from between two weeks before mating to the 21stday of lactation. Results: In both sexes, a decrease in body weight and an increase in the weights of the liver and kidneys were observed. In males, discoloration of the liver, hepatocyte hypertrophy and mineralization in the kidneys were observed. In females, animal deaths, dystocia and pup deaths due to maternal dysfunction were observed. In F1 animals of both sexes, a decrease in body weight was observed at 300 mg/kg/day. An increase in the weights of the liver in both sexes, mineralization in the kidneys of males, animal deaths, hepatocyte hypertrophy and pup deaths due to maternal dysfunction were observed at 50 mg/kg/day. Mineralization in the kidneys of males was observed at 8.3 mg/kg/day. Therefore, the no-observed-adverse-effect levels (NOAELs) of 1,4- dichlorobutane were considered to be under 8.3 mg/kg/day for males, 8.3 mg/kg/day for females, more than 300 mg/kg/day for fertility in both sexes, 8.3 mg/kg/day for maternal functions and 50 mg/kg/day for F1 offspring. The absolute toxic dose was believed to be 8.3 mg/kg/day for males, 50 mg/kg/day for females, 50 mg/kg/day for maternal functions and 300 mg/kg/day for F1 offspring. However NOAEL for fertility could not be determined since there were no treatment-related changes. Conclusions: Under the present experimental conditions, 1,4-dichlorobutane is a Category 1B Reproductive Toxicant (presumed human reproductive or developmental toxicant).

A ROENTGENOCEPHALOMETRIC STUDY ON SOFT TISSUE PROFILE CHANGES IN PRE-POST TREATMENT OF ANGLE'S CLASS III MALOCCULUSION (Angle씨 제 3 급 부정교합 환자 치료 전후의 안모 연조직 변화에 관한 두부방사선 계측학적 연구)

  • Kim, Jai-Woo;Sohn, Byung-Wha
    • The korean journal of orthodontics
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    • v.13 no.2
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    • pp.177-183
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    • 1983
  • The soft tissue covering of the face plays an important role in facial esthetics, speech and other physiologic functions. Thus, it is recognised by all clinical orthodontists that success of orthodontic treatment is closely related to the changes in soft tissues of the face. The purpose of this study was to evaluate the changes of bony and soft tissues in prepost treatment of Angle's Class III malocclusion. The sample consisted of 18 males and 37 females, pretreatment age of 9 years to 11 years. For this study 11 landmarks were plotted, 14 linear length, 4 soft tissue thickness and 2 angles were measured. The obtained results were as follows; 1. In the linear measurements of bony and soft tissue changes, A, Is, Ss, Ls and Li were located more anteriorly in both sexes. However Si and B showed more remarkable anterior movement in female. 2. In the comparison of the changes of the soft tissue thickness, Ss and Li in male subjects and Ss in female subjects increased. 3. In the degree of correlation between changes in the soft tissue profile and changes in the skeletal profile, Is: Ls, Il: Li and B: Si in both sexes had significant correlations. However A:Ss had remarkable significant correlation in female. 4. There were significant correlations between change in ${\angle}A$ and change in ${\angle}B$ in all sexes. 5. There were little correlation between changes in distance difference of Is and Ii and Change in distance difference of Ls and Li in all sexes.

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A ROENTGENOCEPHALOMETRIC STUDY ON SOFT TISSUE PROFILE CHANCES IN PRE-POST TREATMENT OF ANGLE'S CLASS II DIVISION 1 MALOCCLUSION (Angle씨 제 2 급 1류 부정교합환자 치료 전후의 안모 연조직 변화에 관한 두부방사선 계측학적 연구)

  • LEE, Y.W.;Sohn, Byung Hwa
    • The korean journal of orthodontics
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    • v.13 no.2
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    • pp.193-199
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    • 1983
  • The purpose of orthodontic treatment is to produce functional occlusion and to create or maintain facial esthetic harmony. The soft-tissue covering of the face also plays an important role in facial esthetics, speech and other physiologic functions. The study of the soft-tissue profile is important for the planning of orthodontic treatment. The author studied cephalometric X-ray films on 49 patients (23boys, 26 girls) with Angle's class II division 1 malocclusion, ranged from 9 to 13 years of age. Roentgenocephalmetric X-ray films were taken pre and post orthodontic care. Tracings were made in usual manner. The obtained results were as follow. 1. There was no significant sexual difference on mean changes. 2. In the comparison of the soft-tissue thickness changes, Ls-Ls' and Si-Si' in male subjects were remarkable. 9. There were significant correlations between osseous (Ss') change and soft-tissue (Ss) chang, of maxilla in male and female subjects subsequent to orthodontic treatment. 4. The ratios between the protraction of the Ss' and that of the Ss were 1:1.5 in all sexes, the ratios between the Si' and that of the Si were 1:1.4 in male and 1:1.2 in female. 5. There were significant correlations between maxillary central incise. angulation change $({\angle}A)$ and upper lip inclination change $({\angle}B)$ in all sexes. 6. There were little correlations between change in distance difference of Is and Ii and change in distance difference of Ls and Li in all sexes in all sexes.

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An Ananlysis on the Clothing Pracices between Seoul and yanbian -Focusing on the clothing weight- (서울.연변간 착의실태 조사분석 -착의량을 중심으로-)

  • Oh, Soon;Lee, Won-Ja
    • Journal of the Korean Society of Clothing and Textiles
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    • v.23 no.7
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    • pp.1019-1029
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    • 1999
  • In order to find out the influences upon not only the thermal resistance of human body but also the clothing action and the clothing weight which are caused by the differences in the thermal living conditions by using air conditioner and so on to adapt themselves to the changes of their residential environment according to the changes of seasons we investigated the clothing practices upon the male and female students in Seoul and Korean male and female students in Yanbian who are estimated to have different thermal living conditions in spite that they are same folk as well as living in the same age. 1. The total clothing weight of body surface erea was increased in order of summer autumn spring and winter seasons and by seasons the changes of the clothing weight were found in both areas, In Seoul the changes of upper outwear clothing weight were found on both sexes but in Yanbian the changes of underwear weight were found on both sexes. And the underwear weight of both sexes in Seoul was lighter than that of both sexes in Yanbian. 2. Those in Seoul tended to fell colder in winter and hotter in summer than those in Yanbian on account that the formers are more sensitive of thermal conditions than the latters. 3. Comparing clo-value claculated by the fomula of with the Winshlow's clo-value those in Yanbian had higher thermal resistance than those in Seoul. Consequently those in Seoul adapted thermselves to the seasons by controling the upper outwear weight but those in Yanbian did it with underwear weight, The male and female students in Seoul tended to feel colder in winter and hotter in summer than hose in Yanbian because the thermal sense of the former is more sensitive than that of the latter.

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Nationwide Study on the Characteristics of Patients Visiting and Using Korean Medical Facilities by Sex (전국민을 대상으로 한 한방의료기관 이용환자의 성별 이용실태 및 특성비교연구)

  • Jung, HaeChang;Park, HaeMo;Lee, Sundong
    • The Journal of Korean Medicine
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    • v.35 no.1
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    • pp.75-87
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    • 2014
  • Objectives: This study aimed to analyze the utilization of Korean medical clinics by sex. Methods: Data was based on reports about usage and consumption of Korean medicine in 2011 by the Ministry of Health and Welfare and Korea Institute for Health and Social Affairs. 171 Korean medical hospitals and more than 300 Korean medical clinics were selected after 2 rounds of extraction, from the 12,250 Korean medical institutions throughout the country. The investigation was carried out between August 25 and September 30, 2011. The study group was composed of 290 men and 813 women; Korean medical institutions including clinics and hospitals were mainly used for their health care. Results: 1. For sociodemographic distribution, sex, marital status, education level, occupation status, and income level showed statistically significant differences. 2. Females had a lower subjective health status than did males. Muscle injury, hwa-byung, gastric disorder, lumbago, common cold, weight loss, and herbal tonics showed differences in prevalence rates between the sexes. 3. Arthritis, muscle injury, gastric disorder, ankle sprain, herbal tonics, and stroke showed differences in usage rates between the sexes. Likewise, major treatment methods had differences between the sexes. 4. There were no statistically significant differences between the sexes concerning acupuncture. Conclusions: Females were lower than males in several aspects of income and education level and occupation status. Males had a higher subjective health status than did females. Differences by sex of treatment methods and prevalence rates of several diseases existed.

A Study on Gender Images in Men's Fashion -Since the Middle of the 19th century- (남성패션에 표현된 성적 이미지에 관한 연구;19세기 중반 이후를 중심으로)

  • 이민선
    • Journal of the Korean Society of Clothing and Textiles
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    • v.23 no.6
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    • pp.776-787
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    • 1999
  • The purpose of this study is to analyze the factors which have formed gender images in men's fashion since the middle of the 19th century. For this purpose, the images of gender in fashion were analyzed and historical studies about gender images in men's fashion from the middle of the 19th century to the present days were done. Historically images of gender expressed in fashion were masculine image feminine image androgynous image and genderless image. Among those images masculine image and genderless image. Among those image masculine image and androgynous image have been the gender images in men's fashion since the middle of the 19th century. In psychoanalytic view point the factors which have formed the gender images are related with sexual pleasure. Libido for looking narcissism and exhibitionism have produced masculine image and androgynous image in men's fashion, In socioeconomic view point power structure between the sexes have built the gender images in fashion. Masculine image and androgynous image came in to being in men's fashion for the purpose of displaying power or expressing opposition to power structure between the sexes, In aesthetic view point the aesthetic sense of each age about sex have constructed the gender images. Modernism had influence on building masculine image and post-modernism have formed androgynous image in men's fashion.

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Acute and Subacute Toxicity of New Woohwangchungsimwon in Rats (랫드에서 신우황청심원의 급성 및 아급성독성시험)

  • 오승민;남혜윤;김준수;연제덕;신대희;이진영;박대규;조명행;정규혁
    • Toxicological Research
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    • v.14 no.2
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    • pp.237-248
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    • 1998
  • The acute and subacute toxicity of New Woohwangchungsimwon(NWCH) which was used l-muscone as substitutive material of musk were investigated in S.D. rats. In intraperitoneal acute toxicity test. rats(Sprague-Dawley, SPF) were injected intraperitoneally with dosages of 0, 540, 750, 1,070, 1.500 and 3,000 mg/kg. Body weights were significantly decreased at 540 mg/kg dose group in both sexes and abnormal autopsy findings were founded in both sexes at all treated groups. Intraperitoneal $LD_{50}$ of NWCH was 812.3 mg/kg in male and 872.3 mg/kg in female rats. In the subacute toxicity study, NWCH was administrated orally to both sexes of rats for 4 weeks as several doses(0, 320, 800 and 2, 000 mg/kg). There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, hematology, serum biochemical analysis, and other findings. Above data strongly suggest that no observed adverse effect level of NWCH might be over 2,000 mg/kg/day in this study.

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Sweating Rates and Thermoregulation in Male and Female Bali Cattle

  • Kasa, I Wayan
    • Asian-Australasian Journal of Animal Sciences
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    • v.10 no.2
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    • pp.201-205
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    • 1997
  • An experiment has been conducted to compare the sweating rate between male and female Bali cattle under tropical conditions in Bali, Indonesia with dry bulb (DB) temperatures varying from 25 to $34.5^{\circ}C$ and relative humidity (RH) 70 to 98%. Rectal temperature (Tr) was significantly different (p < 0.05) between males and females (39.7 vs $39.4^{\circ}C$ compared to 39.2 vs $38.8^{\circ}C$ on weeks 1 and 8 respectively). There were significant effects on RR associated with both $week{\times}sex$ (p < 0.01) and $sex{\times}time$ (p < 0.01) interactions, with values for males higher than females. Skin temperature (Ts) differed significantly between sexes (p <0.05), weeks (p < 0.05) and times (p < 0.01); being lower in females (36 vs $36.4^{\circ}C$). With prolonged working, there were marked increase in RR were recorded after 30 minutes (the overall increase was $12.4^{\circ}C$). Sweating rate (SR) differed significantly between sexes (p < 0.05), weeks (p < 0.01) and times (p < 0.01) during exercise. Females had a lower mean SR ($225.3g/m^2/h$) than males ($238.8g/m^2/h$). With increasing time, the highest SR was achieved after 30 minutes of exercise of $313.3g/m^2/h$.

A Study on the Men's Underclothes of Renaissance Ages (르네상스시대의 남성속옷에 관한 고찰)

  • 김주애
    • Journal of the Korean Society of Costume
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    • v.40
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    • pp.171-180
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    • 1998
  • This is a study on the Men's Underclothes of Renassience Ages. The changes associated with the Tudor regime were sufficiently profound to afect the nature and purpose of underclothes. Ceasing to be merely a layer serving to protect the skin, they now began to assist the external costume of both sexes in expressing class distinction. In order to attract still greater attention, the edge of the shirt was ruffled at the neck, a decoration which soon developed into a separate accessory, the ruff. The waistcoat, which originally was an under-garment, was shown, when the doublet was taken off, en deshabille. Thus we see that for men in the sixteenth century the undergarment was no longer an obscure drudge, but was promoted to serve in the general mode of expressing what the whole costume so extravagantly announced ; and likewise to share in that extreme degree of the social superior. The pinched waist of both sexes was not so much for sex attraction, but to signify social superiority. In the period under considera-tion, then, from the Tudors to the end of the Jacobeans, the new function of underclothes was much the same for both sexes ; to exploit the grandeur of the costume as evidence of rank, and only by that indirect method to add to the wearer's sex attractions.

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A Study on the Property of the Foot Form of Early Childhood Children from Three to Six Years old(II) - On the Classification of Foot Type - (적료의 말 형태에 관한 연구(II) - 유형분석을 중심으로 -)

  • 문명옥
    • Journal of the Korean Society of Clothing and Textiles
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    • v.21 no.1
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    • pp.144-154
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    • 1997
  • For design of early childhood children's footwear, this study was to analyze the foot type by factor analysis and cluster analysis. This study was performed 200 male and 200 female early childhood children from 3 to 6 years, reported in part 1. The result was as follows : 1. There are no significant differences concerning significances, factor loading, eigenvalues, and contribution rates of factor among the results abtained by analyzing the male, female and both sexes data. 2. The 1st factor signifies the size factor that represents total foot mass. The average scores of the 1st factor significantly increase with age in both sexes, and those scores of male are significantly higher than those of female. 3. The End factor signifies the height of Tarsal, Heel and Arch. The average scores of the 2nd factor significantly increase with age in both sexes, and there are no significant differences between the average scores of male and female's except the age 3. 4. The 3rd factor signifies the shape of Metatarso-phalanx angle. The average scores of the 3rd factor significantly decrease with age in female. 5. There are four clusters selected by fastcluster in every age group. The characteristics of four clusters of every age group are different significantly.

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