• 한방비만학회지
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• 제15권2호
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• pp.111-122
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• 2015

Objectives: Schizandrae fructus (Schizandra chinensis) is one of very common herbs, it is known as natural antioxidants, anti-inflammatory agent. Also some reports show that its extract works to regulate of dyslipidemia. This study was designed to investigate the effects of Schizandrae fructus chloroform fraction (SFCF) on serum lipid levels in dyslipidemic mice. Methods: The levels of total cholesterol, high density lipoprotein-cholesterol, triglyceride, aspartate aminotransferase (AST), alanine aminotransferase (ALT), fasting blood glucose in serum were measured. Histopathological and gene expression changes in liver tissue were also observed. Results: Oral administration of SFCF lowered levels of total cholesterol and triglyceride, which were elevated by high-fat diet. But SFCF did not affect on weight changes and serum AST, ALT levels in dyslipidemic mice. After carrying out gene ontological analysis, large numbers of genes in high-fat diet group were up-(347) or down-regulated (235). In SFCF treated mice, some changed expression of the genes was restored to normal levels, with a recovery rate of 17%. And it seems that fatty acid biosynthesis pathway was one of important key pathways to recovery. Conclusions: SFCF has beneficial effect on dyslipidemia, and could be used to prevent and treat cardiovascular disease.

• Journal of Nutrition and Health
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• 제25권3호
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• pp.211-220
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• 1992

Both hydrolysed guar gum and polydextrose have been used as a major fiber source in preparations of unctional drink products and other food products. In this study we determined the effects of these fibers on lipid metabolism of normal rats with two different dietary fat levels by using cellulose as the control. Serum total lipid triglyceride total cholesterol and HDL-colesterol were determined with proper enzymatic methods. Feed intake weight gain and feed efficiency ratio were also calcula-ted. Polydextrose-fed group showed lower serum triglyceride level than hydrolysed guar gum-fed group regardless of fat level used in this study without changing total lipid level in the serum. We also observed that polydextrose-fed group showed low serum cholesterol level nummerically high serum HDL-cholestrol level and more excretion of fecal neutral sterols when compare with those values of hydrolysed guar gum-fed group. The results indicate that polydextrose might have more beneficial roles in lipid metabolism when compare with hydrolysed guar gum.

• 대한한방내과학회지
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• 제19권1호
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• pp.202-218
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• 1998

In order to evaluate the effects of SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG(Xinnao-Tong, Jiangzhiyanshou-Dan and Qingxintiaoqi-Tang) on hyperlipidemia, the experimental study was performed in rats without or with hyperlipidemia induced by 2% cholesterol fed-diet or Triton WR-1339. And the levels of serum total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and phospholipid were measured. The results are summarized as follows : In the model of hyperlipidemia induced by 2% cholesterol Fed-diet 1. Both low & highly concentrated GANGJIYOUNSOODAN showed significantly decreasing effects on the level of serum total cholesterol while SIMNETONG & CHUNGSIMJOKlTANG didn't. 2. GANGJIYOUNSOODAN, SIMINETONG and CHUNGSIMJOKITANG showed decreasing effects on the level of serum triglyceride with no statistical significance. 3. Only highly concentrated GANGJIYOUNSOODAN showed increasing effects on the level of serum HDL-cholesterol while the others had no effects. 4. Only highly concentrated GANGJIYOUNSOODAN had decreasing effects on the level of serum LDL-cholesterol while the others had no effects. 5. Highly concentrated GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed significantly decreasing effects on the level of serum phospholipid while the other had no effects. In the model of hyperlipidemia induced by Triton WR-1339 6. SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed slightly decreasing effects on the levels of serum total cholesterol and triglyceride with no statistical significance. 7. None of SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed any effects on the level of serum HDL-cholesterol. 8. Highly concentrated GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed decreasing effects on the level of serum LDL-cholesterol but the other had no effects. 9. All of highly concentrated SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed decreasing effects on the level of serum phospholipid with statistical significance. These results show that GANGJIYOUNSOODAN and CHUNGSIMJOKITANG, in orders, have antihyperlipidemic effects. Further study on the mechanism and on the herb screening of these prescription should be followed.

• 생명과학회지
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• 제17권4호
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• pp.529-534
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• 2007

계란 섭취 수준이 흰쥐의 지질대사 및 혈청의 단백질, 무기질, 혈당 농도 및 효소활성에 미치는 영향을 조사하고자, 성숙한 숫쥐를 대조식이군, 대조식이에 계란 분말을 5, 10 및 15%씩 혼합한 식이군(5, 10 및 15% 계란군)등 4군으로 나누어 4주간 사육한 결과는 다음과 같다. 실험동물의 체중증가량은 대조군에 비해 계란군들이 유의성 있는 차이는 나타나지 않았다. 간의 무게 및 간조직의 콜레스테롤과 중성지질 함량은 대조군에 비해 5, 10 및 15% 계란군들이 유의하게 증가되었다. 신장과 부고환 지방의 무게는 대조군과 계란군들이 비슷하였다. 혈청의 중성지질, 총 콜레스테롤, HDL-콜레스테롤 및 LDL+VLDL-콜레스테롤 농도는 대조군에 비해 각 수준별 계란군이 유의성 있는 차이는 나타나지 않았다. 총 콜레스테롤에 대한 HDL-콜레스테롤의 비율은 5% 계란군이 15% 계란군 보다 유의하게 증가되었고, 동맥경화지수는 5% 계란군이 10 및 15% 계란군 보다 유의하게 낮추는 것으로 나타났다. 혈청의 총 단백질과 알부민 농도는 대조군에 비해 및 10 및 15% 계란군이 유의하게 증가되었다. 혈청의 요소질소, 크레아티닌, 혈당, 혈색소 농도 및 효소활성은 계란섭취에 의한 영향은 나타나지 않았다. 혈청의 칼슘 농도는 대조군에 비해 계란 섭취군들이 유의하게 증가되었다.

• 대한의생명과학회지
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• 제16권1호
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• pp.19-24
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• 2010

We analyzed and compared the concentration of total cholesterol (CHOL), high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol and triglyceride (TG) in serum and the serum protein electrophoresis fractions of thyroid disease patients. In comparison with the average of reference, our data showed that the average concentration of CHOL, LDL cholesterol and TG in hyperthyroidism patients were decreased significantly, but HDL cholesterol was increased significantly. In hypothyroidism patients, CHOL, HDL cholesterol, LDL cholesterol and TG were all increased significantly. In comparison of the concentration of lipids in each patient to reference range, 28.3% of hyperthyroidism patients showed abnormally low level of total cholesterol. In the patients with hypothyroidism, the percentage of patients showed abnormally high level of CHOL, HDL cholesterol, LDL cholesterol and TG were 37.7%, 10%, 68.8% and 49.1%, respectively. In our studies of serum protein electrophoresis, the average of ${\alpha}_2$-globulin and $\gamma$-globulin in hyperthyroidism patients were increased and $\beta$-globulin was decreased significantly. In hypothyroidism patients, the average of $\gamma$-globulin was increased and $\beta$-globulin was decreased significantly. In comparison of protein fractions of each patient to reference range, 38.3% and 50.0% of hyperthyroidism patients showed abnormally high levels of ${\alpha}_2$-globulin and $\gamma$-globulin, but 73.3% of patients showed abnormally low level of $\beta$-globulin. In hypothyroidism patients, 70.4% of patients were abnormally decreased in $\beta$-globulin and 63.9% of patients were abnormally increased in $\gamma$-globulin. These data suggest that the concentrations of CHOL, HDL cholesterol, LDL cholesterol and TG are not critical data for clinical interpretation of hyperthyroidism, but the levels of them are useful for interpretation of hypothyroidism patients. Our results of serum protein electrophoresis suggest that the concentration of serum protein electrophoresis fractions can be useful to understand the thyroid disease.

• 동아시아식생활학회지
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• 제16권3호
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• pp.281-291
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• 2006

This study investigated the effect of the powder of the small water dropwort(PSWD) and brewer's yeast(BY) on the liver function and serum lipid metabolism in alcohol-consuming rats. Male Sprague-Dawley rats were fed an AIN-93 diet(control), ethanol plus control(A), ethanol plus PSWD(AS), ethanol plus BY(AB), ethanol plus PSWD and BY(ABS) diet for seven weeks. The feed intake, body weight gain and feed efficiency ratio were the lowest and in the alcohol-consuming groups. The weight of the liver, kidney, spleen and epididymis of the anatomized rats showed positive correlation with the body weight gain. Compared with group A, the content of the lipid in the serum was significantly low in the AS and AB groups. In particular, it was the most effective in the AB group. The GOT, GPT and ALP level in the serum showed a significant difference in the alcohol-consuming groups. Compared with the A group, they showed a significantly low difference in the AS and AB groups. The total cholesterol and triglyceride levels in the liver were similar in all groups. The weight of the feces was significantly different but there was no significant difference in the content of total cholesterol and triglyceride levels in the AS and AB groups. These results suggest that BY and PSWD improve the liver function, and had an effect on reducing the lipid content of the serum and feces of alcohol-consumed rats. In particular, the effect of BY which contained protein, dietary fiber and vitamin B was higher than that of PSWD.

• 한국식품영양과학회지
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• 제37권12호
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• pp.1583-1588
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• 2008

본 연구는 건강진단센터에서 건강검진을 받은 검진자 293 명을 고지혈증 치료지침 혈중지질 농도 기준에 따라 정상군, 경계군, 위험군으로 분류하여 신체계측, 혈액 성분 및 혈압, 영양소 섭취량을 조사하여 혈중지질 농도에 영향을 주는 요인을 분석하였다. 각 군별 체중, 체지방율, 허리둘레, 체질량지수 평균은 정상군에 비해 경계군, 위험군이 유의적으로 높았다. 열량 섭취량은 정상군 1,818.3 kcal, 경계군 1,803.0 kcal, 위험군 1,999.5 kcal로 정상군에 비해 위험군이 유의적으로 높았다. 에너지원인 탄수화물, 지질, 단백질 섭취량에 서 정상군에 비하여 위험군이 모두 유의적으로 높았다. 한편 연구대상자들의 혈중 중성지방 농도에 따라 영양소 섭취량을 비교한 결과 정상혈중중성지방군보다 위험혈중중성지방군인 대상자에서 열량, 탄수화물, 지질, 단백질 섭취량이 유의적으로 높았다. 영양소 섭취와 혈중지질 농도 간의 상관관계 분석 결과 열량, 탄수화물, 지질, 단백질 섭취량이 혈중 중성지방 농도와 양의 상관관계를 나타내었고, 탄수화물 섭취량과 혈중 HDL-콜레스테롤 농도는 음의 상관관계를 나타내었다. 결론적으로 본 연구에서 고지혈증 혹은 혈중 중성지방 농도가 높은 대상자들에게서 모두 열량, 탄수화물, 지질, 단백질 섭취량이 높게 나타나 우리나라 사람들의 고지혈증 요인 중의 하나가 과잉 식이섭취에 의한 것임을 알 수 있다. 따라서 성인의 건강한 혈중지질 농도를 유지하기 위해 과잉 식이섭취에 의한 비만을 예방하고 특히 적절한 지방 및 탄수화물의 섭취를 위한 영양교육이 필요할 것으로 사료된다.

• Journal of Nutrition and Health
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• 제28권9호
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• pp.862-871
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• 1995

This study was designed to investigate the effectiveness of ginseng intakes in modifying serum lipid profiles and plasma clotting factors. The participants in this study were 47 normal healthy volunteers(men 24, women 23) with an age range of 35-49 years and a mean age of 41 years residing in Taejon. Based on the diet intakes, subjects were classed into one of three groups : control, vegetarian, and ginseng consumed over 3-4 years. There was no significant difference in their physical characteristics. Dietary calorie intakes were not significantly different in subjects. The ratio of energy intake in the control and ginseng consumed group was 63-64% : 20-21% : 15-16%(Cho : Fat : Pro), but 70-73% : 13-14% :14-15%(Cho : Fat : Pro) in the vegetarians. The intakes of animal food in the vegetarian was significantly lower than the control and ginseng consumed group in men. The ratio of P/S(1.27) was the highest in the vegetarians. Venous blood samples were taken for serum lipid profiling, plasma clotting assay and platelet function. The concentration of serum triglyceride in the men ginseng group is significantly lower than those of the men control group. Serum lipid profiles values of the men ginseng group, such as total cholesterol and phospholipid were lower those of the men control group, but higher those of the men vegetarian group. the serum lipid profile in the women were not significant, but total cholesterol, triglyceride and LDL cholesterol levels in the ginseng groups were low. The concentration of HDL cholesterol was not significantly different. Platelet cell count and platelet aggregation were low in the ginseng groups. APTT(Activated Partial thromboplastin time) was significantly elongated in ginseng groups in the normal range. In seems that the major beneficial effects of ginseng intakes in especially men were on the blood concentrations of triglyceride, total cholesterol and elongation of plasma clotting time.

• Preventive Nutrition and Food Science
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• 제3권1호
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• pp.71-76
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• 1998

This study investigated the effect of regular exercise on serum lipid profiles and carnitine levels in college students. Daily nutrient intake, anthropometry , serum lipid, and carnitine profiles in serum and urine were evaluated prior to beginning the study and after 35 days of treadmill running for 30 minutes per day. The results obtained were summarized as follows : 1) Concentrations of total lipid and Triglyceride in serum were decreased by regular exercise in female subjects but unaffected in males. 2) Serum LDL-cholesterol was significantly decreased, but total cholesterol and HDL-cholesterol in serum were not affected in both male and female subjects. 3) nonesterified carnitinem, acid-insoluble acylcarnitine, and total carnitine levels in serum were not affected, but acid-soluble acylcarnitine level was increased by regular exercise in both subjects. 4) Urinary excretionof the acid-soluble acylcarnitine level was increased by regular exercise -training. These results suggest that regular exercise -training has different effects on serum lipid oxidation via carnitine metabolism in this condition.

• 동아시아식생활학회지
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• 제8권2호
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• pp.93-106
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• 1998

This study was designed to find out the effects on the lipid metabolism of two herbs used in folk treatment in Korea The two herbs were A: Equisetum arvense L. (Seddugi), B: Eunymus alatus Siebold (Hwasalnamoo). The experiment was performed with the male rats of Sprague-Dawley which fed on high calorie and animal fat supplemented diets from which 30% of the total calories can from lard. Experimental groups were divided into standard (ST) and two other(A, B) groups for the each herb. Each of the two experimental groups consisted of three subgroups (I, II, III) according to the three different doses of the folk remedy used, which were five times and ten times the dose commonly used in a folk remedy. During the experimental period, total food intake and body weight gains were measured, and FER, CER, PER were calculated at the same times. Serum levels of triglyceride, total lipid, ttal cholesterol, HDL-cholesterol, and total lipid as well as cholesterol contents of the liver were measured at the time of sacrifice. Epididymal fat pads were weighted and an indes was calculated. The results of the effects on the lipid metabolism were as follows : 1.Total food intake and body weight gains increased in group A & B. 2. The serum levels of the total lipid and triglyceride decreased in AIII, BI and BIII.3. The serum level of cholesterol decreased in group B, while level of HDL-Cholesterol were increased in all groups and most effectively in group B. 4. The contents of total liver lipid increased in groups A&B. cholesterol decreased in groups A&B. In conclusion, effects on the lipid metabolism associated with the kinds of herbs a diet were the increase of body weighta and the decrease of total lipid and cholesterol levels in serum and liver.