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http://dx.doi.org/10.15429/jkomor.2015.15.2.111

The Effects of Schizandrae Fructus Chloroform Fraction on Gene Expression in Liver Tissue of Dyslipidemic Mice  

Shin, Yoon Ri (Department of Caridovascular and Neurologic Disease, College of Oriental Medicine, Dong-Eui University)
Kim, Young Kyun (Department of Caridovascular and Neurologic Disease, College of Oriental Medicine, Dong-Eui University)
Kim, Kyoung Min (Department of Caridovascular and Neurologic Disease, College of Oriental Medicine, Dong-Eui University)
Publication Information
Journal of Korean Medicine for Obesity Research / v.15, no.2, 2015 , pp. 111-122 More about this Journal
Abstract
Objectives: Schizandrae fructus (Schizandra chinensis) is one of very common herbs, it is known as natural antioxidants, anti-inflammatory agent. Also some reports show that its extract works to regulate of dyslipidemia. This study was designed to investigate the effects of Schizandrae fructus chloroform fraction (SFCF) on serum lipid levels in dyslipidemic mice. Methods: The levels of total cholesterol, high density lipoprotein-cholesterol, triglyceride, aspartate aminotransferase (AST), alanine aminotransferase (ALT), fasting blood glucose in serum were measured. Histopathological and gene expression changes in liver tissue were also observed. Results: Oral administration of SFCF lowered levels of total cholesterol and triglyceride, which were elevated by high-fat diet. But SFCF did not affect on weight changes and serum AST, ALT levels in dyslipidemic mice. After carrying out gene ontological analysis, large numbers of genes in high-fat diet group were up-(347) or down-regulated (235). In SFCF treated mice, some changed expression of the genes was restored to normal levels, with a recovery rate of 17%. And it seems that fatty acid biosynthesis pathway was one of important key pathways to recovery. Conclusions: SFCF has beneficial effect on dyslipidemia, and could be used to prevent and treat cardiovascular disease.
Keywords
Fructus schizandrae; Fraction; Microarray analysis; Dyslipidemias; Gene ontology;
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Times Cited By KSCI : 7  (Citation Analysis)
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