The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Experimental study on the effects of SIMNETONG, GANGJIYOUNSOO-DAN and CHUNGSIMJOKITANG(Xinnao-Tong, Jiangzhiyanshou-Dan and Qingxintiaoqi-Tang) on hyperlipidemia

심뇌통(心腦通),강지연수단(降脂延壽丹) 및 청심조기탕(淸心調氣湯)의 고지혈증(高脂血症)에 대(對)한 실험적(實驗的) 연구(硏究)

  • Kim, Young-Suk (Department of Cardiac Internal Medicine, Kyung Hee University, College of Oriental Medicine) ;
  • Moon, Sang-Kwan (Department of Cardiac Internal Medicine, Kyung Hee University, College of Oriental Medicine) ;
  • Ko, Chang-Nam (Department of Cardiac Internal Medicine, Kyung Hee University, College of Oriental Medicine) ;
  • Joh, Ki-Ho (Department of Cardiac Internal Medicine, Kyung Hee University, College of Oriental Medicine) ;
  • Bae, Hyung-Sup (Department of Cardiac Internal Medicine, Kyung Hee University, College of Oriental Medicine) ;
  • Lee, Kyung-Sup (Department of Cardiac Internal Medicine, Kyung Hee University, College of Oriental Medicine) ;
  • Bao, Pei-Rong (Internal Department, Hospital attached to Shangdong University of TCM) ;
  • Cao, Xiao-Lan (Internal Department, Hospital attached to Shangdong University of TCM) ;
  • 김영석 (경희대학교 한의과대학 심계내과학교실) ;
  • 문상관 (경희대학교 한의과대학 심계내과학교실) ;
  • 고창남 (경희대학교 한의과대학 심계내과학교실) ;
  • 조기호 (경희대학교 한의과대학 심계내과학교실) ;
  • 배형섭 (경희대학교 한의과대학 심계내과학교실) ;
  • 이경섭 (경희대학교 한의과대학 심계내과학교실) ;
  • 노상겸 (산동중의약대학 심혈관과교실) ;
  • 조효란 (산동중의약대학 심혈관과교실) ;
  • 곽위성 (산동중의약대학 심혈관과교실)
  • Published : 1998.08.30
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Abstract

In order to evaluate the effects of SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG(Xinnao-Tong, Jiangzhiyanshou-Dan and Qingxintiaoqi-Tang) on hyperlipidemia, the experimental study was performed in rats without or with hyperlipidemia induced by 2% cholesterol fed-diet or Triton WR-1339. And the levels of serum total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and phospholipid were measured. The results are summarized as follows : In the model of hyperlipidemia induced by 2% cholesterol Fed-diet 1. Both low & highly concentrated GANGJIYOUNSOODAN showed significantly decreasing effects on the level of serum total cholesterol while SIMNETONG & CHUNGSIMJOKlTANG didn't. 2. GANGJIYOUNSOODAN, SIMINETONG and CHUNGSIMJOKITANG showed decreasing effects on the level of serum triglyceride with no statistical significance. 3. Only highly concentrated GANGJIYOUNSOODAN showed increasing effects on the level of serum HDL-cholesterol while the others had no effects. 4. Only highly concentrated GANGJIYOUNSOODAN had decreasing effects on the level of serum LDL-cholesterol while the others had no effects. 5. Highly concentrated GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed significantly decreasing effects on the level of serum phospholipid while the other had no effects. In the model of hyperlipidemia induced by Triton WR-1339 6. SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed slightly decreasing effects on the levels of serum total cholesterol and triglyceride with no statistical significance. 7. None of SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed any effects on the level of serum HDL-cholesterol. 8. Highly concentrated GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed decreasing effects on the level of serum LDL-cholesterol but the other had no effects. 9. All of highly concentrated SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed decreasing effects on the level of serum phospholipid with statistical significance. These results show that GANGJIYOUNSOODAN and CHUNGSIMJOKITANG, in orders, have antihyperlipidemic effects. Further study on the mechanism and on the herb screening of these prescription should be followed.

Keywords

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