• Journal of Sensor Science and Technology
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• v.32 no.6
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• pp.418-424
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• 2023

Natural killer (NK) cells play a crucial role in combating infections and tumors. However, their therapeutic application in solid tumors is hindered by challenges, such as limited lifespan, tumor penetration, and delivery precision. Our research introduces a novel ultrasonic actuation technique to navigate NK cells more effectively in the vascular system, particularly at vessel bifurcations where targeted delivery is most problematic. We use a hemispherical ultrasonic transducer array that generates phase-modulated traveling waves, focusing on an ultrasound beam to steer NK cells using blood-flow dynamics and a focused acoustic field. This method enables the precise obstruction of non-target vessels and efficiently directs NK cells toward the tumor site. The simulation results offer insights into the behavior of NK cells under various conditions of cell size, radiation pressure, and fluid velocity, which inform the optimization of their trajectories and increase targeting efficiency. The experimental results demonstrate the feasibility of this ultrasonic approach for enhancing NK cell targeting, suggesting a potential leap forward in solid tumor immunotherapy. This study represents a significant step in NK cell therapeutic strategies, offering a viable solution to the existing limitations and promising enhancement of the efficacy of cancer treatments.

• Korean Journal of Artificial Intelligence
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• v.12 no.3
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• pp.9-15
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• 2024

This paper addresses the critical need for quadcopters in GPS-denied indoor environments by proposing a novel attitude control mechanism that enables autonomous navigation without external guidance. Utilizing AR marker detection integrated with a dual PID controller algorithm, this system ensures accurate maneuvering and positioning of the quadcopter by compensating for the absence of GPS, a common limitation in indoor settings. This capability is paramount in environments where traditional navigation aids are ineffective, necessitating the use of quadcopters equipped with advanced sensors and control systems. The actual position and location of the quadcopter is achieved by AR marker detection technique with the image processing system. Moreover, in order to enhance the reliability of the attitude PID control, the dual closed loop control feedback PID control with dual update periods is suggested. With AR marker detection technique and autonomous attitude control, the proposed quadcopter system decreases the need of additional sensor and manual manipulation. The experimental results are demonstrated that the quadrotor's autonomous attitude control and operation with the dual closed loop control feedback PID controller with hierarchical (inner-loop and outer-loop) command update period is successfully performed under the non-GPS aided indoor environment and it enhanced the reliability of the attitude and the position PID controllers within 17 seconds. Therefore, it is concluded that the proposed attitude control mechanism is very suitable to GPS-denied indoor environments, which enables a quadcopter to autonomously navigate and hover without external guidance or control.

• Science of Emotion and Sensibility
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• v.9 no.2
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• pp.93-100
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• 2006

This paper aims at the development and clinical evaluation of the wireless gyro-mouse system. The wireless gyro-mouse system is a computer interface with gyro-sensor and wireless communication, for the patients with upper-extremity disabled from the traffic accident or stroke to use the computer software i.e. internet browser. In the development, we focused on, firstly, to make the system wireless for the patients to manipulate the mouse easily even on the bed or wheelchair, secondly, to insert the gyro-sensor into a headband for easy don-and-doff and aesthetic appearance, thirdly, to devise a click switch in case of $C5{\sim}C6$ patients and a head nodding detection in case of C4 patients for sending click message to computer operating system. We performed evaluation experiment for patients with upper-extremities disabled from spinal cord injury. The results show that the displacement error of the cursor position against the target position during linear (vertical/horizontal) movement manipulation decreased with trial number. The click rate per minute also increased with trial number. This indicates the developed wireless gyro-mouse system would be more useful to the patients with repetitive use.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.2451-2456
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• 2003

In biological cell manipulation, manual thrust or penetration of an injection pipette into an egg is currently performed by a skilled operator, relying only on visual feedback information. Massive load of various micro injection of either genes, fluid or cells in the postgenomic era calls a more reliable and automatic micro injection system that can test hundreds of genes or cell types at a single experiment. We initiated to study cellular force sensing in zebrafish eggs as the first step for the development of a more controllable micro injection system by any inexperienced operator. Zebrafish eggs at different developmental stages were collected and an integrated biomanipulation system was employed to measure cellular force during penetrating the egg envelope, the chorion. First of all, the biomanipulation system integrated with cellular force sensing instrument is implemented to measure the penetration force of cell membranes and characterize mechanical properties of zebrafish embryo cells. Furthermore, implementation of cellular force sensing system and calibration are presented. Finally, the cellular force sensing of penetrating cell membranes at each developmental stages was experimentally performed. The results demonstrated that the biomanipulation system with force sensing capability can measure cellular force at real-time while the injection operation is undergoing. The magnitude of the measured force was in the range of several hundreds of uN. The precise real-time measurement should provide the first step forwards for the development of an automatic and reliable injection system of various materials into biological cells.

• Proceedings of the Korea Water Resources Association Conference
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• 2005.09a
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• pp.11-12
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• 2005

With the great advances in process understanding, sensor and instrumentation technology and modelling capability it is important to ask what if any practical benefits can the lake manager and operator look forward to. Here, we examine some of the more important problems facing operators of drinking reservoirs, hydro-lakes and lakes used predominantly for recreation and the environment. In drinking reservoirs the main problems originate from increased loadings of nutrients leading to increased biomass and biomass that may give rise to toxins, of anthropogenic chemicals such as metals and synthetic organics and of pathogens of different types. Hydro-lakes are predominantly plagued by problems arising from low oxygen levels in the hypolimnion and in recreational and environmentally sensitive lakes the biggest challenge for the operator is to maintain an existing or establish a new trophic hierarchy or protect the water body from foreign species. The control variables that are at an operator's disposal are the choice of lake water level, the modification of the water colunm stratification via a de-stratification system, the modification of the lake flow path with flow intervention. curtains, intervention in the catchments to modify the loadings flowing into a lake, manipulation of the trophic chain with introduction of new species and chemical dosing, the latter being of marginal use in a large lake. Each of these options is cost effective under certain-circumstances. We endeavour to provide a users guide for their application and show how, especially new instrumentation and modelling methodologies may be used to achieve an effective intervention.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.1612-1616
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• 2005

In this paper, a Home Mess-Cleanup Robot(HMR), which has a practical function of the automatic mess-cleanup, is developed. The vacuum-cleaner had made the burden of house chore lighten but the operation labour of a vacuum-cleaner had been so severe. Recently, the cleaning robot was producted to perfectly solve the cleaning labour of a house but it also was not successful because it still had a problem of mess-cleaning, which was the clean-up of big trash and the arrangement of newspapers, clothes, etc. The cleaning robot is to just vacuum dust and small trash but has no function to arrange and take away before the automatic vacuum-cleaning. For this reason, the market for the cleaning robot is not yet built up. So, we need a design method and technological algorithm of new automatic machine to solve the problem of mess-cleanup in house. It needs functions of agile automatic navigation, novel manipulation system for mess-cleanup. The automatic navigation system has to be controlled for the full scanning of living room, to recognize the absolute position and orientation of the self, the precise tracking of the desired path, and to distinguish the mess object to clean-up from obstacle object to just avoid. The manipulator, which is not needed in the vacuum-cleaning robot, must have the functions, how to distinguish big trash to clean from mess objects to arrange, how to grasp in according to the form of mess objects, how to move to the destination in according to mess objects and arrange them. We use the RFID system to solve the problems in this paper and propose the reading algorithm of RFID tags installed in indoor objects and environments. Then, it should be an intelligent system so that the mess cleaning task can be autonomously performed in a wide variety of situations and environments. It needs to also has the entertainment functions for the good communication between the human and HMR. Finally, the good performance of the designed HMR is confirmed through the results of the mess clean-up and arrangement.

• Journal of the Korea Convergence Society
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• v.8 no.11
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• pp.21-27
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• 2017

Internet of Things(IoT), which is developing for the hyper connection society, is based on OSHW (Open Source Hardware) such as Arduino and various small products are emerging. Because of the limitation of low performance and low memory, the IoT is causing serious information security problem that it is difficult to apply strong security technology. In this paper, we analyze the vulnerability that can occur as a result of compiling and loading the application program of Arduino on the host computer. And we propose a new attack method that allows an attacker to arbitrarily change the value input from the sensor of the arduino board. Such as a proposed attack method may cause the arduino board to misinterpret environmental information and render it inoperable. By understanding these attack techniques, it is possible to consider how to build a secure development environment and cope with these attacks.

• Convergence Security Journal
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• v.16 no.7
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• pp.139-145
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• 2016

Recently, The attack on the USB and network are increasing in many domestic infrastructure. These attacks are the most independent of insider intention, caused by the Anthropogenic Manipulation. These attacks are Anthropogenic Response Measures for Physical Security. and Representative Technology has CCTV, Access Control System, Sensor Technology. However, Physical Security, it is represented by several Product family according to the Market, has become an obstacle but rather a variety of Physical Security Technology Development and Application. As the Anthropogenic Attacks have occur continually in the network, it need to the proper Physical Response Techniques in this situation. Therefore, In this paper, we will find out about the awareness and demand trends of Physical Security. And The Physical Vulnerable Factors of Network. Thereby this is expected to be utilized as a basis for the domestic Physical Security Technology development and deployment Road-map in a future.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.1D
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• pp.127-132
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• 2011

Load managing method on road became necessary since overloaded vehicles occur damage on road facilities and existing systems for preventing this damage still show many problems. Accordingly, efficient managing system for preventing overloaded vehicles could be organized by using the road itself as a scale by applying genetic algorithm to analyze the load and the drive information of vehicles. First of all, accurate analysis of load using the behavior of road itself is needed for solving illegal axle manipulation problems of overloaded vehicles and for installing intelligent embedded load analyzing system. Accordingly in this study, to use the behavior of road, the transformation was measured by installing underground box type indoor model and indoor experiment was held using genetic algorithm and 10% error were checked.

• Journal of the Korean Society for Marine Environment & Energy
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• v.12 no.1
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• pp.55-59
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• 2009

As one of the methods for recycling the FRP from the small and medium waste ships, separation of roving layer from the mat has some merits in a sense of the recycling energy and the environmental effects. Similar characteristics, however, between the roving and the mat even with different ratio of the resin and the glass and the thickness of the roving, much thinner than the mat, make the mechanically automatic differentiation difficult. In this study spectrochemical differentiation between the two layers has been made using (1) boiling concentrated sulfuric acid which can dissolve the resin in the FRP layer, (2) methanol and isopropanol solution saturated with KOH which can dissolve the glass, or (3) hydrogen fluoride(HF) solution which can reacts with $SiO_2$ fragments of the glass. Furthermore coloring water-soluble dye following the HF treatment makes the roving layer more distinguishable photo-physically.