• Land and Housing Review
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• v.13 no.4
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• pp.91-103
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• 2022

Home has significant meaning in the real world. In contrast, there's a lack of interest in homes in the Metaverse compared to other architectural spaces. This study aims to establish the concept of a home in the Metaverse based on meaning, typology, and characteristics of real-world homes. For this purpose, previous research and existing models of real- world homes were analyzed and case studies and a survey were conducted of homes in the Metaverse. As a result of the research, a model of home in the Metaverse is proposed based on physical, social, and personal models. Modifying one's dwelling, a refuge from the outside world, and self-expression/personalized space was also identified as the most significant characteristic of a home in the Metaverse. The results of this study will be helpful in future Metaverse virtual world research and development of Metaverse service platforms.

• International Journal of Computer Science & Network Security
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• v.21 no.3
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• pp.21-30
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• 2021

Economic transformations have led to an increase in the role of creative assets and their central role in public life. Changes in creative activity have led to a change in the organization of the work of institutes engaged in the training of specialists, in particular teachers of labor education. Methods and approaches to training determine the development of creative industries, being the basis for models of professional training of future teachers of labor training. The purpose of an article was to develop a modern model of professional training of future teachers of labor training based on the concept of creative economy. The methodology is based on the concepts of holistic craft and creative economy. Based on the integration of pedagogical learning models "Craft as design and problem-solving", "Craft as skill and knowledge building", "Craft as product-making" and "Craft as self-expression" developed and experimentally confirmed the conceptual model of professional training of future teachers of labor training. The proposed model forms a practitioner with professional, technical, digital and creative skills who is able to transfer the experience to students. The training course "Creativity and creative thinking" has been developed. The model provided for the development of a course based on the strategy of developing professional creativity, flexibility, improvisation, openness, student activity, joint practice, student-oriented approach. The practical value implies the adaptation of the developed model of professional training of future teachers of labor education during the training of teachers in higher education, which is confirmed in the experiment.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.4
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• pp.177-183
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• 2020

The Hippo-YAP signaling pathway is critical for cell proliferation, survival, and self-renewal in both Drosophila and mammals. Disorder of Hippo-YAP pathway leads to tumor development, progression and poor prognosis in various cancers. YAP/TAZ are the key downstream effectors of the Hippo pathway and they can be inhibited through LATS1/2, core kinases in the Hippo pathway, mediated phosphorylation. In this study, we investigated the effect of Angelica gigas Nakai extract (AGNE) on Hippo-YAP/TAZ pathway. First, ANGE induced YAP/TAZ phosphorylation and dissociation of the YAP/TAZ-TEAD transcription complex. By qRT-PCR, we found that ANGE inhibits the expression of YAP/TAZ-TEAD target gene, CTGF and CYR61. In addition, the transcriptional activity of YAP/TAZ was not suppressed significantly in LATS1/2 double-knockout (DKO) cells by ANGE compared to LATS1/2 wild-type (WT) cells, which means AGNE inhibits YAP/TAZ signaling through direct action on LATS1/2. Further, it was confirmed that AGNE-induced activation of LATS1/2 inhibited the migration potential of the vector-expressing cells by suppressing YAP/TAZ activity. The reduced migration potential was restored in active YAP-TEAD expressing cells. Taken together, the results of this study indicate that ANGE downregulates YAP/TAZ signaling in cells through the activation of LATS1/2.

• Journal of Industrial Convergence
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• v.20 no.6
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• pp.125-133
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• 2022

The purpose of this study was to identify the mediating effects of positive thinking in the relationship between emotional expressivity and public speaking anxiety. Participants were recruited from one university freshmen located in Gwangju city. Data were collected from 146 university freshmen. The self-reported questionnaire was used to assess the level of positive thinking, emotional expressivity, public speaking anxiety. The SPSS WIN 23.0 version program was used with Baron and Kenny's 3-Step mediating effect and Sobel test. It was examined whether there was a mediating effect of positive thinking on emotional expression and presentation anxiety. In the second stage, emotional expressivity showed a significant effect on presentation anxiety. In stage 3, emotional expressivity was not statistically significant in presentation anxiety, and positive thinking was statistically significant in presentation anxiety. Positive thinking had a total mediating effect(z=-4.57, p<.001) in the relationship between emotional expressivity and public speaking anxiety. To reduce the public speaking anxiety among university freshmen, it is necessary to develop interventions that enhance positive thinking in addition to providing emotional expressivity.

• The Journal of the Korea Contents Association
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• v.22 no.7
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• pp.361-369
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• 2022

The purpose of this study was to review the effectiveness of drama program for the people with developmental disabilities in Korea by using method of meta-analysis. At first, master's theses, doctoral dissertations, and journal articles published in Korea up to January, 2022 were reviewed. Resultingly a total of 13 studies were eligible base upon the inclusion criteria. The mean effect sizes and test for homogeneity of effect size (Q-statistic) were analyzed by using Comprehensive Meta-Analysis Software 2.0. The main findings of this study are as follows. First, the average effect sizes for drama program for people with developmental disabilities were ES= 0.8335 for sociality, ES= 0.6512 of self-expression. Second, by analysing the moderate variables of the effect size for drama program for people with developmental disabilities, 'age', 'the number of session' 'the type of drama program', 'the major of drama director' were statistically significant. The research and practice implications of drama programs for people with developmental disabilities in Korea were suggested.

• Molecules and Cells
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• v.45 no.10
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• pp.695-701
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• 2022

Homeostatic regulation of meristematic stem cells accomplished by maintaining a balance between stem cell self-renewal and differentiation is critical for proper plant growth and development. The quiescent center (QC) regulates root apical meristem homeostasis by maintaining stem cell fate during plant root development. Cell cycle checkpoints, such as anaphase promoting complex/cyclosome/cell cycle switch 52 A2 (APC/C^CCS52A2), strictly control the low proliferation rate of QC cells. Although APC/C^CCS52A2 plays a critical role in maintaining QC cell division, the molecular mechanism that regulates its activity remains largely unknown. Here, we identified SCF^FBS1, a ubiquitin E3 ligase, as a key regulator of QC cell division through the direct proteolysis of CCS52A2. FBS1 activity is positively associated with QC cell division and CCS52A2 proteolysis. FBS1 overexpression or ccs52a2-1 knockout consistently resulted in abnormal root development, characterized by root growth inhibition and low mitotic activity in the meristematic zone. Loss-of-function mutation of FBS1, on the other hand, resulted in low QC cell division, extremely low WOX5 expression, and rapid root growth. The 26S proteasome-mediated degradation of CCS52A2 was facilitated by its direct interaction with FBS1. The FBS1 genetically interacted with APC/C^CCS52A2-ERF115-PSKR1 signaling module for QC division. Thus, our findings establish SCF^FBS1-mediated CCS52A2 proteolysis as the molecular mechanism for controlling QC cell division in plants.

• Journal of The Korean Society of Integrative Medicine
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• v.10 no.2
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• pp.95-104
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• 2022

Purpose : This study aimed to investigate the effects of health science majors' communication skills on their adjustment to college life. Methods : The subjects were 336 college students majoring in health science at colleges located in Busan. The survey's questionnaire comprised 38 items, including 15 items for communication skills and 19 items for adjustment to college life. Results : In the gender-based comparison of communication skills and adjustment to college life, female students had better communication skills, with overall higher scores than male students for the understanding others and communication. In the age-based comparison of communication skills and adjustment to college life, students aged 21 to 22 showed the best communication skills, while students aged 18 to 20 exhibited the least communication skills. In terms of adjustment to college life, those aged 25 or older scored the highest, and those aged 21 to 22 scored the lowest. In the school-year-based comparison of communication skills and adjustment to college life, third- and first-year students showed the best and least communication skills, respectively. Overall, third- and fourth-year students were more adjusted at adjusting to college life than first- and second-year students. Third-year students also scored the highest in academic adjustment, whereas second-year students scored the lowest. In terms of relationships between the students' communication skills and their adjustment to college life, communication skills were positively correlated with the following subdomains: understanding of others, self-expression, and communication. Communication skills also showed a positive correlation with adjustment to the college environment, including personal-emotional adjustment. Conclusions : The present study found that communication skills did not significantly affect health science majors' adjustment to college life. However, given that communication skills are an essential factor for effective work performance and greater job satisfaction, it is recommended that colleges provide students with relevant education and experiences to help them enhance communication skills while in school.

• Human Ecology Research
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• v.60 no.1
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• pp.1-20
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• 2022

This paper presents a social network analysis of changes in Home Economics education content loaded on YouTube before and after the outbreak of COVID-19. From January 1, 2008 to June 30, 2021, a basic analysis was conducted of 761 Home Economics education videos loaded on YouTube, using NetMiner 4.3 to analyze important keywords and the centrality of video titles and full texts. Before COVID-19, there were 164 Home Economics education videos posted on YouTube, increasing significantly to 597 following the emergence of the pandemic. In both periods, there was more middle school content than high school content. The content in the child-family field was the most, and the main keywords were youth and family. Before COVID-19, a performance evaluation indicated that the proportion of student content was high, whereas after the outbreak of the disease, teacher content increased significantly due to the effect of distance learning. However, compared with video use, the self-expression and participation of users were lower in both periods. The centrality analysis indicated that in the title, 'family' exhibited a high degree of both centrality and eigenvector centrality over the entire period. Degree centrality of the video title was found to be high in the order of class, online, family, management, etc. after the outbreak of COVID-19, and the connection of keywords was strong overall. Eigenvector centrality indicated that career, search, life, and design were influential keywords before COVID-19, while class, youth, online, and development were influential keywords after COVID-19.

• Journal of Korea Entertainment Industry Association
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• v.14 no.7
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• pp.263-273
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• 2020

In 2019, Disney's musical film "Aladdin" was newly introduced with Princess Jasmine's theme song "Speechless," which was not featured in the animation "Aladdin" in 1992. Written as a theme song, "Speechless" expresses Princess Jasmine as a self-reliant, enterprising and dignified woman. The song made the change in Princess Jasmine's character very articulate. She has developed herself as an active and enthusiastic character from a rather passive and reserved figure. The musical film "Aladdin" has drawn much attention and love from many audiences with its own narrative and original songs, but the addition of a new theme song "Speechless", which was not in the animation in 1992, made the musical film "Aladdin" even more powerful and meaningful. The study examined the organic relationship between the musical features and narratives of the newly included theme song 'Speechless' in the musical film Aladdin. Through the analysis of the six scenes that include the musical features of the theme song "Speechless," the study looked at how the relationship between music and narratives had an influence on cinematic expression.

• Journal of Veterinary Clinics
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• v.39 no.2
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• pp.51-58
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• 2022

Quercetin, a flavonoid found in fruits and vegetables, exhibits a strong anti-inflammatory activity. The objective of this study was to examine the effect of quercetin on chemotactic activity of peripheral blood polymorphonuclear cells (PMNs) to culture supernatant from peripheral blood mononuclear cells (PBMCs) stimulated with lipopolysaccharide (LPS). In addition, we determined whether this effect is related to interleukin (IL)-8 and changes in cytoskeleton. The chemotactic activity of PMNs was evaluated by a modified Boyden chamber assay. Total cellular filamentous (F)-actin levels were measured by method of fluorescence microscopy. The levels of IL-8 mRNA and protein were measured by real time polymerase reaction method and enzyme-linked immunosorbent assay, respectively. Quercetin (0-50 µM) itself has no chemoattractant effect for PMNs. The culture supernatant from PBMCs (2 × 10⁶ cells/mL) treated with LPS (1 ㎍/mL) showed remarkable increase in chemotaxis of PMNs. However, this effect was reduced dose-dependently by treatment with quercetin. In addition, PBMCs treated with LPS revealed enhanced levels in IL-8 protein and mRNA. Co-treatment of LPS with quercetin (50 µM) in PBMCs decreased IL-8 production and expression. Treatment of quercetin (0-50 µM) on PMNs to rpIL-8 (10 nM) decreased dose-dependently the chemotactic activity of PMNs. Treatment of quercetin on PMNs to IL-8 also reduced their total cellular F-actin level. These results suggested that quercetin attenuates chemotactic activity of PMNs, which is mediated by down-regulation of IL-8 production from LPS-stimulated PBMCs and inhibition of F-actin polymerization in PMNs.