• Genomics & Informatics
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• v.14 no.4
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• pp.138-148
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• 2016

The success of genome-wide association studies (GWASs) has enabled us to improve risk assessment and provide novel genetic variants for diagnosis, prevention, and treatment. However, most variants discovered by GWASs have been reported to have very small effect sizes on complex human diseases, which has been a big hurdle in building risk prediction models. Recently, many statistical approaches based on penalized regression have been developed to solve the "large p and small n" problem. In this report, we evaluated the performance of several statistical methods for predicting a binary trait: stepwise logistic regression (SLR), least absolute shrinkage and selection operator (LASSO), and Elastic-Net (EN). We first built a prediction model by combining variable selection and prediction methods for type 2 diabetes using Affymetrix Genome-Wide Human SNP Array 5.0 from the Korean Association Resource project. We assessed the risk prediction performance using area under the receiver operating characteristic curve (AUC) for the internal and external validation datasets. In the internal validation, SLR-LASSO and SLR-EN tended to yield more accurate predictions than other combinations. During the external validation, the SLR-SLR and SLR-EN combinations achieved the highest AUC of 0.726. We propose these combinations as a potentially powerful risk prediction model for type 2 diabetes.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1774-1779
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• 2005

Most of materials receive force in using, therefore, the characteristics of materials must be considered in system design not to occur deformation or destruction. Mechanical properties about materials can be expressed as responsible level of material itself under the exterior operation. Main mechanical properties is strength, hardness, ductility and stiffness etc. Currently, among major measure facilities to measure such mechanical properties, advanced indentation technique has focused in industrial areas as reason of nondestructive and easy applications for mechanical tensile properties and evaluation of residual stress of materials. This study is to find the optimum experimental condition about residual stress advanced indentation technique for accurate analysis of the welded joint of steel materials through indentation load-depth curve obtained from cruciform specimen experiment. Optimum selection was applied to the welded joint of real steel materials to give non-equi-biaxial stress state and compared with general residual stress analyzing method for verification.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.958-964
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• 2001

It is difficult to apply a conventional selection guide for diffusers when the diffuser is installed in a perimeter zone, because the ADPI(Air Diffusion Performance Index) vs. T/L(Throw/Length) curve listed in conventional guide does not consider the perimetric heating load. The objective of this study is to evaluate the effect of the perimetric heating load on the ADPI and to propose a selection guide for proper diffuser when perimetric heating load exists. The velocity and temperature distributions and the ADPI value are obtained numerically with various heat load ratios and air flow rates. The ADPI values by numerical result were compared with existing experimental data to verify the method for evaluation of ADPI proposed in present study. In case of a high side wall diffuser, the ADPI decreased with increases of the flow rate on every heat load ratio of present study except 0.75. Also, the ADPI vs. T/L curves have been proposed for the heat load ratios of 0.25, 0.5, 0.75 to guarantee comport thermal environment when diffusers are installed in perimeter zone.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.51 no.3
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• pp.396-404
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• 2015

Morotoge shrimp Pandalopsis japonica is caught by pot and others in the eastern coastal waters of Korea. Comparative fishing experiments were carried out in the eastern coast of Korea, using the dome-shaped pots with different five mesh sizes (17.1, 24.8, 35.3, 39.8, and 48.3 mm) in order to estimate the mesh selectivity of the pot for the morotoge shrimp, Pandalopsis japonica. The SELECT (Share Each Length's Catch Total) analysis method was applied to the catch data. The master selection curve of the pot for the shrimp was estimated to be s(R) = exp(15.770R-10.573)/[1+exp(15.770R-10.753)], where R is the ratio of carapace length to mesh size. From the selection curves, the carapace lengths of 50% retention were 11.6, 17.0, 23.9, and 34.1 mm for 17, 25, 35, and 50 mm mesh-size pot, respectively. It means that the pots of larger mesh size allow more shrimp of small size to escape.

• Proceedings of the Korean Statistical Society Conference
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• 2005.05a
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• pp.17-23
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• 2005

In this paper we consider the well-known semiparametric proportional hazards models for survival analysis. These models are usually used with few covariates and many observations (subjects). But, for a typical setting of gene expression data from DNA microarray, we need to consider the case where the number of covariates p exceeds the number of samples n. For a given vector of response values which are times to event (death or censored times) and p gene expressions(covariates), we address the issue of how to reduce the dimension by selecting the significant genes. This approach enables us to estimate the survival curve when n ${\ll}$p. In our approach, rather than fixing the number of selected genes, we will assign a prior distribution to this number. The approach creates additional flexibility by allowing the imposition of constraints, such as bounding the dimension via a prior, which in effect works as a penalty To implement our methodology, we use a Markov Chain Monte Carlo (MCMC) method. We demonstrate the use of the methodology to diffuse large B-cell lymphoma (DLBCL) complementary DNA (cDNA) data and Breast Carcinomas data.

• Journal of Environmental Science International
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• v.20 no.11
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• pp.1457-1464
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• 2011

In this study, the method of estimating hydrologic information (water depth, submerged period etc.) on the proper selection of construction point and scale as well as vegetation type suggested for the design of natural riparian rehabilitation structure. Long-term comprehensive watershed model SWAT-K(Korea) was applied to this purpose. Flow duration analysis was conducted to analyze the hydrologic characteristics of Pyungchang watershed at which the 'bangtul' construction method was tested. For this purpose 20 years (1989-2008) rainfall runoff analysis was carried out. Based on the simulated daily streamflow data, flow duration curve was made to analyze the flow characteristics, and the water depth hydrograph was made to analyze the water depth distribution at the cross section. Finally, the information for the selection of proper vegetation according to the submerged period is suggested.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.40 no.3
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• pp.169-175
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• 2004

In order to examine the mesh selectivity and optimum mesh size of gill nets for croaker, Milichthys miiuy, the field experiments were carried out during Aug. 10 to 14, 2002 and Aug. 10 to 17, 2003 at the caostal area of Imja-Do, Shinan, Jeonnam province. The experimental fishing gears were used in two set of gill nets, which one set was consisted of 12 sheets of gill nets, and each set was connected alternatively 4 different sheets that were 129mm, 135mm, 144mm and 150mm in mesh size. The analysis of mesh selectivity curve was done by Kitahara's method. The results obtained are summerized as follows : 1. The total number of catch by the experimental fishing of gill nets for croaker was 719, and it was consisted of 526 croakers (73.1%), 168 blue crabs (23.4%), 17 harvest fishes (2.4%) and 8 other fishes (1.1%). 2. The value of maximum 1/m on the mesh selectivity curve was estimated at 6.91. 3. The value of 1/m on the 50% selection range was estimated at 5.62${\sim}$80.3, and the selection width was 2.41. 4. The optimum mesh size of gill nets for croaker was estimated 142mm, and the 50% selection range of total length of croaker was 798${\sim}$1,140mm.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.40 no.3
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• pp.176-181
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• 2004

In order to examine the mesh selectivity and optimum mesh size of trap nets for purple shell, Rapane venosa, the field experiments were carried out during Jun. 27 to 29, 2003 at the coastal area of Mal-Do, Kunsan, Jeonbuk province. The experimental fishing gears were used in two set of trap nets, which one set was consisted of 210 trap nets that were coverd with 35mm, 50mm and 65mm in mesh size. The analysis of mesh selectivity curve was done by Kitahara's method. The results obtained are summerized as follows : 1. The total number of catch by the experimental fishing of trap nets for purple shell was 1,682, and it was consisted of 1,268 purple shells (75.4%), 225 Glossaulax reiniana (13.4%), 113 green lings (6.7%) and 76 other fishes (4.5%). 2. The value of maximum 1/m on the mesh selectivity curve was estimated at 1.79. 3. The value of 1/m on the 50% selection range was estimated at 1.24${\sim}$2.72, and the selection width was 1.48.. 4. The optimum mesh size of trap nets for purple shell based on the catch prohibition shell height(50mm) was estimated 40.3mm, and the 50% selection range of shell height of purple shell was 50.0${\sim}$109.6mm.

• Analytical Science and Technology
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• v.34 no.6
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• pp.241-250
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• 2021

Calibration curves are essential in quantitative methods and for improving the accuracy of analyte measurements in biological samples. In this study, a statistical analysis model built in the R language (The R Foundation for Statistical Computing) was used to identify a set of weighting factors and regression models based on a stepwise selection criteria. An LC-MS/MS method was used to detect the presence of urinary methamphetamine, amphetamine, and 11-nor-9-carboxy-Δ⁹ -tetrahydrocannabinol in a sample set. Weighting factors for the calibration curves were derived by calculating the heteroscedasticity of the measurements, where the presence of heteroscedasticity was determined via variance tests. The optimal regression model and weighting factor were chosen according to the sum of the absolute percentage relative error. Subsequently, the order of the regression model was calculated using a partial variance test. The proposed statistical analysis tool facilitated selection of the optimal calibration model and detection of methamphetamine, amphetamine, and 11-nor-9-carboxy-Δ⁹-tetrahydrocannabinol in urine. Thus, this study for the selection of weighting and the use of a complex regression equation may provide insights for linear and quadratic regressions in analytical and bioanalytical measurements.

• Journal of Sericultural and Entomological Science
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• v.13 no.2
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• pp.123-133
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• 1971

The author is the first man who tried to use an anesthetic on insect specially for silkworm in orde to evaluate the silkworm health and silk yielding ability and the obtained results are as followings. 1. The necessary ether vapor induction for narcosis on silkworms is varied by the glowth of the silkworm which the larger worm is, the longer induction is required. For instance, it was 2∼3 minutes for the worms of third day fifth instar silkworm in case use of ether anesthetic. 2. The longer anesthetic induction for silkworms, the longer recovery needs from anesthesia. In case five minutes ether vapor induction, silkworms recovered narcosis during in 5∼130 minutes which had varied very much by the health variation. 3. The ether induction caused silkworm to vomit digestive juice from a few per cent of the worms, but the chloroform induction showed majority of the worms to vomit the digestive juice out of mouth. So, the ether was found as better anesthetic for silkworms. 4. When ether induction last more than 20∼30 minutes, the recovered silkworms can eat mulberry, but when it gets more than three hours they can not eat mulberry. And when it last more than ten minutes, the silkworm may eat mulberry leaf, but they can not spinn cocoon properly. 5. In case five minutes ether induction for silkworms on third day fifth instar, the stronger variety is, the rallier recovered from narcosis. 6. The recovering duration from narcosis varies regarding with each worm health which shows Poisson′s distribution even in a same variety silkworm. 7. The female worms recover from narcosis earlier than male worms which means the female worm is stronger than male one. 8. The later recovered silkworm from narcosis spinned more rich cocoon silk and ended with smaller pupae weight. Such a tendency showed until at some recovery duration, then the silk yield droped down on the worms recovered in more longer duration. The author (Choe) had named such a relation curve as "Silk Yield Curve against Silkworm Health." 9. The silk yield or cocoon layer ratio had varied from 13 to 27% even in a same worm varity cocoon which showed serious variation and call attention carefulness for the duplication work of a variety silkworm eggs. 10. Not always the rich silk yielding worm is the best worm during the silkworm selection and it should be considered with the silkworm health evaluation. 11. At present situation, only specific breeding expert is allowed to join in the selection service because of need many years experience by use of visual observation, but the ether anesthesia method may help such an evaluation with more accuracy and easy way even for the people in fresh on the field. 12. The effect of the narcosis on the silkworm for the next generation or hybrid worm will be reported in next publication.