• 한국항해학회지
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• 제20권1호
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• pp.47-58
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• 1996

The use of high tensile steel plates is increasing in the fabrication of ship and offshore structures. The main portion of ship structure is usually composed of stiffened plates. In these structures, plate buckling is one of the most important design criteria and buckling load may usually be obtained as an eigenvalue solution of the governing equations for the plate. To use the high tensile steel plate effectively, its thickness may become thin so that the occurrence of buckling is inevitable and design allowing plate buckling may be necessary. When the panel elastic buckling is allowed, it is necessary to get precise understandings about the post-buckling behaviour of thin plates. It is well known that a thin flat plate undergoes secondary buckling after initial buckling took place and the deflection of the initial buckling mode was developed. From this point of view, this paper discusses the post-buckling behaviour of thin plates under thrust including the secondary buckling phenomenon. Series of elastic large deflection analyses were performed on rectangular plates with aspect ratio 3.6 using the analytical method and the FEM.

• Journal of electromagnetic engineering and science
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• 제12권1호
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• pp.1-7
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• 2012

In this paper, we investigated the throughput of a cognitive radio network where two primary frequency channels (PCs) are sensed and opportunistically accessed by N secondary users. The sharing sensing member (SSM) protocol is introduced to sense both PCs simultaneously. According to the SSM protocol, N SUs (Secondary User) are divided into two groups, which allows for the simultaneous sensing of two PCs. With a frame structure, after determining whether the PCs are idle or active during a sensing slot, the SUs may use the remaining time to transmit their own data. The throughput of the network is formulated as a convex optimization problem. We then evaluated an iterative algorithm to allocate the optimal sensing time, fusion rule and the number of members in each group. The computer simulation and numerical results show that the proposed optimal allocation improves the throughput of the SU under a misdetection constraint to protect the PCs. If not, its initial date of receipt shall be nullified.

• 전산구조공학
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• 제4권4호
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• pp.97-106
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• 1991

주-부 구조물의 진동 특성을 파악하기 위한 새로운 방법인 frequency window method를 다중 지지되고 구조물간의 커플링이 강한 주-부 구조물을 해석하였다. 다항식의 합으로 표현된 특성 방정식과 이 식의 해는 기존의 고유치 해석 방법의 결과와는 다른 새로운 것으로 frequency window method의 주된 장점으로는 공진과 커플링 현상을 정량적으로 파악할 수 있는 피라미터의 정의, 전체 주-부 구조물의 모드특성을 나타내는 해석적인 식과 반복 기법의 도입으로 인한 해석 결과의 정확성등이 있다.

• Journal of Microbiology and Biotechnology
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• 제18권10호
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• pp.1655-1658
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• 2008

Cyanobacteria, blue-green algae, are a rich source of bioactive secondary metabolites with many potential applications. The ubiquitin-proteasome proteolytic system plays an important role in selective protein degradation and regulates cellular events including apoptosis. Cancer cells are more sensitive to the proapoptotic effects of proteasome inhibition than normal cells. Thus, proteasome inhibitors can be potential anticancer agents. Cyanobacteria have been shown to be a rich source of highly effective inhibitors of proteases. A proteasome inhibitor was screened from an extract of the culture of Scytonema hofmanni on the basis of its inhibitory activity, which led to the isolation of nostodione A with an $IC_{50}$ value of 50${\mu}M$. Its structure was determined by spectroscopic methods such as $^{1}H$-NMR and ESI-MS spectral analyses.

• Earthquakes and Structures
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• 제26권5호
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• pp.383-400
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• 2024

For a conventionally repaired frame-supported-transfer-slab (FSTS) reinforced concrete (RC) structure, both the transfer slab and the beam-to-column and transfer slab-to-column joints remain vulnerable to secondary earthquakes. Aimed at improving the seismic performance of a damaged FSTS RC structure, an innovative retrofitting scheme is proposed, which adopts the sector lead rubber dampers (SLRDs) at joints after the damaged FSTS RC structure is repaired by conventional approaches. In this paper, a series of quasi-static cyclic tests was conducted on a large-scale retrofitted FSTS RC structure. The seismic performance was evaluated and the key test results, including deformation characteristics, damage pattern, hysteretic behaviour, bearing capacity and strains on key components, were reported in detail. The test results indicated that the SLRDs started to dissipate energy under the service level earthquake, and thus prevented damages on the beam-to-column and transfer slab-to-column joints during the secondary earthquakes and shifted the plastic hinges away from the beam ends. The retrofitting scheme of using SLRDs also achieved the seismic design concept of 'strong joint, weak component'. The FSTS RC structure retrofitted by the SLRDs could recover more than 85% bearing capacity of its undamaged counterpart. The hysteresis curves were featured by the inverse "S" shape, indicating good bearing capacity and hysteresis performance. The deformation capacity of the damaged FSTS RC structure retrofitted by the SLRDs met the corresponding codified requirements for the case of the maximum considered earthquake, as set out in the Chinese seismic design code. The stability of the FSTS RC structure retrofitted by the SLRDs, which was revealed by the developed stains of the RC frame and transfer slab, was improved compared with the undamaged FSTS RC structure.

• BMB Reports
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• 제28권6호
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• pp.509-514
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• 1995

A putative secondary structure of the mRNA for the human hepatitis B virus (HBV) X gene is proposed based on not only chemical and enzymatic determination of its single- and double-stranded regions but also selection by the computer program MFOLD for energy minimum conformation under the constraints that the experimentally determined nucleotides were forced or prohibited to base pair. An RNA of 536 nucleotides including the 461-nucleotide HBV X mRNA sequence was synthesized in vitro by the phage T7 RNA polymerase transcription. The thermally renatured transcripts were subjected to chemical modifications with dimethylsulfate and kethoxal and enzymatic hydrolysis with single strand-specific RNase T1 and double strand-specific RNase V1, separately. The sites of modification and cleavage were detected by reverse transcriptase extension of 4 different primers. Many nucleotides could be assigned with high confidence, twenty in double-stranded and thirty-seven in Single-stranded regions. These nucleotides were forced and prohibited, respectively, to base pair in running the recursive RNA folding program MFOLD. The results suggest that 6 different regions (5 within X mRNA) of 14~23 nucleotides are Single-stranded. This putative structure provides a good working model and suggests potential target sites for antisense and ribozyme inhibitors and hybridization probes for the HBV X mRNA.

• 무역학회지
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• 제44권6호
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• pp.327-344
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• 2019

This paper explores the hub-and-spoke system as the structure of the global economic network that presents obstacles for international cooperation. With its exclusive jurisdiction and control over the hub, a powerful state can employ coercive economic measures to compel and deter unwanted behavior of rogue states and even its allies. Against this backdrop, this study analyzes the cases of the US blocking access to its market by Chinese Huawei as well as the case of Japan in restricting trade for highly advanced goods to South Korea. This analysis reveals that both measures are forms of secondary boycotts, which affect not only the entities within their jurisdiction but also others located in third countries. In addition, this paper extends its findings to free trade agreements and offers implications on the outward processing scheme for the Gaeseong Industrial Complex in the KORUS FTA and the Korea-China FTA. These events result in a gray-risk for South Korea, a country that aims to resolve North Korea's denuclearization and inter-Korean economic cooperation.

• Earthquakes and Structures
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• 제22권3호
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• pp.231-243
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• 2022

Beam-column joints (BCJs) are recognized among the most crucial zones in reinforced concrete structures, as they are the critical elements subjected to a complex state of forces during a severe earthquake. Under such conditions, BCJs exhibit behaviors with impacts that extend to the whole structure and significantly influence its ductility and capability of dissipating energy. The focus of this paper is to investigate the effect of undamaged transverse beam (secondary beams) on the ductility of concrete BCJs reinforced with conventional steel and shape memory alloys bars using pushover analysis at tip of beam under different axial load levels at the column using a nonlinear finite element model in ABAQUS environment. A numerical model of a BCJ was constructed and the analysis outcomes were verified by comparing them to those obtained from previous experiments found in the literature. The comparison evidenced the capability of the calibrated model to predict the load capacity response of the joint. Results proved the ability of undamaged secondary beams to provide a noticeable improvement to the ductility of reinforced concrete joints, with a very negligible loss in load capacity. However, the effect of secondary beams can become less significant if the beams are damaged due to seismic effects. In addition, the axial load was found to significantly enhance the performance of BCJs, where the increase in axial load magnified the capacity of the joint. However, higher values of axial load resulted in greater initial stiffness of the BCJ.

• Molecules and Cells
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• 제20권3호
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• pp.442-445
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• 2005

HP0894 (SwissProt/TrEMBL ID O25554) is an 88-residue conserved hypothetical protein from Helicobacter pylori strain 26695 with a calculated pI of 8.5 and a molecular weight of 10.38 kDa. Proteins with sequence similarity to HP0894 exist in Vibrio choierae, Enterococcus faecalis, Campylobacter jejuni, Streptococcus pneumoniae, Haemophilus influenzae, Escherichia coli O157, etc. Here we report the sequence-specific backbone resonance assignments of HP0894. About 97.5% (418/429) of the HN, N, CO, $C{\alpha}$, $C{\beta}$ resonances of the 88 residues of HP0894 were assigned. On the basis of these assignments, three helical regions and four strand regions were identified using the CSI program. This study is a prerequisite for calculating the solution structure of HP0894, and studying its interaction with its substrates, if any, and/or with other proteins.

• BMB Reports
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• 제33권1호
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• pp.49-53
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• 2000

PMAP-23 is a 23-residue antimicrobial peptide derived from porcine myloid cells. In order to investigate the effects of two Pro residues at positions 12 and 15 of PMAP-23 on antibiotic activity, two analogues in which Ala was substituted for Pro residue at position 12 or 15 were synthesized. $Pro^{12}{\rightarrow}Ala$ (PMAPl) or $Pro^{15}{\rightarrow}Ala$(PMAP2) substitution in PMAP-23 caused a significant reduction on antitumor and phospholipid vesicle-disrupting activities, but did not cause a significant effect on antibacterial activity. PMAP-23 displayed the type I ${\beta}-turn$ structure with a negative ellipticity at near 205 om in SDS micelle, whereas PMAP1 and PMAP2 had a somewhat ${\alpha}-helical$ propensity in TFE solution, as compared to PMAP-23. These results suggest that two Pro residues of positions 12 and 15 in PMAP-23 play important roles in the formation of ${\beta}-turn$ structure on lipid membrane and its ${\beta}-turn$ structure may be essential for antibiotic activity including phospholipid vesicle-disrupting property.