• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.3051-3056
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• 2014

Previous studies have demonstrated that JMJD2A is a potential oncogene and is overexpressed in human tumors. However, its role in the endometrial carcinoma remains largely unknown. In this study, we discovered that JMJD2A was overexpressed in endometrial carcinoma, using immunohistochemistry, quantitative realtime polymerase chain reaction, and western blotting. Downregulation of JMJD2A led to reduced endometrial carcinoma RL95-2 and ISK cell proliferation, invasion and metastasis as asessed with cell counting kit-8, cell migration and invasive assays. Collectively, our results support that JMJD2A is a promoter of endometrial carcinoma cell proliferation and survival, and is a potential novel drug target.

• Korean Journal of Childcare and Education
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• v.13 no.4
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• pp.53-73
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• 2017

Objective: This study intended to examine whether working mothers' job satisfaction has a moderating effect on the relationship between their parenting stress and second childbearing intention. Methods: The subjects were 202 working mothers in Seoul and Gyeonggi province, all of who had a single child under 36 months old. Working mothers' parenting stress, job satisfaction and second childbearing intention were assessed with questionnaires completed by the mothers. The data were analyzed using descriptive statistics, t-test, one-way ANOVA, Duncan test, Pearson's correlation, and moderator regression analysis. Results: First, a significant difference was revealed in the mothers' second childbearing intention depending on the type of their child's main caregiver. The second childbearing intention of the mothers who relied on babysitters to care for their children was lower than that of the mothers whose mothers, mother-in-laws or child care teachers cared for their children. Secondly, working mothers' parenting stress and job satisfaction significantly affected their second childbearing intention. Thirdly, the mothers' job satisfaction moderated the relationship between their parenting stress and second childbearing intention. Conclusion/Implications: It is necessary to provide working mothers with social support for enhancing their job satisfaction and alleviating their job stress, in order to increase their second childbearing intention.

• The Korean Journal of Community Living Science
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• v.18 no.4
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• pp.639-653
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• 2007

The purpose of this study was to investigate factors affecting the decisions regarding second births. Especially, analysis focused on the connections between desire for a second birth and the family factors such as family values and marital relations because they have been rarely known until now. Data was from 1,156 married women that had only one child and had been part of the national data collected by KIHASA in 2003. Major findings can be summarized as follows. First, it was found that value-related factors affect the likelihood of a second birth. The degree of parental responsibility is negatively related with the desire for a second birth. However, the perceived ideal number of children is positively related to it. Second, it was found that the quality of family relations influences the decision for the second birth. Particularly, marital satisfaction is likely to be the most important factor tending to mediate the effects of socio-demographic factors and value-related factors on the plan for a second birth. These results suggest that the effects of social norms on the number of children and timing of childbearing which exist in the family are becoming weaker. Nevertheless, the traditional value of children such as a preference for a son can still be found.

• Journal of Applied Reliability
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• v.17 no.2
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• pp.159-167
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• 2017

Purpose: The purpose of this research is to study research trend in the field of warranty and maintenance policy of second-hand products. Methods: To this end, we consider research articles, which deal with warranty and maintenance of the second-hand products, published on journals during the past 20 years and classify them by taxonomy scheme proposed by Shafiee and Chukova (2013). The taxonomy scheme consists of three maintenance models in warranty for second-hand product. In each models, we analyze proposed maintenance and warranty policies with respect to types of upgrade models, types of preventive maintenances, decision variables and decision criteria model. Results: We obtain the scheme of maintenance and warranty of the second-hand products and define cost related to warranty and maintenance of the second-hand item. Also, we summarize the characteristics of maintenance and warranty policies in each classified model. Conclusion: There have been several research reviews on maintenance and warranty polity of new products. This research surveys researches of authors during the past 20 years and classifies, summarizes and compares proposed maintenance and warranty policies of the second-hand products. This research provides useful information to researchers who are interested in maintenance and warranty of the second-hand products.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3509-3514
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• 2013

The prognostic value of the fibroblast growth factor-inducible 14 (Fn14) expression in hepatocellular carcinoma (HCC) is unknown. Real-time PCR (RT-PCR), western blot assays and immunohistochemistry analysis were here performed in order to compare Fn14 expressios in paired liver samples of HCC and normal liver tissue. Most of the tumor tissues expressed significantly higher levels of Fn14 compared to adjacent non-tumor tissues, with Fn14High accounting for 54.6% (142/260) of all patients. The Pearson ${\chi}^2$ test indicated that Fn14 expression was closely associated with serum alpha fetal protein (AFP) (P=0.002) and tumor number (p=0.019). Univariate and multivariate analyses revealed that along with tumor diameter and portal vein tumor thrombosis (PVTT ) type, Fn14 was an independent prognostic factor for both overall survival (OS) (HR=1.398, p=0.008) and recurrence (HR=1.541, p=0.001) rates. Fn14 overexpression HCC correlated with poor surgical outcome, and this molecule may be a candidate biomarker for prognosis as well as a target for therapy.

• BMB Reports
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• v.44 no.8
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• pp.547-552
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• 2011

MED19 is a member of the Mediator that plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas. To tested the functional role of MED19 in human prostate cancer, we downregulated MED19 expression in prostate cancer cells (PC-3 and DU145) by lentivirus-mediated short hairpin (shRNA), and analyzed the effect of inhibition of MED19 on prostate cancer cell proliferation and tumorigenesis. The in vitro prostate cancer cell proliferation, colony formation, and in vivo tumor growth in nude mice xenografts was significantly reduced after the downregulation of MED19. Knockdown of MED19 caused S-phase arrest and induced apoptosis via modulation of Bid and Caspase 7. It was suggested that MED19 serves as a novel proliferation regulator that promotes growth of prostate cancer cells.

• Journal of Oral Medicine and Pain
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• v.16 no.1
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• pp.121-136
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• 1991

This study was undertaken to obtain the data for age determination following the calcification degree of the second molar, third molar in the point of forensic odontology. The intraoral panoramic radiograph of 1600 male and 1600 female (100 persons each age) ranging from 7 to 2 years of age were studied. The developmental state of the second molar and third molar were divided into 12 stages following the calcification degree and correlations of second molar developmental stage and statistically analyzed. The results were as follows : 1. There was remarkable correlation between the development of the second molar, the third molar and age. 2. There was no significant developmental differences between the right and left second molar, third molar.(p>0.05) 3. The developmental stages of the lower second molar was more advanced than those of upper second molar. (p<0.05) 4. The developmental stages of upper third molar was more advanced than those of lower third molar. (p<0.05) 5. Both the developmental stages of second, third molars were earlier in the female than in the male. (p<0.001) 6. For the purpose of age estimation according to developmental stages of the second, third molar, linear equations are as follows. (p<0.001) second molar : male upper : Y=1.3927X + 0.2213 (r=0.72) lower : Y=1.4132X + 0.0012 (r=0.78) female upper : Y=1.4914X + 0.2151 (r=0.73) lower : Y=1.5429X - 0.0911 (r=0.78)

• Quality Improvement in Health Care
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• v.23 no.2
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• pp.23-34
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• 2017

Purpose: Nurse's second victim experiences could influence organizational negative work-related outcome. The purpose of this study was to investigate the casual relationship between nurses' second victim experience and third victim experience and multiple mediation effects of second victim supports. Methods: A cross-sectional, self-report survey (the Second Victim Experience and Support Tool) was conducted with 305 nurses working in a general hospital. Data were collected from October 20 to November 25, 2016 and analyzed using SPSS Win version 23.0. Results: The nurses' perceived second victim experience was $3.24{\pm}0.61$ and the third victim experience was $3.12{\pm}0.92$. Nurses' second victim experience was found to have a direct effect on increasing third victim experience and indirect effect of colleague support as mediator (p<.05). However, institutional support and supervisor support had not a partial and indirect effect on third victim experience. Conclusion:This study is one of the first to connect second victim experience to third victim experience in South Korea. This study broadens the understanding of the negative effects of a second victim experience influence third victim experience. When involvement in patient safety events, the important role of colleague support in limiting nurse's third victim experience have been acknowledged. This study reinforces the efforts health care leaders are making to develop interventional programs to colleague support their staff as they recover from adverse event involvement.

• The korean journal of orthodontics
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• v.13 no.2
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• pp.201-204
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• 1983

To study the calcification of second molars in Class I malocclusion with normal craniofacial structure, the author examined cephalograms, orthopantomograms, periapical films of 538 children from 7 y 0 m to 15y 11m old who had Class I malocclusion with normal craniofacial structure, and observed the calcification stage of upper and lower second molars. The results are as follows. 1. The mean ages of crown completion of upper and lower second molars are $8.82{\pm}1.14,\;8.72{\pm}0.75$ in boys, and $8.60{\pm}1.46,\;8.22{\pm}0.92$ in girls. 2. The mean ages of root completion of upper and lower second molars are $14.25{\pm}1.46,\;14.15{\pm}0.83$ in boys, and $14.12{\pm}0.93,\;14.15{\pm}0.83$ in girls. 3. There are no difference between the calcification stages of upper second molars and those of lower second molars in both sexes.

• Korean Journal of Materials Research
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• v.13 no.11
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• pp.756-760
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• 2003

Two dimensional computer simulations were conducted on percolative structure in which second phases with various short diameter were arranged in matrix phase. In case of prohibiting the overlap among the second phases, the maximum area fraction of second phase arranged in matrix was increased with higher short diameter. In case of allowing the overlap among the second phases, the critical area fraction was increased with higher short diameter and the total number of distributed second phase was decreased. This results represented that thickness variation of short diameter by grain growth on the production processes affect significantly forming the completion path.