• Quality Improvement in Health Care
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• v.21 no.1
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• pp.66-76
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• 2015

Objectives: The purpose of this study is to develop a case review form for detecting adverse events through a medical records review in hospitalized patients in South Korea. Methods: To develop the case review form, several literatures were reviewed, first. Through the clinical expert meeting, screening criteria were selected and case review form was developed. Result: The Korean version of case review form consisted of the review form-1 for adverse event screening and form-2 for adverse event identification. The applied methodology for the case review form is determined according to the previous studies. For example, the method used in the first stage review is nurse review. Furthermore, the National Coordinating Council for Medication Errors Reporting and Prevention index is used to categorize disability, and a scale of 1 to 6 was used in the causation scores and preventability scores, respectively. Through the clinical expert meeting, a total of 41 screening criteria were selected. Conclusion: The Korean specific case review form was developed for detecting adverse events in hospitalized patients. The results from this study can be used in a large-scale study regarding the nationwide incidence of adverse events.

• Weed & Turfgrass Science
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• v.4 no.2
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• pp.118-123
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• 2015

Metagenomics is a powerful tool to isolate novel biocatalyst and biomolecules directly from the environmental DNA libraries. Since the metagenomics approach bypasses cultivation of microorganisms, un-cultured microorganisms that are majority of exists can be the richest reservoir for natural products discovery. To discover novel herbicidal substances from soil metagenome, we established three easy, simple and effective high throughput screening methods such as cucumber cotyledon leaf disc assay, microalgae assay and seed germination assay. Employing the methods, we isolated two active single clones (9-G1 and 9-G12) expressing herbicidal activity which whitened leaf discs, inhibited growth of microalgae and inhibited root growth of germinated Arabidopsis seeds. Spraying butanol fraction of the isolated active clones' culture broth led to growth retardation or desiccation of Digitalia sanguinalis (L) Scop. in vivo. These results represent that the screening methods established in this study are useful to screen herbicidal substances from metagenome libraries. Further identifying molecular structure of the herbicidal active substances and analyzing gene clusters encoding synthesis systems for the active substances are in progress.

• Journal of Life Science
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• v.26 no.5
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• pp.571-583
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• 2016

Biogenic amines are produced primarily by microorganisms found in fermented foods and are often implicated in poisoning incidents in humans. In this study, 620 strains of microorganisms were isolated from traditional Korean fermented food in Sunchang in order to screen for non-biogenicamine-producing microorganisms present in these foods. One strain was identified and named Bacillus subtilis SCJ1, by using 16S rRNA sequencing and biochemical characterization. We investigated the cell growth of this organism in order to understand its potential for industrial application. To this end, we optimized the culture medium constituents by using the response surface methodology. The Plackett-Burman experimental design was used for screening of the medium constituents, such as molasses, yeast extract and peptone, for improving cell growth. In order to determine the optimal concentration of each constituent, we used a central composite design. Consequently, the optimized concentrations of molasses, yeast extract and peptone were predicted to be 27.5 g/l, 7.5 g/l and 17.5 g/l, respectively. By model verification, we confirmed that a 1.49-fold increase in dry cell weight compared to the basal medium-from 1.32 g/l, to 1.9722 g/l-was achieved.

• Corrosion Science and Technology
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• v.8 no.3
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• pp.119-125
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• 2009

Corrosion assessment has a number of uses but the use considered here is as a precursor to Risk-Based Inspection (RBI) planning. Systematic methods consisting of technical modules of RBI program were used to assess the effect of specific corrosion mechanism on the probability of failure in equipments of petrochemical plants. Especially in part of the damage and corrosion assessment, screening step involved evaluating the combinations of process conditions and construction materials for each equipment item in order to determine which damage mechanisms are potentially active. For general internal corrosion, either API 510 or API 570 was applied as the damage rate in the calculation to determine the remaining life and inspection frequency. In some cases, a measured rate of corrosion may not be available. The technical modules of RBI program employ default values for corrosion, typically derived from published data or from experience with similar processes, for use until inspection results are available. This paper describes the case study of corrosion and damage assessment by using RBI methodology in petrochemical plant. Specifically, this paper reports the methodology and the results of its application to the petrochemical units using the $KGS-RBI^{TM}$ program, developed by the Korea Gas Safety Corporation to suit Korean situation in conformity with API 581 Codes.

• Food Science of Animal Resources
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• v.39 no.1
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• pp.114-120
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• 2019

Response surface methodology (RSM) is a useful set of statistical techniques for modeling and optimizing responses in research studies of food science. As a design for a response surface experiment, a central composite design (CCD) with multiple runs at the center point is frequently used. However, sometimes there exist situations where some among the responses at the center point are outliers and these outliers are overlooked. Since the responses from center runs are those from the same experimental conditions, there should be no outliers at the center point. Outliers at the center point ruin statistical analysis. Thus, the responses at the center point need to be looked at, and if outliers are observed, they have to be examined. If the reasons for the outliers are not errors in measuring or typing, such outliers need to be deleted. If the outliers are due to such errors, they have to be corrected. Through a re-analysis of a dataset published in the Korean Journal for Food Science of Animal Resources, we have shown that outlier elimination resulted in the increase of the maximum possible R-square that the modeling of the data can obtain, which enables us to improve the quality of response surface analysis.

• Child Health Nursing Research
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• v.28 no.2
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• pp.91-102
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• 2022

Purpose: This study systematically analyzed cases in South Korea wherein nurses were prosecuted for involuntary manslaughter or injury due to professional negligence in pediatric care. Methods: We analyzed the precedents using the methodology of Hall and Wright (2008) and Austin (2010). Of the 618 cases retrieved from the Supreme Court Decisions Retrieval System in South Korea, we selected the 12 cases in which children were the victims and nurses were the defendants, using a case screening methodology. Results: The most frequent penalty was a fine, and newborns were the most frequent victims. The distribution of cases according to Austin's violation categories was: improper administration of medications (n=5), failure to monitor for and report deterioration (n=4), ineffective communication (n=4), failure to delegate responsibly (n=4), failure to know and follow facility policies and procedures (n=1), and improper use of equipment (n=1). Conclusion: To ensure the safety of children, nurses are required to teach and practice a high standard of care. Nursing education programs must improve nurses' awareness of their legal obligations. Nursing organizations and leaders should also work towards enacting effective nursing laws and ensuring that nurses are aware of their legal rights and responsibilities.

• The Journal of Industrial Distribution & Business
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• v.14 no.10
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• pp.1-9
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• 2023

Purpose: In an increasingly globalized world, foreign direct investment (FDI) plays an essential role in the economic improvement of countries. This study aims to delve into the topic of overseas direct investment (FDI) and offer a complete analysis of its strategic advantages and disadvantages. By thoroughly examining the present literature, this study aims to discover and explore the diverse advantages and drawbacks. Research design, data and methodology: The information analysis system systematically and rigorously examined the selected studies. The evaluation will follow a thematic technique in which conventional subject matters and styles associated with FDI's strategic benefits and downsides can be recognized and synthesized. Data extraction contained relevant facts from the chosen research, along with the study objectives. Results: This study provides the findings of the, which explores the strategic advantages and disadvantages of foreign direct investments (FDI) primarily based on the evaluation of previous research. A comprehensive review of the identified benefits and drawbacks highlights their implications for businesses engaged in FDI. Conclusions: In sum, the findings offer valuable insights for practitioners, guiding their decision-making methods in the international commercial enterprise landscape. Organizations can function for fulfillment and sustainable development in the global marketplace by leveraging the advantages and effectively managing demanding situations.

• Journal of Microbiology and Biotechnology
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• v.27 no.5
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• pp.965-974
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• 2017

The single-chain variable fragment (scFv) against lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a promising molecule for its potential use in the diagnosis and immunotherapy of atherosclerosis. Producing this scFv in several milligram amounts could be the starting point for further engineering and application of the scFv. In this study, the abundant expression of the anti-LOX-1 scFv was attempted using Escherichia coli (E. coli) and Brevibacillus choshinensis (B. choshinensis). The scFv had limited soluble yield in E. coli, but it was efficiently secreted by B. choshinensis. The optimized fermentation was determined using the Plackett-Burman screening design and response surface methodology, under which the yield reached up to 1.5 g/l in a 5-L fermentor. Moreover, the properties of the scFvs obtained from the two expression systems were different. The antigen affinity, transition temperature, and particle diameter size were 1.01E-07 M, $55.2{\pm}0.3^{\circ}C$, and 9.388 nm for the scFv expressed by B. choshinensis, and 4.53E-07 M, $52.5{\pm}0.3^{\circ}C$, and 13.54 nm for the scFv expressed by E. coli. This study established an efficient scale-up production methodology for the anti-LOX-1 scFv, which will boost its use in LOX-1-based therapy.

• Journal of Korean Society for Atmospheric Environment
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• v.15 no.2
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• pp.139-150
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• 1999

The ozone concentrations measured at the National Air Monitoring Stations between 1990 and 1995 were reviewed to detect any anomalies in the measurements. By screening the cases, in which variation of the ozone concentration from the previous measured value is greater than 75ppb, 125 station-days were identified as the test cases for the anomaly test. Historical and parallel consistencies of the measured concentrations were examined by plotting data for each test case. The detected anomalies can be classified into four categories; single outliers, anomalous variations during the startup period, baseline rises, and fluctuations in th diurnal variations. Anomalies were detected in as many as 80 cases among 125 test cases. Because of these anomalies, the number of hours exceeding 100ppb in the areas other than the Greater Seoul Area(GSA) could decrease from 157 to 107. Further studies for developing the methodology for eliminating the abnormal monitoring data are warranted for the data from the National Air Monitoring Stations are official to the both inside and outside of the country.

• Nuclear Engineering and Technology
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• v.45 no.1
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• pp.99-106
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• 2013

Thermal fatigue is a significant long-term degradation mechanism in nuclear power plants. In particular, as operating plants become older and life time extension activities are initiated, operators and regulators need screening criteria to exclude risks of thermal fatigue and methods to determine significant fatigue relevance. In general, the common thermal fatigue issues are well understood and controlled by plant instrumentation at fatigue susceptible locations. However, incidents indicate that certain piping system Tee connections are susceptible to turbulent temperature mixing effects that cannot be adequately monitored by common thermocouple instrumentations. Therefore, in this study thermal fatigue evaluation of piping system Tee-connections is performed using the fluid-structure interaction (FSI) analysis. From the thermal hydraulic analysis, the temperature distributions are determined and their results are applied to the structural model of the piping system to determine the thermal stress. Using the rain-flow method the fatigue analysis is performed to generate fatigue usage factors. The procedure for improved load thermal fatigue assessment using FSI analysis shown in this study will supply valuable information for establishing a methodology on thermal fatigue.