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Association between the TP53BP1 rs2602141 A/C Polymorphism and Cancer Risk: A Systematic Review and Meta-Analysis

  • Liu, Lei;Zhang, Dong;Jiao, Jing-Hua;Wang, Yu;Wu, Jing-Yang;Huang, De-Sheng
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.6
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    • pp.2917-2922
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    • 2014
  • Background: The p53-binding protein 1 (TP53BP1) gene may be involved in the development of cancer through disrupting DNA repair. However, investigation of associations between TP53BP1 rs2602141 A/C polymorphism and cancer have yielded contradictory and inconclusive outcomes. We therefore performed a meta-analysis to evaluate the association between the TP53BP1 rs2602141 A/C polymorphism and cancer susceptibility. Materials and Methods: Published literature from PubMed, Medline, the Cochrane Library, EMbase, Web of Science, Google (scholar), CBMDisc, Chongqing VIP database, and CNKI database were retrieved. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed or random-effects models. Publication bias was estimated using funnel plots, Begg's and Egger's test. Results: A total of seven studies (3,018 cases and 5,548 controls) were included in the meta-analysis. Our results showed that the genotype distribution of TP53BP1 rs2602141 A/C was not associated with cancer risk overall. However, on subgroup analysis, we found that TP53BP1 rs2602141 A/C was associated with cancer risk within an allele model (A vs C, OR=1.14, 95%CI: 1.01-1.29) and a codominant model (AA vs CC, OR=1.36, 95%CI: 1.06-1.74) in Asians rather than in Caucasians. Subgroup analysis by cancer type, genotype, and with or without adjustment for controls showed no significant association. Conclusions: The findings suggested an association between rs2602141 A/C polymorphism in TP53BP1 gene and increased risk of cancer in Asians.

Research Productivity and Citation Performance of Researchers by Co-authorship Type in the Biological Sciences (생명과학 분야 연구자들의 공동연구 유형별 연구 생산성과 인용 성과 분석)

  • Kim, Mee-Jean
    • Journal of the Korean Society for Library and Information Science
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    • v.52 no.3
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    • pp.149-169
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    • 2018
  • The purpose of this study is to provide an in-depth analysis on the research productivity and the research performance of the School of Biological Sciences' faculty at the S University by their co-authorships and further to identify any difference in the citedness by their co-authorships. For the years 2004-2013, a total of 1,135 publications, published by thirty-nine faculty members, were collected and their publication patterns were analyzed by co-authorships. For the years 2004-2016, the citations to the 1,135 publications were analyzed by co-authorships. Among the four co-authorship types, the total number of publications by the domestic and international co-authorships amounted to 832(73.3%), and the study also found a statistical difference in the citation performance, i.e., the average number of citations per paper by co-authorships (F =4.830, $p=0.003^{**}$).

Comparison on Effects of Face-to-face Reading Discussion and Web-based's (면대면 독서토론과 웹기반 독서토론의 효과 비교)

  • Jung Jong-Kee
    • Journal of Korean Library and Information Science Society
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    • v.36 no.3
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    • pp.291-312
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    • 2005
  • The purpose of this study is to compare the reading effects of face-to-face reading discussion with those of web-based leading discussion. For doing this, 1 made experimental processes: firstly, to select two discussion methods(face-to-face and web-based) on the reading discussion, secondly to apply each of those methods to experimental groups(2 classrooms, 72 middle school students). The results were that there were no differences from both discussion methods in the understanding the book, in the performance degree on discussion process among higher level groups, but the web-based reading discussion model had an impact on the attitude degree of the reading discussion, the preference degree of reading, the attendance degree of reading discussion, and especially, in the lower level groups, the web-based reading discussion method was better for the attendance degree of leading discussion, the attitude of reading discussion than the face-to-face reading discussion.

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Problem-Solving Model to Improve Scientific Literacy of Youth (청소년의 과학적 소양 향상을 위한 문제해결 모형 개발 연구)

  • Kwak Seung-Jin
    • Journal of Korean Library and Information Science Society
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    • v.36 no.3
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    • pp.21-38
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    • 2005
  • This study aims to find methods to improve the scientific literacy of the youth, which comprise the group who will lead the upcoming era of knowledge and science. To do this, the study focuses on improving the youth's understanding of science and their ability to utilize it. It is widely recognized that scientific literacy Is highly essential in this era of scientific revolution and innovations. Accordingly, various kinds of programs are being developed in Korea and other countries. In particular, 'Project 2061' is designed to enable a permanent learning system by improving problem-solving ability through the scientific process. This system plays an Important role In supporting the Americans' Pursuit of Increased literacy in the fields of science, mathematics, and engineering. To improve the scientific literacy of young people, content development in relation with school courses as well as information services that arouse Interest and curiosity In the field of science is very important. In addition, It is necessary to develop a problem-solving program by stages. Further studies focusing on methods of improving scientific literacy of the youth are recommended.

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A Study on the Tacit Knowledge of Attitude toward Reading (독서태도에 관한 암묵적 지식 연구 사서교사와 초등교사 및 초등학생의 인식 조사를 중심으로)

  • Park, Ju-Hyeon
    • Journal of Korean Library and Information Science Society
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    • v.47 no.1
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    • pp.305-337
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    • 2016
  • The purpose of this study is to obtain basic information and suggestions needed to measure reading attitude by obtaining the tacit knowledge. For this, a semi-structured interviews were carried out with teacher librarians and elementary school teachers and elementary students in five elementary schools. The results were as follows: Students and Teachers divided standard and attribute for assessing reading attitudes as student's ability, personality and behavioral aspects towards reading. Students were aware of the necessity of reading and accepted a pleasant feeling of reading. However, group of students with low reading skill recognized reading as an academic purpose as compared to other student groups and expressed a negative feeling on reading. Peers, teachers and family members were recognized as figures who make an impact on reading by students and further considered the subject, content and physical attribute of book as important factors. Teachers recognized reading attitude as a concept on attitude about book and book reading. Further they mentioned reading environment, interests, habits, books, and experience as factors affect reading attitude.

Effects of Non-pharmacological Interventions on Primary Insomnia in Adults Aged 55 and Above: A Meta-analysis (수면장애가 있는 중장년 환자에게 적용한 비약물적 중재의 효과: 메타분석)

  • Kim, Ji Hyun;Oh, Pok Ja
    • Korean Journal of Adult Nursing
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    • v.28 no.1
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    • pp.13-29
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    • 2016
  • Purpose: This study was performed to evaluate the effects of non-pharmacological interventions on sleep disturbance amongst adults aged 55 and above. Methods: PubMed, Cochrane Library, EMBASE, CINAHL and several Korean databases were searched. The main search strategy combined terms including non-pharmacological interventions and presence of insomnia. Non-pharmacological interventions included cognitive behavioral therapy, auricular acupuncture, aromatherapy, and emotional freedom techniques. Methodological quality was assessed using Cochrane's Risk of Bias for randomized studies and Risk of Bias Assessment tool for non randomized studies. Data were analyzed by the RevMan 5.3 program of Cochrane Library. Results: Sixteen clinical trials met the inclusion criteria with a total of 962 participants. Non-pharmacological interventions was conducted for a mean of 5.5 weeks, 7.7 sessions, and an average of 70 minutes per session. The effects of non-pharmacological interventions on sleep quality (ES=-1.18), sleep efficiency (ES=-1.14), sleep onset latency (ES=-0.88), awakening time after sleep onset (ES=-0.87), and sleep belief (ES=-0.71) were significant, and their effect sizes were ranged from moderate to large. However, the effects on total sleep time and insomnia severity were not significant. Conclusion: The findings of the current study suggest that non-pharmacological interventions have a positive impact on attitudes and beliefs about sleep, sleep quality, sleep duration, and sleep efficiency. Therefore, the findings of the study provide an evidence to incorporate various non-pharmacological interventions into nursing practice to improve both sleep quality and quantity in patients with insomnia.

A Study on Reading Instruction of Subject Orientation in the Focus Before Reading and After Reading (주제 중심 독서지도에 관한 연구 - 독서 전과 독서 후를 중심으로 -)

  • Lee, Sun-Oak;Chang, Woo-Kwon
    • Journal of the Korean Society for Library and Information Science
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    • v.43 no.1
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    • pp.161-187
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    • 2009
  • Today's society demands that Individuals need to acquire skills to select information they need, read critically that have been gathered and use them for their advantage. The ability to actively respond to information can be cultivated through reading which facilitates creative, critical thinking, and self-initiated learning. This research presents results from a study in which subject-centered approach to reading guidance was applied to elicit positive changes in reading attitudes and to contribute to the elevation of self-concept among adolescents. Using survey questionnaire, we compared the changes in reading attitude before and after treatment. The results indicate that subject-centered reading instruction brought positive changes in reading attitude among middle school students, contributed positively to the formation of self-concept and the improved student initiated learning.

Examining Categorical Transition and Query Reformulation Patterns in Image Search Process (이미지 검색 과정에 나타난 질의 전환 및 재구성 패턴에 관한 연구)

  • Chung, Eun-Kyung;Yoon, Jung-Won
    • Journal of the Korean Society for information Management
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    • v.27 no.2
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    • pp.37-60
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    • 2010
  • The purpose of this study is to investigate image search query reformulation patterns in relation to image attribute categories. A total of 592 sessions and 2,445 queries from the Excite Web search engine log data were analyzed by utilizing Batley's visual information types and two facets and seven sub-facets of query reformulation patterns. The results of this study are organized with two folds: query reformulation and categorical transition. As the most dominant categories of queries are specific and general/nameable, this tendency stays over various search stages. From the perspective of reformulation patterns, while the Parallel movement is the most dominant, there are slight differences depending on initial or preceding query categories. In examining categorical transitions, it was found that 60-80% of search queries were reformulated within the same categories of image attributes. These findings may be applied to practice and implementation of image retrieval systems in terms of assisting users' query term selection and effective thesauri development.

A Study on the Identifier Pattern of Digital Contents of the Journal (학술지 디지털 콘텐츠 식별패턴에관한 연구)

  • Kim, Moon-Jung
    • Journal of Information Management
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    • v.33 no.2
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    • pp.67-94
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    • 2002
  • With the development of modern society, we are all living in a world where information is shared through mass media and environment. Just as there was an identifier for the approach of information in the past analog environment, there is a demand for the continuous development and research of an original identifier for each and every digital contents of the changing digital environment. In order to present the need for standardization of effective construction concerning digital contents, this study examines the identifiers system structure of ISBN and ISSN of the analog environment and URL, URN, URC, which are under the URI system of the digital environment. After analyzing the problems of different URL identifiers construction in each university library's OPAC system, this study presents a standard device of effective identifiers patterns.

A Study on the Empathy Competence of Adolescents Using Empathic Reading Based on Online Remote Classes (비대면 온라인 원격수업 기반의 공감독서를 활용한 청소년의 공감역량에 관한 연구)

  • Song, Jiae
    • Journal of the Korean Society for Library and Information Science
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    • v.55 no.1
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    • pp.541-565
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    • 2021
  • The study is aimed at designing an effective edutech platform based on online remote classes, and clarifying the effect of empathy competence of youths through the operation linked with the empathic reading program focusing on reading. To this end, after constructing the environment for education and drawing a class model based on components of edutech for remote classes on the basis of previous studies and elaborating the empathic reading education program, this study has been conducted for one semester for 107 students in 4 classes in their 1st grade at S middle school, Gyeonggi-do in order to apply them to fields. As a result of the study, the empathy reading program that a remote class model was applied has shown a meaningful difference among groups in cognitive empathy and emotional empathy, and it was found that there was a statistically meaningful difference between the two groups in total scores. Besides, the effect and meaning of adolescents' empathy competence have been verified through the remote empathy reading education and the empirical analysis, and the direction to develop the empathy reading program has been suggested for a solution to settle differences in students' learning due to COVID-19.