• 제목/요약/키워드: scale-up production

검색결과 346건 처리시간 0.029초

질병진단을 위한 나노자임 연구의 최근 동향 (Recent Advances in Nanozyme Research for Disease Diagnostics)

  • 신호연;윤태영;김문일
    • KSBB Journal
    • /
    • 제30권1호
    • /
    • pp.1-10
    • /
    • 2015
  • Nanomaterial-based artificial enzymes (Nanozymes) have attracted recent attention because of their unique advantageous characteristics such as excellent robustness and stability, low-cost production by facile scale-up, and longterm preservation capability that are critically required as an alternative to natural enzymes. These nanozymes exhibit natural enzyme-like activity, and they have been applied to diverse kinds of detection methods for disease-associated biomolecules such as DNAs, proteins, cells, and small molecules including glucose. To highlight the progress in the field of disease diagnostics using nanozyme, this review discusses many nanozyme-based detection methods categorized by the types of target biomolecules. Finally, we address the current challenges and perspectives for the widespread utilization of nanozyme-based disease diagnostics.

초고추파 집적 회로를 위한 새로운 실리콘 MEMS 패키지 (THe Novel Silicon MEMS Package for MMICS)

  • 권영수;이해영;박재영;김성아
    • 대한전기학회논문지:전기물성ㆍ응용부문C
    • /
    • 제51권6호
    • /
    • pp.271-277
    • /
    • 2002
  • In this paper, a MEMS silicon package is newly designed, fabricated for HMIC, and characterized for microwave and millimeter-wave device applications. The proposed package is fabricated by using two high resistivity silicon substrates and surface/bulk micromachining technology. It has a good performance characteristic such as -20㏈ of $S_11$/ and -0.3㏈ of $S_21$ up to 20㎓, which is useful in microwave region. It has also better heat transfer characteristics than the commonly used ceramic package. Since the proposed silicon MEMS package is easy to fabricate and wafer level chip scale packaging is also possible, the production cost can be much lower than the ceramic package. Since it will be a promising low-cost package for mobile/wireless applications.

Design on Integrated Land and Water Resources Management System Based on Remote Sensing and GIS in Shehezi City

  • Zhu, Gaolong;Chen, Xiuwan
    • 대한원격탐사학회:학술대회논문집
    • /
    • 대한원격탐사학회 2002년도 Proceedings of International Symposium on Remote Sensing
    • /
    • pp.500-505
    • /
    • 2002
  • Based on the real-time monitoring by remote sensing and dynamic management by GIS on agricultural land and water resources in arid area, we solved the practicability and popularization of small-scale spatial information service system. Through demonstration, the standards of spatial information service database of agricultural land and water resources is set up, and the agricultural land and water resources management system in Shehezi City of Xinjiang Autonomy is established, which provides periodically the spatial information services needed by agricultural production to support for sustainable development in arid area.

  • PDF

Monitoring on Alcohol Fermentations Properties for Aronia Juice for Aronia(Aronia melanocarpa) Vinegar

  • Sun-Sun Hur
    • 한국응용과학기술학회지
    • /
    • 제40권4호
    • /
    • pp.699-709
    • /
    • 2023
  • This study is to establish optimizing condition of alcohol fermentation in vinegar production with aronia, to confirm whether this can be industrially used, and to compare and analyze a change in anti-oxidative activity and quality characteristic according to alcohol fermentation of aronia. The optimized conditions for alcohol fermentation were as follows: Saccharomyces cerevisiae 5645 of yeast strain, a 5% inoculum size, aronia juice with a brix value of 14, and a glucose content of 7%. As a result to conduct scale up with optimizing conditions of alcohol fermentation of aronia, 8 days (192 hrs) of total alcohol fermentation time and 7.4% of the final alcohol content. The harvest volume accounted for approximately 90.2% with a loss of about 2.8%. As a result of antioxidant test, anti-oxidative activity of alcohol fermented liquor is lower than anti-oxidative activity of aronia extract, because of the decrease of antioxidant by oxidation of the fermentation process. However, the decrease of tannin by the fermentation process reduces acerbity of aronia, so increases overall preference

푸르푸랄의 화학적 촉매전환을 통한 테트라히드로푸르푸릴 알코올 생산 공정 개발 및 경제성 평가 (Process Development and Economic Evaluation for Catalytic Conversion of Furfural to Tetrahydrofurfuryl Alcohol)

  • 변재원;한지훈
    • Korean Chemical Engineering Research
    • /
    • 제55권5호
    • /
    • pp.609-617
    • /
    • 2017
  • 목질계 바이오매스는 바이오 연료 및 바이오 화학제품 생산을 위한 재생 가능 자원이다. 푸르푸랄(furfural, FF)은 목질계 바이오매스의 헤미셀룰로스로부터 화학적 촉매전환으로 유도되는 주요한 플랫폼 케미칼이다. 테트라히드로푸르푸릴 알코올(Tetrahydrofurfuryl alcohol, THFA)은 FF의 유도체로 열적 화학적 안정성을 지닌 친환경 용매로 이용 가능하다. FF를 THFA로 전환하는 실험적 연구가 다수 존재함에도 불구하고, FF로부터 THFA의 대량생산에 관한 경제적 실현가능성에 관한 연구는 거의 수행되지 않았다. 개발된 전환기술의 상용화 단계에서 기술적 병목점 확인과 스케일업 문제의 해결을 위한 정보를 얻기 위해 실증플랜트 규모의 연구가 필요하다. 본 연구에서는 FF의 THFA로의 화학적 촉매전환에 대해 공정 시뮬레이션 및 기술경제성 평가가 수행되며, 3가지 단계(통합 공정 디자인, 열 통합, 경제성 평가)를 거친다. 실험연구 결과를 기반으로 전환공정과 분리공정을 포함하는 실증플랜트 규모의 통합공정이 설계된다. FF 처리량은 일일 255톤이며, FF로부터 THFA로의 수율은 63.2~67.9 mol%이다. 통합공정에 대해 열 통합을 수행하여 가열요구량을 최초 대비 14.4~16.4% 감소시킬 수 있었다. 최종적으로 경제성 평가를 통해 전체 공정의 주요 비용원을 분석하고 THFA의 최소판매가격을 결정하였다. 개발된 공정에서 생산되는 THFA의 최소판매가격은 1톤당 2,120~2,340 달러로, 현재 THFA의 시장 가격에 근접한다.

고속 자동정렬 케이블 와인딩을 위한 가이딩 시스템 개발 (A Development of a Guiding System for the High-Speed Self-Align Cable Winding)

  • 이창우;강현규;지혁종;안영세;신기현
    • 한국정밀공학회:학술대회논문집
    • /
    • 한국정밀공학회 2002년도 춘계학술대회 논문집
    • /
    • pp.478-482
    • /
    • 2002
  • Recently, the demand for the optical cable is rapidly glowing because the number of internet user increases and high speed internet data transmission is required. To meet this demand, it is necessary to have a sufficient manufacturing capability for mass and high-quality production. But the present optical cable winding system has some serious problems such that the optical cable of radius (6 mm -40 mm) is often piled up and collapsed usually at the edge of the bobbin in the process of the cable winding. It is often necessary to have an additional operator in order to adjust the cable, which causes the productivity decrease. In order to improve a performance of cable winding system which deals with relatively thick cable( radius : 6 mm -40 mm ), we developed a new guiding system for a high-speed self-align cable winding. First of all, the winding mechanism was analyzed. Synchronization logics for the motions of winding, traversing, and the guiding were created and implemented by using the PLC and guiding system controller in a prototype cable winding system manufactured in the CILS( Computer Integrated Large scale System ) lab. An experimental verification was carried out to validate the logic. Results showed that the winding system with the developed guiding system outperformed in reducing pile-up and collapse in the high-speed winding(up to 300 mm/s) compared with the system without the guiding system.

  • PDF

Effective Heat Treatment Techniques for Control of Mung Bean Sprout Rot, Incorporable into Commercial Mass Production

  • Lee, Jung-Han;Han, Ki-Soo;Kim, Tae-Hyoung;Bae, Dong-Won;Kim, Dong-Kil;Kang, Jin-Ho;Kim, Hee-Kyu
    • The Plant Pathology Journal
    • /
    • 제23권3호
    • /
    • pp.174-179
    • /
    • 2007
  • Seedlot disinfection techniques to control mung bean sprout rot caused by Colletoricum acutatum and C. gloeosporioides were evaluated for commercial production scheme. Soaking seedlots in propolis (100 X) and ethanol (20% for 30 min) appeared promising with control values of 85.5 and 80.8 respectively, but still resulted in up to 20% rot incidence. None of the C. acutatum conidia survived through hot water immersion treatment (HWT) for 10 min at temperatures of 55, 60 and $65^{\circ}C$, whereas the effective range of the dry heat treatment (DHT) was $60-65^{\circ}C$. Tolerance of mung bean seedlot, as estimated by hypocotyl elongation and root growth, was lower for HWT than for DHT. Germination and growth of sprouts were excellent over the range of $55-65^{\circ}C\;at\;5^{\circ}C$ intervals, except for HWT at $65^{\circ}C$ for 5 min. At this marginal condition, heat damage appeared so that approximately 2% of seeds failed to sprout to normal germling and retarded sprouts were less than 5% with coarse wrinkled hypocotyls. These results suggested that DHT would be more feasible to disinfect mung bean seedlots for commercial sprout production. Heat treatment at above ranges was highly effective in eliminating the epiphytic bacterial strains associated with marketed sprout rot samples. HWT of seedlot at 55 and $60^{\circ}C$ for 5 min resulted in successful control of mung bean sprout rot incidence with marketable sprout quality. DHT at 60 and $65^{\circ}C$ for 30 min also gave good results through the small-scale sprouting system. Therefore, we optimized DHT scheme at 60 and $65^{\circ}C$ for 30 min, considering the practical value of seedlot disinfection with high precision and accuracy. This was further proved to be a feasible and reliable method against anthracnose incidence and those bacterial strains associated with marketed sprout rot samples as well, through factory scale mung bean sprout production system.

Effects of high temperature on the flowering & pod setting and rain in the seed elongation stage on the soybean growth

  • Han, Won Young;Park, Hyeon Jin;Jeon, Weon Tai;Ryu, Jong Soo;Bae, Jin Woo;Park, Jin Ki;Kwak, Kang Su;Baek, In Youl;Kang, Hang Won
    • 한국작물학회:학술대회논문집
    • /
    • 한국작물학회 2017년도 9th Asian Crop Science Association conference
    • /
    • pp.326-326
    • /
    • 2017
  • Climate warming is the issue on the global scale. Soybean can be seriously damaged when high temperature occurs during a reproductive stage such as the flowering and pod-setting period according to the Representative Concentration Pathway (RCP) (2021~2100) 8.5 scenarios. The weather in 2016 was very different from other years (average for 30 years from 1980 to 2010) ; the highest temperature was $33.7^{\circ}C$ which was higher $3.29^{\circ}C$ than average temperature from last 30 years and average rainfall was 26.5 mm, lower 140.9 mm than average rainfalls from other years. Especially, the highest temperature during soybean flow-ering and pod setting stage was $26.8^{\circ}C$ which was higher $0.1^{\circ}C$ and rainfall was 172.2 mm, higher 47.8 mm than other years from the first to the 20th in the October at soybean seed elongation stage. Soybean leaves were turned upside down by the drought stress during the flowering and pod-setting stage. The numbe-r of pods and seeds per unit area decreased 11.0% and 30.3% compared with the previous year, respectively. The ripening period was prolonged by 21 days because of high temperature and soil moisture contents due to the continual rainmade increase of the seed weight up to 15.6% and the yield decreased 7.1% compared to the previous year.

  • PDF

갈조류 급속열분해 공정의 모사와 설계 (Process Design and Simulation of Fast Pyrolysis of Brown Seaweed)

  • ;우희철;유준
    • 청정기술
    • /
    • 제23권4호
    • /
    • pp.435-440
    • /
    • 2017
  • 바이오 연료 생산을 위한 3세대 바이오매스, 즉 미세조류 및 거대조류의 급속 열분해는 최근 1 세대 및 2 세대 바이오매스와 비교하여 실험적으로 연구된 바 있다. 하지만 거대조류의 경우 스케일업을 위한 공정모사 및 공정설계 연구는 거의 전무한 실정이다. 이 연구에서는 갈조류 급속 열분해의 벤치 스케일 실험 데이터에 근거하여 갈조류로부터 최종적으로 디젤을 생산하는 산업 규모의 공정을 상용 공정모사기를 이용하여 설계하고 모사하였다. 이때 육상 바이오매스 대비 갈조류의 조성 차이를 수용하기 위해 공정 설계에 특별한 주의를 기울였다. 연간 380,000톤의 건조 갈조류 원료를 바이오 디젤로 전환하는 전체 공정을 경제적으로 평가하고 최소 (디젤) 판매 가격 또한 산정하였다.