• KSBB Journal
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• v.24 no.3
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• pp.303-311
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• 2009

A scaling up study for the exopolysaccharide (EPS) production by submerged culture of Ganoderma lucidum was carried out in jar fermenter systems (2.6, 20 and 75 L) under bi-staged pH process. Profiles of dissolved oxygen (DO) and volumetric coefficient of oxygen transfer ($k_La$) as a function of operating variables (agitation speed and aeration rate) was investigated, and a correlation between $k_La$ and operating variables was analysed statistically. Under bi-staged pH process, no limitation of DO was observed at agitation speeds tested in the range of 200 and 600 rpm, and the highest EPS production was obtained at the level of DO of $40{\sim}80%$. From the regression analysis, the relation between $k_La$, gas velocity (Vs), stirrer speed (N) and impeller diameter (Di) could be expressed as : $$k_La=0.555{\times}Vs^{0.42}{\times}(N^3{\times}Di^2)^{0.33}\;(R^2=0.925,\;p<0.05)$$ It was found that under 2.6 L jar fermenter, the optimum agitation speed and aeration rate was 400 rpm and 1 vvm, respectively, obtaining the EPS production of 15.43 g/L. Under the submerged cultivation of G. lucidum in jar fermenters of $2.6{\sim}75\;L$, the similar EPS yields at each fermenter were achieved during scaling up based on $k_La$, and $k_La$ value for maximum EPS production was $85.4{\pm}26.70\;h^{-1}$.

• Journal of The Korean Astronomical Society
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• v.29 no.spc1
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• pp.155-158
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• 1996

Magnetic fields correlated on several kiloparsec scales are seen in spiral galaxies. Their origin could be due to the winding up of a primordial cosmological field or due to amplification of a small seed field by a turbulent galactic dynamo. Both options have difficulties: There is no known battery mechanism for producing the required primordial field. Equally the turbulent dynamo may self destruct before being able to produce the large scale field, due to excess generation of small scale power. The current status of these difficulties is discussed. The resolution could depend on the nature of the saturated field produced by the small scale dynamo. We argue that the small scale fields do not fill most of the volume of the fluid and instead concentrate into intermittent ropes, with their peak value of order equipartition fields, and radii much smaller than their lengths. In this case these fields neither drain significant energy from the turbulence nor convert eddy motion of the turbulence on the outer scale to wave like motion. This preserves the diffusive effects needed for the large scale dynamo operation.

• Korean Journal of Biological Psychiatry
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• v.8 no.1
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• pp.140-146
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• 2001

In clinical setting, treatment-refractoriness, medication induced tardive dyskinesia and amenorrhea in chronic schizophrenia are frequently problematic. However, there are few guideline solving these problem available to clinicians. The goal of this study was collecting clinical data on clinical effectiveness and predictors of response of switching to olanzapine. We attempted to switch to olanzapine from risperidone and clozapine in chronic 31(risperidone 17, clozapine 14) schizophrenia and schizoaffective disorder patients suffering from sustained symptoms, weekly blood monitoring, medication induced tardive dyskinesia and amenorrhea. Previous antipsychotics dosage was gradually decreased for 2 or 3weeks, at the same time olanzapine dosage was gradually increased. At baseline, after 1 week, after 2 weeks and after 4 weeks we checked Brief Psychiatric Rating Scale, Clinical Global Impression Scale, Sympson-Angus Rating Scale, Barnes Akathisia Rating Scale and followed up after 12 months. Successful switch after 4 weeks was achieved in 25 patients(clozapine 9(64.2%), risperidone 16(94.1%)). Overall, mean BPRS and CGI scores increased significantly. Successful maintenance after 12 months was achieved in 17 patients(clozapine 5(35.7%), risperidone 12(70.5%)). Overall, mean BPRS and CGI scores increased significantly too. Switching to olanzapine from other atypical antipsychotics is recommendable in chronic schizophrenia with treatment refractoriness and drug induced side effect.

• Journal of the Korean Society of Physical Medicine
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• v.15 no.1
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• pp.33-42
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• 2020

PURPOSE: This study examined the effects of a whole body vibration-exercise program on the muscle strength, balance, and falling efficacy of super-aged women. METHODS: Thirty participants, who are over 75 years of age, were recruited. They were assigned randomly to an experimental group (n=15), which received whole body vibration exercise, and a control group (n=15), which received an exercise program that did not include vibration. The interventions lasted for four weeks, three times a day, and 25 minutes per session. To compare the effects of the intervention, a 30-second chair stand test (CST), Korean version of Berg balance scale (K-BBS), functional reach test (FRT), timed up and go test (TUG), and Korean version of the falls efficacy scale (K-FES) was used. RESULTS: The experimental group showed a significant increase (p.<05) before and after the intervention in the chair stand test (CST), Korean version of the Berg balance scale (K-BBS), functional reach test (FRT), timed up-and-go (TUG), and Korean version of the fall efficacy scale (K-FES). Compared to the control group, the experiment group showed a more significant increase (p.<05) in the CST, K-BBS, and FRT. CONCLUSION: A whole body vibration exercise program could be suggested as an effective intervention method for muscle and balance strengthening for super-aged women.

• Journal of Microbiology and Biotechnology
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• v.20 no.4
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• pp.763-766
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• 2010

An efficient and simple fermentation process was developed for the production of ${\gamma}$-aminobutyric acid (GABA) by Lactobacillus sakei B2-16. When the L. sakei B2-16 was cultivated in the rice bran extracts medium containing 4% sucrose, 1% yeast extract, and 12% monosodium glutamate, the maximum GABA concentration reached 660.0 mM with 100% conversion yield, showing the 2.4- fold higher GABA concentration compared with the modified MRS medium without the rice bran extracts. The GABA production was scaled-up from a laboratory scale (5 l) to a pilot (300 l) and a plant (5,000 l) scale to investigate the application possibility of GABA production to industrial fields. The production yields at the pilot and plant scales were similar to the laboratory scale using rice bran extracts medium, which could be effective for the low-cost production of GABA.

• Environmental and Resource Economics Review
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• v.19 no.1
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• pp.3-21
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• 2010

By the significant structural change in 1999, a partial privatization has occurred in Korean fossil-fuel power generation sector. Under the current price scheme wholesale electricity price is dependent on output size, and hence, may not satisfy the assumption of price-taking producers. The purpose of our study is constructing the productivity change measurements of Korean power generation sector taking into account possibly imperfect competition and variable returns to scale. Our approach based on Harrison (1994) and Levinsohn (1993) derives the plant-level productivity measurements of the period between 2001 and 2007, as well as the measurements of mark-ups and returns to scale. It is shown that the mark-up size is dependent on the plants' fuel type and is decreasing over time. Allowing for imperfect competition and variable returns to scale adjusts the productivity measurements substantially.

• Genomics & Informatics
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• v.19 no.3
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• pp.24.1-24.7
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• 2021

Tracking the most recent advances in Coronavirus disease 2019 (COVID-19)-related research is essential, given the disease's novelty and its impact on society. However, with the publication pace speeding up, researchers and clinicians require automatic approaches to keep up with the incoming information regarding this disease. A solution to this problem requires the development of text mining pipelines; the efficiency of which strongly depends on the availability of curated corpora. However, there is a lack of COVID-19-related corpora, even more, if considering other languages besides English. This project's main contribution was the annotation of a multilingual parallel corpus and the generation of a recommendation dataset (EN-PT and EN-ES) regarding relevant entities, their relations, and recommendation, providing this resource to the community to improve the text mining research on COVID-19-related literature. This work was developed during the 7th Biomedical Linked Annotation Hackathon (BLAH7).

• Journal of the Korean Society of Systems Engineering
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• v.18 no.2
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• pp.11-23
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• 2022

Although artificial intelligence(AI) is a key technology in the digital transformation among the emerging technologies, there are concerns about the use of AI, so many countries have been trying to set up a proper regulation system. This study analyzes the cases of the regulation policies on AI in USA, EU and Korea with the aim to set up and improve proper AI policies and strategies in Korea. In USA, the establishment of the code of ethics for the use of AI is led by private sector. On the other side, Europe is strengthening competitiveness in the AI industry by consolidating regulations that are dispersed by EU members. Korea has also prepared and promoted policies for AI ethics, copyright and privacy protection at the national level and trying to change to a negative regulation system and improve regulations to close the gap between the leading countries and Korea in AI. Moreover, this study analyzed the course of policy changes of AI regulation policy centered on ACF(Advocacy Coalition Framework) model of Sabatier. Through this study, it proposes hyper-scale AI regulation policy recommendations for improving competitiveness and commercialization in Korea. This study is significant in that it can contribute to increasing the predictability of policy makers who have difficulties due to uncertainty and ambiguity in establishing regulatory policies caused by the emergence of hyper-scale artificial intelligence.

• Journal of Institute of Control, Robotics and Systems
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• v.5 no.4
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• pp.403-410
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• 1999

In this study, a parallel algorithm has been developed that can quickly solve the optiaml control problem of large-scale dynamic systems. The algorithm adopts the sequential quadratic programming methods and achieves domain decomposition-type parallelism in computing sensitivities for search direction computation. A silicon wafer thermal process problem has been solved using the algorithm, and a parallel efficiency of 45% has been achieved with 16 processors. Practical methods have also been investigated in this study as a way to further speed up the computation time.

• Journal of the Korean Data and Information Science Society
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• v.15 no.4
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• pp.981-992
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• 2004

In this paper, we develop the noninformative priors for the common scale parameter in the inverse gaussian distributions. We developed the first and second order matching priors. Next we revealed that the second order matching prior satisfies a HPD matching criterion. Also we showed that the second order matching prior matches alternative coverage probabilities up to the second order. It turns out that the one-at-a-time reference prior satisfies a second order matching criterion. Some simulation study is performed.