• Title/Summary/Keyword: savinin

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Phytochemical Studies on the Barks of Acanthopanax senticosus forma intermis (좀가시 오갈피나무의 성분연구)

  • 육창수;김선창;김창종;한덕룡
    • YAKHAK HOEJI
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    • v.35 no.3
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    • pp.147-153
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    • 1991
  • Chemical constituents of fruits, leaves and barks of Acanthopanax senticosus forma inermis were studied. Their fruits have higher contents of crude ash, crude protein, crude fat, fructose and glucose than those of other Acanthopanax species, and contained larger amount of glutamic acid and malic acid among amino acid and organic acid, respectively. The compounds identified from their barks and leaves, were $\beta$-sitosterol and stigmasterol, sesamin, savinin, syringaresinol diglucoside, oleanolic acid, chiisanoside and polyacetytene ($C_9H_{10}O_2$, mp. 62~63).

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Neuroprotective Lignans from Biota orientalis leaves

  • Yoon, Jeong-Seon;Koo, Kyung-Ah;Ma, Choong-Je;Sung, Sang-Hyun;Kim, Young-Choong
    • Natural Product Sciences
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    • v.14 no.3
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    • pp.167-170
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    • 2008
  • We previously reported that 90% MeOH fraction of Biota orientalis leaves (L.) ENDL. had significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells. In the present study, (-)-savinin (1), (-)-hinokinin (2), dehydroheliobuphthalmin (3) were isolated by bioactivity-guided fractionation from the 90% MeOH fraction. All three lignans had significant neuroprotective activities against glutamate-induced neurotoxicity at the concentrations ranging from 0.1 to 10.0 ${\mu}M$.

Lignans from the Root of Acanthopanax chiisanensis Nakai

  • Lee, Sang-Hyun;Shin, Kuk-Hyun;Lee, Sang-Chul;Cho, Seon-Haeng
    • Korean Journal of Medicinal Crop Science
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    • v.11 no.4
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    • pp.279-283
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    • 2003
  • Five lignans were isolated from the chloroform fraction of Acanthopanax chiisanensis Nakai root by open column chromatography. Their structures were elucidated as (-)-sesamin (1), helioxanthin (2), savinin (3), taiwanin C (4), and 3-(3",4"-dimethoxybenzyl)-2-(3',4'-methylenedioxybenzyl) butyrolactone (5) by spectral analysis. Among them, compounds 2, 3, 4, and 5 were isolated for the first time from this plant.

Anti-Estrogenic Activity of Lignans from Acanthopanax chiisanensis Root

  • Lee Sanghyun;Yoo Hye Hyun;Piao Xiang Lan;Kim Ju Sun;Kang Sam Sik;Shin Kuk Hyun
    • Archives of Pharmacal Research
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    • v.28 no.2
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    • pp.186-189
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    • 2005
  • Anti-estrogenic activity of (-)-sesamin (1), helioxanthin (2), savinin (3), taiwanin C (4), and 3­(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone (5) isolated from the root of Acanthopanax chiisanensis was tested using Ishikawa cells. Among them, compound 3 exhibited anti-estrogenic activity ($IC_{50}\;=\;4.86\;{\mu}M$).

NMR Techniques for the Structure Elucidation and Conformational Analysis of Natural Products

  • Cordell, Geoffrey A.
    • Korean Journal of Pharmacognosy
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    • v.19 no.3
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    • pp.153-169
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    • 1988
  • The combined use of the J-modulated selective INEPT and CSCM 1DNMR techniques is described for the structure elucidation of several new classes of compound including prionitin, the loureirins and larreantin, and for the regiosubstitution of the furanonaphthoquinones. Spectroscopic studies on the conformation of the cytotoxic agent savinin are also described, together with the NMR assignments and preliminary biosynthetic experiments on the antitumor antibiotic staurosporine.

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