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Neuroprotective Lignans from Biota orientalis leaves  

Yoon, Jeong-Seon (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University)
Koo, Kyung-Ah (Biohealth Product Research Center (BPRC), Inje University)
Ma, Choong-Je (School of Bioscience and Biotechnology, Kangwon National University)
Sung, Sang-Hyun (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University)
Kim, Young-Choong (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University)
Publication Information
Natural Product Sciences / v.14, no.3, 2008 , pp. 167-170 More about this Journal
Abstract
We previously reported that 90% MeOH fraction of Biota orientalis leaves (L.) ENDL. had significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells. In the present study, (-)-savinin (1), (-)-hinokinin (2), dehydroheliobuphthalmin (3) were isolated by bioactivity-guided fractionation from the 90% MeOH fraction. All three lignans had significant neuroprotective activities against glutamate-induced neurotoxicity at the concentrations ranging from 0.1 to 10.0 ${\mu}M$.
Keywords
Biota orientalis; (-)-savinin; (-)-hinokinin; dehydroheliobuphthalmin; glutamate; primary cultures of rat cortical cells;
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Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By SCOPUS : 3
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