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Anti-Estrogenic Activity of Lignans from Acanthopanax chiisanensis Root  

Lee Sanghyun (College of Pharmacy, Seoul National University)
Yoo Hye Hyun (College of Pharmacy, Seoul National University)
Piao Xiang Lan (College of Pharmacy, Seoul National University)
Kim Ju Sun (Natural Products Research Institute, Seoul National University)
Kang Sam Sik (Natural Products Research Institute, Seoul National University)
Shin Kuk Hyun (Natural Products Research Institute, Seoul National University)
Publication Information
Archives of Pharmacal Research / v.28, no.2, 2005 , pp. 186-189 More about this Journal
Abstract
Anti-estrogenic activity of (-)-sesamin (1), helioxanthin (2), savinin (3), taiwanin C (4), and 3­(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone (5) isolated from the root of Acanthopanax chiisanensis was tested using Ishikawa cells. Among them, compound 3 exhibited anti-estrogenic activity ($IC_{50}\;=\;4.86\;{\mu}M$).
Keywords
Acanthopanax chiisanensis; Araliaceae; Lignan; Savinin; Anti-estrogenic activity;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 6  (Related Records In Web of Science)
Times Cited By SCOPUS : 4
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