• Title/Summary/Keyword: safety tests

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Genotoxicological Safety of the Gamma-Irradiated Medicinal Herbs (감마선 조사 생약재의 안전성에 관한 유전독성학적 평가)

  • 조성기
    • Journal of Food Hygiene and Safety
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    • v.12 no.3
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    • pp.217-227
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    • 1997
  • These experiments were performed to investigate the safety of the three medicinal herbs- Curcuma longa Linne, Paeonia japonica Miyabe, Scutellaria baikalensis George-irradiated with gamma rays in respect of genotoxicity. The methanol-soluble and water-soluble fractions of the methanol-water extracts of the 10 kGy gamma-irradiated herbs were examined in two short-term in vitro tests : (1) Salmonella typhimurium reversion assay (Ames test) in strain TA 98, TA 100 and TA 012 (2) Micronucleus test in cultured Chinese hamster ovary (CHO) cells. No mutagenicity was detected in the assays with or without metabolic activation. From these results, the safety of the herbs irradiated with gamma rays at practical doses could be revealed in further tests of genotoxicity in vivo, chronic and reproductive toxiceity.

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A Wearable Safety Device for the Body Protection of Motorcyclists (모터사이클 운전자 신체보호용 안전장치 개발 프로세스)

  • Jang, Dong-Hwan
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.20 no.1
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    • pp.25-33
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    • 2021
  • This paper presents the development process for airbag safety devices fitted in motorcyclists' garments. Motorcycle riders often sustain multiple injuries in crashes since rider post-impact kinematics depend on several variables. This study proposes a newly inflatable safety system connected to the motorcycle by a cable. An airbag device with a mechanical triggering system is deployed when the cable detaches from its mounting clip. Airbag filling tests are performed to determine the mixing ratio of compressed gases with the severance of temperature. To estimate the airbag effectiveness to reduce riders' injuries, numerical analysis is performed using the finite element method. A comparative analysis (i.e., with and without the chosen device) was conducted to evaluate its protective efficacy. Prototype garments based on the proposed design have been created and have undergone sled tests. The proposed safety device could also be beneficial in accidents during other sports activities.

Research and Developement of Herbal Medicine(Taeumbiman-tang) on Obesity (복합한약물(가칭; 태음비만탕)을 이용한 비만치료약물 개발을 위한 연구)

  • Kwak, Chang-Kyu;Sohn, Eun-Hae;Yoo, Jung-Hee;Koh, Byung-Hee;Song, Il-Byung;Lee, Eui-Ju
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.19 no.2
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    • pp.530-535
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    • 2005
  • A Korean traditional herbal formular, Taeumbiman-tang(TBT), was based on Taeumjowi-tang, currently the most widely used herbal formula compound, and which is known to be safe and have a positive effect on adult obesity. TBT was given to obese children for thirty days, and was found to be clinically safe and effective. The subjects were children who had been admitted into the hospital to be treated for obesity, that had more than 20% relative body weight. Originally there were 19 subjects, but 5 dropped out of the experiment. There were 5 girls and 9 boys, whose average ages were $11.00\;{\pm}\;2.60$ years, average weight was $54.01\;{\pm}\;18.59\;kg$. As a pretest, all of the volunteers were examined for height, weight, blood pressure, pulse rate, EKG, and chest radiography. The subjects underwent interview, body measurement tests, blood tests, and safety tests under 8 hour fasting state. After 15 days of TBT intake, the safety tests and the interview were conducted. The interview, body measurement tests, blood tests, and safety tests were conducted again after the 30 day trial was completed. The short term effects of TBT on obese children is weight loss. It did not cause any significant changes in the subject's livers, hearts, and kidneys, and clinically dangerous side effects or withdrawal symptoms were not observed.

Contribution of thermal-hydraulic validation tests to the standard design approval of SMART

  • Park, Hyun-Sik;Kwon, Tae-Soon;Moon, Sang-Ki;Cho, Seok;Euh, Dong-Jin;Yi, Sung-Jae
    • Nuclear Engineering and Technology
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    • v.49 no.7
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    • pp.1537-1546
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    • 2017
  • Many thermal-hydraulic tests have been conducted at the Korea Atomic Energy Research Institute for verification of the SMART (System-integrated Modular Advanced ReacTor) design, the standard design approval of which was issued by the Korean regulatory body. In this paper, the contributions of these tests to the standard design approval of SMART are discussed. First, an integral effect test facility named VISTA-ITL (Experimental Verification by Integral Simulation of Transients and Accidents-Integral Test Loop) has been utilized to assess the TASS/SMR-S (Transient and Set-point Simulation/Small and Medium) safety analysis code and confirm its conservatism, to support standard design approval, and to construct a database for the SMART design optimization. In addition, many separate effect tests have been performed. The reactor internal flow test has been conducted using the SCOP (SMART COre flow distribution and Pressure drop test) facility to evaluate the reactor internal flow and pressure distributions. An ECC (Emergency Core Coolant) performance test has been carried out using the SWAT (SMART ECC Water Asymmetric Two-phase choking test) facility to evaluate the safety injection performance and to validate the thermal-hydraulic model used in the safety analysis code. The Freon CHF (Critical Heat Flux) test has been performed using the FTHEL (Freon Thermal Hydraulic Experimental Loop) facility to construct a database from the $5{\times}5$ rod bundle Freon CHF tests and to evaluate the DNBR (Departure from Nucleate Boiling Ratio) model in the safety analysis and core design codes. These test results were used for standard design approval of SMART to verify its design bases, design tools, and analysis methodology.

Development of Non-Redirective Crash Cushion for Bridge Piers Considering Occupant Safety (탑승자 안전도를 고려한 교각 방호시설물 개발에 관한 연구)

  • Park, Jaehong;Sung, Jung Gon;Nam, Min Gyun;Yun, Duk Geun
    • Journal of the Korean Society of Safety
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    • v.33 no.5
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    • pp.120-126
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    • 2018
  • The traffic accident types are largely classified into vehicle to vehicle accident, vehicle-to-person accident and single-vehicle. Especially, the single-vehicle accident types are severe when the vehicle crashed into road facilities such as bridge, piers, utility poles. The severity of single-vehicle accidents are ten times higher than that of all other accidents types. It is needed to consider to reduce accident severity. This study was conducted to develop crash worthy safety design facility to ensure the vehicle occupant safety. The simulation and the crash tests were conducted for assessment of the safety performance to check the criteria of CC2(Crash Cushion 2) level. THIV(Theoretical Head Impact Velocity) and PHD(Post-impact Head Deceleration) were used to assess occupant impact severity for crashes. The non-redirection collision test conditions for 900 kg and 1,300 kg-head on crash tests, 900 kg-1/4 offset crash tests, 1,300 kg-head on crash test with $15^{\circ}$angle were conducted. The simulation and experiment test result showed that THIV values were below 44 km/h criterion, PHD values were below the 20G. The development non-redirective crash cushion is expected to be used for the fixed object such as bridge piers for assuring occupant safety.

The Stability Analysis of Submerged Excavated Slopes (수중 굴착사면의 안정해석)

  • Lee, M.W.;Lee, C.K.;Kim, H.J.;Ahn, K.K.;Heo, Y.
    • Journal of the Korean Society of Safety
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    • v.12 no.3
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    • pp.147-154
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    • 1997
  • The main purpose of this study is to investigate the failure surface in a soil mass by a excavation of the model ground. The failure mechanism of an earth structure is usually determined from field failure observations or from laboratory model tests at failure. To study the failure surface for the excavated slope, laboratory model tests were performed by changing the angle of the excavated slope and the ground condition. Results of the laboratory model tests were compared with those obtained with theoretical solutions using limit equilibrium analysis method. The results of model tests show that, there is a failure to create a straight line in the low angle of excavated surface and a create a circle as the angle increases. As the angle of excavated surface is increasing, the angle of the failure surface increases too. In the angle of the failure surface, the submerged ground is less than the dry ground at $3.2^{\circ}$.

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Stress-Strain Properties of Geosynthetics by Confined Extension Tests (구속신장시험에 의한 토목섬유의 인장력-변형률거동 특성)

  • Bang, Yoon-Kyung;Jeon, Young-Dae;Lee, Jun-Dae
    • Journal of the Korean Society of Safety
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    • v.17 no.2
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    • pp.52-57
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    • 2002
  • In this study. stress-strain relationships were investigated by performing the confined extension tests for seven types of geosynthetics such as geotextiles, composite geosynthetics and geogrids. A comparison was made between unconfined and confined moduli for each geosynthetic material to quantify the soil confinement effect on stress-strain properties. A comparison was also made between the increase of moduli at the same strain level with the types of the geosynthetics to demonstrate the different stress-strain responses. Based on the result of the extension tests, the higher the confining stress, the larger the secant modulus of geosynthetics. The secant modulus at 5% strain is twice as much as that of 10% strain, especially there is a noticeable increasing of secant modulus for the two nonwoven geotextiles.

Safety Evaluation of Bogie Frame for Tilting Railway Vehicles by Fatigue and Nondestructive Tests (피로시험 및 비파괴 검사를 통한 틸팅열차용 주행장치 프레임의 안전성 평가)

  • Kim Jung-Seok;Kim Nam-Po
    • Journal of the Korean Society for Railway
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    • v.8 no.5
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    • pp.419-424
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    • 2005
  • This paper has performed fatigue and nondestructive test of bogie frame for Korean tilting train. Before the fatigue test, static tests were carried out. From the test, the structural safety was investigated using Goodman diagram. After the static test, the fatigue test were conducted under tilting load conditions. The fatigue test was conducted for $10{\times}10^6$ cycles. During the fatigue test, the nondestructive tests using magnetic particle and liquid penetrant were performed at $6{\times}10^6$ cycle and $10{\times}10^6$cycle. From the crack detection tests, it was known that there was no fatigue crack in the bogie frame.

Evaluation of Measurement Precisions Using Approximate F Tests and EMS in the Gauge R&R Studies (게이지 R&R 연구에서 근사 F검정과 EMS를 이용한 측정 정밀도의 평가)

  • Choi, Sung-Woon
    • Journal of the Korea Safety Management & Science
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    • v.11 no.3
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    • pp.209-216
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    • 2009
  • A development in method of evaluating the measurement precisions using approximate F tests and variance components from expected mean square (EMS) is investigated. The research proposes three-factor mixed measurement models with the fixed and random factors. Unrestricted and unconstrained design work was rarely studied, while restricted and constrained designs have been significantly discussed. The unrestricted and unconstrained designs assume to be an independence of interaction. The proposed evaluation method about the measurement precisions can be extended to four-factor random measurement model or mixed measurement model. The study also presents the three evaluation indexes of precisions such as R&RTR (Reproducibility & Repeatability-To-Total Precision Ratio), PTR (Precision-To-Tolerance Ratio), and SNR (Signal-To-Noise Ratio). Numerical examples are proposed to evaluate the approximate F tests with Satterthwaite degrees of freedom and three indexes using the measurement precisions from EMS.

Test-Retest Reliability of Paper-Pencil Test for Investigating Stereotypes of Controls of Passenger Cars (승용 자동차 조종장치 스테레오타입 조사를 위한 설문조사법의 신뢰성)

  • Kee, Dohyung
    • Journal of the Korea Safety Management & Science
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    • v.17 no.2
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    • pp.201-206
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    • 2015
  • This study aims to investigate test-retest reliability or reproducibility of the paper-pencil test for investigating stereotypes of seven principal controls of passenger cars. The controls include wiper, head light, high beam, door window, ignition key, door key and door lock. Sixty two college-aged students participated in the paper-pencil tests and the tests were conducted twice with an in-between period of 4 weeks. The results showed that the stereotypes of motion-directions for the seven controls by the two paper-pencil tests were the same, and that the percentage agreements between two tests by subjects were ranged from 60.0% to 80.6%. There was a weak linear relationship between averaged rates of responses for the stereotypes of motion-directions for the seven controls and percentage agreements by subjects. Based on these results, it is concluded that the paper-pencil test collects reliable or reproducible data on the stereotypes of motion-directions for passenger cars' controls within four weeks.