• Journal of Animal Reproduction and Biotechnology
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• v.38 no.2
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• pp.47-53
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• 2023

Despite numerous advances in in-vitro embryo production (IVP), many documented factors have been shown to influence the development of mammalian preimplantation embryos and the success of IVP. In this sense, elevated levels of reactive oxygen species (ROS) correlate with poor outcomes in assisted reproductive technologies (ART) due to oxidative stress (OS), which results from an imbalance between ROS production and neutralization. Indeed, excessive production of ROS compromises the structural and functional integrity of gametes and embryos both in vivo and in vitro. In particular, OS damages proteins, lipids, and DNA and accelerates cell apoptosis. Several in-vivo and in-vitro studies report an improvement in qualityrelevant parameters after the use of various antioxidants. In this review, we focus on OS and the source of free radicals and their effects on oocytes, sperm, and the embryo during IVP. In addition, antioxidants and their important role in IVP, supplementation during oocyte in vitro maturation (IVM), in vitro culture (IVC), and semen extenders were discussed. Nevertheless, various methods for determining the level of ROS in germ cells have been briefly described. Still, it is crucial to develop standardized antioxidant supplement systems to improve overall IVP success. Further studies should explore the safety, efficacy, mechanism of action, and combination of different antioxidants to improve IVP outcomes.

• Proceedings of the KSR Conference
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• 2007.05a
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• pp.1187-1192
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• 2007

Recently, many organizations such as, including government, railroad operational, railroad facilities managemental and research authorities have made a lot of efforts to identify and prevent hazards from leading to accidents and solve them all over the railroad industry. Railroad total safety technology development project conducted as one of national R&D projects has established business formation structure based on system engineering as an effort to define and give a solution to facing problems in the field of railroad. This paper is building procedures to verify the outcomes derived from this project. The verification process is the one for verifying the outcome produced in the final stage of the project or during the project. It makes sure that the system is satisfying the system requirements through verification of the outcomes produced after conducting the project for verification. We've made verification plan for technically reasonable verification using verification process developed through this research, and established master verification plan in the level of 15 detailed projects for interim and final outcomes produced.

• Journal of Korean Neurosurgical Society
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• v.64 no.4
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• pp.495-504
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• 2021

Three-dimensional printing (3DP) applications possess substantial versatility within surgical applications, such as complex reconstructive surgeries and for the use of surgical resection guides. The capability of constructing an implant from a series of radiographic images to provide personalized anatomical fit is what makes 3D printed implants most appealing to surgeons. Our objective is to describe the process of integration of 3DP implants into the operating room for spinal surgery, summarize the outcomes of using 3DP implants in spinal surgery, and discuss the limitations and safety concerns during pre-operative consideration. 3DP allows for customized, light weight, and geometrically complex functional implants in spinal surgery in cases of decompression, tumor, and fusion. However, there are limitations such as the cost of the technology which is prohibitive to many hospitals. The novelty of this approach implies that the quantity of longitudinal studies is limited and our understanding of how the human body responds long term to these implants is still unclear. Although it has given surgeons the ability to improve outcomes, surgical strategies, and patient recovery, there is a need for prospective studies to follow the safety and efficacy of the usage of 3D printed implants in spine surgery.

• Journal of the Korean Society of Safety
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• v.38 no.1
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• pp.1-8
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• 2023

It is extremely important to design safety-guaranteed industrial processes because such process determine the ultimate outcomes of industrial activities, including worker safety. Application of artificial intelligence (AI) in industrial safety involves modeling industrial safety systems by using vast amounts of safety-related data, accident prediction, and accident prevention based on predictions. As a preliminary step toward realizing AI-based industrial safety in Korea, this study discusses neural network-based modeling of industrial safety systems. The input variables that are the most discriminatory relative to the output variables of industrial safety processes are selected using two information-theoretic measures, namely entropy and cross entropy. Normalized frequency and severity of industrial accidents are selected as the output variables. Our simulation results confirm the effectiveness of the proposed neural network model and, therefore, the feasibility of extending the model to include more input and output variables.

• International conference on construction engineering and project management
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• 2015.10a
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• pp.138-141
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• 2015

The South Korean construction industry has shown a high proportion of industrial accidents (approximately 28% of whole injuries) and the continuously increasing accident rate. Although many safety research emphasized that the 3E (Enforcement, Education, and Engineering) approach is a potential solution to enhance workplace safety, there should be benefits to consider psychological (i.e., Emotional) effects on the safety performance since most construction works are human-oriented. Thus, understanding construction workers' psychological conditions can be a priority. This research studied the relationships between psychological conditions-which cover stress, personal temperament, emotional disturbance, and drinking habit-and specific safety-related factors including safety motivation and knowledge, and safety performance of individual workers at a construction site. This study conducted a survey of 430 respondents and analyzed the data with the multiple linear regressions. The results imply persistence, trait anxiety, and problem-focused coping style are the critical factors that should be controlled for enhancing jobsite safety. Finally, the research outcomes could be applied to build a strategic safety management plan for a construction manager.

• Korean Journal of Construction Engineering and Management
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• v.24 no.6
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• pp.91-98
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• 2023

Construction accidents result from a combination of factors, including both the actions of workers and the safety conditions on site. Despite advancements in enhancing construction site safety, there remains a gap in comprehending the cognitive processes underlying workers' unsafe behavior. This paper investigates and validates a qualitative model that delves into the potential causes of workers' unsafe actions by examining their cognitive processes, employing a system dynamics approach. By analyzing the interplay of various loops within this model, it offers both short- and long-term safety strategies for managers intent on minimizing unsafe behavior among workers. Specifically, safety managers should prioritize increasing workers' awareness of hazards through education and fostering a positive safety mindset. Moreover, they should task frontline supervisors with directly addressing and rectifying instances of unsafe behavior by workers. Lastly, construction safety managers ought to formulate safety strategies that take into account the cognitive states of workers to mitigate any adverse consequences of biased safety management. The outcomes of this research contribute to our comprehension of methods to enhance hazard perception among workers, curtail unsafe actions, and ultimately reduce construction accidents from a cognitive standpoint.

• Journal of Ginseng Research
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• v.42 no.2
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• pp.144-148
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• 2018

Background: Panax ginseng is a well-known immune modulator, and there is concern that its immune-enhancing effects may negatively affect patients with rheumatoid arthritis (RA) by worsening symptoms or increasing the risk of adverse effects from other drugs. In this randomized, crossover clinical trial, we evaluated the impact of Korean Red Ginseng (KRG) on disease activity and safety in RA patients. Methods: A total of 80 female RA patients were randomly assigned to either the KRG (2 g/d, n = 40) treatment or placebo (n = 40) groups for 8 wk, followed by crossover to the other treatment group for an additional 8 wk. The primary outcome was the disease flare rate, defined as worsening disease activity according to the disease activity score 28 joints-erythrocyte sedimentation rate (DAS28-ESR). The secondary outcomes were development of adverse events (AEs) and patient reported outcomes. Outcomes were evaluated at baseline and 8 wk and 16 wk. The outcomes were compared using the Chi-square test. Results: Of the 80 patients, 70 completed the full study. Their mean age was 51.9 yr, and most exhibited low disease activity (mean DAS28-ESR $3.5{\pm}1.0$) at enrollment. After intervention, the flare rate was 3.7% in each group. During KRG treatment, 10 AEs were reported, while five AEs were developed with placebo; however, this difference was not statistically significant (p = 0.16). Gastrointestinal- and nervous system-related symptoms were frequent in the KRG group. Conclusion: KRG is not significantly associated with either disease flare rate or the rate of AE development in RA patients.

• Safety and Health at Work
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• v.14 no.3
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• pp.250-258
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• 2023

The effectiveness of mindfulness techniques in addressing mental health conditions in workers is uncertain. However, it could represent a therapeutic tool for workers presenting with such conditions. Our objective was to assess the effects of mindfulness-based practices for workers diagnosed with mental health conditions. We conducted a systematic review of randomized controlled trials. Participants included were workers with a mental health condition. Interventions included any mindfulness technique, compared to any nonmindfulness interventions. Outcomes were scores on validated psychiatric rating scales. A total of 4,407 records were screened; 202 were included for full-text analysis; 2 studies were included. The first study (Finnes et al., 2017) used Acceptance and Commitment Therapy (ACT) associated or not with Workplace Dialogue Intervention (WDI), compared to treatment as usual. At 9 months follow-up, for the ACT group, depression scores improved marginally (standardized mean difference [SMD]: -0.06, p = 0.021), but anxiety scores were worse (SMD: 0.15, p = 0.036). Changes in mental health outcomes were not statistically significant for the ACT + WDI group. In the second study (Grensman et al., 2018), no statistically significant change in mental health scales has been observed after completion of mindfulness-based cognitive therapy compared to cognitive behavioral therapy. Substantial heterogeneity precluded meta-analysis. This systematic review did not find evidence that mindfulness-based practices provide a durable and substantial improvement of mental health outcomes in workers diagnosed with mental health conditions.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.3
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• pp.127-138
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• 2005

Purpose : This study was designed to establish safety and efficacy of using herbal medicine in pregnancy and to investigate patient's treatment satisfaction. Methods : We investigated general pregnancy outcomes of twenty-five gynecological outpatients who visited Dongguk univ. Kangnam Oriental Hospital, from July 1, 2002 through December 31, 2004 and have taken herbal medicine in pregnancy. Additionally we investigated newborn's growth status and patient's treatment satisfaction. Results : The rate of normal delivery of patients used herbal medicine for diseases that possibility of abortion is not high was 100% and there was no malformation in normally delivered 21 cases. Most of Newborn's growth status was normal and the average score of patient's satisfaction was 3.5(absolutely satisfied=5). Conclusion : The results of this study show safety and efficacy of using herbal medicine in pregnancy. And In the future, It is thought that more exactly constructed clinical survey need to be carried out.

• Safety and Health at Work
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• v.8 no.4
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• pp.407-409
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• 2017

Air pollutants of concern include traffic-related air pollution, including particulate matter in respirable coarse and fine size fractions. There are no critical studies to date into associations between knowledge, awareness, and attitudes in using proper respiratory masks and prevalence of respiratory symptoms among urban street vendors in Thailand. In this study, we estimated adverse respiratory health outcomes among street vendors, in particular young adults, in Bangkok, Thailand, using a self-report questionnaire. Street vendors, who were not currently smoking and not having known diagnosed respiratory diseases, were recruited. They were selected from selected roadsides at Chong Nonsi, Bangkok. Participants (n = 30) reported having lower respiratory (50%), upper respiratory (37%), and other symptoms (70%). Also, 53% of participants had never used respiratory personal protective equipment (PPE: masks). Among those using PPE, all used masks not proper for particulate matter. Results suggested knowledge, awareness, and attitudes concerning proper PPE use needs to be increased among street vendors in Bangkok, Thailand.