• Pediatric Infection and Vaccine
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• v.25 no.3
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• pp.141-147
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• 2018

Purpose: Despite effectiveness and safety of maternal tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccination, Tdap vaccination coverage during pregnancy remains quite low. We assessed the knowledge, attitude and practice on maternal Tdap vaccination among pregnant women. Methods: This study was a cross-sectional survey of pregnant women who visited tertiary obstetrics and gynecologic units in Seoul and Gyeonggi province of Korea. Individual questionnaires were administered to assess knowledge, attitude and practice on maternal immunization with Tdap. Results: The questionnaires were completed by 184 pregnant women; 158 (86%) had not received information from doctors about pertussis and Tdap, and 166 (90%) did not know the need for Tdap vaccination. Only 7% of pregnant women unlikely to receive Tdap vaccine during current pregnancy answered 3 or more of the 5 knowledge-based questions correctly. By logistic regression analysis, recommendation by doctor (adjusted odd ratio [OR], 236.2; 95% confidence interval [CI], 12.6-4,432), belief that the vaccine is effective (adjusted OR, 40.21; 95% CI, 2.35-687.7), and belief that the vaccine is safe (adjusted OR, 19.83; 95% CI, 1.54-255.9) were significantly important factors to respondents' intention to be vaccinated. Conclusions: Most pregnant women seem to be neither recommended nor adequately informed about Tdap vaccination. Information given by health care professionals is very important to increase Tdap coverage among pregnant women.

• The Journal of the Korea Contents Association
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• v.19 no.3
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• pp.365-374
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• 2019

Unlike benign tumors, malignant tumors are capable of metastasis, easy to relapse, poor survival, and low quality of life. In Korea, here is a tendency to treat the tumors collectively according to the General Principles of Cancer Chemotherapy(GPCC) of the Health Insurance Review & Assessment Service (HIRA). But recently, companion diagnostics(CDx) is recommended rather than unilateral medication because biomarker-based molecular diagnostics is possible to predict the drug response of patients before drug treatment. Not only domestic but also overseas Food and Drug Administratio (FDA) recommends the development of the CDx system at the stage of drug development to ensure the responsiveness and safety of medicines. In this study, I focused on the necessity of CDx development direction as well as CDx development status through literature review. Furthermore I also discussed CDx types according to the molecular diagnostic technology such as immunohistochemistry (IHC), polymerase chain reaction (PCR), in situ hybridization (ISH), and next-generation sequencing (NGS) not only in the approved CDx but also in the developing one by US FDA. And I suggested the technology issue of CDx development process such as a selection of molecular diagnostics at the time of release, a clear understanding of the CDx mechanism, and a convergence of drug with CDx development. The necessity of social insurance system also was proposed for CDx development.

• Journal of the Korean Recycled Construction Resources Institute
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• v.6 no.4
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• pp.324-330
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• 2018

In accordance with the amendment of the Industrial Safety and Health Act of 2007, Korea completely prohibited the import, distribution and manufacture of asbestos like Europe and Japan. Accordingly, the current problem of asbestos is the safe maintenance and disposal of asbestos construction material, the disposal of asbestos, and the final disposal of asbestos building materials. In the past, Korea used 100,000 tons of asbestos every year, and the building materials using it exceeded 1 million tons per year. These asbestos building materials continued to be used until 2006, and the Ministry predicted that these materials would continue to be maintained until 2044. When the permeable hardening agent is applied to the asbestos building material installed in the pre-pretreatment step for the harmless treatment of the asbestos waste and the dismantling is carried out, the scattering of the asbestos is suppressed in the disassembling step, detoxification treatment conditions can be improved. Therefore, permeable hardeners should be stably penetrated into asbestos building materials. In this study, it is suggested that pre - pretreatment methods for the harmlessization of waste asbestos building materials with medium density level can be presented. In order to efficiently perform pre - treatment for chemical harmlessness in the future, the mixing ratio of permeable hardener and middle water Optimization is the most important factor.

• 재활복지
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• v.20 no.1
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• pp.1-22
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• 2016

This research aimed to examine the problems in a current national emergency management system that does not consider the disabled in the face of manmade catastrophes and natural disasters, and to conduct an expert opinion survey to explore the direction of disabled-inclusive public disaster management system. As a result of the analysis, the respondents of the survey revealed a need for a designated government department for disaster management systems for the disabled and the experts preferred the Ministry of Public Safety and Security (50%) than the Ministry of Health and Welfare (37.5%). However, 12.5% of the surveyed experts perceived cooperation between the two Ministries, rather than selecting a certain ministry, as necessary to establish a disaster management system for the disabled. Additionally, the experts recognized the response period (43.8%) of the disaster management life cycle to be the most important phase. Thus, at the disaster response period, the experts suggested utilizing an emergency alarm system to effectively rescue the disabled in the face of disaster. Based on this discussion, the paper explores ways to establish a disabled-inclusive public disaster management system.

• Applied Chemistry for Engineering
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• v.29 no.6
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• pp.670-676
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• 2018

Experiments on combustion gases generation of untreated cypress specimens or treated with boric acid, ammonium pentaborate, and boric acid/ammonium pentaborate additive were carried out. Test specimens were painted three times with 15 wt% boron compound aqueous solutions. After drying, the generation of combustion gas was analyzed using a cone calorimeter (ISO 5660-1). As a result, comparing to untreated specimen, the smoke performance index (SPI) of the specimens treated with the boron compound increased by 1.37 to 2.68 times and the smoke growth index (SGI) decreased by 29.4 to 52.9%. The smoke intensity (SI) of the specimens treated with boron compounds is expected to be 1.16 to 3.92 times lower than that of untreated specimens, resulting in lower smoke and fire hazards. Also, the maximum carbon monoxide ($CO_{peak}$) concentration of specimens treated with boron compounds was 12.7 to 30.9% lower than that of untreated specimens. However, it was measured to produce fatal toxicities from 1.52 to 1.92 times higher than that of permissible exposure limits (PEL) by Occupational Safety and Health Administration (OSHA). The boron compounds played a role in reducing carbon monoxide, but it did not meet the expectation of reduction effect because of the high concentration of carbon monoxide in cypress itself.

• Journal of the Korean Society of Radiology
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• v.13 no.4
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• pp.605-611
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• 2019

The purpose of this study is to manufacture a multi-function device (MFD) which can be applied to various types of weight-bearing view of the lower leg, and to compare the results with the images from the existing weight-bearing platforms (WBPs), thereby suggesting a clinical utilization. The MFD was manufactured, by considering the minimum adjustable heights of the platform for weight-bearing foot/ankle, platform for hindfoot alignment view, and X-ray tube of the X-ray device. A foot/ankle phantom was used to take the images of weight-bearing lateral foot in MFD and WBPs to compare the resolutions of the X-ray images using a quick modulation transfer function (MTF) program. Between both the images taken from the MFD and WBPs, there was no statistically significant difference found in the mean cycles per pixel (C/P) and the lines per image height (LPH) of the 50%-Contrast Spatial Frequency (MTF50), and 10-90% of Maximum Energy Rise Distance (10-90%), where p>0.05. The MFD is suggested for its clinical trial as a useful positioning device that can secure the patient's safety and manifoldly perform various inspections. Also, the recommendation of the positioning device as a policy can activate dedicated manufacturers, while also improving the quality of medical services.

• The Journal of Society for e-Business Studies
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• v.24 no.2
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• pp.143-163
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• 2019

The purpose of this study is to identify acceptance factors and influencing factors of respondents' adoption of smart IoT technology to companion animal health based on the integrated technology acceptance model. Based on the previous studies, we constructed the hypotheses by defining the technical factors, social factors, control variables, and mediating variables (UTAUT), and set the hypotheses between the independent variables of each factor and the dependent intention. A research model was designed to verify the relationship between variables. We developed questionnaires on the items and verified them through data collected from 494 people. As a result, product design, quality of service, product performance, and quality service of technological factors had a significant effects on performance expectancy and effort expectancy. However, product safety, product function awareness, and product price did not significantly affect performance expectancy and effort expectancy. Social influence had significant effects on cognitive effect, welfare system, and welfare facilities. In conclusion, the comparative analysis of technical factors and social factors showed that social factors have more significant effects on welfare systems and facilities.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.32 no.2
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• pp.68-93
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• 2019

Objective : This study summarized the characteristics of clinical trials for atopic dermatitis medicines approved by the Ministry of Food and Drug Safety(MFDS). This study may be a reference for the design of clinical trials of atopic dermatitis herbal medicine treatment which may be carried out later. Method : The characteristics of the clinical trial were analyzed for clinical trials registered with ClinicalTrials.gov, CRIS, and the Korea Health Industry Development Institute among the clinical trial approval statuses posted on the website of the MFDS. Result : 1. Clinical trial drugs were developed in various formulations such as oral medicines, injections, dermatologic agents, and similar proportions. Relatively little clinical trials were found for herbal medicine. 2. In the control evaluation test, most of the treatments for the control group were performed with placebo using Vehicle. 3. In most clinical trials, one intervention group was in the form of a parallel assignment with only one treatment. 4. The age of the subjects was 11 out of 28 studies including minors, and clinical trials targeting minors were also found to be significant. 5. In the case of atopic dermatitis, the cases of subacute chronic or atopic dermatitis more than 6 months or more than 1 year were often used. 6. Most clinical trials were divided into mild to moderate atopic dermatitis or moderate to severe atopic dermatitis. The SCORAD index, EASI, IGA, BSA, and NRS were used as the evaluation criteria. 7. Regulations for the drugs used prior to the trial period for the treatment of atopic dermatitis vary somewhat from one clinical trial to another. 8. IGA was used most often as a primary efficacy tool, and SCORAD index, EASI, and NRS were also used.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.36 no.4
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• pp.80-93
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• 2018

The following results could be obtained from the research on awareness and satisfaction of the tourists who joined the program 'A Journey in Search of King Mu's Road'. With regard to awareness of the site tour program, tourists replied that they participated in the program mainly because of their interest in education for their children. They expressed great needs for the municipal government office to maintain walkways, signboards and guide maps as well as to reinforce safety facilities as a measure to increase satisfaction with the site tour on the part of visitors and tourists. In terms of satisfaction with operation and management of the site tour program, the contents of the program were highly appreciated while it turned out necessary to rediscover garden culture resources and to develop and operate an expanded internal tour course for tourists to look around inside the relics by utilizing the recently excavated Baekje historical resources. As a consequence, it might be expected possible to experience and educate the local history and garden culture thanks to the historical culture and environmental values that have been preserved in the Baekje cultural circles. Moreover, the importance of walking trips will be recognized for its effects to allow those who get tired from daily life to come into contact with nature, practice self-reflection and care for their health as well.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2019.05a
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• pp.533-536
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• 2019

Recombinant baculoviruses are widely used to express heterologous genes in cultured insect cells. Recombinant baculoviruses can serve as gene-transfer vectors for expression of recombinant proteins in a wide range of mammalian cell types. Baculovirus system has significant benefits in view of safety, large-scale, and high level of gene expression. In this study, baculoviral vectors which were reconstructed from pOPINEneo-3C-GFP vector, were recombined with cytomegalovirus (CMV) promoter, green fluorescent protein (GFP), and p53 with NcoI and XhoI. These recombinant vectors were infected with various cells and cell lines. The baculovirus vector thus developed was analyzed by comparing the metastasis and expression of the recombinant genes with conventional vectors. These results suggest that the baculovirus vector has higher efficiency in metastasis and expression than the control vector. This work was supported by a grant from Mid-Career Researcher Program(NRF-2016R1A2B4016552) through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT & Future Planning(MSIP).