• Journal of Gastric Cancer
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• v.23 no.1
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• pp.194-206
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• 2023

Although continuous improvement in the treatment outcome of localized gastric cancer has been achieved through early screening, diagnosis, and treatment and the active application of surgery and adjuvant chemotherapy, the necessity of adjuvant radiotherapy (RT) remains controversial. In this review, based on the results of two recently published randomized phase III studies (Adjuvant Chemoradiation Therapy In Stomach Cancer 2 and ChemoRadiotherapy after Induction chemoTherapy of Cancer in the Stomach) and a meta-analysis of six randomized trials including these two studies, the role of adjuvant RT in gastric cancer was evaluated and discussed, especially in patients who underwent curative gastrectomy with D2 lymphadenectomy. This article also reported the possible indications for adjuvant RT in the current clinical situation and in future research to enable patientspecific treatments according to the risk of recurrence.

• International Journal of Internet, Broadcasting and Communication
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• v.16 no.3
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• pp.98-112
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• 2024

As digital education progresses, MOOC (Massive Open Online Courses) are increasingly utilized by learners, making research on MOOC learning outcomes a necessary endeavor. In this study, we systematically investigated the impact of audiovisual elements on learning outcomes in MOOC, highlighting the nuanced role these components play in enhancing educational effectiveness. Through a comprehensive survey and rigorous analysis involving descriptive statistics, reliability metrics, and regression techniques, we quantified the influence of text, graphics, color, teacher images, sound effects, background music, and teacher's voice on learner attention, cognitive load, and satisfaction. We discovered that background music and text layout significantly improve engagement and reduce cognitive burden, underscoring their pivotal role in the instructional design of MOOC. We findings contribute new insights to the field of digital education, emphasizing the critical importance of integrating audiovisual elements thoughtfully to foster better learning environments and outcomes. Not only advances academic understanding of multimedia learning impacts but also offers practical guidance for educators and course designers seeking to enhance the efficacy of MOOC.

• Journal of Korean Academy of Nursing
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• v.36 no.1
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• pp.103-113
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• 2006

Introduction: It is important to understand the nature of the identity through the live experiences of Home Care Nurse Practitioner(HCNP) because the role identity of a professional is constructed by continuous social interactions, This study aims to understand the construction of the role identity of HCNP. Method: Data was collected from 12 hospital based HCNPs. This study involved two focus group discussion sand four in-depth individual interviews. The main question was 'what is the role of HCNP?' The debriefing notes and field notes were analyzed using consistent comparative data analysis method. Result: First, Home care (He) is a small clinic. HCNP brings it to home to provide various services. Second, HC is the real nursing and HCNP is the 'genuine' nurse who actualizes the essence of nursing in practice. Third, HC is empowering activity to promote self-care ability of the patients and their caregivers. Forth, HC is like the dish-spinning required high-level mastery and HCNP is an expert who provides the most appropriate services to the patients. Conclusion: HCNPs have the role identity as a highly qualified professional who delivers services from hospital to home, actualizes the essence of nursing in practice, empowers the patients and their caregivers to have self-efficacy to recover, and offers the most appropriate nursing care.

• International Commerce and Information Review
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• v.12 no.3
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• pp.267-288
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• 2010

The collapse of housing market bubble in United States had a considerable impact on the world economy. The collapse of housing market bubble in United States generates the global financial crisis at the worldwide level. The housing market bubble question the efficacy of fundamental proposition of orthodox economics based on the rationality of human choice. According to neuroeconomics and neuroscience, emotion and affect play the important role in purchasing the commodity in retails market. On the basis of the neuroeconomics, this study focuses on the role of affect and emotion in the purchase of subprime loan in United States. Robert Schiller suggests that one of the causes of housing market bubble is the contagion effect of human belief in the society. The structure of this paper is as follows. First, this study investigates the mechanism of human brain and role of various neurons to influence the human behavior in the purchase of house in United States, such as Dophamine neuron and mirroring neuron. Second, this study shows the possibility that the mirror neuron might explain the contagion of human belief in housing transaction market. It can be a seed of housing market bubble. Furthermore, this study show the implications of neuroeconomics is suggestive to the negotiation process in commercial policy in United States.

• Radiation Oncology Journal
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• v.38 no.1
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• pp.1-10
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• 2020

Radiotherapy (RT) has been used for decades as one of the main treatment modalities for cancer patients. The therapeutic effect of RT has been primarily ascribed to DNA damage leading to tumor cell death. Besides direct tumoricidal effect, RT affects antitumor responses through immune-mediated mechanism, which provides a rationale for combining RT and immunotherapy for cancer treatment. Thus far, for the combined treatment with RT, numerous studies have focused on the immune checkpoint inhibitors and have shown promising results. However, treatment resistance is still common, and one of the main resistance mechanisms is thought to be due to the immunosuppressive tumor microenvironment where myeloid-derived suppressor cells (MDSCs) play a crucial role. MDSCs are immature myeloid cells with a strong immunosuppressive activity. MDSC frequency is correlated with tumor progression, recurrence, negative clinical outcome, and reduced efficacy of immunotherapy. Therefore, increasing efforts to target MDSCs have been made to overcome the resistance in cancer treatments. In this review, we focus on the role of MDSCs in RT and highlight growing evidence for targeting MDSCs in combination with RT to improve cancer treatment.

• Journal of Information Technology Applications and Management
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• v.17 no.2
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• pp.19-45
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• 2010

This research has analyzed the differentiated influence of organizational variables(an organization's learning culture and organizational support networks) and personal variables(the individual's motivation to learn and self-efficacy) on the process of gaining and using of knowledge. These two variables have been regarded as the major variables for the successful learning of 6Sigma, according to Social Cognitive Theory. In addition, this research has proven the role structure of the abovementioned two variables through a suitable methodology(Hierarchical Linear Model). In regard to this methodology, the different hierarchical level of the personal variable and organizational variable was especially focused on, and the effect of interaction between the high level and the low level was considered in detail. Considering the current situation, in that the importance of organizational factor and personal factor has been emphasized but the accurate role of each variable has not been verified, the research model is thought to help to establish an effective strategy to implement 6 Sigma.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.2
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• pp.789-806
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• 2020

The 4^th Industrial Revolution (FIR) has already begun. Corporations have to fulfill their social responsibilities to the FIR. This study explores the leadership and attitudes required in the FIR era for companies to fulfill their social responsibilities. In the FIR era, workers should have certain attitudes, such as self-efficacy, expectancy, and acceptance of change. If workers have these attitudes, they will be able to make a difference in the future. This study suggests the leadership styles that are needed to improve these attitudes. Participation, creativity, delegation of leadership, and inspirational motivation of leaders involves organizational change and improvement of organizational performance. This paper demonstrates the kind of leadership that is more important for each attitude through statistical analysis. Furthermore, when workers have these attitudes, not only the future, but also their current performance can be improved. To explain this relationship, the paper describes the effect of attitudes on job satisfaction. If workers have certain attitudes, their current and future performance will improve. As a result of the research, all four leadership styles had positive effects on attitudes toward FIR, and attitudes showed a mediating effect on the relationship between leadership styles and job satisfaction. In addition, it has been proven that the role of participative and delegating leadership, which is more member-oriented leadership, is more important. Leadership will enable workers to have a particular attitude through member-centered leadership, and workers will be able to increase current and future performance. Through these efforts, companies will be able to increase their performance in the current and FIR era, and fulfill their social responsibilities more faithfully. Therefore, in the FIR era, companies will play an important role in the development of society, and create new values.

• Research in Community and Public Health Nursing
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• v.16 no.1
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• pp.13-22
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• 2005

Purpose: The purpose of this study is to compare health promotion behavior and influencing factors between aged women of rural areas and urban areas, to investigate factors affecting their behavior, and to provide the primary data for developing heath enhancing program that is appropriate for the population. Method: A survey was conducted on 221 aged women 100 from urban areas and 121 from rural area. The data were collected through a questionnaire and interview. Descriptive statistics, ANOVA and multiple stepwise regression were found by using SPSS PC Win. Package. Result: There were significant difference of factors relating health promotion behavior in Pender model between the aged women in urban areas and rural areas, urban women showed higher scores in factors such as previous heath relating behavior, perceived confidence, self-efficacy, social support, satisfaction with marriage, situational influence, and behavioral plan involvement, while rural women showed higher scores in the factors of fixed idea regarding gender role, perceived disabled feeling, and activity related emotions. At the subscale of HPLP, interpersonal relation, nutrition, health responsibility, stress management, spiritual growth of rural group was lower than urban group. With the multiple stepwise regression analysis, commitment to a plan of action, social support, activity related affect, self efficacy were proved to be significant to urban group, while commitment to a plan of action. activity related affect, social support, sex-role stereotype were proved to be significant to rural group statistically. Conclusion: There were differences of health promotion behavior and influencing factors between aged women in urban areas and rural areas and women in rural areas were found to have more weakness than women in urban areas. With the results, it is concluded that health promotion programs for aged woman should be designed differently between urban and rural area regarding the factors affecting health promotion behaviors.

• Human Ecology Research
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• v.53 no.4
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• pp.391-404
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• 2015

This study examined job satisfaction and relevant variables for multi-cultural family home-visiting educators. The selected study subjects were 192 home-visiting educators who work at Multi-Cultural Family Support Centers in the Seoul, Gyeonggi-do, and Chungcheongnam-do areas. Data analysis was conducted using SPSS ver. 18.0. The main results were as follows. First, the job satisfaction level in multi-cultural family visiting educators stood at 3.29 points, subjects' age, averagely monthly income, marital status, and activity career were shown to influence generally upon job satisfaction, self-efficacy, job stress, and cultural competency. Job satisfaction was high in groups with: a high age, small career, low averagely monthly income, and married. Second, self-efficacy and job stress were big in the job satisfaction of multi-cultural family visiting educators. The same outcome as the existing prior research was indicated. Cultural competency was not significant. Third, an examination of relative influence upon job satisfaction in home visiting educators indicated that the explanation power was 29.0%. Significant influential variables included academic background, marital status, self-regulation, and role ambiguity. Self-regulation was greater for those with lower academic backgrounds and unmarried. Job satisfaction was higher in the lower role ambiguity. Thus, the same outcome as the existing prior research was indicated. Cultural competency wasn't indicated to be significant. This has significance in having shown characteristics of job satisfaction in multi-cultural family visiting educators.

• Journal of Ginseng Research
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• v.45 no.6
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• pp.695-705
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• 2021

Background: Ginsenosides have beneficial effects on several airway inflammatory disorders primarily through glucocorticosteroid-like anti-inflammatory activity. Among inflammatory cells, eosinophils play a major pathogenic role in conferring a risk of severe refractory diseases including chronic rhinosinusitis (CRS). However, the role of ginsenosides in reducing eosinophilic inflammation and CRS pathogenesis is unexplored. Methods: We investigated the therapeutic efficacy and underlying mechanism of ginsenoside F1 (G-F1) in comparison with those of dexamethasone, a representative glucocorticosteroid, in a murine model of CRS. The effects of G-F1 or dexamethasone on sinonasal abnormalities and infiltration of eosinophils and mast cells were evaluated by histological analyses. The changes in inflammatory cytokine levels in sinonasal tissues, macrophages, and NK cells were assessed by qPCR, ELISA, and immunohistochemistry. Results: We found that G-F1 significantly attenuated eosinophilic inflammation, mast cell infiltration, epithelial hyperplasia, and mucosal thickening in the sinonasal mucosa of CRS mice. Moreover, G-F1 reduced the expression of IL-4 and IL-13, as well as hematopoietic prostaglandin D synthase required for prostaglandin D2 production. This therapeutic efficacy was associated with increased NK cell function, without suppression of macrophage inflammatory responses. In comparison, dexamethasone potently suppressed macrophage activation. NK cell depletion nullified the therapeutic effects of G-F1, but not dexamethasone, in CRS mice, supporting a causal link between G-F1 and NK cell activity. Conclusion: Our results suggest that potentiating NK cell activity, for example with G-F1, is a promising strategy for resolving eosinophilic inflammation in CRS.