• Title/Summary/Keyword: rodent population

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Differences in Characteristics of Habitat and Rodent Populations Between Before and After Damaged Tree Removals at Forest Fired Areas in Samcheok, Gangwon Province, Korea (강원도 삼척 산불피해지역에서 피해목 제거 전과 후의 서식환경 및 설치류 개체군 특성 차이)

  • Lee, Eun Jae;Lee, Woo-Shin;Lee, Young-Geun;Lee, Myung-Bo;Rhim, Shin-Jae
    • Journal of Korean Society of Forest Science
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    • v.97 no.1
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    • pp.113-117
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    • 2008
  • This study was conducted to clarify the differences in habitat characteristics and rodent populations between before and after damaged tree removals at forest fired areas in coniferous forest, Samcheok, Gangwon Province, Korea. The understory coverage and the number of shrub stem were increased by forest succession. Number of snags and downed CWD (coarse woody debris) were decreased after damaged tree removals. Population density of Apodemus agrarius was increased after damaged tree removal. However, population density of total rodents, Apodemus peninsulae and Eothenomys regulus were decreased. Changes in habitat structures may be influenced in rodent species composition. Especially, that would be negative effect on forestdwelling rodents.

Predictive Value of Excision Repair Cross-complementing Rodent Repair Deficiency Complementation Group 1 and Ovarian Cancer Risk

  • He, Shan-Yang;Xu, Lin;Niu, Gang;Ke, Pei-Qi;Feng, Miao-Miao;Shen, Hong-Wei
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.5
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    • pp.1799-1802
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    • 2012
  • Objective: We aimed to analyze the association between excision repair cross-complementing rodent repair deficiency complementation group 1 (XRCC1) and ovarian cancer risk. Methods: We performed a hospital-based case-control study with 155 cases and 313 controls in China. All Chinese cases with newly diagnosed primary ovarian cancer between May 2005 to May 2010 in our hospital were invited to participate within 2 months of diagnosis. Controls were randomly selected from people who requested general health examinations in the same hospital during the same period. SNPs in EXCC1, ERCC1 C8092A and ERCC1 T19007C, were analyzed by PCR-RFLP method. Results: We observed a non-significantly increased risk of ovarian cancer among individuals with ERCC1 8092TT compared with those with the 8092CC genotype (adjusted OR=1.55, 95% CI%=0.74-2.97). Moreover, 19007TT genotype carriers also showed a non-significant increased risk of ovarian cancer over those with the 19007CC genotype (adjusted OR=1.78, 95% CI%=0.91-3.64). Conclusion: Our firstly investigation of links between polymorphisms in the ERCC1 gene and the risk of ovarian cancer in Chinese population demonstrated no significant association. Further large sample studies in Chinese populations are needed.

Current Status of Quantitative Trait Locus Mapping in Livestock Species - Review -

  • Kim, Jong-Joo;Park, Young I.
    • Asian-Australasian Journal of Animal Sciences
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    • v.14 no.4
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    • pp.587-596
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    • 2001
  • In the last decade, rapid developments in molecular biotechnology and of genomic tools have enabled the creation of dense linkage maps across whole genomes of human, plant and animals. Successful development and implementation of interval mapping methodologies have allowed detection of the quantitative trait loci (QTL) responsible for economically important traits in experimental and commercial livestock populations. The candidate gene approach can be used in any general population with the availability of a large resource of candidate genes from the human or rodent genomes using comparative maps, and the validated candidate genes can be directly applied to commercial breeds. For the QTL detected from primary genome scans, two incipient fine mapping approaches are applied by generating new recombinants over several generations or utilizing historical recombinants with identity-by-descent (IBD) and linkage disequilibrium (LD) mapping. The high resolution definition of QTL position from fine mapping will allow the more efficient implementation of breeding programs such as marker-assisted selection (MAS) or marker-assisted introgression (MAI), and will provide a route toward cloning the QTL.

A Phylogenetic Study of Korean Rodents (Muridae, Sciuridae) Based on Mitochondrial and Nuclear DNA

  • Jung, Gi-La;Lee, Seo-Jin;Kim, Chuel-Kyu;Lee, Hang;Kim, Chang-Bae
    • Animal Systematics, Evolution and Diversity
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    • v.26 no.2
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    • pp.99-104
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    • 2010
  • The subfamily Murinae is a very controversial group concerning their phylogenetic relationship. Previous studies could not resolve phylogeny among four genera Apodemus, Micromys, Mus and Rattus of the Muridae. In the present study, eight rodent species resident in South Korea were collected and phylogenetically analyzed based on sequence data of five mitochondrial and nuclear DNA regions: 12S rRNA, cytochrome b gene (cyt b), cytochrome oxidase II (COII), control region of mitochondrial DNA, and a thyroglobulin (Tg) of nuclear DNA. According to the phylogeny of the concatenated data, M. musculus separated early in Murinae (ML 100%; BA 1.00 pp) and the genus Rattus grouped with the harvest mouse, M. minutes; these were separated from the genus Apodemus with relatively strong support (ML 74%; BA 0.76 pp). The Siberian chipmunk population was also examined using the five genes to obtain better resolution. The phylogeny for Korean rodents determined using the 12S rRNA, cyt b, COII and control regions discriminated the Siberian chipmunk populations from Korea, Russia, and China.

Distribution and Population Density of Rodents and Chigger Mites in Gokseong-gun of Jeollanam-do, Korea (전남 곡성군에서 포획한 들쥐 분포 및 털진드기의 개체군 밀도)

  • Song, Hyeonje
    • Korean Journal of Clinical Laboratory Science
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    • v.48 no.3
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    • pp.242-246
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    • 2016
  • The distribution and population density of rodents and chigger mites were investigated between April 2013 and November 2013 in the Gokseong-gun of Jeollanam-do, Korea. A total of 79 rodents were collected using Sherman collapsible traps, and among them, 73 were Apodemus agrarius (92.4%), 4 were Crocidura lasiura (5.0%), and 2 were Microtus fortis (2.5%). Sixty-eight out of the 79 rodents were parasitized by chiggers, showing an infestation rate of 86.0% and a chigger index of 74.5; the chigger index of A. agrarius was 75.4. From the trapped field rodents, 5,063 chigger mites were collected and identified with 6 species of 2 genera. Leptotrombidium scutellare was the dominant species with 3,535 chiggers (69.8%), followed by L. pallidum with 777 chiggers (15.3%). This results showed that the distribution of chigger mites differ in dominant species according to seasons. L. pallidum was the predominant chigger collected in April (34.3%), May (70.0%), and June (55.1%); whereas L. scutellare was the predominant chigger collected in September (75.5%), October (71.8%), and November (74.2%).

Comparative epidemiological studies on vector/reservoir animals of tsutsugamushi disease between high and low endemic areas in Korea (쯔쯔가무시병 다발생지역과 저발생지역간의 매개/숙주동물의 역학적 비교조사)

  • 이한일;조민기
    • Parasites, Hosts and Diseases
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    • v.33 no.1
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    • pp.27-36
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    • 1995
  • Comparative epidemiological studies on vector reservoir animals of tsutsugamushi disease were carried out in between south coast (the highest endemic) areas and east coast flow endemicl areas in October 1993. Fauna of field rodents and their population densities were not different between two areas. Antibody positive rate of Apodemus agrarius sera was higher in east coast (43.2% in south coast and 63.6% in east coast). High correlation (r = 0.87) was shown between antibody positive rate of A. osrwiur sera and population density of the vector mites (Leptotrombidium scutellare and 1. pnllidunl). L. scutellare was predominant in south coast, showing 110.6 chigger index (74.9% of the total chiggersl , whereas L. pcllidum was predominant in east coast, showing 126.3 chigger index (60.4% of the total). As higher population density of 1. scutellare was found in south coast where the prevalence rate of tsutsugamushi disease is the highest, it is believed that L. scutellare is more important vector species than L. pallidum which may result from more frequent vector-human contact.

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Differences in Population Density of 3 Rodent Species Between Natural Restored and Red Pine Silvicultured Forests after Forest fire (산불피해 후 자연복원과 소나무 조림을 실시한 지역에서 설치류 3종의 개체군 밀도 차이)

  • Lee, Eun-Jae;Son, Seung-Hun;Lee, Woo-Shin;Eo, Soo-Hyung;Rhim, Shin-Jae
    • Journal of Korean Society of Forest Science
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    • v.99 no.4
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    • pp.553-558
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    • 2010
  • This study was conducted to clarify the differences in rodents population densities between natural restored and red pine silvicultured forests after forest fire in Samcheok, Gangwon Province, Korea from March to December 2008. One ha size of 3 study plots were set up in each natural restored and silvicultured stand. We trapped the small rodents during 4 consecutive nights every 2 months in each stand. Understory coverage and number of shrub stems were higher in silvicultured stand than in natural restored stand. Coverage of overstory, suboverstory and midstory, number of tree stem, woody seedling stems and dead wood, and amount of coarse woody debris were higher in natural restored stand than in silvicultured stand. Six hundred eighty eight individuals of four species, such as Apodemus agrarius, A. peninsulae, Eothenomys regulus and Tamias sibiricus were captured in our study. Number of captured small rodents were higher in natural restored stand than in silvicultured stand. Also, species compositions were differed in both stands. The captured number of A. agrarius and A. peninsulae were most highest in April and December. E. regulus were shown higher number of captured in April and June, and T. sibiricus were in June and October. Removal of coarse woody debris and silvicultural practice would not be good for the inhabitation of small rodents. For the conservation of small rodents diversity, management of understory and canopy would be needed in forest fired area.

Computational Prediction of Alzheimer's and Parkinson's Disease MicroRNAs in Domestic Animals

  • Wang, Hai Yang;Lin, Zi Li;Yu, Xian Feng;Bao, Yuan;Cui, Xiang-Shun;Kim, Nam-Hyung
    • Asian-Australasian Journal of Animal Sciences
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    • v.29 no.6
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    • pp.782-792
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    • 2016
  • As the most common neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the main health concerns for the elderly population. Recently, microRNAs (miRNAs) have been used as biomarkers of infectious, genetic, and metabolic diseases in humans but they have not been well studied in domestic animals. Here we describe a computational biology study in which human AD- and PD-associated miRNAs (ADM and PDM) were utilized to predict orthologous miRNAs in the following domestic animal species: dog, cow, pig, horse, and chicken. In this study, a total of 121 and 70 published human ADM and PDM were identified, respectively. Thirty-seven miRNAs were co-regulated in AD and PD. We identified a total of 105 unrepeated human ADM and PDM that had at least one 100% identical animal homolog, among which 81 and 54 showed 100% sequence identity with 241 and 161 domestic animal miRNAs, respectively. Over 20% of the total mature horse miRNAs (92) showed perfect matches to AD/PD-associated miRNAs. Pigs, dogs, and cows have similar numbers of AD/PD-associated miRNAs (63, 62, and 59). Chickens had the least number of perfect matches (34). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses suggested that humans and dogs are relatively similar in the functional pathways of the five selected highly conserved miRNAs. Taken together, our study provides the first evidence for better understanding the miRNA-AD/PD associations in domestic animals, and provides guidance to generate domestic animal models of AD/PD to replace the current rodent models.

Isolation and Genetic Study of Hantavirus from Apodemus peninsulae Captured in Yeuncheon-gun, Kyunggi-do (경기도에서 채집한 Apodemus peninsulae에서 한탄바이러스 분리와 유전학적 연구)

  • Song, Ki-Joon;Kim, Yong-Soo;Lee, Yong-Ju;Kang, Ju-Il;Song, Jin-Won;Baek, Luck-Ju
    • The Journal of Korean Society of Virology
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    • v.28 no.4
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    • pp.337-345
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    • 1998
  • Hantaviruses are distributed in rodent population world-widely even in geographical areas where hemorrhagic fever with renal syndrome (HFRS) has not been reported. Various species of Family Muridae and Arvicolidae serve as the natural reservoirs of hantaviruses. Hantaan virus, Seoul virus, Puumala virus, Prospect HII virus, Sin Nombre virus and New York virus are members of genus Hantavirus and isolated from lungs of A. agrarius, R. norvegicus, C. glareolus, M. pennsylvanicus, P. maniculatus and P. leucopus respectively. This experiment was intended to find the distribution of hantavirus infection among wild rodents and isolate the hantavirus from lung tissue of seropositve Apodemus peninsulae, and compared the nucleotide and amino acid sequences with prototype of hantaan virus 76-118 strain. Hantaviral sequences were amplified from lung tissues of A. peninsulae by reverse-transcriptase polymerase chain reaction. Alignment and comparison of the 324 nucleotide of G2 region of M-genomic segment diverged 4.6% and 0% at the nucleotide and amino acid levels, and complete N protein-coding region of S-genomic segment diverged 3.7% and 1.4% nucleotide and amino acid levels, respectively. This is the report to spill-over on the hantaan virus from A. agrarius to A. peninsulae in Korea.

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Genome-Wide Association Study of Orthostatic Hypotension and Supine-Standing Blood Pressure Changes in Two Korean Populations

  • Hong, Kyung-Won;Kim, Sung Soo;Kim, Yeonjung
    • Genomics & Informatics
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    • v.11 no.3
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    • pp.129-134
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    • 2013
  • Orthostatic hypotension (OH) is defined by a 20-mm Hg difference of systolic blood pressure (dtSBP) and/or a 10-mm Hg difference of diastolic blood pressure (dtDBP) between supine and standing, and OH is associated with a failure of the cardiovascular reflex to maintain blood pressure on standing from a supine position. To understand the underlying genetic factors for OH traits (OH, dtSBP, and dtDBP), genome-wide association studies (GWASs) using 333,651 single nucleotide polymorphisms (SNPs) were conducted separately for two population-based cohorts, Ansung (n = 3,173) and Ansan (n = 3,255). We identified 8 SNPs (5 SNPs for dtSBP and 3 SNPs for dtDBP) that were repeatedly associated in both the Ansung and Ansan cohorts and had p-values of < $1{\times}10^{-5}$ in the meta-analysis. Unfortunately, the SNPs of the OH case control GWAS did not pass our p-value criteria. Four of 8 SNPs were located in the intergenic region of chromosome 2, and the nearest gene (CTNNA2) was located at 1 Mb of distance. CTNNA2 is a linker between cadherin adhesion receptors and the actin cytoskeleton and is essential for stabilizing dendritic spines in rodent hippocampal neurons. Although there is no report about the function in blood pressure regulation, hippocampal neurons interact primarily with the autonomic nervous system and might be related to OH. The remaining SNPs, rs7098785 of dtSBP trait and rs6892553, rs16887217, and rs4959677 of dtDBP trait were located in the PIK3AP1 intron, ACTBL2-3' flanking, STAR intron, and intergenic region, respectively, but there was no clear functional link to blood pressure regulation.