• 한국신뢰성학회지:신뢰성응용연구
• /
• 제15권3호
• /
• pp.149-153
• /
• 2015

One common roadblock to innovation is the inability to define the problem that needs to be solved. Main contributors to this situation are the complexity of real field and the psychological inertia. 9-Windows can help break the complexity and the psychological inertia. In this article, we attempt to propose how to link resources to space and time framework through 9-Windows. Also, we propose how to use the 9-Windows to find multiple perspectives and explore solutions to a problem. This research is expected to be a vehicle to make an effective use of 9-Windows along with TRIZ, SIT, CT, FMEA and QFD.

• International Journal of Costume and Fashion
• /
• 제4권
• /
• pp.113-130
• /
• 2004

Korea may have the social environment that has a high interest and demand for the fashion industry, but the relative importance that the Hanbok industry occupies in the fashion industry is very low. It can be found that this is attributed to the difficulty in identifying the trends of Hanbok due to the smallness of Hanbok material producers and Hanbok producers, a change in consumers' consciousness of Hanbok, the difficulty of ties and integration between Hanbok-related organizations, the lack of support from government and the like. Given the recent trend that the principal factor that enables the Korean fashion industry to be competitive in the world fashion business community is based on the beauty of Hanbok, this indifference to the Korean Hanbok industry would be the roadblock to internationalizing the Korean fashion industry. Accordingly, this study attempted to identify the problem of Hanbok-rela1ed department as the basic work for the development of the Hanbok industry and present the plan to activate it, thereby providing basic materials for exploiting the new arena of the Hanbok cultural industry the domestic and foreign fashion market in the 21st century.

• 전기학회논문지P
• /
• 제59권2호
• /
• pp.222-231
• /
• 2010

This paper presents numerical analysis of measurement errors of ground electrode using the fall-of-potential method. In order to analyze ground resistance error according to the positions of auxiliary probes, firstly, national and international standards were researched. Secondly, numerical ground resistance error of hemispheric electrode was analyzed according to the locations of auxiliary probes and the angle between probes. Then, error-reduced positions of auxiliary probes were shown according to the distance to auxiliary current probe versus ground electrode size. Finally, error compensation method was presented. The results presented in this paper provide useful information regarding ground resistance error of alternative positions of auxiliary probes in case that the auxiliary probes could not be located at the proper position in such cases as there are buildings, roadblock or underground metallic pipe at that position.

• Journal of Contemporary Eastern Asia
• /
• 제19권2호
• /
• pp.148-168
• /
• 2020

In April, 2020, amid widespread fear of a second wave of infections of the novel coronavirus in China, local authorities in Guangzhou cracked down on the city's black population, resulting in mass evictions of Africans. The incident raises several questions about racism in China. How should we interpret this heavy-handed treatment of black people? Was this an isolated incident? What motivated such operations? In this article, I explain social control of Guangzhou's African communities as a problem of municipal politics. What underlies the government's heavy handed approach, I argue, are those communities' ties to rurality, which constitute a roadblock in the city's urban upgrade. Using Dengfeng Village, one of the best known African communities in China, as a case study, I show that efforts to upgrade the area by the local state and the real estate industry were frustrated by the community's status as an urban village. Africans, whom Chinese have historically associated with rurality, are seen as contributing to a space that has long been stigmatized as a spatial manifestation of rural people's lack of self-discipline. To better reveal the interconnection between social control and urban politics, I place official action in context of the history of the community's formation and the lived experience. This analysis of Dengfeng applies to various extents to other major African communities in Guangzhou.

• Journal of Korean Neurosurgical Society
• /
• 제57권1호
• /
• pp.12-18
• /
• 2015

Objective : Covered stent has been recently reported as an effective alternative treatment for direct carotid cavernous fistulas (DCCFs). The purpose of this study is to describe our experiences with the treatment of DCCF with covered stents and to evaluate whether a covered stent has a potential to be used as the first choice in selected cases. Methods : From February 2009 through July 2013, 10 patients underwent covered stent placement for a DCCF occlusion. Clinical and angiographic data were retrospectively reviewed. Results : Covered stent placement was performed for five patients primarily as the first choice and in the other five as an alternative option. Access and deployment of a covered stent was successful in all patients (100%) and total occlusion of the fistula was achieved in nine (90%). Complete occlusion immediately after the procedure was obtained in five patients (50%). Endoleak persisted in five patients and the fistulae were found to be completely occluded by one month control angiography in four. The other patient underwent additional coil embolization by a transvenous approach. Balloon inflation-related arterial dissection during the procedure was noted in two cases; healing was noted at follow-up angiography. One patient suffered an asymptomatic internal carotid artery occlusion noted seven months post-treatment. Conclusion : Although endoleak is currently a common roadblock, our experience demonstrates that a covered stent has the potential to be used as the first choice in DCCF; this potential is likely to increase as experience with this device accumulates and the materials continue to improve.

• 한국건설관리학회논문집
• /
• 제3권1호
• /
• pp.97-106
• /
• 2002

설계단계에서 VE를 적용하면 커다란 효과를 볼 수 있음에도 불구하고 국내에서는 설계단계의 VE가 활성화되지 못하고 있다. 특히 적절한 VB수행에 대한 적절한 용역대가 산정 기준의 부재는 설계VE의 적극적 활용을 가로막는 주요원인이 되고 있다. 본 논문에서는 설계YE와 유사한 용역업무의 대가산정 현황과 국내외 설계YE 용역대가 산정현황을 분석하여 현재 YE 용역대가 산정의 주요한 문제점을 도출하고 개선방향을 제시하였다. 다음으로 VE 용역대가 산정방안과 수행결과에 따른 인센티브 지급 방안을 제시하였다 마지막으로 면담을 통해 제안된 방안의 유효성을 검증하였다.

• Molecules and Cells
• /
• 제39권9호
• /
• pp.669-679
• /
• 2016

N-acetyl-D-glucosamine kinase (GlcNAc kinase or NAGK) primarily catalyzes phosphoryl transfer to GlcNAc during amino sugar metabolism. Recently, it was shown NAGK interacts with dynein light chain roadblock type 1 (DYNLRB1) and upregulates axo-dendritic growth, which is an enzyme activity-independent, non-canonical structural role. The authors examined the distributions of NAGK and NAGK-dynein complexes during the cell cycle in HEK293T cells. NAGK was expressed throughout different stages of cell division and immunocytochemistry (ICC) showed NAGK was localized at nuclear envelope, spindle microtubules (MTs), and kinetochores (KTs). A proximity ligation assay (PLA) for NAGK and DYNLRB1 revealed NAGK-dynein complex on nuclear envelopes in prophase cells and on chromosomes in metaphase cells. NAGK-DYNLRB1 PLA followed by Lis1/NudE1 immunostaining showed NAGK-dynein complexes were colocalized with Lis1 and NudE1 signals, and PLA for NAGK-Lis1 showed similar signal patterns, suggesting a functional link between NAGK and dynein-Lis1 complex. Subsequently, NAGK-dynein complexes were found in KTs and on nuclear membranes where KTs were marked with CENP-B ICC and nuclear membrane with lamin ICC. Furthermore, knockdown of NAGK by small hairpin (sh) RNA was found to delay cell division. These results indicate that the NAGK-dynein interaction with the involvements of Lis1 and NudE1 plays an important role in prophase nuclear envelope breakdown (NEB) and metaphase MT-KT attachment during eukaryotic cell division.

• Molecules and Cells
• /
• 제38권10호
• /
• pp.876-885
• /
• 2015

N-acetyl-D-glucosamine kinase (NAGK) plays an enzyme activity-independent, non-canonical role in the dendritogenesis of hippocampal neurons in culture. In this study, we investigated its role in axonal development. We found NAGK was distributed throughout neurons until developmental stage 3 (axonal outgrowth), and that its axonal expression remarkably decreased during stage 4 (dendritic outgrowth) and became negligible in stage 5 (mature). Immunocytochemistry (ICC) showed colocalization of NAGK with tubulin in hippocampal neurons and with Golgi in somata, dendrites, and nascent axons. A proximity ligation assay (PLA) for NAGK and Golgi marker protein followed by ICC for tubulin or dynein light chain roadblock type 1 (DYNLRB1) in stage 3 neurons showed NAGK-Golgi complex colocalized with DYNLRB1 at the tips of microtubule (MT) fibers in axonal growth cones and in somatodendritic areas. PLAs for NAGK-dynein combined with tubulin or Golgi ICC showed similar signal patterns, indicating a three way interaction between NAGK, dynein, and Golgi in growing axons. In addition, overexpression of the NAGK gene and of kinase mutant NAGK genes increased axonal lengths, and knockdown of NAGK by small hairpin (sh) RNA reduced axonal lengths; suggesting a structural role for NAGK in axonal growth. Finally, transfection of 'DYNLRB1 (74-96)', a small peptide derived from DYNLRB1's C-terminal, which binds with NAGK, resulted in neurons with shorter axons in culture. The authors suggest a NAGK-dynein-Golgi tripartite interaction in growing axons is instrumental during early axonal development.

• 조명전기설비학회논문지
• /
• 제15권2호
• /
• pp.97-104
• /
• 2001

본 논문에서는 전위강하법에 의한 접지저항 측정시 전위보조전극 위치의 영향에 대하여 기술하였다. 전위강하법에서 접지저항은 이론적으로 전위보조전극을 피측정 접지전극과 전류보조전극이 이루는 일직선상에 위치시킬때 61.8[%]법칙을 적용하여 측정한다. 하지만 측정현장의 사정상 전위보조전극의 위치를 피측정 접지전극과 전류 보조전극이 이루는 일직선과 어느 정도의 각도를 가지도록 시설하여 접지저항을 측정하게 될 경우에 측정오차가 발생하게 되고 보정이 필요하다. 본 연구에서의 측정대상 전극은 길이 2.4 [m]의 봉형 접지전극으로 하였으며, 피측정 접지전극, 전위보조전극, 전류보조전극이 일직선상에 놓이지 않은 상태에서 접지저항을 측정하면 측정값은 항상 (-)의 오차를 나타내었고, 이들 전극이 이루는 각도가 증가함에 따라 측정 오차도 증가하였다.

• 생명과학회지
• /
• 제24권9호
• /
• pp.927-934
• /
• 2014

혈근초(Sanguinaria canadensis) 뿌리에서 유래된 benzophenanthridine alkaloid의 일종인 sanguinarine은 항균, 항산화 및 항암작용 등 다양한 생리활성을 지니고 있는 것으로 알려져 있다. 비록 TRAIL이 암세포에서는 apoptosis를 유도하지만 정상세포에서는 세포독성을 나타내지 않는다는 큰 장점으로 제 2 임상 단계에서 유의적인 성과를 이루었지만, TRAIL 저항성을 극복해야 하는 큰 어려움이 남아있다. 본 연구실에서는 TRAIL이 세포독성을 나타내지 않는 범위의 sanguinarine과 혼합처리에 의하여 TRAIL 저항성 AGS 위암세포에서 apoptosis를 유발하였음을 보고한 바 있으며, 본 연구에서는 sanguinarine의 TRAIL 저항성 관련 극복에 대한 추가적인 기전 연구를 실시하였다. 본 연구의 결과에 의하면, sanguinarine과 TRAIL의 혼합처리는 각각의 단독 처리에 비하여 AGS 세포의 증식억제 및 apoptosis 유도의 상승 효과가 있었으며, 이를 MTT assay, agarode gel 전기영동, 염색질 응축 현상 및 flow cytometry 분석을 통하여 확인하였다. 또한 sanguinarine과 TRAIL의 혼합처리는 DR5의 발현을 증가시켰으며, ROS의 생성을 촉진시켰다. 그러나 동일 조건에서 MAPKs 신호 전달계에는 큰 영향을 주지 않았다. 아울러 ROS 생성을 인위적으로 차단하였을 경우, sanguinarine과 TRAIL의 혼합처리에 의한 생존도 저하가 유의적으로 회복되었다. 이러한 결과는 sanguinarine과 TRAIL이 DR5의 발현 증가와 ROS의 생성을 촉진시킴으로서 apoptosis 신호를 활성화하였음을 의미하는 결과로서 TRAIL 저항성 극복을 위한 sanguinarine 활용의 유용성을 보여주는 것이다.