• Proceedings of the Korea Contents Association Conference
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• 2014.11a
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• pp.107-108
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• 2014

본 연구는 브랜드에 대한 소비자의 태도 변화를 유도할 수 있는 브랜드 광고 전략을 모색하기 위한 선행연구로써, 연구 목적은 소비자 태도 변화의 결정 요인 중 하나인 관여도가 인쇄광고에 어떻게 표현 되었고, 소비자의 요구가 이에 상응하는지에 대해 분석하는 것이다. 관여도의 3가지 결정 요인 중 브랜드에 대한 신념 형성에 영향력이 높은 제품 요인 중 지각위험 요소를 연구범위로 제한하고, 국내 화장품 4개 브랜드의 인쇄광고를 대상으로 활용 빈도에 대한 분석을 실시하였다. 분석 결과를 토대로 한 설문을 실시하여, 인쇄광고에서 사용하는 지각위험요소와 사용자가 요구하는 지각 위험요소에 대한 중요도와 차이를 도출하였다.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.4
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• pp.131-137
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• 2014

The SUV has a risk of rollover because of the highness of center of mass. In this paper the roll-behavior of a SUV in turning motion is analyzed. Dynamic model of the vehicle on the slope is developed and simulation is carried out using the software ADAMS/Car. The results show that the relational expression between the ground force acting on the tire and the roll motion is well established. It is also identified that the driving state of the vehicle becomes unstable at the lower or upper position of the slope.

• Clinical and Experimental Pediatrics
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• v.50 no.4
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• pp.335-339
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• 2007

The link between upper airway disease (allergic rhinitis and sinusitis) and lower airway disease (asthma) has long been of interest to physicians. Many epidemiological and pharmacological studies have provided a better understanding of pathophysiologic interrelationship between allergic rhinitis and asthma. The vast majority of patients with asthma have allergic rhinitis, and rhinitis is a major independent risk factor for asthma in cross-sectional and longitudinal studies. The association between sinusitis and asthma has long been appreciated. Through the recent evidences, allergic rhinitis, sinusitis, and asthma may not be considered as different diseases but rather as the expression in different parts of the respiratory tract of same pathological process in nature. Various mechanisms have been proposed to explain the relationship between asthma and upper airway diseases, but the underlying mechanisms are not completely discovered. The implications for the one-airway hypothesis are important not only academically but also clinically for diagnostic and therapeutic purposes.

• Biomedical Science Letters
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• v.24 no.3
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• pp.143-149
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• 2018

Excessive exposure to estrogens is the most important risk factor for the development of hormone-sensitive cancers, especially breast cancer. Estrogen stimulates the expression of genes and proteins involved in cell proliferation by binding to estrogen receptor (ER). Another possible mechanism of ER-independent carcinogenicity of estrogens is based on the hydroxylation of estradiol resulting in the formation of catechol estrogens. Catechol estrogen 4-hydroxyestradiol ($4-OHE_2$) is further oxidized to catechol estrogen-3,4-quinones, the major carcinogenic metabolites of estrogens. Evidence increasingly supports the critical role of $4-OHE_2$ in hormonal carcinogenesis via DNA adduct formation or production of reactive oxygen species, which finally contribute to the transformation of normal mammary epithelial cells and the enhanced growth of breast cancer cells. It is also reported that the level of $4-OHE_2$ or its quinones is highly up-regulated in urine or tissues of breast cancer patients. Thus, we highlight the oncogenic roles of $4-OHE_2$ in catechol estrogen-induced breast carcinogenesis.

• 대한생식의학회:학술대회논문집
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• 2002.11a
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• pp.15-21
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• 2002

In order to keep the normal pregnancy, a number of gene products are required at the feto-matemal interface. We have isolated approximately 30 genes, involved in keeping the normal pregnancy, via subtractive hybridization and RT-PCR analyses of cDNAs from the chorionic villi of normal and RPL patients. Characterizing their functions will help us to understand the process of establishing and maintaining pregnancy. In addition, more detailed studies of their expression in normal and RPL patients are required to evaluate their clinical relevance. Further identification of genes aberrantly expressed in RPL patients will help the prognosis of the pregnancy, identifying pregnancies with a high risk of miscarriage and enabling management of those pregnancies.

• Molecules and Cells
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• v.27 no.2
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• pp.211-215
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• 2009

Toll-like receptors (TLRs) play a critical role in sensing microbial components and inducing innate immune and inflammatory responses by recognizing invading microbial pathogens. Lipopolysaccharide-induced dimerization of TLR4 is required for the activation of downstream signaling pathways including nuclear factor-kappa B ($NF-{\kappa}B$). Therefore, TLR4 dimerization may be an early regulatory event in activating ligand-induced signaling pathways and induction of subsequent immune responses. Here, we report biochemical evidence that 6-shogaol, the most bioactive component of ginger, inhibits lipopolysaccharide-induced dimerization of TLR4 resulting in the inhibition of $NF-{\kappa}B$ activation and the expression of cyclooxygenase-2. Furthermore, we demonstrate that 6-shogaol can directly inhibit TLR-mediated signaling pathways at the receptor level. These results suggest that 6-shogaol can modulate TLR-mediated inflammatory responses, which may influence the risk of chronic inflammatory diseases.

• Journal of the Korean Home Economics Association
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• v.34 no.5
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• pp.223-234
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• 1996

This paper intends to examine the relationship between the consumer's enduring involvement toward clothing product, fashion innovativeness, and fashion opinion leadership. Specific purposes of the study are: 1) to identify dimensions of the enduring involvement toward clothing based on the theoretical framework; 2) to find out the effects of clothing involvement on fashion innovativeness and fashion innovativeness,m fashion opinion leadership, and demographic variables. The Likert Type questionnaires were used to measure clothing involvement, fashion innovativeness, and fashion opinion leadership. Samples of 389 women(college students, career women, housewives) living in Taegu area were analyzed by factor analysis, Pearson's correlations, t-test, and multiple regression analysis. Main results of the study are as follows: 1) Concept of the enduring involvement toward clothing is composed of five dimensions: fashion, importance, pleasure, self-expression, and perceived buying risk. 2) The clothing involvement is found to have significant influences on fashion innovativeness and fashion opinion leadership. 3) The relationships between the clothing involvement, age, educational level, and marital status are found to be statistically significant.

• Journal of Ginseng Research
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• v.43 no.3
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• pp.335-341
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• 2019

Background: Inflammation is a host-defensive innate immune response to protect the body from pathogenic agents and danger signals induced by cellular changes. Although inflammation is a host-defense mechanism, chronic inflammation is considered a major risk factor for the development of a variety of inflammatory autoimmune diseases, such as rheumatic diseases. Rheumatic diseases are systemic inflammatory and degenerative diseases that primarily affect connective tissues and are characterized by severe chronic inflammation and degeneration of connective tissues. Ginseng and its bioactive ingredients, genocides, have been demonstrated to have antiinflammatory activity and pharmacological effects on various rheumatic diseases by inhibiting the expression and production of inflammatory mediators. Methods: Literature in this review was searched in a PubMed site of National Center for Biotechnology Information. Results: The studies reporting the preventive and therapeutic effects of ginseng and ginsenosides on the pathogenesis of rheumatic diseases were discussed and summarized. Conclusion: Ginseng and ginsenosides play an ameliorative role on rheumatic diseases, and this review provides new insights into ginseng and ginsenosides as promising agents to prevent and treat rheumatic diseases.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.6
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• pp.439-446
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• 2022

The antitumoral effects of valdecoxib (Val), an United States Food and Drug Administration-approved anti-inflammatory drug that was withdrawn due to the side effects of increased risk of cardiovascular adverse events, were investigated in hypopharyngeal squamous cell carcinoma cells by performing a cell viability assay, transwell assay, immunofluorescence imaging, and Western blotting. Val markedly inhibited cell viability with an IC50 of 67.3 µM after 48 h of treatment, and also downregulated cell cycle proteins such as Cdks and their regulatory cyclin units. Cell migration and invasion were severely suppressed by inhibiting integrin α4/FAK expression. In addition, Val activated the cell cycle checkpoint CHK2 in response to excessive DNA damage, which led to the activation of caspase-3/9 and induced caspase-dependent apoptosis. Furthermore, the signaling cascades of the PI3K/AKT/mTOR and mitogen-activated protein kinase pathways were significantly inhibited by Val treatment. Taken together, our results indicate that Val can be used for the treatment of hypopharyngeal squamous cell carcinoma.

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2020.10a
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• pp.218-218
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• 2020

Astaxanthin, a natural antioxidant carotenoid, has been thought to provide health benefits by decreasing the risk of oxidative stress?related diseases. In the present study, we investigated the effect of an astaxanthin during the autophagic cell death induced by bisphenol A (BPA) which is known major environmental pollutants. We found that astaxanthin significantly blocked the autophagic cell death via inhibition of intracellular Reactive Oxygen Species (ROS) in normal human dermal fibroblasts. Astaxanthin significantly inhibited the phosphorylation mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) responsible for the expression of LC3-II and Beclin-1 in BPA-treated normal human dermal fibroblasts. We suggest that astaxanthin blocks autophagic cell death induced by BPA via the inhibition of ROS-mediated signaling events in human dermal fibroblasts.