• Tuberculosis and Respiratory Diseases
• /
• v.78 no.4
• /
• pp.436-439
• /
• 2015

Small cell lung cancer (SCLC), which originated from neuroendocrine tissue, can develop into paraneoplastic endocrine syndromes, such as Cushing syndrome, because of an inappropriate secretion of ectopic adrenocorticotropic hormone (ACTH). This paraneoplastic syndrome is known to be a poor prognostic factor in SCLC. The reason for poor survival may be because of a higher risk of infection associated with hypercortisolemia. Therefore, early detection and appropriate treatment for this syndrome is necessary. But the diagnosis is challenging and the source of ACTH production can be difficult to identify. We report a 69-year-old male patient who had severe hypokalemia, metabolic alkalosis, and hypertension as manifestations of an ACTH-secreting small cell carcinoma of the lung. He was treated with ketoconazole and spironolactone to control the ACTH dependent Cushing syndrome. He survived for 15 months after chemotherapy, which is unusual considering the poor outcome of the ectopic ATH syndrome associated with SCLC.

• Smart Structures and Systems
• /
• v.26 no.3
• /
• pp.345-360
• /
• 2020

Modern swarm intelligence heuristic search methods are widely applied in the field of structural health monitoring due to their advantages of excellent global search capacity, loose requirement of initial guess and ease of computational implementation etc. To this end, a hybrid strategy is proposed based on butterfly optimization algorithm (BOA) and differential evolution (DE) with purpose of effective combination of their merits. In the proposed identification strategy, two improvements including mutation and crossover operations of DE, and dynamic adaptive operators are introduced into original BOA to reduce the risk to be trapped in local optimum and increase global search capability. The performance of the proposed algorithm, hybrid butterfly optimization and differential evolution algorithm (HBODEA) is evaluated by two numerical examples of a simply supported beam and a 37-bar truss structure, as well as an experimental test of 8-story shear-type steel frame structure in the laboratory. Compared with BOA and DE, the numerical and experimental results show that the proposed HBODEA is more robust to detect the reduction of stiffness with limited sensors and contaminated measurements. In addition, the effect of search space, two dynamic operators, population size on identification accuracy and efficiency of the proposed identification strategy are further investigated.

• Journal of Advanced Marine Engineering and Technology
• /
• v.38 no.4
• /
• pp.456-462
• /
• 2014

In this paper, we develop a facility management system which provides fault effect and replacement alarm function of each component for supporting effective maintenance of facility. To do this, we use weighting method to each component, calculate importance of each component, and make them to hierarchy structure using bill of materials of facility. Also, we draw fault cause and fault effect of components based on failure modes effects and criticality analysis, and define criteria of severity, occurrence and detection to get risk priority number. To apply these concepts, we develop and test the facility management system to verify its practicality. In the future, we expect the developed system to apply many domains such as maintenance of ship and offshore plant.

• Journal of Fisheries and Marine Sciences Education
• /
• v.27 no.4
• /
• pp.1184-1193
• /
• 2015

Monitoring for megalocytivirus infection was conducted for ten months from March to December in 2013 in 15 aquatic farms culturing, red sea bream, rock bream, rock fish and black sea bream around Tongyoung coastal area in Korea, to assess spatial and temporal variability of detection prevalence, and to explore possible links with seawater temperature. In nested-PCR targeted major capsid protein (MCP) gene, asymptomatic megalocytivirus infection was detected in the externally healthy farmed fish with a significant prevalence in range from 0 to 58.3% for ten months. Higher prevalence of megalocytivirus (46.7% - 57.1%) was observed in high water temperature season from September to November than that in other months with lower prevalence of 0.0% to 20.0%. Even though an acute infection of megalocytivirus was occurred in rock bream (positive in the first PCR) with high mortality in one of fifteen farms, there was no expansion or transmission of the disease to the rock fish and red sea bream culturing in net cage just proximal to the rock bream cage in which disease outbreaked. Nucleotide sequence analysis of the cloned MCP gene isolated asymptomatically infected rock fish revealed that the megalocytivirus in this study was clustered together with the rock bream iridovirus (RBIV) under the subgroup II of the genus megalocytivirus (Iridoviridae), which is known to be the major megalocytivirus strain in Korea. The typical histopathological signs were not found in the spleen of rock fish asymptomatically infected by megalocytivirus. Experimental infection of rock bream with the spleen homogenate of the rock fish infected asymptomatically did not induce any mortality unlike the homogenate of infected rock bream with hih mortlity. However, these results may suggest that the asymptomatic infection of megalocytivirus in other fish species can be a potential risk threatening aquaculture industries as a transmission factor of megalocytivirus to susceptible fish species, especially rock bream.

• Clinical and Experimental Reproductive Medicine
• /
• v.31 no.3
• /
• pp.149-154
• /
• 2004

Objective: To assess the association with autoimmune endocrine diseases and detection rate of autoimmune antibodies and its clinical significance in patients with premature ovarian failure. Methods: Twenty eight patients with primary or secondary amenorrhea manifesting hormonal and clinical features of premature ovarian failure (primary POF: 7, secondary POF: 21) were investigated. We tested them TFT, 75 g OGTT, ACTH and S-cortisol for thyroiditis, IDDM, Addison's disease, and antithyoglobulin antibody, antimicrosomal antibody, antinuclear antibody, rheumatic factor, anti-smooth muscle antibody, anti-acetylcholine receptor antibody for non-organ specific autoimmune disorders. Results: Only one patient was diagnosed as IDDM and no patients had abnormal TFT or adrenal function test. More than one kind of autoantibody was detected in 11 patients of all (39.2%): 5 patients (71.4%) of primary POF group and 6 patients (21.4%) of secondary POF group. Eleven patients (39.3%) had antithyroglobulin antibody, 4 (14.3%) had antimicrosomal antibody, 2 (7.1%) had antinuclear antibody, 2 (7.1%) had rheumatic factor, 1 (3.6%) had anti-smooth muscle antibody, 1 (3.6%) had anti-acetylcholine receptor antibody. Conclusions: Premature ovarian failure may occur as a component of an autoimmune polyglandular syndrome, so patients should be measured with free thyroxine, thyroid-stimulating hormone, fasting glucose and electrolytes. Measurement of thyroid autoantibodies in POF patients may be important in identifying patients at risk of developing overt hypothyoidism, but other autoantibodies may not be suitable for screening test.

• Journal of the Korea Society of Computer and Information
• /
• v.17 no.12
• /
• pp.251-258
• /
• 2012

The protection of medical information by major Issues on medical information to protect the individuals' privacy on medical information. Especially, Issues of medical service information, medical record, insurance, employment, Genetic technology including genetic test and screening, gene therapy and genetic enhancement is developing rapidly. Defensibility of medical information documentation is tested in the courts. medical information can be illicitly accessed from anywhere and transmitted across the quickly and with risk of detection. Once data is distributed on the internet, it may become available to anyone who wishes to purchase it, and it cannot be expunge. Patient privacy protection of medical information is controlled mostly by patient consent laws that define how and when a patient must consent before a physician may disclose the patient's medical information to anyone else. enterprise that offers consumers commodities or services is checking problem about customer information of management system is checking problem about customer information of management system essentially. Therefore, in this paper will find a way out to Protection of medical information by major Issues on medical information.

• Journal of Microbiology
• /
• v.45 no.3
• /
• pp.256-261
• /
• 2007

Apoptosis is a step of the cell cycle which is important in the regulation of immune cell populations. Chungkookjang is a Korean traditional fermented soybean containing microorganisms, enzymes, and bioactive compounds which was used in the treatment of mouse spleen as well as thymus cells (CH1-fermented soybean containing barley, wormwood, and sea tangle; CH2-fermented soybean) and was found to exhibit substantially reduced small DNA fragmentation. An MTT assay showed that the treatment of CH1 and CH2 into the mouse splenocytes and thymocytes sharply increased their survival. Moreover, a FACS analysis also showed that CH1 and CH2 are effective at suppressing the apoptosis of splenocytes and thymocytes. The fermented soybean isoflavone concentrations, which are implicated in lowering breast and prostate cancers, lowering the risk of cardiovascular diseases, and improving bone health, were determined using Capillary Electrophoresis-Electrochemical Detection (CE-ED). The amount of Daidzein in fermented soybean significantly increased by 44-fold dramatically, compared with those in unfermented soybean. In this study, we demonstrated that ethanol extracts of Chungkookjang promote the survival of the mouse spleen and thymus cells in culture by suppressing their apoptotic death. Future studies should investigate which genes are related to apoptosis of the immune cells.

• Smart Structures and Systems
• /
• v.21 no.3
• /
• pp.287-303
• /
• 2018

Applications of energy harvesting from mechanical vibrations is becoming popular but the full potential of such applications is yet to be explored. This paper addresses this issue by considering an application of energy harvesting for the dual objective of serving as an indicator of structural health monitoring (SHM) and extent of control. Variation of harvested energy from an undamaged baseline is employed for this purpose and the concept is illustrated by implementing it for active vibrations of a pipe structure. Theoretical and experimental analyses are carried out to determine the energy harvesting potential from undamaged and damaged conditions. The use of energy harvesting as indicator for control is subsequently investigated, considering the effect of the introduction of a tuned mass damper (TMD). It is found that energy harvesting can be used for the detection and monitoring of the location and magnitude of damage occurring within a pipe structure. Additionally, the harvested energy acts as an indicator of the extent of reduction of vibration of pipes when a TMD is attached. This paper extends the range of applications of energy harvesting devices for the monitoring of built infrastructure and illustrates the vast potential of energy harvesters as smart sensors.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.18 no.4
• /
• pp.358-368
• /
• 2015

Recently, unmanned systems are largely utilized in various fields due to the persistency and the least operational risk and an unmanned surface vehicle(USV) is the one of the representative application in the naval field. To assign multiple roles to an USV, we developed a sonar system which consists of a forward detecting sonar for the long-range detection, a downward detecting sonar for the small target scan and identification, and a strut type body for mounting sonar systems. In this paper, we described the developed sonar system for USV and the sea test results for verifying system performance. The test results showed that the developed sonar system was able to detect the underwater target about several kilometers away and could recognize a small object at the downside of the sonar system. We expect that the developed sonar system will be easily applied to other unmanned platforms without serious consideration.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2010.05a
• /
• pp.307-310
• /
• 2010

Ubiquitous society to build basic infrastructure in the power supply and power equipment safety is important. U-City in order to prevent the disaster of U-IT Power Equipment Performance Module and the security for the safety of the U-City is necessary. In this paper, the power unit of U-IT module, temperature sensor, humidity sensor, equipped with sensors arranged throughout the fire, and home distribution boards, Home Network Wall-Pad, Blocker, MPNP black boxes, arc detection, arc safety equipment, outlet of the modular performance evaluation and security measures will be studied. U-IT power devices and sensors to analyze the information conveyed by proactive risk and ensure safety, access control, authentication, security safeguards, such as U-IT integrated management system for electrical safety and strengthen the security, safety and security with a U-City will contribute to the construction and operation.