• 한국콘텐츠학회논문지
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• 제20권4호
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• pp.553-563
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• 2020

자살은 우리 사회의 주요한 사회문제이며 현재 우리나라의 자살률은 OECD 국가 중 가장 높다. 자살의 주요 요인 중 하나로 노동시장에서의 고용불안정성이 자살 생각에 영향을 미친다고 알려져 있다. 무직 또는 한시적·일시적 고용형태의 근로자는 불안정한 고용 때문에 자살 생각이 높으며 향후 자살 위험군 또는 고위험군이 될 가능성이 높으므로 고용안정성이 자살에 미치는 요인 및 이를 완충시키는 보호요인에 대한 주의 깊은 연구가 필요하다. 이에 본 연구는 고용안정성이 자살생각에 미치는 영향을 살펴보고 보호요인으로서 가족기능의 조절효과를 검증하였다. 이를 위해 전국규모의 종단연구인 '사회적 관계 내에서 자살을 경험한 자살생존자의 정신건강 추적연구'의 자료(N=1,235)를 분석하였다. 분석결과 고용안정성은 자살생각과 유의한 연관성이 있었으며(B=-.904, p<.001) 무직자가 가장 높은 자살생각을 가진 것으로 나타났다. 또한 가족기능의 조절효과가 유의하여(B=-.218, p<.05) 불안정한 고용상태가 자살생각에 영향을 미치는 관계에서 가족기능이 완충작용을 함이 나타났다. 이러한 결과에 근거해 불안정한 고용상태에서 가족 차원의 자살예방 개입을 위한 정책적, 실천적 함의를 논의하였다.

• 대한한의학방제학회지
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• 제25권1호
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• pp.51-68
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• 2017

Objectives : Oxidative stress due to excessive accumulation of reactive oxygen species (ROS) is one of the risk factors for the development of several chronic diseases, including neurodegenerative diseases. Methods : In the present study, we investigated the protective effects of cheongnoemyeongsin-hwan (CNMSH) against oxidative stress‑induced cellular damage and elucidated the underlying mechanisms in neuronal-derived SH-SY5Y cells. Results : Our results revealed that treatment with CNMSH prior to hydrogen peroxide (H2O2) exposure significantly increased the SH-SY5Y cell viability, indicating that the exposure of the SH-SY5Y cells to CNMSH conferred a protective effect against oxidative stress. CNMSH also effectively attenuated H2O2‑induced comet tail formation, and decreased the phosphorylation levels of the histone ${\gamma}H2AX$, as well as the number of apoptotic bodies and Annexin V‑positive cells. In addition, CNMSH exhibited scavenging activity against intracellular ROS generation and restored the mitochondria membrane potential (MMP) loss that were induced by H2O2, suggesting that CNMSH prevents H2O2‑induced DNA damage and cell apoptosis. Moreover, H2O2 enhanced the cleavage of caspase-3 and degradation of poly (ADP-ribose)-polymerase, a typical substrate protein of activated caspase-3, as well as DNA fragmentation; however, these events were almost totally reversed by pretreatment with CNMSH. Furthermore, CNMSH increased the levels of heme oxygenase-1 (HO-1), which is a potent antioxidant enzyme, associated with the induction of nuclear factor-erythroid 2-related factor 2 (Nrf2). According to our data, CNMSH is able to protect SH-SY5Y cells from H2O2-induced apoptosis throughout blocking cellular damage related to oxidative stress through a mechanism that would affect ROS elimination and activating Nrf2/HO-1 signaling pathway. Conclusions : Therefore, we believed that CNMSH may potentially serve as an agent for the treatment and prevention of neurodegenerative diseases caused by oxidative stress.

• 한국화재소방학회논문지
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• 제33권5호
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• pp.94-102
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• 2019

원전의 안전관리에서 화재 대응의 중요성이 강조되는 시점에서, 화재 대응 인력의 심리적 상태와 역량을 체계적으로 접근할 필요가 있다. 본 연구는 원전 관할 지역 소방관들의 위험인식 구성개념을 규명하고, 이를 측정하는 측정도구를 개발 및 타당화 하였다. 원전 관할 소방관을 대상으로 실시된 인터뷰 분석과 문헌연구를 바탕으로 원전 화재에 대한 위험인식의 문항을 개발하였다. 개발된 문항들에 대한 타당화 연구에는 전라남도, 경상북도 및 부산 소재 원전 관할 소방서 및 119안전센터 5곳에서 참가자를 모집하여 총 180명의 소방관들이 참가하였다. 탐색적 요인분석 결과, 원전 화재의 재난적 결과 및 두려움을 반영하는 '두려움', 원전에서의 화재 및 방사능 누출에 대한 대응 절차와 지침의 부족을 반영하는 '매뉴얼', 원전 화재에 대응할 소방 인력 및 안전장치의 부족을 나타내는 '대응자원', 원전 소방활동을 위한 관계 기관과의 공조와 신뢰를 나타내는 '신뢰', 방사능 및 원전 소방 활동에 대한 지식을 의미하는 '지식'의 5개 요인 구조가 추출되었다. 최종 선별된 15개 문항으로 구성된 척도의 신뢰도와 타당도를 확인하였다. 본 연구 결과를 바탕으로 원전 관할 소방관들의 위험인식의 구성적 특성에 대해서 논의하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.6019-6026
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• 2015

Background: The aim of this study was to assess the relationship between IL-18 gene polymorphisms and HBV-related diseases and whether these polymorphisms influence its expression in the Guangxi Zhuang population. Materials and Methods: We enrolled 129 chronic HBV infected (CHB) patients, 86 HBV-related liver cirrhosis (LC) patients and 160 healthy controls in our study. Polymerase chain reaction-restriction fragment length polymorphism methods were used to detect IL-18 gene -607C/A, -137G/C polymorphisms, and an ELISA kit was employed to determine serum IL-18 levels. Results: No correlation was found between the -607C/A polymorphism and risk of HBV-related disease. For the -137G/C polymorphism, the GC genotype and C allele were associated with a significantly lower risk of CHB (95%CI: 0.32-0.95, p=0.034 and 95%CI: 0.35-0.91, p=0.018) and HBV-related LC (95%CI: 0.24-0.89, p=0.022 and 95%CI: 0.28-0.90, p=0.021). A similar decreased risk was also found with the A-607C-137 haplotype. With respect to IL-18 expression, it was significantly lower in both patient groups, but no association was noted between the two polymorphisms in the IL-18 gene and its expression. Conclusions: Our study indicated that the -137C allele in the IL-18 gene may be a protective factor for HBV-related disease, and serum IL-18 level may be inversely associated with CHB and HBV-related LC.

• 스마트미디어저널
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• 제11권9호
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• pp.30-38
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• 2022

안전사고의 위험성이 상존하는 작업 현장에서 안전사고 발생 시 신속한 조치를 위해서는 생체 데이터를 실시간으로 파악하는 것이 중요하다. 그 중 혈중산소포화도는 인간이 생명을 유지하는 데 있어서 가장 중요한 요소이므로 작업자의 안전관리를 위한 선제 대응으로 상황에 따라서 실시간 산소포화도 측정과 모니터링이 필요하다. 건강 및 생명 위험 보호복을 착용한 작업자로부터 실시간 생체 신호를 수신하고, 외부 시스템에서 작업자의 위험 상태를 공유 및 분석함으로써 작업자의 현재 상태를 진단하고 작업자에게 발생할 수 있는 응급 상황에 효율적으로 대응할 수 있다. 본 논문에서는 사고 현장에서 응급 상황에 대처하기 위해 보호복 착용자의 유해 가스와 산소포화도 위험도를 실시간 모니터링할 수 있고, 착용자의 활동성과 안전성을 보장할 수 있는 웨어러블 산소포화도 측정 플랫폼 기술을 제안하였다. 추후 제안한 시스템의 결과를 통해 확인한 한계점을 극복하고, 움직임 보정 등 개선된 생체 데이터를 플랫폼에 적용한다면 유해 가스 환경뿐만 아니라 응급 환자를 대상으로 하는 병원이나 가정에서도 활용할 수 있을 것이라 기대한다.

• 농약과학회지
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• 제9권4호
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• pp.347-353
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• 2005

한국 농업환경에서 benzimidazole계 살균제의 안전사용 및 농약살포자를 보호하기 위하여 단기(30일 이내) 및 장기(6개월 이상) 노출에 대한 농작업자 위해성평가를 수행하였다. 농작업자의 노출량 산출은 일본의 EPN 45% 유제 노출시나리오를 이용하였으며, 일일 작업시간은 4시간으로 가정하였고, 작업자에 대한 급성 및 만성 허용노출량(AOEL)은 단기노출은 기형독성, 만성노출은 만성독성 NOAEL로부터 산출하였다. Benzimidazole계 농약들은 US/EPA가 $Q_1^*$를 설정하여 발암성평가를 하고 있는 농약들로서 본 연구에서도 작업자의 만성 노출에 대한 발암성평가를 평균일일노출량(LADD)를 일생 동안 농업에 종사하는 연수, 농약살포 횟수, 농업형태 등을 고려하여 평가하였다. 농작업자에 대한 농약 노출량은 benomyl, carbendazim 및 thiophanate-methyl에 대하여 각각 0.2, 0.36 및 0.42 mg/kg/day 이었고, sAOEL은 0.3, 0.1 및 0.2 mg/kg/day 이었으며, cAOEL의 경우 benomyl과 carbendazim은 0.025, thiophanate-methyl은 0.08 mg/kg/day이었다. 만성 및 발암위해성평가를 위한 LADD는 benomyl 0.0038, carbendazim 0.0067 및 thiophanate-methyl 0.0081mg/kg/day로 산출되었다. 위의 수치를 이용하여 AOEL/exposure를 산출한 결과 급성위해성은 $0.28{\sim}1.5$, 만성 위해성은 $3.73{\sim}9.88$로서 작업자에 대한 급성 위해성은 보호장비를 착용할 경우 최대 90%까지 노출량이 감소하므로 보호장비 착용시 안전할 것으로 생각되었으며, 만성 위해성은 AOEL/exposure가 1 이상으로서 안전한 것으로 판단되었다. 발암위해성평가 결과는 보호장비를 착용할 경우 $9.12{\times}10^{-7}{\sim}1.13{\times}10^{-5}$으로 실제적인 농약살포 인자를 고려하여 평가하면 농약살포자에 대한 위해성은 없을 것으로 추정되나 보다 실제적인 노출성적을 이용한 농약살포 작업자 위해성평가가 필요하리라 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5929-5934
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• 2013

Background: Primary brain tumors constitute a small percent of all malignant cancers, but their etiology remains poorly understood. ${\beta}3$ integrin (ITGB3) has been recognized to play influential roles in angiogenesis, tumor growth and metastasis. Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and ITGB3 could be associated with brain cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between brain tumor risk and ICAM-1 and ${\beta}3$ integrin gene polymorphisms. Materials and Methods: The study covered 92 patients with primary brain tumors and 92 age-matched healthy control subjects. Evaluation of ${\beta}3$ integrin (Leu33Pro (rs5918)) and ICAM-1 (R241G (rs1799969) and K469E (rs5498)) gene polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: According to results of our research, the A allele of the ICAM-1 R241G gene polymorphism appeared to be a risk factor for primary brain tumors (p<0.001). Similarly, the frequency of the A mutant allele of ICAM-1 R241G was statistically significant in patients with brain tumors classified as glioma (p<0.001). When allele and genotype distributions of ICAM-1 K469E, ICAM-1 R241G and ${\beta}3$ integrin Leu33Pro gene polymorphisms were evaluated with age, sex, and smoking, there were no statistically significant differences. Haplotype analysis revealed that the frequencies of GAC (rs1799969-rs5498-rs5918) and GAT (rs1799969-rs5498-rs5918) haplotypes were significantly lower in patients as compared with controls (p=0.001; p=0.036 respectively). Conclusions: This study provides the first evidence that ICAM-1 R241G SNP significantly contributes to the risk of primary brain tumors in a Turkish population. In addition, our results suggest that ICAM-1 R241G in combination ICAM-1 K469E may have protective effects against the development of brain cancer.

• 재무관리연구
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• 제1권1호
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• pp.119-131
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• 1985

Although Korea is short of capital technology, and natural resources, she has achieved an outstanding progress by the export-drive policies by Korean government and the creative endeavor of Korean firms. As a result of that, Korean economy and enterprises are in the same file of newly industrialized countries and Korea is ready for an economic take-off as a developed country. But in the early 1980s, each country strengthens protective trade theory and resources nationalism, and this has a great influence on the field of international trade environment. In spite of that, to continue the same high development as that of the past. Korea must try to secure and find export markets, solve trade barriers, make sure of the long-term security of resources, develop technology, and strengthen economic cooperations. To satisfy these desires by 2000s, we must try to make Korean enterprises have the global competitive power and them grow strongly among world wide firm through capital and technology accumulated during the passed years, and to do so, there must be a foreign production and marketing management, too, this can be achieved only through foreign overseas direct investment. This investment has various forms, to say, verifical integrated, horizontal integrated. conglomerate integrated forms, and the amount of investment in each country from 18 century to today reaches 500 billion dollars. This investment is done by strategic, behavioral economic, and financial motives. So I am going to approach the fields of like these; in spite of the differences among political, economical, caltural, and social systems, and many risk compared with domestic enterprises, why do Korean firms witsh to transfer the productive facilities to overseas countries and run them there? What is the comparative advantage of foreign direct investment compared with domestic investment ?. why is the factor of comparative advantage transferred through foreign direct investment?, what is the motive of foreign overseas direct investment?, and last the ownership-specific factors and the theory of internalization, and the location specific factors were analysed chiefly. But in consideration of the given condition in Korea, Korean overseas direct investment must be propelled rationally on the basis of the above mentioned theory.

• 한국학교보건학회지
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• 제27권2호
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• pp.100-108
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• 2014

Purpose: The purpose of this study is to examine the effects of clinical art therapy programs utilized at schools on adolescents' suicidal thoughts and stress relief and to validate their effectiveness as a type of adolescent suicide prevention program. Methods: 12 sessions of clinical art therapy for youth suicide prevention were provided, once a week for 90 minutes, for 20 students at five middle schools in Seoul who were at high risk of committing suicide. By using the paired sample t-test, the study presented qualitative data on the analysis of pre- and post- questionnaires and on the subjects' EEG test and saliva test. Results: First, through the clinical art therapy program, the subjects' happiness index improved significantly while their scores of depression and suicidal ideation (suicidal thoughts) decreased. Second, in the EEG and saliva test conducted after the art therapy sessions, emotional stability increased and stress was reduced significantly. Third, according to the results of pre- and post- K-HTP tests and individual activities, the subjects started to recognize the seriousness of suicide and show emotional stability and positive changes in overall attitudes, valuing the rights and life of their own 'precious selves' (self respect). Conclusion: The results of this study indicate that the clinical art therapy program is significantly effective at preventing suicidal ideation by reducing suicidal impulses and depression, by increasing the happiness index, which can serve as a protective factor against suicide, and by increasing emotional stability while reducing stress. Based on the results, there is a need to develop policy measures regarding art therapy programs which can be utilized at schools.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8775-8778
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• 2014

Background: To explore the relationship between polymorphisms of interleukin17 (IL-17) gene(A-832G 7488A/G) and the susceptibility to silicosis, a risk factor for lung cancer. Materials and Methods: A total of 113 silicosis patients and 116 workers without silicosis were enrolled in the case-control study. IL-17A A-832G and IL-17F 7488A/G polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequencies of AA,GG and AG of IL-17A A-832G locus in the case and control groups were 46.9%, 8.0%, 45.1%, and 49.2%, 7.6%, 43.2%, respectively, with no significant differences (p>0.05).The GG genotype in the IL-17F (7488A/G) locus was not found. The frequencies of AA and GA of IL-17F 7488A/G locus in the case and control groups were 84.1%, 15.9% and 66.4%, 33.6%, respectively (p<0.05). Analysis of combined effects showed that the individuals with GG+AG genotype of IL-17A and GG+GA genotype of IL-17F are protected against silicosis (OR=0.469). Conclusions: IL-17F 7488A/G is associated with susceptibility to silicosis, and G allele may have a protective effect. No relationship was found between IL-17A gene polymorphisms at A-832G and silicosis.