• 농약과학회지
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• 제12권1호
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• pp.9-17
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• 2008

일련의 새로운 cyclohexanone 유도체(5-benzofuryl-2-[1-(alkoxyimino)alkyl]-3-hy-droxycyclohex-2-en-1-ones)와 벼(Oryza sativa L.) 및 돌피(Echinochloa crus-galli)에 대한 제초활성과의 정량적인 구조-활성관계(QSARs)를 2D-QSAR 및 HQSAR 방법으로 검토하였다. 일반적으로 HQSAR 모델이 2D-QSAR 모델보다 예측성과 적합성이 좋았다. 2D-QSAR II 모델로부터 돌피의 제초활성은 분자의 Balaban 지수(BI)와 $R_1$ 및 $R_3$-기의 소수성에 의존적이었다. 또한, HQSAR IV 모델에 따라 $R_3=ethyl$ 기가 벼의 제초활성에 기여하는 반면에 5-(cyclohex-3-enyl)-2,3-dihydrobenzofuran 고리 부분은 두 초종의 제초활성에 기여하지 않았다.

• 한국위성정보통신학회논문지
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• 제10권3호
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• pp.121-126
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• 2015

본 논문에서는 원형 편파 다이버시티를 구현하기 위하여 교차형 섭동 구조에 기반을 둔 새로운 원형 편파 재구성 마이크로스트립 안테나를 제안하였다. 제안한 안테나는 우회전 원형 편파와 좌회전 원형 편파를 동시에 구현하기 위하여 링 구조 방사체와 원형 편파의 방향을 선택하기 위한 두 개의 PIN 다이오드로 구성되었다. 방사체의 대각선 한 모서리에 슬롯 섭동과 스터브 섭동을 다이오드의 ON/OFF 상태를 조절함으로써, 제안한 안테나의 재구성 원형 편파는 잘 동작되고 또한 교차할 수 있었다. 또한 위성 통신 시스템 동작을 위하여 2.4 GHz의 S 대역에서 제안한 안테나는 이론적으로 분석하였고, 실험적으로 검증하였다. 제작된 안테나의 모의실험과 측정실험결과는 반사계수, 축비, 안테나 이득, 및 방사패턴에서 잘 일치함을 확인하였다.

• 한국항행학회논문지
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• 제10권1호
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• pp.13-19
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• 2006

본 논문에서는 FCC의 방사 스펙트럼 제한 규정에 따라 5 GHz-WLAN 주파수 대역을 억제한 DS-UWB 가우시안 임펄스 생성기를 제안하고, 이를 실험적으로 구현하였다. 단극 구형파를 가우시안 임펄스로 변환하기 위해 SRD를 이용한 첫 번째 임펄스 생성기와 반도체 레이저의 이득 스위칭을 이용한 두 번째 임펄스 생성기로 구성된 2단 구조의 임펄스 생성기를 사용하였다. 출력된 가우시안 임펄스의 폭은 약 180 psec로 매우 짧다. 또한 WLAN 주파수 대역을 제거하기 위해 4단 링 공진기 구조의 고차 미분 가우시안 필터를 설계 및 제작하여 최종적으로 WLAN 신호 대역은 약 25 dB의 억제 효과를 갖는 DS-UWB 신호의 발생기를 실험적으로 구현하였다.

• Journal of Microbiology and Biotechnology
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• 제21권10호
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• pp.1001-1011
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• 2011

To explore bacterial diversity for elucidating genetic variability in acylhomoserine lactone (AHL) lactonase structure, we screened 800 bacterial strains. It revealed the presence of a quorum quenching (QQ) AHL-lactonase gene (aiiA) in 42 strains. These 42 strains were identified using rrs (16S rDNA) sequencing as Bacillus strains, predominantly B. cereus. An in silico restriction endonuclease (RE) digestion of 22 AHL lactonase gene (aiiA) sequences (from NCBI database) belonging to 9 different genera, along with 42 aiiA gene sequences from different Bacillus spp. (isolated here) with 14 type II REs, revealed distinct patterns of fragments (nucleotide length and order) with four REs; AluI, DpnII, RsaI, and Tru9I. Our study reflects on the biodiversity of aiiA among Bacillus species. Bacillus sp. strain MBG11 with polymorphism (115Alanine > Valine) may confer increased stability to AHL lactonase, and can be a potential candidate for heterologous expression and mass production. Microbes with ability to produce AHL-lactonases degrade quorum sensing signals such as AHL by opening of the lactone ring. The naturally occurring diversity of QQ molecules provides opportunities to use them for preventing bacterial infections, spoilage of food, and bioremediation.

• 제어로봇시스템학회논문지
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• 제19권7호
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• pp.605-613
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• 2013

This research proposes a vibration pattern algorithm to implement the haptic joystick to control a mobile robot at the remote site without watching the navigation environment. When the user cannot watch the navigation environment of the mobile robot, the user may rely on the haptic joystick solely to avoid obstacles and to guide the mobile robot to the target. To generate vibration patterns, there is a vibration motor at the bottom of the joystick which is held by the user to control the motion direction of the mobile robot remotely. When the mobile robot approaches to an obstacle, a pattern of vibration is generated by the motor, and by feeling the vibration pattern which is determined by the relative position of the mobile robot to the obstacle, the user can move the joystick to avoid the collision to the obstacle for the mobile robot. To generate the vibration patterns to convey the relative location of the obstacle near the mobile robot to the user, Fuzzy interferences have been utilized. To measure the distance and location of the obstacle near the mobile robot, ultrasonic sensors with the ring structure have been adopted and they are attached at the front and back sides of the mobile robot. The precise location of the obstacle is obtained by fusing the multiple data from ultrasonic sensors. Effectiveness of the proposed algorithm has been verified through the real experiments and the results are demonstrated.

• Bulletin of the Korean Chemical Society
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• 제35권6호
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• pp.1789-1793
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• 2014

Pseudo-first-order rate constants ($k_{obsd}$) have been measured spectrophotometrically for the reactions of 5-nitro-8-quinolyl nicotinate (4) and 5-nitro-8-quinolyl isonicotinate (5) with alkali metal ethoxides (EtOM; M = K, Na and Li) in anhydrous ethanol at $25.0{\pm}0.1^{\circ}C$. The plots of $k_{obsd}$ vs. [EtOM] curve slightly upward for the reactions with EtOK and EtONa but are linear for the reactions with EtOLi and for those with EtOK in the presence of 18-crown-6-ether. Dissection of $k_{obsd}$ into $k_{EtO^-}$ and $k_{EtOM}$ (i.e., the second-order rate constants for the reactions with the dissociated $EtO^-$ and ion-paired EtOM, respectively) has revealed that the reactivity increases in the order $EtO^-{\approx}EtOLi$ < EtOK < EtONa for the reactions of 4 and EtOLi < $EtO^-$ < EtOK < EtONa for the reactions of 5. Comparison of the kinetic results for the reactions of 4 and 5 with those reported previously for the corresponding reactions of 5-nitro-8-quinolyl benzoate (2) and picolinate (3) has revealed that the esters possessing a pyridine ring (i.e., 3-5) are significantly more reactive than the benzoate ester 2 due to the presence of the electronegative N atom (e.g., 2 << 3 < 4 < 5). It has been concluded that $M^+$ ion catalyzes the reactions of 3-5 by increasing the electrophilicity of the reaction center through a five-membered cyclic transition state (TS) for the reaction of 3 and via a four-membered cyclic TS for the reactions of 4 and 5.

• Bulletin of the Korean Chemical Society
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• 제28권12호
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• pp.2261-2265
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• 2007

Prevention of thermal aggregation of the denatured protein by the group II chaperonin from the aerobic hyperthermophilic crenarchaeon Aeropyrum pernix K1 (ApcpnA) has been investigated. ApcpnA exists as a homo-oligomer in a ring structure, which protects thermal aggregation of the chemically denatured bovine rhodanese at 50 oC. ApcpnA alone is not sufficient for chaperonin activity, but the chaperonin activity is greatly enhanced in the presence of manganese ion and ATP. Compared to the mesophilic chaperonin GroEL/GroES, ApcpnA is more activated at a higher temperature and protects the aggregation-prone unfolded state of the denatured rhodanese from thermal aggregation. Binding of ATP is sufficient for ApcpnA to perform the chaperonin function in vitro, but hydrolysis of ATP is not necessarily required. We propose that utilization of Mn2+ and adenosine nucleotide regardless of ATP hydrolysis may be one of peculiar properties of archaeal chaperonins.

• Archives of Pharmacal Research
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• 제13권1호
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• pp.82-96
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• 1990

Ten (E)-and (Z)-isomers of 2-phenylcyclopropylamine (PCA), 1-Me PCA, 2-Me-PCA, N-Me-PCA, and N, N-diMe PCA and fifteen o-. m-, p- isomers of (E) PCA with substituents of Me, Cl, F, OMe, OH were synthesized in this laboratory and tested for the inhibition of rat brain mitochondrial MAO-A and MAO-B. The effects of substituents, their positions, and stereochemistry on the inhibition were assessed for the compounds with substituents at cyclopropyl and amino groups and QSAR analyses were performed using the potency data of ring-substituted compounds. The best correlated QSAR equations are as follows : pI$_{50}$ = 0.804 $\pi^2$-0.834 Blo-1.069 Blm + 0.334 Lp-1.709 HDp +7.897 (r = 0.945, s =0.211, F = 16.691, p = 0.000) for the inhibition of MAO-A;PI$_{50}$= 1.815$\pi$-0.825 $\pi^2$-1.203R + 0.900 Es$^2$ + 0.869 Es$^3$ + 0.796 Es$^4$-0.992 HDp + 0.562 HAo + 3.893 (r = 0.982, s =0.178, F = 23.351, p = 0.000) for the inhibition of MAO-B. Based on the potency difference between stereoisomers of cyclopropylamine-modified compounds and an QSAR cavity near para position, two hydrophobic carities interacting with Me group, a hydrophobic site near para position, and an amino group binding site and that in addition to the same two hydrophotic cavities, hydrophotic area, steric boundaries, hydrogen-acceptor site, and amino group binding site, another steric boundary near para position and a hydrogen donating site near ortho position constitute active sites of MAO-B.

• 한국경제지리학회지
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• 제21권2호
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• pp.107-118
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• 2018

급속한 경제발전에 따라 중국 베이징에서 교통혼잡이 심각한 문제로 대두되고 있다. 혼잡통행료는 도로의 정체를 해결해주는 매우 효율적인 방법인데, 이의 시행에 있어 가장 중요한 과제는 혼잡통행료의 산출모형을 개발하는 것이다. 기존연구와 달리 본 논문은 이론적 논의에 그치지 않고 세 가지의 현실적 문제, 즉, 통행속도와 밀도의 관계, 통행의 시간비용, 최적통행량 산정방법의 도출에 집중하였다. 먼저 회귀분석을 통하여 통행속도와 밀도의 관계를 파악하고, 이어 설문조사 결과를 이용하여 통행의 시간비용을 추정하였다. 또한 수요곡선에 대한 정확한 정보가 없더라도 시행착오를 거쳐서 최적통행량을 산정할 수 있음을 보였다. 마지막으로 베이징 제2순환도로의 혼잡통행료 책정시스템을 설계하고 요금의 적절한 징수방안을 제안하였다.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제48권12호
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• pp.761-767
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• 1999

Poly-Si TFTs(polycrystalline silicon thin film transistors) fabricated on a low cost glass substrate have attracted a considerable amount of attention for pixel elements and peripheral driving circuits in AMLCS(active matrix liquid crystal display). In order to apply poly-Si TFTs for high resolution AMLCD, a high operating frequency and reliable circuit performances are desired. A new poly-Si TFT with CLBT(counter doped lateral body terminal) is proposed and fabricated to suppress kink effects and to improve the device stability. And this proposed device with BC(buried channel) is fabricated to increase ON-current and operating frequency. Although the troublesome LDD structure is not used in the proposed device, a low OFF-current is successfully obtained by removing the minority carrier through the CLBT. We have measured the dynamic properties of the poly-Si TFT device and its circuit. The reliability of the TFTs and their circuits after AC stress are also discussed in our paper. Our experimental results show that the BC enables the device to have high mobility and switching frequency (33MHz at $V_{DD}$ = 15 V). The minority carrier elimination of the CLBT suppresses kink effects and makes for superb dynamic reliability of the CMOS circuit. We have analyzed the mechanism in order to see why the ring oscillators do not operate by analyzing AC stressed device characteristics.