• 제목/요약/키워드: rheumatoid arthritis

검색결과 904건 처리시간 0.023초

홍화자약침(紅花子藥鍼)의 항염증능이 백서의 LPS로 유발된 류마티스성 관절염에 미치는 영향 (Anti-inflammatory Effect of Hong Hua Za Pharmacupuncture on Rheumatoid Arthritis that Caused by Lipopolysaccharide in Mouse)

  • 임대정;조재용;정웅채;박인식;김갑성;김경호
    • Journal of Acupuncture Research
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    • 제25권3호
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    • pp.95-106
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    • 2008
  • Objectives : This study is to evaluate Effect of Hong Hua Za acupuncture anti-inflammatory on rheumatoid arthritis that caused by Lipopolysaccharide in mouse. Methods : Hong Hua Za(Carthami Tinctorii Fructus) acupuncture(HA) was prepared and tested for therapeutic potential of rheumatoid arthritis, by measuring the inhibition of inducible nitric oxide synthase (iNOS) expression, nitric oxide(NO) production in vitro experiment, by measuring Tumpr Necrosis Factor-$\alpha$(TNF-$\alpha$) & Nuclear Factor kappa B(NF-$\kappa$B) p65 activation, synovial hyperplasia, angiogenesis and fibrosis in synovial membrane of knee joint of mice. Results : HA showed therapeutic effects on Lipopolysaccharide(LPS)-induced rheumatoid arthritis. HA inhibited iNOS mRNA and NO in RAW264.7cell of LPS-induced rheumatoid arthritis in a dose dependent manner. HA also showed significant inhibition of TNF-$\alpha$ & NF-$\kappa$B p65, activation, synovial hyperplasia, angiogenesis and fibrosis in synovial membrane of knee joint of mice. Conclusions : These results suggest that HA has an therapeutic effects on LPS induced-rheumatoid arthritis by inhibiting TNF-$\alpha$ activation.

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류마티스 관절염환자의 피로에 대한 조사 (Study of Fatigue in Patients with Rheumatoid Arthritis)

  • 박정숙;조혜명
    • 한국간호교육학회지
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    • 제7권2호
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    • pp.245-253
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    • 2001
  • The aim of this study is to describe degree of fatigue and factors related to fatigue in patients with rheumatoid arthritis. The subjects of the study consist of one hundred fifty-eight outpatients with rheumatoid arthritis at three university hospitals in Taegu between July 10 and August 30, 1999. The instrument used in this study was the Multidimensional Assessment of Fatigue developed by Belza et al.(1995) and revised by Jung, Bok Hee. Kim, Myung Ae(1998). Analysis of data was done by using the descriptive statistics, t-test, ANOVA and Duncan with SPSS program. The major findings can be summarized as follows: 1. Degree of fatigue in patient with Rheumatoid Arthritis was shown the average 22.91 out of the total scores 40. Four subscales of fatigue scores are common fatigue degree 6.37, fatigue timing at the last week 5.92, distress due to fatigue 5.40 and degree of daily activity fatigue 5.22. Among the realms of daily activity fatigue, outdoor activity(6.00), sexual life(5.84), doing the household(5.66), shopping(5.61), other exercise except stroll(5.54) were shown the high degree of fatigue and cooking(4.97), a stroll(4.48), recreation(4.35) showed the low degree of fatigue. 2. There were no significant differences on the total degree of fatigue according to demographic variables. But there were some significant differences on the subscale fatigue scores according to demographic variables. Degree of daily activity fatigue according to sex was shown significant difference (t=-2.358, p=.020), and according to education level was shown significant difference(F=3.938, p=.005) and common fatigue degree according to age was shown significant difference(F=2.853, p=.026). Conclusively fatigue is one of difficult problems for patients with rheumatoid arthritis. Therefore it is necessary to develop some nursing intervention for reducing fatigue of rheumatoid arthritis patients.

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류마티스 관절염 환자의 원인지각, 대응양상, 사회심리적 적응과의 관계 (Causal Perceptions, Coping Patterns and Psychosocial Adaptation in Rheumatoid Arthritis Patients)

  • 장세영;박상연
    • 근관절건강학회지
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    • 제9권2호
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    • pp.187-202
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    • 2002
  • This study was aim to provide rheumatoid arthritis patients the basic data of development of nursing intervention to help psychosocial adaptation of rheumatoid arthritis patients as exploring the relationship among causal perception, coping pattern, psychosocial adaptation of rheumatoid arthritis. As the results of this study the mean score of causal perception of the subjects was 3.37. The score of the internal-unstable was the highest. which was followed by extra-stable, internal factor, internal-stable, external factor and external-unstable in order among the factor of causal perception. The mean score of coping pattern was 2.64. The type of coping patterns the score of the receptive coping was the highest, which was followed by wishful coping active coping and negative coping in order among the type of coping pattern. The mean score of psychosocial adaptation was 3.28. The subconcept of psychosocial adaptation the score for personal relationship was the highest, which was followed by role function and mental state in order among the psychosocial adaptation. The analysis of the relation among causal perception, coping pattern and psychosocial adaptation showed significant negative correlation between causal perception and psychosocial adaptation(r=-0.3219, P=0.002). The analysis of the relation between the type of coping pattern and psychosocial adaptation showed significant negative correlation between psychosocial adaptation and active coping(r=-0.3210, P=0.002), negative coping(r=-0.2296, P=0.032). Only causal perception(-.36) and period of illness(-.26) effected on the psychosocial adaptation were shown to the negative direction significantly. The psychosocial adaptation was explained the 17% by these two variables. Based on this study results the factor of causal perception and the type of coping pattern of rheumatoid arthritis were shown significant relations between psychosocial adaptation. We suggests that nurses in practice apply to assessing the factor of causal perception of individuals illness and the type of coping patterns when nursing interventions in rheumatoid arthritis patients.

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류마티스 관절염 백서 모델에서 작약감초부자탕의 효과: 체계적 문헌고찰 및 메타분석 (Effects of Jakyakkamchobuja-tang on Rheumatoid Arthritis in Rat Model: Systemic Review and Meta-Analysis)

  • 김채연;이상현;황만석
    • 한방재활의학과학회지
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    • 제33권3호
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    • pp.79-96
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    • 2023
  • Objectives This study was designed to review the effect of Jakyakkamchobuja-tang on rat model with rheumatoid arthritis. Methods We used seven databases (PubMed, EMBASE, Cochrane CENTRAL, China National Knowledge Infrastructure, Oriental Medicine Advanced Searching Integrated System, Korean studies Information Service System, National Digital Science Library) from their inception to May 2023 without language restrictions. Systematic Review Centre for Laboratory Animal Experimentation's tool was used to evaluate the risk of bias. RevMan software (V5.4) was used for the meta-analysis. Results Five studies were selected following our inclusion criteria. The arthritis index decreased significantly (standardized mean difference=-2.06; 95% confidence interval=-3.07 to -1.04; p<0.0001) in Jakyakkamchobuja-tang group. Also, serum cytokines in serum and paw swelling degree decreased in Jakyakkamchobuja-tang group. Conclusions Jakyakkamchobuja-tang may be effective in treating rheumatoid arthritis. Although there is a limitation that the design of drug dosage varies between papers, it can be expected to be applied as an alternative to Western medicine, and it is believed to contribute to the standardization of herbal treatment for rheumatoid arthritis.

류마티스 환자의 발목 인공관절 치환술 이후 발생한 정복되지 않는 충전물의 아탈구: 증례 보고 (Irreducible Spacer Subluxation after Total Ankle Replacement Arthroplasty in a Patient with Rheumatoid Arthritis: A Case Report)

  • 서동교;김상영
    • 대한족부족관절학회지
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    • 제25권4호
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    • pp.181-184
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    • 2021
  • End-stage ankle arthritis is a debilitating condition that causes functional limitations and consequently a poor quality of life. Total ankle replacement arthroplasty is a good alternative to arthrodesis for preserving the ankle's range of motion. However, many complications can occur in patients with rheumatoid arthritis and with poor soft tissue and bone conditions. A 61-year-old female experienced spacer subluxation after surgery, which was not reduced by medial soft tissue release and spacer change. Buttress plating was found to be a good treatment option to prevent spacer subluxation and can be considered in patients with rheumatoid arthritis with bone erosion and soft tissue damage.

Health-related quality of life among home-dwelling people with arthritis in Korea: Comparative study of osteoarthritis and rheumatoid arthritis

  • Joung, Kyoung-Hwa;Chung, Sung-Suk
    • Journal of the Korean Data and Information Science Society
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    • 제22권3호
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    • pp.555-563
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    • 2011
  • Osteoarthritis (OA) and rheumatoid arthritis (RA) are most popular types of arthritis in Korea. This study compared health-related quality of life (HRQoL) of homedwelling people with OA and RA in Korea. Data were drawn from the Korean nationwide representative survey. Subjects were 3,352 people with arthritis over 19 years of age (2,953 OA respondents and 399 RA respondents). Good HRQoL in OA respondents was dierentiated with limitation of mobility, perceived health status, age, economic status, presence of arthralgia, gender, medical coverage, and educational level. Good HRQoL in RA respondents was dierentiated with limitation of mobility, perceived health status, economic status, educational status, and presence of arthralgia. In conclusion, HRQoL and predictors of good HRQoL among people with arthritis diers for OA or RA. These results can be of use in development of health programs and clinical interventions for community-dwelling people with arthritis.

봉약침요법(蜂藥鍼療法)을 이용한 고관절병변(股關節病變) 치험(治驗) 증례보고(症例報告) (Three cases of affections of the hip treated with Korean Bee-Venom therapy)

  • 김태희;강계성;권기록
    • 대한약침학회지
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    • 제4권3호
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    • pp.127-134
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    • 2001
  • Objective : In this study, we have discovered that Korean Bee-Venom therapy is effective in treating various hip joint diseases. For example, A vacular Necrosis, Degenerative Arthritis and Rheumatoid Arthritis. Methods & Results: We have treated three cases of affections of the hip(eg. Degenerative arthritis, Rheumatoid arthritis and Avascular Necrosis of Femoral Head) with Korean Bee-Venom therapy and herbal acupuncture treatments. For acupuncture, Korean Bee-Venom therapy was observed for its pain relieving effects. Korean Bee-Venom therapy was treated on the following acupuncture points: GB29(Koryo), GB30(Hwando:環跳), ST36(Chok-samni:足三理). As the results of these treatments, a little change of inflammation around the hip joint on X-ray scan study was observed. but the degree of pain and range of motion were improved. in addition to general conditions of the patients. Conclusions: Based on the clinical results, Korean Bee-Venom therapy is believed to be effective for treating Avascular Necrosis of Femoral Head, Degenerative arthritis and Rheumatoid arthritis of hip joint. However, it is expected that further studies should be conducted to provide more objective information.

전방머리자세가 음향학적 특성과 호흡 시 근활성도에 미치는 영향 (The Effect of the Forward Head Posture on Acoustic Characteristics and Muscle Activity during Respiration)

  • 신혜림;박희준;이상빈;이상열
    • PNF and Movement
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    • 제21권3호
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    • pp.357-366
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    • 2023
  • Purpose: The purpose of this study was to investigate the characteristics and grip strength of people with osteoarthritis and rheumatoid arthritis using data from the Korea National Health and Nutrition Examination Survey. Methods: This was a retrospective study that analyzed raw data from the first year of the 8th Korea National Health and Nutrition Examination Survey (2019). The study population was 780 people in total, ranging in age from their teens to their 80s. These were people who had been diagnosed with osteoarthritis and rheumatoid arthritis, and the presence of arthritis in and grip strength of these subjects were determined using the average value of three measurements. Results: According to the National Health and Nutrition Examination Survey, the prevalence of arthritis in Korea was 2.5% in men, 10.7% in women, and 13.1% overall. More women than men had osteoarthritis and rheumatoid arthritis, and the number of people with osteoarthritis increased with age. In this study, of those with osteoarthritis, 13.5% were men and 88% were women; of those with rheumatoid arthritis, 19.3% were men and 56.3% were women. The number of patients with osteoarthritis increased with age, and rheumatoid arthritis was more common in older people. Subjects with osteoarthritis had lower grip strength than those without the disease, and the older the age at which rheumatoid arthritis was first diagnosed, the lower the grip strength. Conclusion: Grip strength is lower in patients with osteoarthritis than in those without osteoarthritis, and it is possible to estimate the degree to which muscle strength decreases.

한약의 류마티스 관절염 동물 모델에 대한 치료효과: 국내 및 국외 논문에 대한 체계적 문헌 고찰 (The Effect of Herbal Medicine on Rheumatoid Arthritis Animal Model: A systematic Review of Animal Experiment Studies Published in Korea and Overseas)

  • 오승준;하현주;구지향;박양춘;오민석;정인철;이은정
    • 한방재활의학과학회지
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    • 제30권3호
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    • pp.103-116
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    • 2020
  • Objectives This study was designed to review the effect of herbal medicine on animal model with rheumatoid arthritis. Methods We reviewed studies published both in Korea and overseas, all published after 2008. We investigated 8 databases, 6 Korean databases and 2 of abroad. Searching was conducted through flowchart and 24 studies met our guideline. Datas were extrated and organized as animal model characteristics, experimental period, study design, herbal medicine used as intervention and rheumatoid arthritis indicator. Results 336 articles were primarily selected. After screening, 24 articles were left in the end. All 24 studies showed that the herbal medicine used in the animal experiment was effective on treating rheumatoid arthris, proven by macroscopic, histological, hematological and osteological indicators. Conclusions The result showed that herbal medicine is effective in treating rheumatoid arthritis through various pathways. However, study design and intervention were all different from each other and we could not specify the certain compound, material or substance of efficacy. Further study should be conducted to figure out the effectiveness of herbal medicine on rheumatoid arthritis.

류마토이드 관절염에서 슬관절의 관절경적 활액막 절제술 (Arthroscopic Synovectomy of the Knee in Rheumatoid Arthritis)

  • 정재훈;박일성;양동현
    • 대한관절경학회지
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    • 제1권1호
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    • pp.91-97
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    • 1997
  • There has been a controversy about the effectiveness of the synovectomy of the knee in the rheumatoid arthritis. So we studied to determine if the arthroscopic synovectomy of the knee was of benefit in the rheumatoid arthritis. We ana lysed 25 knees of 15 patients who underwent the arthroscopic synovectomy of the knee joint for their rheumatoid arthritis from Jun. 1995 to Oct. 1996. The average follow-up period was 20.1 months($12\~28$ months). The results were as follows; 1. Satisfactory results were obtained in 20 knees $(80\%)$ for the pain and the effusion each, 23 $(92\%)$ for the range of motion and 19 $(76\%)$ for the functional capacity. 2. In the overall results for the pain. effusion. range of motion and the functional capacity. we obtained excellent results in 14 knees $(56\%)$ and satisfactory results in 9 knees $(32\%)$. 3. In the patient's self assessment, 11 patients $(44\%)$ were delighted and 10 patients $(40\%)$ were satisfactory. 4. In the overall results according to the articular cartilage damage, satisfactory results were obtained in 15 $(93\%)$ out of 16 knees in Grade I and II, and 6 $(75\%)$ out of 8 knees in Grade III and IV. In conclusion, arthroscopic synovectomy could be one of very useful treatments for the rheumatoid knee. But further study is needed to get the long-term results of the synovectomy because there's many reports saying gradual decrease of good results with increasing time. And continuous and proper medical treatment including DMARDs, is needed to effectively control the rheumatoid arthritis even after the synovectomy.

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