Browse > Article
http://dx.doi.org/10.18325/jkmr.2020.30.3.103

The Effect of Herbal Medicine on Rheumatoid Arthritis Animal Model: A systematic Review of Animal Experiment Studies Published in Korea and Overseas  

Oh, Seung-Joon (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Daejeon University)
Ha, Hyun Ju (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Daejeon University)
Gu, Ji-Hyang (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Daejeon University)
Park, Yang-Chun (Department of Internal Medicine, College of Korean Medicine, Daejeon University)
Oh, Min-Seok (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Daejeon University)
Jung, In-Chul (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University)
Lee, Eun-Jung (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Korean Medicine Rehabilitation / v.30, no.3, 2020 , pp. 103-116 More about this Journal
Abstract
Objectives This study was designed to review the effect of herbal medicine on animal model with rheumatoid arthritis. Methods We reviewed studies published both in Korea and overseas, all published after 2008. We investigated 8 databases, 6 Korean databases and 2 of abroad. Searching was conducted through flowchart and 24 studies met our guideline. Datas were extrated and organized as animal model characteristics, experimental period, study design, herbal medicine used as intervention and rheumatoid arthritis indicator. Results 336 articles were primarily selected. After screening, 24 articles were left in the end. All 24 studies showed that the herbal medicine used in the animal experiment was effective on treating rheumatoid arthris, proven by macroscopic, histological, hematological and osteological indicators. Conclusions The result showed that herbal medicine is effective in treating rheumatoid arthritis through various pathways. However, study design and intervention were all different from each other and we could not specify the certain compound, material or substance of efficacy. Further study should be conducted to figure out the effectiveness of herbal medicine on rheumatoid arthritis.
Keywords
Rheumatoid arthritis; Korean traditional medicine; Chinese herbal drugs; Systematic review; Animal experimentation;
Citations & Related Records
Times Cited By KSCI : 9  (Citation Analysis)
연도 인용수 순위
1 Healthcare Bigdata Hub [Internet] 2020 [cited 2020 Jun 1]. Available from: URL: http://opendata.hira.or.kr/op/opc/olapMfrnIntrsIlnsInfo.do.
2 Scott DL, Wolfe F, Huizinga TWJ. Rheumatoid arthritis. Lancet. 2012;376(9746):1094-108.   DOI
3 Yoo DH. Recent trend in the treatment of rheumatoid arthritis. Journal of the Korean Orthopaedic Association. 2010;45(6):419-25.   DOI
4 Firestein GS. Evolving concepts of rheumatoid arthritis. Nature. 2003;423(6937):356-60.   DOI
5 Furneri G, Mantovani LG, Belisari A, Mosca M, Cristiani M, Bellell S, Cortesi PA, Turchetti G. Systematic literature review on economic implications and pharmacoeconomic issues of rheumatoid arthritis. Clin Exp Rheumatol. 2013;30(4):72-84.
6 Obiri DD, Osafo N, Ayande PG, Antwi AO, Xylopia aethiopica (Annonaceae) fruit extract suppresses Freund's adjuvant-induced arthritis in Sprague-Dawley rats. J Ethnopharmacol. 2014;152(3):522-31.   DOI
7 Jeong JW, Bae KJ, Won JY, Jung MY, Kim SJ. Reviewing research on the study of rheumatoid arthritis model treated by pharmacopuncture in Korean journals objective. J Korean Med Rehabil. 2015;25(3):37-49.   DOI
8 Choi DY, Lee JD, Back YH, Lee SS, Yoo MC, Han CS, Yang HI, Park SD, Ryu MH, Park EK, Park DS. Recent trends of immunologic studies of herbal medicine on rheumatoid arthritis. The Journal of Korean Acupuncture & Moxibustion Society. 2004;21(4):177-96.
9 Yoo CK, Lee YJ. A case report of oligoarticular juvenile idiopathic arthritis with oriental medication and DMARDs & NSAIDs tapering. J Pediatr Korean Med. 2013;27(4):31-8.   DOI
10 Song YW. Updated pathosiology of rheumatoid arthritis. The Korean Journal of Medicine. 2009;76(1):1-6.
11 The Korean Orthopaedic Association. Orthopaedics. 7th ed. Seoul:Coishin Medical Publlishing Co. 2013:296.
12 Lee OJ, Lee DG, Lee JH, Lee JH, Lee SH, Park GH, Shin JC. Effects of curcuma longa LINNE pharmacopuncture at ST36 on adjuvant induced arthritis in rats. The Acupuncture. 2013;30(4):95-105.
13 Kim KY, Sim KC, Kim GY, Choi CH, Jung JG, Chung JS, Jeong HW. Effects of acanthopanax senticosus and onion mixture extract on the collagen-induced arthritis in rat model. Korean J Oriental Physiology & Pathology. 2011;25(6):1000-7.
14 Choi SH, Yoon IJ. An analysis of the study tendency on rheumatoid arthritis -focusing on domestic theses for a degree and journal since 2004-. J Korean Med Rehabil. 2009;19(2):125-56.
15 Won JY, Jeon CH, Song HJ, Jeong JW, Kim TG, Kim HH, Leem JT. The effect of orally administered herbal medicines in collagen, LPS, CFA induced rheumatoid like arthritis animal model: a systematic review of animal study articles published in Korea after 2008. J Korean Med Rehabil. 2017;27(4):33-53.   DOI
16 Kim SY, Park JE, Seo HJ, Lee YJ, Jang BH, Son HJ, Suh HS, Shin CM. NECA's guidance for undertaking systematic reviews and meta-analysis for intervention. 1st ed. Seoul:National Evidence-based Healthcare Collaborating Agency. 2011:24-5, 64-75.
17 Kim HS, Heo DS, Oh MS, Hong SY. Suppressive effect of Kwanjulbang-6 on collagen-induced arthritis in mice. Journal of Physiology & Pathology in Korean Medicine. 2009;23(5):1003-11.
18 Kung SE, Oh MS. The experimental effect of Haedongpibokhap-bang (Haitongpifuhe-fang) on collagen-induced arthritis group. Journal of Oriental Rehabilitation Medicine. 2008;18(2):1-15.
19 Kim MK, Oh MS. Inhibitory effects of Gamidaeganghwaltang on rheumatoid arthritis induced by type II collagen. Journal of Oriental Rehabilitation Medicine. 2009;19(2):89-102.
20 Kim JG, Oh MS. Inhibitory effect of Esubwhaltong-tang on rheumatoid arthritis induced by type II collagen. Journal of Oriental Rehabilitation Medicine. 2009;19(1):57-71.
21 Min BK, Oh MS. Suppressive effect of GJB-7 on collagen-induced arthritis in mice. Journal of Korean Medicine. 2010;31(4):63-78.
22 Kim JK, Oh MS. Effects of Gwanjul8-bang on collagen induced arthritis in DBA/1J mice. Journal of Oriental Rehabilitation Medicine. 2010;20(2):17-34.
23 Kim EH, Oh MS. Inhibitory effects of Gwanjul9-bang on collagen induced arthritis in DBA/1J Mouse. Journal of Physiology & Pathology in Korean Medicine. 2010;24(3):490-503.
24 Park JW, Oh MS. Inhibitory effects of Changchuldointang gamibang on collagen induced arthritis in DBA/1J mouse. Journal of Korean Medicine. 2010;31(2):19-35.
25 Bae BC, Choi ES, Kwon OG, Woo CH, An HD. Suppressive effects of Imyo-san on Freund's complete adjuvant (FCA)-induced arthritic rats. J Korean Med Rehabil. 2013;22(1):23-42.
26 Lim JS, Kim SJ. Anti-pathogenetic and curative effects of Gyehyeoldeungbokhap -bang on the collagen-induced arthritis. Journal of Oriental Rehabilitation Medicine. 2010;20(4):33-49.
27 Yun SM, An HD, Woo CH, Kwon OG, Jeong MJ. Suppressing effects of Sowhalrack-dan(Xiaohuoluo-dan) on Freund's complete adjuvant induced arthritic rats. Journal of Oriental Rehabilitation Medicine. 2011;21(1):97-114.
28 Xu W, Li H, Chu K, Zhang Y, Zheng H, Huang M, Zhang X, Chen L. Effects of Shuangtengbitong tincture on collagen-induced arthritis in rats. Mol Med Rep. 2013;8(5):1479-85.   DOI
29 Kwon OG, An HD. Articular cartilage protective effects of Kangwhaldoche-tang aqueous extracts on the adjuvant-induced rat rheumatoid arthritis. J Korean Med Rehabil. 2013;23(2):49-61.
30 Liu C, Kong X, Li X, Guo W, Zhang C, Sun Y, Su X, Liu X, Lu A, Lin N. Wen Luo Yin inhibits angiogenesis in collagen-induced arthritis rat model and in vitro. J Ethnopharmacol. 2013;149(2):478-89.   DOI
31 Sim BY, Bak JW, Kim DH. Effect of Gamikyejakjimotang ethanol extract on rheumatoid arthritis factors. The Korea Journal of Herbology. 2014;29(5):65-73.   DOI
32 Sim BY, Choi HJ, Bak JW, Kim DH. Effects of GamiBangkeehwangkee-tang ethanol extract on collagen-induced rheumatoid arthritis model of DBA/1 mice. The Korea Journal of Herbology. 2014;29:95-102.   DOI
33 Qian C, Kuang M, Wang Y. Effect of Qianghuo Erhuang decoction on T regulatory and T helper 17 cells in treatment of adjuvant-induced arthritis in rats. Sci Rep. 2017;7(1):17198.   DOI
34 Chang XL, Liu XG, Wang Q, Zhou L, Qi LW, Ping L, Liu EH. Anti-inflammatory and anti-arthritic effects of Guge Fengtong Formula: in vitro and in vivo studies. Chin J Nat Med. 2015;13(11):842-53.   DOI
35 Jia P, Chen G, Qin WY, Zhong Y, Yang J, Rong XF. Xitong Wan attenuates inflammation development through inhibiting the activation of nuclear $factor-{\kappa}B$ in rats with adjuvant-induced arthritis. J Ethnopharmacol. 2016;193:266-71.   DOI
36 Pan T, Chen TF, Jia YR, Li P, Li F. Anti-rheumatoid arthritis effects of traditional Chinese herb couple in adjuvant-induced arthritis in rats. J Ethnopharmacol. 2017;205:1-7.   DOI
37 He L, Liu C, Sun C, Wang J, Zhi K, Sun D, Wang H, Wang Q, Lin N. Wu-Tou decoction inhibits angiogenesis in experimental arthritis by targeting VEGFR2 signaling pathway. Rejuvenation Res. 2018;21(5):442-55.   DOI
38 Cao YX, Huang D, Liu J, Zong RK, Wan L, Huang CB, Zhang WD, Wang Y. A novel Chinese medicine, Xinfeng capsule, modulates proinflammatory cytokines via regulating the toll-like receptor 4 (TLR4)/mitogenactivated protein kinase (MAPK)/nuclear kappa B ($NF-{\kappa}B$) signaling pathway in an adjuvant arthritis rat model. Med Sci Monit. 2019;25:6767-74.   DOI
39 Wang K, Zhang D, Liu Y, Wang X, Zhao J, Sun T, Jin T, Li B, Pathak JL. Traditional Chinese medicine formula Bi-Qi capsule alleviates rheumatoid arthritis-induced inflammation, synovial hyperplasia, and cartilage destruction in rats. Arthritis Res Ther. 2018;20(1):43-54.   DOI
40 Kim BH. The protective effects of Mahaegeuigam-Tang against monosodim lodoacetate induced osteoarthritis in rats. Herbal Formula Science. 2018;26(4):283-94.   DOI
41 Harris ED. Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med, 1990;322(18):1277-89.
42 Kwon YJ, Shung SJ, Kim TY, Park MC. Peroxisome proliferator-activated receptor-${\gamma}$ agonist inhibits pro-inflammatory gene expressions and cellular proliferation of fibroblast like synoviocytes from patients with rheumatoid arthritis by down-regulation of NF-kappaB. J Korean Rheum Assoc. 2010;17(2):153-61.   DOI
43 Hunt KJ, Coelho HF, Wider B, Perry R, Hung SK, Terry R, Ernst E. Complementary and alternative medicine use in England: results from a national survey. Int J Clin Pract. 2010;64(11);1496-502.   DOI
44 Manheimer E, Wieland S, Kimbrough E, Cheng K, Berman BM. Evidence from the cochrane collaboration for traditional Chinese medicine therapies. J Altern Complement Med. 2009;15(9):1001-14.   DOI
45 Goldrosen MH, Straus SE. Complementary and alternative medicine: assessing the evidence for immunological benefits. J Nat Rev Immunol. 2004;4(11):912-21.   DOI
46 Mateen S, Zafar A, Moin S, Khan AQ, Zubair S, Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis. Clin Chim Acta. 2016;455:161-71.   DOI
47 The Society of Korean Medicine Rehabilitation. Korean Rehabilitation Medicine. 3rd ed. Paju:Koonja Publishing. 2011:210-1, 237-8.
48 Kim MG, Seo IB, Leem KH, Jeong T, Kim J. Effects of Achyranthis Japonicae Radix-containing mixture on monosodium iodoacetate-induced osteoarthritis in rats. The Korean Journal of Herbology. 2017;32:83-9.   DOI
49 Kim JK, Oh MS. Inhibitory effect of Esubwhaltong-tang (Lishihuotong-tang) on rheumatoid arthritis induced by type collagen. J Korean Med Rehabil. 2009;19(1):57-71.
50 Fan HY, Yang MY, Che X, Zhang ZL, Xu H, Liu K, Meng QG. Activity study of a hydroxynaphthoquinone fraction from Arnebia euchroma in experimental arthritis. Fitoterapia. 2012;83(7):1226-37.   DOI