• Toxicological Research
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• 제31권1호
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• pp.1-9
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• 2015

Environmental toxicants such as toxic metals can alter epigenetic regulatory features such as DNA methylation, histone modification, and non-coding RNA expression. Heavy metals influence gene expression by epigenetic mechanisms and by directly binding to various metal response elements in the target gene promoters. Given the role of epigenetic alterations in regulating genes, there is potential for the integration of toxic metal-induced epigenetic alterations as informative factors in the risk assessment process. Here, we focus on recent advances in understanding epigenetic changes, gene expression, and biological effects induced by toxic metals.

• Molecules and Cells
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• 제45권7호
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• pp.435-443
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• 2022

In response to environmental changes, signaling pathways rewire gene expression programs through transcription factors. Epigenetic modification of the transcribed RNA can be another layer of gene expression regulation. N⁶-adenosine methylation (m⁶A) is one of the most common modifications on mRNA. It is a reversible chemical mark catalyzed by the enzymes that deposit and remove methyl groups. m⁶A recruits effector proteins that determine the fate of mRNAs through changes in splicing, cellular localization, stability, and translation efficiency. Emerging evidence shows that key signal transduction pathways including TGFβ (transforming growth factor-β), ERK (extracellular signal-regulated kinase), and mTORC1 (mechanistic target of rapamycin complex 1) regulate downstream gene expression through m⁶A processing. Conversely, m⁶A can modulate the activity of signal transduction networks via m⁶A modification of signaling pathway genes or by acting as a ligand for receptors. In this review, we discuss the current understanding of the crosstalk between m⁶A and signaling pathways and its implication for biological systems.

• 한국의류학회지
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• 제15권2호
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• pp.211-227
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• 1991

The purpose of this study was to investigate the effects of design modification, decoration and color scheme of traditional Korean women's clothing on impression formation by 2 age groups of women. The instruments developed for the study were 2 sets of stimuli and a response scale. Stimuli I (design stimuli) consisted of 6 line drawings of female figures in Korean clothing and modified Korean style clothing, whereas stimuli II (color stimuli) consisted of 6 colored drawings of female figures in different color schemes. The 7-point semantic differential scale of 14 bipolar adjectives were used for the response scales. 144 female college students and 144 middle·aged women subjects were randomly assigned to one of 6 drawings from each set of stimuli. The data were analyzed by factor analysis, ANOVA and t-test. 1) There factors emerged to account for dimensions of design and color scheme, respectively. The first factor was interpreted as Evaluation/prestige both in design (stimuli I) and color scheme (stimuli II), the second factor was Modernity for stimuli I, and the third factor for stimuli I was Practicality. On the other hand, the Luxuriousness/Individuality was factor 2 and Modernity was factor 3 for stimuli ll. 2) Modification had the largest effect on impressions regarding design and decorated designs had a partial effect on the impression of Modernity and Practicality. The female figures in modified Korean style clothing were perceived as more prestigious, modern and practical than those in traditional Korean clothing. 3) Color schemes had little effect on impressions, while perceiver's age had a larger effect. Middle·aged women formed more positive impressions toward Korean clothing of various color schemes than female college students.

• Earthquakes and Structures
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• 제5권1호
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• pp.49-65
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• 2013

This article presents the statistical characteristics of elastic floor acceleration spectra that represent the peak response demand of non-structural components attached to a nonlinear supporting frame. For this purpose, a set of stiff and flexible general moment resisting frames with periods of 0.3-3.6 sec. are analyzed using forty-nine near-field strong ground motion records. Peak accelerations are derived for each single degree of freedom non-structural component, supported by the above mentioned frames, through a direct-integration time-history analysis. These accelerations are obtained by Floor Acceleration Response Spectrum (FARS) method. They are statistically analyzed in the next step to achieve a better understanding of their height-wise distributions. The factors that affect FARS values are found in the relevant state of the art. Here, they are summarized to evaluate the amplification and/or reduction of FARS values especially when the supporting structures undergo inelastic behavior. The properties of FARS values are studied in three regions: long-period, fundamental-period and short-period. Maximum elastic acceleration response of non-structural component, mounted on inelastic frames, depends on the following factors: inelasticity intensity and modal periods of supporting structure; natural period, damping ratio and location of non-structural component. The FARS values, corresponded to the modal periods of supporting structure, are strongly reduced beyond elastic domain. However, they could be amplified in the transferring period domain between the mentioned modal periods. In the next step, the amplification and/or reduction of FARS values, caused by inelastic behavior of supporting structure, are calculated. A parameter called the response acceleration reduction factor ($R_{acc}$), has been previously used for far-field earthquakes. The feasibility of extending this parameter for near-field motions is focused here, suggested repeatedly in the relevant sources. The nonlinearity of supporting structure is included in ($R_{acc}$) for better estimation of maximum non-structural component absolute acceleration demand, which is ordinarily neglected in the seismic design provisions.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8715-8718
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• 2014

Background: ABVD (doxorubicin, bleomycin, vinblastine (Vb) and dacarbazine) is the standard regimen in Hodgkin's lymphoma (HL).Vincristine (O) is a mitotic spindle agent like Vb. We aimed to evaluate the efficacy and safety of O as a part of ABOD in HL. Materials and Methods: Patients who had ABOD were enrolled. Stage I-II HL were evaluated for unfavorable risk factors according to NCCN. National Cancer Institute Common Toxicity Criteria was used for toxicity. Results: Seventy-nine HL patients in our center between 2003 and 2007 were evaluated retrospectively. Median follow-up was 54 months. Most of the patients were male in their third decade. Median ABOD cycles were 6 (2-8). Primary refractory disease rate was 17.7% whereas it was 5.1% for early relapse and 5.1% for late relapse disease. Response rates were as 82.3% for complete response, 11.4% for partial response, 5.1% for stable disease and 1.3% for progressive disease. Half of relapsed patients had autologous stem cell transplantation. Estimated 5-year failure-free survival was 71% and significantly longer in early stage patients without risk factors, bulky disease or radiotherapy (RT) (p=0.05, p<0.0001, p=0.02; respectively). Estimated 5-year overall survival was 74% and significantly longer in those who had no RT (p=0.001). Dose modification rate was 5.1% and chemotherapy delay rate was 19%. There were no toxicity-related deaths. Conclusions: ABOD seems to be effective with managable toxicity in HL, even in those with poor prognostic factors.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2000년도 추계 학술발표회 논문집 Proceedings of EESK Conference-Fall 2000
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• pp.372-380
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• 2000

Seismic forces for member design of bridges may be determined by modifying elastic member forces induced by design earthquakes using appropriate response modification factors according to national design code of bridges. Modeling of soil/foundation system is one of the critical parameter in the process of elastic seismic analysis of bridge system which greatly affects on the analysis results. In this paper, a simplified modelling procedure of soil/foundation system which gives practically reasonable results is presented and its applicability has been validated through example bridge. Based on the results, it has been shown that the procedure is acceptable in modelling soil/foundation system for practical seismic analysis of bridges.

• Earthquakes and Structures
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• 제23권1호
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• pp.23-34
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• 2022

This paper presents experimental studies on reinforced concrete moment resisting frames that have engineered cementitious composite (ECC) in plastic hinge length (PHL) of beam/column members and beam-column joints. A two-story frame structure reduced by a 1:3 scale was further tested through a shake-table (seismic simulator) using multiple levels of simulated earthquake motions. One model conformed to all the ACI-318 requirements for IMRF, whereas the second model used lower-strength concrete in the beam/column members outside PHL. The acceleration time history of the 1994 Northridge earthquake was selected and scaled to multiple levels for shake-table testing. This study reports the observed damage mechanism, lateral strength-displacement capacity curve, and the computed response parameters for each model. The tests verified that nonlinearity remained confined to beam/column ends, i.e., member joint interface. Calculated response modification factors were 11.6 and 9.6 for the code-conforming and concrete strength deficient models. Results show that the RC-ECC frame's performance in design-based and maximum considered earthquakes; without exceeding maximum permissible drift under design-base earthquake motions and not triggering any unstable mode of damage/failure under maximum considered earthquakes. This research also indicates that the introduction of ECC in PHL of the beam/column members' detailing may be relaxed for the IMRF structures.

• Computers and Concrete
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• 제25권3호
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• pp.273-282
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• 2020

A new seismic design methodology for precast concrete diaphragms has been developed and incorporated into the current American seismic design code. This design methodology recognizes that diaphragm inertial forces during earthquakes are highly influenced by higher dynamic vibration modes and incorporates the higher mode effect into the diaphragm seismic design acceleration determination using a first mode reduced method, which applies the response modification coefficient only to the first mode response but keeps the higher mode response unreduced. However the first mode reduced method does not consider effects of diaphragm flexibility, which plays an important role on the diaphragm seismic response especially for the precast concrete diaphragm. Therefore this paper investigated the effect of diaphragm flexibility on the diaphragm seismic design acceleration for precast concrete shear wall structures through parametric studies. Several design parameters were considered including number of stories, diaphragm geometries and stiffness. It was found that the diaphragm flexibility can change the structural dynamic properties and amplify the diaphragm acceleration during earthquakes. Design equations for mode contribution factors considering the diaphragm flexibility were first established through modal analyses to modify the first mode reduced method in the current code. The modified first mode reduced method has then been verified through nonlinear time history analyses.

• 한국지진공학회논문집
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• 제8권6호통권40호
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• pp.67-72
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• 2004

본 논문에서는 좌굴방지 가새 (BRBF)가 설치된 중저층 철골조 구조물의 초과강도계수를 평가하였다. 해석 모델의 설계변수로는 건물의 층 수, 경간의 길이, 가새의 항복강도, 지진하중의 크기, 반응수정계수 등 다양하게 설정하였다. 초과강도계수는 ATC-19에서 제시하고 있는 방법에 따라 정적 비탄성해석을 이용하여 산정하였다. 해석결과에 따르면 본 연구에서 구한 BRBF의 초과강도계수는 AISC/SEAOC에서 BRBF에 관하여 제시한 초과강도계수 값보다 전체적으로 크게 나타났다.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2005년도 춘계 학술발표회 논문집
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• pp.97-104
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• 2005

The seismic behavior of framed structure with Chevron-type bucking restrained braces were investigated and their behavior factors were evaluated following the procedure proposed in ATC-19 & ATC-34. Two types of structures, building frame systems and dual systems, with 4, 8, 12, and 16 stories were designed per the IBC 2000, the AISC LRFD and the AISC/SEAOC Recommended Provisions for BRBF. Nonlinear static pushover analyses were carried out to observe the plastic hinge formation and to identify the loads and the displacements at the yield and the ultimate states. Time history analyses were also carried out to compute the permanent displacement md the dissipated hysteretic energy. According to the analysis results, the response modification factors of model structures fumed out to be larger than what is proposed in the provision in low story structures, and a little smaller in medium-story structures. The dual systems, even though designed with smaller seismic load, showed superior static and dynamic performances.