• Toxicological Research
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• v.25 no.1
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• pp.9-15
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• 2009

Historically, research in toxicology has utilized non-human mammalian species, particularly rats and mice, to study in vivo the effects of toxic exposure on physiology and behavior. However, ethical considerations and the overwhelming increase in the number of chemicals to be screened has led to a shift away from in vivo work. The decline in in vivo experimentation has been accompanied by an increase in alternative methods for detecting and predicting detrimental effects: in vitro experimentation and in silico modeling. Yet, these new methodologies can not replace the need for in vivo work on animal physiology and behavior. The development of new, non-mammalian model systems shows great promise in restoring our ability to use behavioral endpoints in toxicological testing. Of these systems, the zebrafish, Danio rerio, is the model organism for which we are accumulating enough knowledge in vivo, in vitro, and in silico to enable us to develop a comprehensive, high-throughput toxicology screening system.

• IE interfaces
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• v.9 no.3
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• pp.306-316
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• 1996

The easily use of WWW and Web browser of INTERNET makes the world our stage. But when we search for the information and resource that we want, the information supplied by search engine (e.g., Yahoo, Lycos, WebCrawler, Alta Vista) is inadequate to acquire the necessary and related information of research issues. This paper surveys AMT(Advanced Manufacturing Technology) which is the research topics recently on the WWW(WorLd Wide Web) and provides searching methods and information for academic research, technical report, proceedings, software, etc. It also briefly surveys WWW-VL(Virtual Library) and reviews the major three technology, CALS (Commerce At Light Speed), AMS(Agile Manufacturing System), CE(Concurrent Engineering), that is recently the focus of the research issue of Industrial Engineer.

• BMB Reports
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• v.37 no.1
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• pp.28-34
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• 2004

The discovery of biochemical and cellular functions of unannotated gene products begins with a database search of proteins with structure/sequence homologues based on known genes. Very recently, a number of frontier groups in structural biology proposed a new paradigm to predict biological functions of an unknown protein on the basis of its three-dimensional structure on a genomic scale. Structural proteomics (genomics), a research area for structure-based functional discovery, aims to complete the protein-folding universe of all gene products in a cell. It would lead us to a complete understanding of a living organism from protein structure. Two major complementary experimental techniques, X-ray crystallography and NMR spectroscopy, combined with recently developed high throughput methods have played a central role in structural proteomics research; however, an integration of these methodologies together with comparative modeling and electron microscopy would speed up the goal for completing a full dictionary of protein folding space in the near future.

• Journal of Navigation and Port Research
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• v.27 no.3
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• pp.335-343
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• 2003

Currently serious conflicts of interests are arisen for the use of coastal area in Korea. However, there no mediation program, mediators' consistent policies and reasonable laws to resolve conflict of interests which may be arisen when developing coastal area. The objective of this study is to lay the evaluation criteria for the formalized objective evaluation among disputants of coastal conflicts for the better understanding and characterizing of coastal conflicts in Korea. In order to do so, this study has adopted for the extraction of the evaluation factors to describe the present conditions of conflicts in the selected study area(Sihwa lake), to analyze the problems, and then to explore alternative approaches for resolving the conflicts. As research methodologies, we have depended upon literature review and field survey methods. As field survey methods, we employed structured questionnaires for the various samples from the experts of research institutes, professors, representatives of NGOs and citizens. Survey results suggested that 5 representative elements comprising 35 detailed elements could be identified. Based on these results, this study was able to identify and classify the evaluation factors and help to resolve coastal conflicts in Korea.

• Journal of The Korean Association For Science Education
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• v.27 no.6
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• pp.519-528
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• 2007

Although science continues to be a key subject in the education of the majority of young people throughout the world, it is becoming increasingly clear that school science is failing to win the hearts and minds of many of today's younger generation. Researchers have begun to look at ways in which the learning that takes place in museums, science centres and other informal settings can add value to science learning in schools. Four case studies are used to illustrate the potential afforded by informal contexts to research aspects of science learning. The case studies involve: the European Union PENCIL (Permanent European Resource Centre for Informal Learning) project (a network of 14 museums and science centres working with schools to enhance learning in maths and science); a large natural history museum in England; the Tate Modernart gallery in London, and the Outdoor Classroom Action Research Project which involved researchers working in school grounds, field centres and farms. The range of research questions that were asked are examined as are the methodological approaches taken and the methods used to collect and analyse data. Lessons learned from the studies about research in the informal contexts are discussed critically.

• Computers and Concrete
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• v.21 no.3
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• pp.269-278
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• 2018

In this paper, two methods M1 and M2 to determine long-term deflection through finite element analyses including the effect of creep and relaxation are proposed and demonstrated for a PSC box-girder. In both the methods, the effect of creep is accounted by different models from international standards viz., ACI-209R-92, CEB MC 90-99, B3 and GL2000. In M1, prestress losses due to creep and relaxation and age adjusted effective modulus are estimated through different models and have been used in finite element (FE) analyses for individual time steps. In M2, effects of creep and relaxation are implemented through the features of FE program and the time dependent analyses are carried out in single step. Variations in time-dependent strains, prestress losses, stresses and deflections of the PSC box-girder bridge through M1 and M2 are studied. For the PSC girder camber obtained from both M1 and M2 are lesser than simple bending theory based calculations, this shows that the camber is overestimated by simple bending theory which may lead to non-conservative design. It is also observed that stresses obtained from FEM for bottom fibre are lesser than the stresses obtained from bending theory at transfer for the PSC girder which may lead to non-conservative estimates.

• International Journal of Computer Science & Network Security
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• v.23 no.6
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• pp.107-114
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• 2023

Successful implementations of DevOps practices significantly improvise software efficiency, collaboration and security. Most of the organizations are adopting DevOps for faster and quality software delivery. DevOps brings development and operation teams together to overcome all kind of communication gaps responsible for software failures. It relies on different sets of alternative tools to automate the tasks of continuous integration, testing, delivery, deployment and monitoring. Although DevOps is followed for being very reliable and responsible environment for quality software delivery yet it lacks many quantifiable aspects to prove it on the top of other traditional and agile development methods. This research evaluates quantitative performance of DevOps and traditional/ agile development methods based on software metrics. This research includes three sample projects or code repositories to quantify the results and for DevOps integrated selective tool chain; current research considers our earlier proposed and implemented DevOps hybrid model of integrated automation tools. For result discussion and validation, tabular and graphical comparisons have also been included to retrieve best performer model. This comparative and evaluative research will be of much advantage to our young researchers/ students to get well versed with automotive environment of DevOps, latest emerging buzzword of development industries.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.2
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• pp.145-152
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• 2008

Nuclear medicine imaging has an unique advantage of absolute quantitation of radioactivity concentration in body. Tracer kinetic analysis has been known as an useful investigation methods in quantitative study of in-vivo physiological function. The use of nuclear medicine imaging and kinetic analysis together can provide more useful and powerful intuition in understanding biochemical and molecular phenomena in body. There have been many development and improvement in kinetic analysis methodologies, but the conventional basic concept of kinetic analysis is still essential and required for further advanced study using new radiopharmaceuticals and hybrid molecular imaging techniques. In this paper, the basic theory of kinetic analysis and imaging techniques for suppressing noise were summarized.

• Structural Engineering and Mechanics
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• v.35 no.6
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• pp.735-758
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• 2010

The paper proposes two methodologies for damage identification from measured natural frequencies of a contiguously damaged reinforced concrete beam, idealised with distributed damage model. The first method identifies damage from Iso-Eigen-Value-Change contours, plotted between pairs of different frequencies. The performance of the method is checked for a wide variation of damage positions and extents. The method is also extended to a discrete structure in the form of a five-storied shear building and the simplicity of the method is demonstrated. The second method is through smeared damage model, where the damage is assumed constant for different segments of the beam and the lengths and centres of these segments are the known inputs. First-order perturbation method is used to derive the relevant expressions. Both these methods are based on distributed damage models and have been checked with experimental program on simply supported reinforced concrete beams, subjected to different stages of symmetric and un-symmetric damages. The results of the experiments are encouraging and show that both the methods can be adopted together in a damage identification scenario.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.729-734
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• 2005

One of the important research issues in mobile robot is how to detect the 3D environment fast and accurately, and recognize it. Sensing methods of utilizing laser structured light and/or stereo vision are representatively used among a number of methodologies developed to date. However, the methods are still in need of achieving high accuracy and reliability to be used for real world environments. In this paper to implement a new robotic environmental sensing algorithm is presented by combining the information between intensity image and that of laser structured light image. To see how effectively the algorithm applied to real environments, we developed a sensor system that can be mounted on a mobile robot and tested performance for a series of environments.