• 동의생리병리학회지
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• 제19권2호
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• pp.329-338
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• 2005

Breast milk is general term for crude milk and mature that is secrete after two-three days of delivery. Because amount of milk secretion is different, disorder of milk secretion is to be classified into galactostasis and spontanous flow of milk. According to this point, we considered thirty four papers and got the conclusion about the concept, cause, therapeutic method and medication of secreation disorder. Therefore we report the result. galactostasis due to deficiency of the qi and blood, depression of liver qi, blood stasis of postpartum, excessiveness and so on. If the qi and blood is deficient, therapeutic method is enriching qi and benefiting blood, if the liver qi is deprssive, treatment is relieving the deprssive liver and regulating the circulation of qi. The milk is flowing spontanously and continously due to a prosperous condition of qi and blood, too deficiency of the qi and blood, depression of liver qi and so on. If the qi and blood is deficient, therapeutic method is tonifying and arresting the qi and blood, if Liver channel is stagnated fire, puring the liver of pathologic fire, relieving the deprssive liver and regulating the circulation of qi. Clinical study for the 1 case of the recurrent cervical cancer patient.

• Journal of Industrial and Engineering Chemistry
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• 제68권
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• pp.399-405
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• 2018

We report the fabrication of organic field-effect transistors (OFETs) via spray coating of electrochemically exfoliated graphene (EEG) and conducting polymer hybrid as electrodes. To reduce the roughness and sheet resistance of the EEG electrodes, subsequent coating of conducting polymer (poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS)) and acid treatment was performed. After that, active channel layer was developed by spin coating of semiconducting poly(3-hexylthiophene) on the hybrid electrodes to define the bottom gate bottom contact configuration. The OFET devices with the EEG/PEDOT:PSS hybrid electrodes showed a reasonable electrical performances (field effect mobility = $0.15cm^2V^{-1}\;s^{-1}$, on/off current ratio = $10^2$, and threshold voltage = -1.57V). Furthermore, the flexible OFET devices based on the Polydimethlsiloxane (PDMS) substrate and ion gel dielectric layer exhibited higher electrical performances (field effect mobility = $6.32cm^2V^{-1}\;s^{-1}$, on/off current ratio = $10^3$, and threshold voltage = -1.06V) and excellent electrical stability until 1000 cycles of bending test, which means that the hybrid electrode is applicable to various organic electronic devices, such as flexible OFETs, supercapacitors, organic sensors, and actuators.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2016년도 학술발표회
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• pp.198-198
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• 2016

The Citarum River Basin is the biggest river basin in West Java Province, Indonesia and it plays strategic roles in providing water for irrigation, domestic and industrial uses, and power generation, besides controlling the flood during rainy season. Flowing through seven major cities makes the river flow and water demand are vulnerable to land use change around the river. The present water resources management has involved the regulator, operator, and users in deciding an appropriate water management plan for the entire basin. The plan includes an operation plan for three reservoirs, construction or maintenance of the river channel, and water allocation for all users along the river. Following this plan, a smaller operation group will execute and evaluates the plan based on the actual flow condition. Recently, a deforestation, environment degradation, river sedimentation, a rapid growth of population and industry, also public health become new issues that should be considered in water basin planning. Facing these arising issues, a new development program named ICWRMIP was established to advance the existing management system. This program includes actions to strengthen institutional collaboration, do the restoration and conservation of the river environment, improve water quality and public health, also advance the water allocation system. At present, the water allocation plan is created annually based on a forecasted flow data and water usage prediction report. Sometimes this method causes a difficulty for the operator when the actual flow condition is not the same as the prediction. Improving existing system, a lot of water allocation studies, including a development of the database and water allocation simulation model have been placed to help stakeholders decide the suitable planning schemes. In the future, this study also tries to contribute in advancing water allocation planning by creating an optimization model which ease stakeholders discover a suitable water allocation plan for individual users.

• 반도체디스플레이기술학회지
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• 제17권3호
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• pp.41-45
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• 2018

Two-dimensional (2D) materials have been studied extensively due to their excellent physical, chemical, and electrical properties. Among them, we report the material and device characteristics of tin disulfide ($SnS_2$). To apply $SnS_2$ as a channel layer in a transistor, $SnS_2$ channels were formed by a stripping method and a transfer method. The limitation of this method is that it is difficult to produce uniform device characteristics over a large area. Therefore, we directly deposited $SnS_2$ by atomic layer deposition (ALD) and then performed lithography. This method was able to produce devices with repeatable characteristics over a large area. However, the $SnS_2$ film was damaged by the acetone used as a photoresist (PR) developer during the lithography process, with the electrical properties of mobility of $2.6{\times}10^{-4}cm^2/Vs$, S.S. of 58.1 V/decade, and on/off current ratio of $1.8{\times}10^2$. These results are not suitable for advanced electronic devices. In this study, we analyzed the effect of acetone on $SnS_2$ and studied the device process to prevent such damage. Using polyvinyl alcohol (PVA) as a passivation layer during the lithography process, the electrical characteristics of the $SnS_2$ transistor had $2.11{\times}10^{-3}cm^2/Vs$ of mobility, 11.3 V/decade of S.S, and $2.5{\times}10^3$ of the on/off current ratio, which were 10x improvements to the $SnS_2$ transistor fabricated by the conventional method.

• 문화기술의 융합
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• 제8권5호
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• pp.749-754
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• 2022

다양한 의료 응용 분야에서 웨어러블 및 피부 부착형 전자 패치에 피부 표면의 높은 접착력과 내수성이 요구된다. 본 연구에서는 탄소 기반 전도성 고분자 복합 소재에 개구리 발바닥의 육각 채널와 문어 빨판의 흡착 구조 패턴을 모사한 신축성 있는 전자 패치를 보고한다. 개구리의 발바닥을 모사한 육각 채널 구조는 수분을 배수하며, 균열억제 효과를 통해 점착력을 향상 시키며, 문어 빨판을 모사한 흡착 구조는 젖은 표면에서 높은 점착력을 나타낸다. 또한 고점착 전자패치는 실리콘(max. 4.06 N/cm²), 피부 복제 표면(max. 1.84 N/cm²) 등 다양한 표면에 건조 및 젖은 조건에서 우수한 접착력을 가지고 있다. 고분자 매트릭스와 탄소 입자를 기반으로한 고분자 복합소재를 통해 제작된 고점착 전자 패치는 건조 및 습한 환경에서 심전도(ECG)을 안정적으로 감지할 수 있다. 이 연구에서 보여진 특성을 기반으로 제안된 전자 패치는 다양한 생체 신호의 진단을 위한 웨어러블 및 피부 부착 센서 디바이스를 구현하는 잠재적 응용 가능성을 제시한다.

• Human Ecology Research
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• 제61권3호
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• pp.459-474
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• 2023

This study aimed to examine the effect of parentification on the smartphone dependency of upper elementary school children in double-income families and to verify whether ambivalence over emotional expression and loneliness sequentially mediates the relationship between parentification and smartphone dependency. The participants were 311 upper-elementary school students (4th to 6th graders; 126 boys, 40.5%) in doubleincome households residing in Seoul, Gyeong-gi, and Incheon. The data were collected through an online self-report questionnaire completed by the participants and were analyzed using SPSS 26.0 and Mplus 8.7 software. The results can be summarized as follows. Firstly, the direct effect of parentification on the smartphone dependency of the children from double-income families was statistically insignificant. Secondly, ambivalence over emotional expression mediated the effect of parentification on smartphone dependency, while loneliness did not. Lastly, parentification influenced smartphone dependency through the sequential mediating channel of ambivalence over emotional expression and loneliness. In conclusion, these findings indicate that interventions for smartphone-overdependent children from double-income families should place emphasis on children's psychological difficulties attributed to parentification. Specifically, this study highlights the importance of alleviating the levels of ambivalence over emotional expression and loneliness to address the issue of children's smartphone dependency in double-income families, suggesting possible involvement and support at both household and societal levels.

• IMMUNE NETWORK
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• 제21권4호
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• pp.31.1-31.16
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• 2021

Gastric cancer (GC) is the fourth most common cause of cancer-related death globally. The classification of advanced GC (AGC) according to molecular features has recently led to effective personalized cancer therapy for some patients. Specifically, AGC patients whose tumor cells express high levels of human epidermal growth factor receptor 2 (HER2) can now benefit from trastuzumab, a humanized monoclonal Ab that targets HER2. However, patients with HER2^negative AGC receive limited clinical benefit from this treatment. To identify potential immune therapeutic targets in HER2^negative AGC, we obtained 40 fresh AGC specimens immediately after surgical resections and subjected the CD45⁺ immune cells in the tumor microenvironment to multi-channel/multi-panel flow cytometry analysis. Here, we report that HER2 negativity associated with reduced overall survival (OS) and greater tumor infiltration with neutrophils and non-classical monocytes. The potential pro-tumoral activities of these cell types were confirmed by the fact that high expression of neutrophil or non-classical monocyte signature genes in the gastrointestinal tumors in The Cancer Genome Atlas, Genotype-Tissue Expression and Gene Expression Omnibus databases associated with worse OS on Kaplan-Meir plots relative to tumors with low expression of these signature genes. Moreover, advanced stage disease in the AGCs of our patients associated with greater tumor frequencies of neutrophils and non-classical monocytes than early stage disease. Thus, our study suggests that these 2 myeloid populations may serve as novel therapeutic targets for HER2^negative AGC.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2010년도 춘계학술대회 초록집
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• pp.64.1-64.1
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• 2010

The morphology of mesoporous $TiO_2$ films plays an important role in the operation of a DSSC. For example, the energy conversion efficiency of DSSCs with well-organized mesoporous $TiO_2$ films is much higher than those with traditional films possessing a random morphology. In previous research, well-organized mesoporous $TiO_2$ films have mainly been synthesized using an amphiphilic block copolymer, e.g., a poly(ethylene oxide) (PEO)-based template. A graft copolymer is more attractive than a block copolymer due to its low cost and the ease with which it can be synthesized. In this work, we provide the first report on the successful synthesis of well-organized mesoporous $TiO_2$ films templated by an organized graft copolymer as a structure directing agent. Well-organized mesoporous $TiO_2$ films with excellent channel connectivities were developed via the sol gel processusing an organized PVC-g-POEM graft copolymer synthesized by one-pot ATRP. The careful adjustment of copolymer composition and solvent affinity using a THF/$H_2O$/HCl mixture was used to systematically vary the material structure. The influence of the material structure on solar cell performance was then investigated. A solid-state DSSC employing both the graft copolymer templated organized 700 nm-thick $TiO_2$ films and graft copolymer electrolytes exhibited a solar conversion efficiency of 2.2% at 100 $mW/cm^2$. This value was approximately two-fold higher than that attained from a DSSC employing a random mesoporous $TiO_2$ film. The solar cell performance was maximized at 4.6% when the film thickness was increased to $2.5{\mu}m$. We believe that this graft copolymer-directed approach introduces a new and simple route toward the synthesis of well-organized metal oxide films as an alternative to a conventional block copolymer-based template.

• 전기전자학회논문지
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• 제9권2호
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• pp.123-135
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• 2005

3GPP는 RLC 프로토콜 명세서에서 신뢰할 수 있는 데이타 전송을 위해 window에 의해 조절되는 selective-repeat ARQ 방식을 채택하였다. 3GPP의 ARQ는 selective-repeat ARQ 부류에 속하므로 재정렬 문제가 불가피하게 야기된다. 긴 재정렬 시간은 throughput 및 지연 성능의 열화를 빚어내고 재정렬 버퍼의 범람을 불러올 수 있다. 또한 데이타의 상실 및 지연에 모두 민감한 서비스의 요구 조건을 수용하기 위해 재정렬 시간은 반드시 통제되어야 한다. 3GPP ARQ에서 window의 크기나 상태 보고 주기를 줄여 재정렬 버퍼의 점유량을 감소시킬 수 있다. 이로 인해 throughput 및 지연 성능이 저하되고 역방향 채널의 자원이 잠식된다. 재정렬 버퍼의 점유량을 줄이는 동시에 throughput 및 지연 성능의 열화를 억제하기 위한 방안으로 본 논문에서는 post-threshold 방식과 pre-threshold 방식이라는 threshold에 의존하는 점유량 조절 방식을 제안한다. 제안한 방식의 효과성을 판단하기 위해 fading 채널 등 실제적인 환경에서 최고 점유량, 최대 throughput, 평균 지연을 조사한다. 모의 실험 결과로부터 제안한 방식이 점유량과 throughput 간에 trade-off를 불러옴을 관찰한다. 또한 post-threshold 방식은 3GPP의 ARQ와 비교하여 재정렬 버퍼의 점유량을 증가시키지 않고 throughput 및 지연 성능을 향상시킬 수 있음을 확인한다.

• The Korean Journal of Physiology and Pharmacology
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• 제2권6호
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• pp.733-742
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• 1998

Background: We have previously reported that not only cGMP but also 8-Br-cGMP or 8-pCPT-cGMP, specific and potent stimulators of cGMP-dependent protein kinase (cGMP-PK), increased basal L-type calcium current $(I_{Ca})$ in rabbit ventricular myocytes. Our findings in rabbit ventricular myocytes were entirely different from the earlier findings in different species, suggesting that the activation of cGMP-PK is involved in the facilitation of $I_{Ca}}$ by cGMP. However, there is no direct evidence that cGMP-PK can stimulate $I_{Ca}}$ in rabbit ventricular myocytes. In this report, we focused on the direct effect of cGMP-PK on $I_{Ca}}$ in rabbit ventricular myocytes. Methods and Results: We isolated single ventricular myocytes of rabbit hearts by using enzymatic dissociation. Regulation of $I_{Ca}}$ by cGMP-PK was investigated in rabbit ventricular myocytes using whole-cell voltage clamp method. $I_{Ca}}$ was elicited by a depolarizing pulse to +10 mV from a holding potential of -40 mV. Extracellular 8-(4-Chlorophenylthio)-guanosine-3',5'-cyclic monophosphate (8-pCPT-cGMP), potent stimulator of cGMP-dependent protein kinase (cGMP-PK), increased basal $I_{Ca}}$. cGMP-PK also increased basal $I_{Ca}}$. The stimulation of basal $I_{Ca}}$ by cGMP-PK required both 8-Br-cGMP in low concentration and intracellular ATP to be present. The stimulation of basal $I_{Ca}}$ by cGMP-PK was blocked by heat inactivation of the cGMP-PK and by bath application of 8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate, Rp-isomer (Rp-pCPT-cGMP), a phosphodiesterase-resistant cGMP-PK inhibitor. When $I_{Ca}}$ was increased by internal application of cGMP-PK, IBMX resulted in an additional stimulation of $I_{Ca}}$. In the presence of cGMP-PK, already increased $I_{Ca}}$ was potentiated by bath application of isoprenaline or forskolin or intracellular application of cAMP. Conclusions: We present evidence that cGMP-PK stimulated basal $I_{Ca}}$ by a direct phosphorylation of L-type calcium channel or associated regulatory protein in rabbit ventricular myocytes.