• Biomolecules & Therapeutics
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• 제14권3호
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• pp.125-131
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• 2006

The inhibitory effects of (-)-epigallocatechin gallate (EGCG), a major compound of green tea, on the development of locomotor sensitization, conditioned place preference (CPP) and dopamine receptor supersensitivity induced by the repeated administration of morphine were investigated in mice. A single administration of morphine produces hyperlocomotion. The repeated administration of morphine develops sensitization, a progressive enhancement of locomotion, which is used as a model for studying the craving and drug-seeking behaviors characterizing addiction, and CPP, which is used as a model for studying drug reinforcement, respectively. EGCG inhibited morphine-induced hyperlocomotion, sensitization and CPP. In addition, EGCG inhibited the development of postsynaptic dopamine receptors supersensitivity, which may be an underlying common mechanism that mediates the morphine-induced dopaminergic behaviors such as sensitization and CPP. Apomorphine (a dopamine agonist)-induced climbing behaviors also were inhibited by a single direct administration of EGCG These results provide evidence that EGCG has anti-dopaminergic activity, as inhibiting the development of dopamine receptor supersensitivity and apomorphine-induced climbing behaviors. Therefore, it is suggested that green tea may be useful for the prevention and therapy of these adverse actions of morphine.

• Archives of Pharmacal Research
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• 제29권10호
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• pp.904-910
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• 2006

The inhibitory effects of paeonol, a major compound of Paeoniae radix, on the development of locomotor sensitization, conditioned place preference (CPP) and dopamine receptor supersensitivity induced by the repeated administration of morphine were investigated through behavioral experiments. A single administration of morphine produces hyperlocomotion. Repeated administration of morphine develops sensitization (reverse tolerance), a progressive enhancement of locomotion, which is used as a model for studying the drug-induced drug-seeking behaviors, and CPP, which is used as a model for studying drug reinforcement. Paeonol inhibited morphine-induced hyperlocomotion, sensitization and CPP. In addition, paeonol inhibited the development of postsynaptic dopamine receptors supersensitivity, which may be an underlying common mechanism that mediates the morphine-induced dopaminergic behaviors such as sensitization and CPP. Apomorphine (a dopamine agonist)-induced climbing behaviors also were inhibited by a single direct administration of paeonol. These results provide evidence that paeonol exerts anti-dopaminergic activity, and it is suggested that paeonol may be useful for the prevention and therapy of these adverse actions of morphine.

• 한국융합학회논문지
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• 제8권9호
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• pp.117-125
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• 2017

본 연구는 간호학생들의 간호학과 입학 전 과학과목학습과 기초간호과학 및 학업적응을 알아보기 위한 서술적 조사연구로 수집된 자료는 SPSS 19.0으로 분석하였다. 입학 전 과학과목학습은 부분적으로 기초간호과학성적에 차이를 가져왔고, 입학 전, 생물 I, 화학 I, 물리 I, 지구과학 I 학습은 기초간호과학평균점수를 높였다(p<.05). 입학 전 과학과목학습과 학업적응 간에는 물리 I을 제외하고는 상관관계가 없었으나, 기초간호과학성적과 학업적응 간에는 양의 상관관계가 있었고(r=0.296, p<.001), 입학 전 과학과목학습은 기초간호과학 성적에, 기초간호과학 성적은 학업적응에 긍정적인 영향을 미치는 것으로 나타나(p=.001) 추후 반복연구 후 신입생 학업지도에 응용할 수 있다.

• 아동학회지
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• 제22권1호
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• pp.97-107
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• 2001

This study argues the nature of the microgenetic method in respect to child development research and explores its merits and limitations. The microgenetic method focuses on observations that span the entire period from the beginning of developmental change to the time it reaches a relatively stable state. This produces a high density of observations relative to the rate of change in the phenomenon. In this way, observed behavior may be used in intensive trial-by-trial analysis. The microgenetic method is superior to other methods in the possibilities for observing developmental changes as they occur, examining various aspects of change, detecting variability in behavior, and flexibility in application regardless of theoretical perspectives. Limitations of this method include reliability problems due to repeated observations, artificiality relative to the natural situation, inconsistency of short-and long-term change, and demands on children's motivation for participation in research.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.189.1-189.1
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• 2013

Titanium dioxide (TiO2) is a wide bandgap semiconductor possessing photochemical stability and thus widely used for photocatalysis. However, enhancing photocatalytic efficiency is still a challenging issue. In general, the efficiency is affected by physio-chemical properties such as crystalline phase, crystallinity, exposed crystal facets, crystallite size, porosity, and surface/bulk defects. Here we propose an alternative approach to enhance the efficiency by studying interfaces between thin TiO2 layers to be stacked; that is, the interfacial phenomena influencing on the formation of porous structures, controlling crystallite sizes and crystallinity. To do so, multi-layered TiO2 thin films were fabricated by using a sol-gel method. Specifically, a single TiO2 thin layer with a thickness range of 20~40 nm was deposited on a silicon wafer and annealed at $600^{\circ}C$. The processing step was repeated up to 6 times. The resulting structures were characterized by conventional electron microscopes, and followed by carrying out photocatalytic performances. The multi-layered TiO2 thin films with enhancing photocatalytic efficiency can be readily applied for bio- and gas sensing devices.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2007년도 춘계학술발표대회
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• pp.558-559
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• 2007

The detection of neural spike activity is a technical challenge that is very important for studying many types of brain function. On temporal recordings of firing events or interspike interval series of neural signal, spike pattern correspond to action will be repeated in the presence of background noise and they need to be detected to develop higher applications. We will introduce new method to find these patterns in raw multitrial data and is tested on surrogate data sets with the main target to get meaningful analysis of electrophysiological data from microelectrode arrays (MEA).

• 한국가정과교육학회지
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• 제1권1호
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• pp.1-17
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• 1989

Present, we cannot expect the maximum studying effect in a home economics and the drill unit of secondary schools because of several problems. Such problems can be enumerated as follows. 1. The explaination of a making process in texts would be difficult for the students who have a poor understanding to grasp. 2. The much effort would be made due to teacher’s repeated exhibition, by which the progress of a text might be unreasonable. 3. The teachers unaccustomed to the drill might treat it carelessly and become to avoid it. 4. The skill to grasp a general work flow might be lack. Baseing on such problems, this researcher did using a medium of Video in teaching method of home economics. For this purpose, the quality of Video Tape would be important. Above all, we made out the script of Video Tape through advices of specialists in Video medium, majors in home economics, and the students teaching of home economics and the concerned persons, by which we recorded a gather skirt, as a finished goods, especially of the characteristics of each kind of a skirt. Next, we recorded and produced the total steps from a preparation of skirt-making to a finishing as using a V.T.R. shot technique. The Video would be screened and the supplemented explaination of a teacher would be added in a step of instruction. In the development of instruction, students would begin the making. The expected effects according to using Video Tape are as follows. 1. The making order of text would be exhibited by a model directly and the explaination of a narrator would be added concurrently, by which students would understand it easily as confirming each step. 2. All students can watch these steps owing to a close up, one of the V.T.R Techniques. Accordingly, the teacher’s efforts would be decreased and the proper progress of a text could be maintained because of no repeated exhibition of a teacher. 3. To the teachers unaccustomed to and interested in a drill, the medium would become a subsidiary means. 4. Study all steps of a making, students would become to understand the general flow of a work. Therefore, it might be possible to generalize another units of a making. However though this study was designed don a basis of such effects, the using effects based on only the existing study results, and was focused on the production of a medium. Because this research would be a teacher and there was noncooperation of secondary schools, it was impossible to experiment in schools, which was the prime limitation of this study. Therefore we should be experiment further for the continuous studying.

• 한국의상디자인학회지
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• 제13권3호
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• pp.149-163
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• 2011

Hanjisa(Korean paper yarn), a new material made from the traditional Korean paper, has been developed through local R&D efforts, reflecting the current trend highly valuing environmental friendly. This new material is considered suitable for the 21C lifestyle and culture pursuing improved quality of human life and the environment. Therefore, this study aims to widely make known the originality and functions of the environmentally friendly Korean paper yarn, as well as to increase its commercial value. Furthermore, a new category of apparel design is presented by studying painting dyeing based on transformational tuck techniques and wax resist dyeing with formative features of repeated lines and rhythms of shells in order to implement three-dimensional and decorative artistic expressions. The texture of the Korean cotton paper yarn was particularly suitable to employ tuck and dyeing techniques Which express formative features of shell. Also, the material was useful for expressing the three-dimensional feelings with repeated curves and cross sections of shells. Moreover, paraffin resist dyeing and stitch techniques were used in order to avoid monotony and the images of shells visually materialized. Through the results stated above, this study could explore how to overcome obstacles to globalization of the Korean modern apparel such as its uniqueness, limit of materials or absense of internationality by applying modern design to the Korean paper fabrics. In the future, it is expected that more manufactures could produce and supply the new materials so as to make widely known the originality of the Korean paper fabrics and develop the material into a popular organic product fitting the modern lifestyle.

• 한국측량학회지
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• 제18권1호
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• pp.19-23
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• 2000

1990년 이래로, GPS 기술은 지각 움직임 연구에 적용되어 왔으며 본 논문은 반복된 GPS 관측으로부터 (1995-1998) Cam Lo 단층(Quang Tri province, Vietnam)의 지각 운동에 대한 연구 결과를 설명하였다 연구 대상지역은 위도 N 16 40' 10", 경도 E 106 58' 40"의 Vietnam 중앙부에 위치하며 그 규모는 상대적으로 작다. GPS네트워크는 6개의 관측점들로 이루어져 있으며 기선거리는 3-11 km이고, 3개의 tectonic 지역에 위치한다. GPS 데이터 획득은 1995년 5월과 1998년 3월에 두 개의 캠패인으로 모든 관측점들에서 수행되어졌다. 연구결과, 좌표 변화와 표준편차를 고려할 때 대상지역이 움직이고 있었고, 수평 변화보다는 수직 변화가 더 크게 발생하였다. 본 논문의 결과는 지질 전문가에 Cam Lo 단층지역의 지구물리 해석에 흥미로운 자료를 제공할 것이고 베트남의 단층 활동 연구를 고무시킬 것으로 기대된다. 것으로 기대된다.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.285-290
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• 2003

Living cells are continuously subject to all sorts of stress such as ultraviolet rays on skin cells. Tests made in various laboratories show that when young fibroblasts (Le. at the beginning of their proliferate life) were repeatedly put under stress at subletal doses, they acquired a phenotype similar to Senescence Induced Prematurely by Stress (SIPS). The work presented hereafter was made on a new model of senescence induced prematurely by stress from ultraviolet Brays (UVB). The human fibroblast model was put under repeated UVB stress, causing SIPS. Several ageing biomarkers were used in order to characterise the cells that underwent stress:. an increase in the proportion of positive cells with senescence associated $\beta$-galactosidase activity (SA $\beta$-gal) measured by a specific coloration,. the proportion in the different morphological stages that fibroblasts undergo during culture visualised by microscopic observation,. the expression of genes known for overexpressing during senescence, particularly fibronectin and apolipoprotein J, measured by Real Time-PCR,. the common deletion of 4,977 bp in mitochondrial DNA, evaluated by nested PCR. Studying the variation of these 4 biomarkers, we have evaluated the protective effect of a Laminaria digitata extract (LDE) that can be used as a natural active ingredient for anti-ageing cosmetics.