• 한국식품영양과학회지
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• 제27권4호
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• pp.585-590
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• 1998

To renew interest in Chrysanthemum boreale as a traditional food material, response surface methodology was used for optimizing extraction conditions and monitoring physicochemical properties of ethanol extracts from Chrysanthemum petal. The phenolic compounds of ethanol extracts were minimized in 87ml/g(solvent per sample), 21%(ethanol concentration), and 15 hours(extraction time). The physicochemical properties of ethanol extracts were maximized in the conditions of 115ml/g, 98% and 16 hours on yellow color intensity, 143ml/g, 75% and 19 hours on carotenoid content, and 148ml/g, 53% and 18 hours on soluble solid content. Optimum ranges of extraction condition for physicochemical properties of Chrysanthemum boreale were 130~150ml/g, 70~85% and 20~28 hours, respectively. Predicted values at the optimum extraction condition were in good agreement with experimental values.

• World Technopolis Review
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• 제3권2호
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• pp.66-77
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• 2014

This paper aims at exploring a conceptual framework of analyzing the evolutionary processes of regional economies by reconciling the notion of regional resilience and the concepts prevailing in the disciplines of evolutionary economics and geography. The resilience framework appears to offer a promising outlet with which combination of the seemingly contradictory conceptions is made possible. It can address why some regions manage to adapt to external shocks, renew themselves, or lock out themselves, while others are more locked in decline. In addition, it can also explain how the spatial organization of economic production, distribution, and consumption is transformed over time. Then, regional economic resilience, together with its accompanying vehicle of panarchy, emerges as a workable framework of explaining regional differentiation in regional economic performance and trajectories. Despite the risk of being a fuzzy concept, the resilience conception can be properly operationalized to provide policy principles of regional economic innovation adjusted to region-specific contexts.

• Molecules and Cells
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• 제37권4호
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• pp.337-344
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• 2014

Adipose-derived stem cells represent a type of mesenchymal stem cells with the attendant capacity to self-renew and differentiate into multiple cell lineages. We have performed a microarray-based gene expression profiling of osteogenic differentiation and found that the transcription factor Sox11 is down-regulated during the process. Functional assays demonstrate that down-regulation of Sox11 is required for an efficient differentiation. Furthermore, results from forced expression of constitutively-active and dominant-negative derivatives of Sox11 indicate that Sox11 functions as a transcriptional activator in inhibiting osteogenesis. Sox11 thus represents a novel regulator of osteogenesis whose expression and activity can be potentially manipulated for controlled differentiation.

• 한국농촌건축학회논문집
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• 제17권2호
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• pp.27-34
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• 2015

As part of the waterway restoration to renew traditional urban area, this paper is to assume and research Gyoseocheon(Gyoseo waterway) in Late 1960s Cheongju Korea. The main stream of Gyoseocheon flew from Sangjwagol(the head of the valley) of Uam Mt. to the north gate under Cheongju castle at first, and meandering from Sangdang Park, flew through Sudongseongdang and Bangadari Road to Musimcheon since open railroad of 1920s. This waterway, the eco-friendly figure of Gyoseocheon, that flew to inside the downtown with a planted tree and that is open space was so. The sub stream of Gyoseocheon originated in Seoundong and Tapdong were divided into two parts. One was to join the main stream of Gyoseocheon on Sangdang Park via Munhwadong, and the other was to join the sub stream of Musimcheon at northwest corner via south and west gate of Cheongju castle. This waterway as branch sewer were built into the road culvert.

• Preventive Nutrition and Food Science
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• 제3권2호
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• pp.175-179
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• 1998

Some functional properties and nutritive value were determined for the protein concentrated fractionated from chrysanthemum flower in orer to renew interest in the flowers as food. Proximate components of chrysanthemum flower protein concentration (FPC) showed 61.2% protein, 2.0% fat and 35.2% carbhydrate on a dry basis. In amino acid composition of FPC, glutamic acid was the highest in the content, follwoed by aspartic acid, leucine and lysine. The ratio of essential/ total amino acids(E/T) was 0.42, showing a higher level of essential amino acids compared to the FAO reference protein. Digestibility of chrysanthemum FPC by pepsin and trypsin was lwoer than that of casein and was negatively correlative to both water and fat absorptions. Similar characteristics were determined between chrysanthemum FPC and milk casein in their emulsifying activity and emulsion stability. This results indicate that flowers or petals of chrysanthemum might be developed as a good source of protein.

• 한국동물생명공학회지
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• 제36권4호
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• pp.175-182
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• 2021

Pluripotent stem cells could self-renew and differentiate into various cells. In particular, porcine pluripotent stem cells are useful for preclinical therapy, transgenic animals, and agricultural usage. These stem cells have naïve and primed pluripotent states. Naïve pluripotent stem cells represented by mouse embryonic stem cells form chimeras after blastocyst injection. Primed pluripotent stem cells represented by mouse epiblast stem cells and human embryonic stem cells. They could not produce chimeras after blastocyst injection. Populations of embryonic stem cells are not homogenous; therefore, reporter systems are used to clarify the status of stem cells and to isolate the cells. For this reason, studies of the OCT4 reporter system have been conducted for decades. This review will discuss the naïve and primed pluripotent states and recent progress in the development of porcine OCT4 reporter systems.

• Journal of applied mathematics & informatics
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• 제40권5_6호
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• pp.857-871
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• 2022

In this work, we formulated a mathematical model for divorce in marriage and extended in to an optimal control model. Firstly, we qualitatively established the model positivity and boundedness. Also we saw sensitivity analysis of the model and identified the positive and negative indices parameters. An optimal control model were developed by incorporating three time dependent control strategies (couple relationship education, reducing getting married too young & consulting separators to renew their marriage) on the deterministic model. The Pontryagin's maximum principle were used for the derivation of necessary conditions of the optimal control problem. Finally, with Newton's forward and backward sweep method numerical simulation were performed on optimality system by considering four integrated strategies. So that we reached to a result that using all three strategies simultaneously (the strategy D) is an optimal control in order to effectively control marriage divorce over a specified period of time. From this we conclude that, policymakers and stakeholders should use the indicated control strategy at a time in order to fight against Divorce in a population.

• Medical Lasers
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• 제9권2호
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• pp.134-141
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• 2020

The use of stem cell therapy to treat various diseases has become a promising approach. The ability of stem cells to self-renew and differentiate can contribute significantly to the success of regenerative medical treatments. In line with these expectations, there is a great need for an efficient research methodology to differentiate stem cells into their specific targets. Photobiomodulation (PBM), formerly known as low-level laser therapy (LLLT), is a relatively non-invasive technique that has a therapeutic effect on damaged tissue or cells. Recent advances in adapting PBM to stem cell therapy showed that stem cells and progenitor cells respond favorably to light. PBM stimulates different types of stem cells to enhance their migration, proliferation, and differentiation in vitro and in vivo. This review summarizes the effects of PBM on targeted differentiation across multiple stem cell lineages. The analytical expertise gained can help better understand the current state and the latest findings in PBM and stem cell therapy.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• 제56권12호
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• pp.749-753
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• 2013

Basically stem cells have characteristics of multi-potency, differentiation into multiple tissue types, and self-renew through proliferation. Recent advances in stem cell biology can make identifying the stem-cell like cells in various mammalian tissues. Stem cells in various tissues can restore damaged tissue. Stem cells from the adult nervous system proliferate to form clonal floating colonies called spheres in vitro, and recent studies have demonstrated sphere formation by cells in the tympanic membrane, vestibular system, spiral ganglion, and partly in the organ of Corti. The presence of stem cells in the ear raises the possibilities for the regeneration of the tympanic membrane & inner ear hair cells & neurons. But the gradual loss of stem cells postnatally in the organ of Corti may correlate with the loss of regenerative capacity and limited hearing restoration. Future strategies using endogenous stem cells in the ear can be the another treatment modality for the patients with intractable inner ear diseases.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권11호
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• pp.3145-3162
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• 2023

As an important technology of the internetwork, wireless sensor network technique plays an important role in indoor localization. Non-line-of-sight (NLOS) problem has a large effect on indoor location accuracy. A location algorithm based on improved particle filter and directional probabilistic data association (IPF-DPDA) for WSN is proposed to solve NLOS issue in this paper. Firstly, the improved particle filter is proposed to reduce error of measuring distance. Then the hypothesis test is used to detect whether measurements are in LOS situations or NLOS situations for N different groups. When there are measurements in the validation gate, the corresponding association probabilities are applied to weight retained position estimate to gain final location estimation. We have improved the traditional data association and added directional information on the original basis. If the validation gate has no measured value, we make use of the Kalman prediction value to renew. Finally, simulation and experimental results show that compared with existing methods, the IPF-DPDA performance better.