• Clinical Pain
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• v.18 no.2
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• pp.142-146
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• 2019

This is a case report of the provocative discographic findings before and after focal selective coagulation of the major annular fissure using intradiscal navigable catheter. A 46-year-old woman had a 30-month history of axial low back pain and magnetic resonance imaging findings suspicious for painful L4/5 disc. The provocative discography confirmed painful disc before coagulation. The final electrode tip position in the coagulation procedure was at the largest fissure within the outer annular margin identified through the discography. Six months after the successful coagulation therapy, inadvertently performed discography resulted in decreased pressure rise over time. Neither evoked pain nor change in the integrity of outer annulus as compared with the previous results was reported. Such an interventional method has not been reported previously, and the analytic results suggest that it may be possible to relocate the pressure of the entire nucleus pulposus only by focal selective coagulation of the fissure.

• Nuclear Engineering and Technology
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• v.56 no.2
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• pp.644-654
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• 2024

After the Tohoku earthquake and tsunami (Japan, 2011), regulatory efforts to mitigate external hazards have increased both the safety requirements and the total capital cost of nuclear power plants (NPPs). In these circumstances, identifying not only disaster robustness but also cost-effective capacity setting of NPPs has become one of the most important tasks for the nuclear power industry. A few studies have been performed to relocate the seismic capacity of NPPs, yet the effects of multiple hazards have not been accounted for in NPP capacity optimization. The major challenges in extending this problem to the multihazard dimension are (1) the high computational costs for both multihazard risk quantification and system-level optimization and (2) the lack of capital cost databases of NPPs. To resolve these issues, this paper proposes an effective method that identifies the optimal multihazard capacity of NPPs using a multi-objective genetic algorithm and the two-stage direct quantification of fault trees using Monte Carlo simulation method, called the two-stage DQFM. Also, a capacity-based indirect capital cost measure is proposed. Such a proposed method enables NPP to achieve safety and cost-effectiveness against multi-hazard simultaneously within the computationally efficient platform. The proposed multihazard capacity optimization framework is demonstrated and tested with an earthquake-tsunami example.

• Journal of Korea Multimedia Society
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• v.15 no.2
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• pp.234-241
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• 2012

The purpose of this study is to analyze the economic effects of telepresence system for public sector relocation. As a Green IT system, the importance of telepresence is being recognized increasingly as a means to replacing a majority of business trips and thereby reducing greenhouse gases emitted in the process. However, there are only a few related researches that analyze the economic effects of telepresence at the moment. This study conducts the cost-benefit analysis of 157 public sectors which are to relocate from 2012 based on the sample case of National Information Society Agency. The results obtained reveals that telepresence would save about 180 billion won and reduce about 580t $CO_2$ emission. This study are expected to provide the academic framework for organizations contemplating the adoption of Green IT system moving forward.

• Journal of Korean Society of Transportation
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• v.30 no.1
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• pp.125-133
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• 2012

This paper deals with the passenger transfer trips counted from smart bus-card data from Seoul transit network to understand the current operational condition of the system. Objective of this study is to relocate the location of the transit transfer centers. It delivers a bi-level programing model. The upper model is a linear 0-1 binary integer program having the objective of total travel cost minimization constrained by the number of transfer centers and the total construction budget. The lower model is an user equilibrium assignment model determining the passengers' route choice according to the transfer center locations. The proposed bi-level programming model was tested in an example network. The result showed that the proposed was able to find the optimal solution.

• World Technopolis Review
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• v.1 no.3
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• pp.206-225
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• 2012

The development of the Surrey Research Park by the University of Surrey is an addition to a number of existing strategies to collaborate with industry that it has developed over its 120 year history. The potential to undertake this development was based on owning a substantial land holding that the University acquired when the Borough Council for the town of Guildford invited the University to relocate from Battersea in London to its new location in 1966. Initial plans for the Park in 1979 were accelerated in 1981 in response to plans by the then government to reduce funding for Higher Education in the UK. Beyond a broad master plan for the site that was based on topography and access to the site the plans that were developed were based on a survey of 100 companies that were deemed to be in the target market for the site and a review of the other 7 science parks that were being developed in the UK in 1981. The findings from this proved to be important in developing the master plan for the site. Another important influence on the project was the objectives that were defined for the 3 stakeholders in the project of the University, the tenant companies and the planning authority relate to economic development, a competitive advantage of tenant companies, knowledge transfer, the profile for the University and the capacity to generate income proved to be a valuable framework on which to develop a master plan. These details were underpinned by five objectives which served the three stakeholders in the site. Those for the University included commercial potential, knowledge transfer and image and reputation; those for the town primarily related to economic development and the plan was to help tenants gain a competitive advantage by locating on the site. In addition a number of success indicators were defined for the project against which to measure performance and have remained as a useful set of parameters on which to base the assessment of the performance of the site. In combination with these indicators a further analysis deals with the success factors that are considered as important in influencing performance. The paper sets details the history of the park and covers the success indicators and factors and reviews these in the context of the original objectives for the site.

• Asian-Australasian Journal of Animal Sciences
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• v.22 no.1
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• pp.20-25
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• 2009

Xenotransplantation of pig organs into humans is a potential solution for the shortage of donor organs for transplantation. However, multiple immune barriers preclude its clinical application. In particular, the initial type of rejection in xenotransplantation is an acute cellular rejection by host $CD8^+$ cytotoxic T lymphocyte (CTL) cells that react to donor major histocompatibility complex (MHC) class I. The human cytomegalovirus (HCMV) glycoprotein Unique Short (US) 2 specifically targets MHC class I heavy chains to relocate them from the endoplasmic reticulum (ER) membrane to the cytosol, where they are degraded by the proteasome. In this study we transfected the US2 gene into minipig fetal fibroblasts and established four US2 clonal cell lines. The integration of US2 into transgenic fetal cells was confirmed using PCR and Southern blot assay. The reduction of Swine Leukocyte Antigen (SLA)-I by US2 was also detected using Flow cytometry assay (FACS). The FACS analysis of the US2 clonal cell lines demonstrated a substantial reduction in SLA-I surface expression. The level (44% to 76%) of SLA-I expression in US2 clonal cell lines was decreased relative to the control. In cytotoxicity assay the rate of $CD8^+$ T cell-mediated cytotoxicity was significantly reduced to 23.8${\pm}$15.1% compared to the control (59.8${\pm}$8.4%, p<0.05). In conclusion, US2 can directly protect against $CD8^+$-mediated cell lysis. These results indicate that the expression of US2 in pig cells may provide a new approach to overcome the CTL-mediated immune rejection in xenotransplantation.

• Korean Institute of Interior Design Journal
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• v.26 no.3
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• pp.71-80
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• 2017

Korea is facing various social problems including single elderly household, increase in the number of disabled people and poverty rate and a difference in the proportion of males to females between urban areas and rural areas along with the advent of rapid aging society. Especially, the ratio of poor households in rural areas residing in housing which falls below the minimum housing level and most of them are in the dead zone of housing welfare. In addition, if it is impossible for them to move (relocate) to new housing, the house remodeling is the only measure for improving their housing welfare. However, we don't have enough prior relevant academic and practical experience, and house remodeling requires a series of process including prior planning construction and post-occupancy evaluation, but almost no fundamental research that provides relevant insight has been carried out. Therefore, the purpose of this study is to describe all field situations that occur in the whole customized house remodeling process for disabled female senior citizens living alone in a rural area. The remodeling process was classified into initial planning stage, field verification and adjustment stage and construction stage as the method to participate in the field directly, and any change in the remodeling plan and its causes at each stage were analyzed. As a result, some remodeling items were changed from the main viewpoint of participating parties before the beginning of construction and for reasons such as the deterioration level of housing site, limitation in building equipment and rearrangement of housing, etc., and the remodeling method and its details were developed. It was identified that constant change that occurred in the remodeling process resulted from 1) unique poor characteristics of existing housing and 2) physical condition of residents and their unique lifestyle characteristics that were two aspects required to be emphasized by customized remodeling.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.7
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• pp.1269-1276
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• 2016

Recently, natural disasters including earthquakes, tsunamis, floods, and snowstorms, in addition to disasters of human origin such as arson, and acts of terror, have caused numerous injuries and fatalities around the world. During such disasters, victims need to obtain information such as the exact location of the disaster and appropriate evacuation routes in order to relocate to safe areas. In this study, We propose the algorithm for Emergency Rescue Evacuation Support System(ERESS). In case a emergency disaster occurs, ERESS is possible to detect it quickly using through the movement of people. The mobile terminal analyzes behavior and location of indoor pedestrian. And it sends the result to the server. The server determines whether an emergency situation occurred or not based on the received transmission information. When an emergency situation occurs, the server will notify it to the mobile terminal. Then, indoor pedestrian conduct emergency evacuation using mobile terminal.

• Current Research on Agriculture and Life Sciences
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• v.33 no.1
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• pp.19-24
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• 2015

Due to various environmental changes, the current location of the Gyeongsangbuk-do Agricultural Research & Extension Services needs to be changed to provide an appropriate environment and ecosystem for agricultural research and the efficient provision of public services. Accordingly, this study proposes a standard for selecting the new location. First, the location theory for the transfer of public facilities is investigated, and candidate filtration methods considered for the location selection. The candidate filtration methods include a component inspection, branch shape analysis, and mixed analysis. This study uses a component inspection, where the component criteria include the economic feasibility and ease of development, accessibility and convenience, agricultural conditions, soil conditions, connectivity, fairness, and human resource-richness of the region.

• Smart Structures and Systems
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• v.16 no.2
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• pp.243-262
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• 2015

Optimal sensor placement (OSP) is a critical issue in construction and implementation of a sophisticated structural health monitoring (SHM) system. The uncertainties in the identified structural parameters based on the measured data may dramatically reduce the reliability of the condition evaluation results. In this paper, the information entropy, which provides an uncertainty metric for the identified structural parameters, is adopted as the performance measure for a sensor configuration, and the OSP problem is formulated as the multi-objective optimization problem of extracting the Pareto optimal sensor configurations that simultaneously minimize the appropriately defined information entropy indices. The nondirective movement glowworm swarm optimization (NMGSO) algorithm (based on the basic glowworm swarm optimization (GSO) algorithm) is proposed for identifying the effective Pareto optimal sensor configurations. The one-dimensional binary coding system is introduced to code the glowworms instead of the real vector coding method. The Hamming distance is employed to describe the divergence of different glowworms. The luciferin level of the glowworm is defined as a function of the rank value (RV) and the crowding distance (CD), which are deduced by non-dominated sorting. In addition, nondirective movement is developed to relocate the glowworms. A numerical simulation of a long-span suspension bridge is performed to demonstrate the effectiveness of the NMGSO algorithm. The results indicate that the NMGSO algorithm is capable of capturing the Pareto optimal sensor configurations with high accuracy and efficiency.