• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.10
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• pp.933-940
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• 2013

In this study, we evaluated the heat release performance of two extruded-type and two swaged-type heat sinks used in an inverter for solar power generation. The number of fins and heat transfer areas of the two swaged-type heat sinks, namely S-62 and S-98, are 62 and 98 and $2.8m^2$ and $5.3m^2$, respectively. Those for the two extruded-type heat sinks, namely, E-38 and E-47, are 38 and 47 and $1.8m^2$ and $1.9m^2$, respectively. The heat release fractions of S-62 and S-98 were measured as 82.7 % and 86.3 %, respectively. Those of E-38 and E47 were measured to be 79.6 % and 81.6 %, respectively. In this experiment, despite the mass flow rates of air entering the heat sinks being almost the same, the heat release fractions increased with heat transfer area. Furthermore, despite S-62's heat transfer area being 47.4 % higher than that of E-47, its heat release fraction was higher by only 1.3 %. We believe that this indicates the better heat transfer property of the extruded-type heat sink. S-98's heat release is only 4.4 % higher than that of S-62, but its heat transfer area is 89.3 % higher; this suggests that its heat transfer area need to be optimized.

• Journal of Pharmaceutical Investigation
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• v.26 no.2
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• pp.71-82
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• 1996

This study has been undertaken to evaluate hydrophobic cyclodextrin(CD) derivatives as a sustained release carrier of azidothymidine(AZT), AZT, which has potent activity against AIDS and AIDS-related complex as thymidine analogue, has been reported that it has significant toxicity and short half life. Therefore, it is necessary to design sustained release oral dosage form to avoid undesirable side effects attributable to an excessive plasma concentration and to reduce the frequency of administration of AZT. Inclusion complexes of AZT with $acetyl-{\beta}-cyclodextrin\;(AC{\beta}CD)$ and $triacetyl-{\beta}-cyclodextrin(TA{\beta}CD)$ were prepared by solvent evaporation method. Interactions of AZT with CD were investigated by Differential Scanning Calorimetry(DSC) and Infrared Spectrophotometry(IR). The decreasing order of water solubilities of AZT and AZT-CD inclusion complexes were as follows; $AZT\;(27.873{\pm}0.015,mg/ml)\;>\;AZT-AC{\beta}CD\;(3.377{\pm}0.003)\;>\;AZT-TA{\beta}CD\;(2.528{\pm}0.001)$. Partition coefficients of $AZT-AC{\beta}CD\;and;\AZT-TA{\beta}CD$ inclusion complexes were increased by 1.27-fold, 1.54-fold in pH 1.2 and 1.32-fold, 1.47-fold in pH 6.8 in comparison with that of AZT. The mean dissolution time (MDT, min) which represents the rapidity of dissolution rate of AZT, $AZT-AC{\beta}CD,\;AZT-TA{\beta}CD$ were 5.12, 14.02 and 19.38 min in pH 1.2 and 2.52, 15.19 and 18.19 min in pH 6.8. AZT was very rapidly and completely dissolved in pH 1.2 and pH 6.8 within 5 minutes. But AZT-CD inclusion complexes showed the sustained release pattern in comparison with AZT alone. The simultaneous in situ nasal and jejunal recirculation study to compare the intrinsic absorptivity and the property of absorption sites revealed that the absorption of $AZT-TA{\beta}CD\;(N:35.35{\pm}1.08%,\;J:27.47{\pm}1.18%)$ was more than that of $AZT\;(N:16.89{\pm}2.25%,\;J:15.86{\pm}2.33%)$. The above results suggest that $TA{\beta}CD$ which is a hydrophobic cyclodextrin may serve as sustained release carrier with absorption enhancing effect.

• Molecules and Cells
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• v.38 no.6
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• pp.518-527
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• 2015

Controlled release of medications remains the most convenient way to deliver drugs. In this study, we precipitated gold nanoparticles with quercetin. We loaded gold-quercetin into poly(DL-lactide-co-glycolide) nanoparticles (NQ) and tested the biological activity of NQ on HepG2 hepatocarcinoma cells to acquire the sustained release property. We determined by circular dichroism spectroscopy that NQ effectively caused conformational changes in DNA and modulated different proteins related to epigenetic modifications and c ell cycle control. The mitochondrial membrane potential (MMP), reactive oxygen species (ROS), cell cycle, apoptosis, DNA damage, and caspase 3 activity were analyzed by flow cytometry, and the expression profiles of different anti- and pro-apoptotic as well as epigenetic signals were studied by immunoblotting. A cytotoxicity assay indicated that NQ preferentially killed cancer cells, compared to normal cells. NQ interacted with HepG2 cell DNA and reduced histone deacetylases to control cell proliferation and arrest the cell cycle at the sub-G stage. Activities of cell cycle-related proteins, such as $p21^{WAF}$, cdk1, and pAkt, were modulated. NQ induced apoptosis in HepG2 cells by activating p53-ROS crosstalk and induces epigenetic modifications leading to inhibited proliferation and cell cycle arrest.

• Proceedings of the Korean Society of Dyers and Finishers Conference
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• 2011.03a
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• pp.98-98
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• 2011

직물의 경우 드레이프성을 줄이고 KOSHI감(stiffness)을 부여하기 위해 일반적으로 나이프(knife) 코팅가공을 주로 사용한다. 하지만 니트는 워낙 신축성이 뛰어나기 때문에 큰 장력을 요구하는 일반 코팅공정을 적용할 경우 원단이 나이프에 밀리는 현상과 신장 상태에서 경화되어 니트 특유의 신축성을 완전히 읽어버리는 문제가 발생한다. 따라서 니트 코팅 가공을 위해 원단에 장력이 걸리지 않으며 니트 원단에 직접 수지를 도포하는 방식이 아닌 간접 도포가 가능한 장비를 고안하였다. 즉, 아래에 나타낸 모식도와 같이 프로팅이나 over roll 나이프 방식을 사용하여 전사에 필요한 수지를 R/F에 코팅하고 이를 니트와 붙인 후 열풍 건조기와 열실린더를 통과시켜 수지가 니트에 전사되도록 하는 것이다. 본 연구에서는 고신축성과 탁월한 포면 터치감을 가지는 니트를 겉옷 및 다양한 용도로 전개하기 위해 R/F(releas fabric)의 조건을 설정 및 코팅 조건 설정을 통해 니트 가공 직물의 성능 변화를 살펴보기로 한다.

• Journal of Microbiology and Biotechnology
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• v.13 no.4
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• pp.613-619
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• 2003

The polyketide backbone of rifamycin B is assembled by the type I rifamycin polyketide synthase (PKS) encoded by the rifA-rifE genes. In order to produce novel analogs of rifamycin via engineering of the PKS genes, inactivation of the ${\beta}-ketoacyl:acyl$ carrier protein reductase (KR) domain in module 8 of rifD, by site-specific mutagenesis of the NADPH binding site, was attempted. Module 8 contains a nonfunctional dehydratase (DH) domain and a functional KR domain that is involved in the reduction of the ${\beta}-carbonyl$ group, resulting in the C-21 hydroxyl of rifamycin B. This mutant strain produced linear polyketides, from tetraketide to octaketide, which were also produced by a rifD-disruption mutant as a consequence of premature termination of the polyketide assembly. Another attempt to replace the DH domain of module 7, which has been considered nonfunctional, with a functional homolog derived from module 7 of rapamycin-producing PKS also resulted in the production of linear polyketides, including the heptaketide intermediate and its precursors. Premature release of the carbon chain assembly intermediates is an unusual property of the rifamycin PKS. that is not seen in other PKSs such as the erythromycin PKS.

• Composites Research
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• v.27 no.2
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• pp.72-76
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• 2014

This study is investigated by experiments and analyses at rates of 2.5m/s, 7.5m/s and 12.5m/s on the impact of tapered double cantilever beam specimens with aluminium alloy. It aims to examine the mechanical property of aluminum alloy by evaluating energy release rate and equivalent stress happened at the bonded part of specimen. Because bonding force remains after the separation of specimen, the energy release rate at the bonded part becomes highest. As crack propagates and the high stress happens at the end of the bonded part, the maximum equivalent stress becomes higher at the last stage, regardless of impact rate. These results of experiments and analyses are the data necessary to develop the safe design of composite material to prevent crack propagation due to impact.

• Journal of Korean Tunnelling and Underground Space Association
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• v.9 no.4
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• pp.343-349
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• 2007

The reduced scale fire test provides basic data but it is not enough to analysis real fire problem directly because there is no exact analogy theory between a real fire and the reduced scale model. Therefore we have developed the large scale calorimeter in order to the real scale fire test. This advanced large scale calorimeter used for physical properties such as a heat release rate, based upon consumption of $O_2$ method. Using this large scale calorimeter, we cameo out the real scale vehicle fire test in order to evaluation for heat release rate. We obtained the calculated result for HRR $2.3{\sim}3.4\;MW$ and this result is very similar to the PIARC candidate HRR. It is approve that this facility has the reliability and it is capable of applying to the advance fire research in the future.

• Applied Chemistry for Engineering
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• v.20 no.6
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• pp.632-637
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• 2009

Poly(${\varepsilon}-caprolacton$)/ethyl cellulose (PCL/EC) microcapsules containing pluronic F127 were prepared by a spray drying method. The aqueous phase, 20% of pluronic F127 was dissolved in distilled water, and the organic phase, 5% of PCL and EC were dissolved in dichloromethane. The microcapsules were obtained by spray drying the water-in-oil (W/O) emulsion. According to the data of scanning electron microscopy and particle analyzer, tens of micro size microcapsules were observed. On a differential scanning calorimeter, the phase transition temperatures of microcapsules were observed and they were found around those of pluronic F127 and poly(${\varepsilon}-caprolacton$), which were the main components of the microcapsules. At the range of $30{\sim}45^{\circ}C$, temperature-dependent release properties were investigated using fluorescein isothicyanate-dextran (FITC-dextran) and blue dextran as a model drug. When the temperature was increased, the degree of release of microcapsule was also increased. FITC-dextran, the relative low molecular weight, was more released than blue-dextran.

• Polymer(Korea)
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• v.36 no.2
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• pp.182-189
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• 2012

In this study, poloxamer hydrogels were prepared by electron beam irradiation and evaluated for potential application as a buccal mucoadhesive drug delivery system. Poloxamer, one of typical thermoresponsive polymers, was modified to have vinyl end groups for crosslinking reaction, and its hydrogels were fabricated by irradiation crosslinking reaction. Carbopol as a mucoadhesive polymeric additive was introduced to improve the mucoadhesive property of the hydrogels and its effect on the mucoadhesion and drug release properties was investigated. The results showed that the end group modification of poloxamer and the addition of carbopol improved mucoadhesive force and mechanical properties and led to a sustained drug release behavior.

• Journal of the Korean Society of Safety
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• v.37 no.2
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• pp.1-9
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• 2022

Most factories deal with toxic or flammable chemicals in their industrial processes. These hazardous substances pose a risk of leakage due to accidents, such as fire and explosion. In the event of chemical release, massive casualties and property damage can result; hence, quantitative risk prediction and assessment are necessary. Several methods are available for evaluating chemical dispersion in the atmosphere, and most analyses are considered neutral in dispersion models and under far-field wind condition. The foregoing assumption renders a model valid only after a considerable time has elapsed from the moment chemicals are released or dispersed from a source. Hence, an initial dispersion model is required to assess risk quantitatively and predict the extent of damage because the most dangerous locations are those near a leak source. In this study, the dispersion model for initial consequence analysis was developed with three-dimensional unsteady advective diffusion equation. In this expression, instantaneous leakage is assumed as a puff, and wind velocity is considered as a coordinate transform in the solution. To minimize the buoyant force, ethane is used as leaked fuel, and two different diffusion coefficients are introduced. The calculated concentration field with a molecular diffusion coefficient shows a moving circular iso-line in the horizontal plane. The maximum concentration decreases as time progresses and distance increases. In the case of using a coefficient for turbulent diffusion, the dispersion along the wind velocity direction is enhanced, and an elliptic iso-contour line is found. The result yielded by a widely used commercial program, ALOHA, was compared with the end point of the lower explosion limit. In the future, we plan to build a more accurate and general initial risk assessment model by considering the turbulence diffusion and buoyancy effect on dispersion.