• Journal of Pharmaceutical Investigation
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• 제31권1호
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• pp.19-25
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• 2001

The purpose of this study was to use a ternary polymeric matrix system for high drug loading of a highly soluble drug for controlled release delivery. The controlled drug delivery of diltiazem HCl (solubility > 50% in water at $25^{\circ}C$) with high loading dose (the final loading dose of drug was 34%) from a ternary polymeric matrix (gelatin, pectin, HPMC) was successfully accomplished. This simple monolithic system with 240 mg drug loading provided near zero-order release over a 24 hour-period by which time the system was completely dissolved. The release kinetics of diltiazem HCl tablet with high loading dose from the designed ternary polymeric system was dependent on the ratios of HPMC : pectin binary mixture. The release rate increased as pectin : HPMC ratio were increased. Swelling behavior of the ternary system and the ionic interaction of formulation components with cationic diltiazem molecule appear to control drug diffusion and the release kinetics. Comparable release profiles between commercial product and the designed system were obtained. The binding study between gelatin with diltiazem HCl showed the presence of two binding sites for drug interaction with subsequent controlled diffusion upon swelling. This designed delivery system is easy to manufacture and drug release behavior is highly reproducible and offers advantages over the existing commercial product.

• 한국화재소방학회:학술대회논문집
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• 한국화재소방학회 2008년도 춘계학술논문발표회 논문집
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• pp.7-10
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• 2008

Heat release characteristics of live fire load are an important parameter for performance oriented fire safety design of a building. While investigations have been carried out on the fire load and its burning behavior in office, residential and commercial buildings and so on, little effort has been paid for the rational treatment of fire load in post office buildings in Japan. In this report, burning behavior of typical combustible objects in post office buildings are studied by measuring heat release rates of plastic palettes with and without postal envelopes or packages and special containers loading numbers of palettes. The test results suggest that dynamic heat release rate is highly dependent on the condition of palettes especially if they load appropriate amount of postal envelopes or not.

• Macromolecular Research
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• 제16권1호
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• pp.45-50
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• 2008

This study examined the swelling behavior and in vitro release of a model drug, tetracycline-HCl, from alginate and alginate-polyaspartate (Alg-PASP) composite gel beads. The alginate and Alg-PASP composite beads were prepared using an ionic crosslinking method with aqueous $Ca^{2+}$. Their microporous morphology was observed by scanning electron microscopy. The swelling ratio of the beads in different media varied according to their composition, cross-linking density ($Ca^{2+}$ concentration), and pH of the aqueous medium. The in vitro release experiment of the tetracycline-HCl encapsulated beads in different media suggests that the release of the drug is governed mainly by the swelling properties of the polymer network. The presence of PASP was found to significantly influence the swelling properties and drug release profile.

• Coupled systems mechanics
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• 제12권1호
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• pp.69-81
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• 2023

This paper considers a delamination analysis of a statically undetermined inhomogeneous beam structure of rectangular section with viscoelastic behavior under torsion. The beam is built in at its two ends. The beam has two longitudinal inhomogeneous layers with a delamination crack between them. A notch is made in the upper crack arm. The external torsion moment applied on the beam is a function of time. Under these conditions, the beam has one degree of indeterminacy. In order to derive the strain energy release rate, first, the static indeterminacy is resolved. Then the strain energy release rate is obtained by analyzing the balance of the energy with considering the viscoelastic behavior. The strain energy release rate is found also by analyzing the compliance of the beam for checkup. Solution of the strain energy release rate in a beam without a notch in the upper crack arm is derived too. In this case, the beam has two degrees of static indeterminacy (the torsion moment in the upper crack arm is treated as an additional internal redundant unknown). A parametric investigation of the strain energy release rate is carried-out.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 2002년도 Proceedings of the International Welding/Joining Conference-Korea
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• pp.372-377
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• 2002

Residual stress by welding should be reduced because that decreases the reliability on strength of welded structure. The reason is that the total stiffness of structure decreases by non-linear behavior of weldment under external load. The release of residual stress by mechanical loading and unloading is often performed in the fabrication of box structure for steel bridge. The proper degree of loading and unloading is significant at release method of residual stress by mechanical loading because that degree is changed by material and geometric shape of welded structure. Therefore, the simulation model that could exactly analyze the release of residual stress by mechanical loading is to be necessary. This simulation model should be established on the based of variable and accurate measurement data. In this study, the non-linear behavior of weldments under external loading and unloading, such as the decrease and increase of structure stiffness, was investigated by monitoring of nominal stress and strain. Tensile loading and unloading test under variable load was performed and the proper degree of stress relaxation was measured by sectioning technique using strain gauge.

• International Journal of Korean Welding Society
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• 제2권1호
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• pp.40-44
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• 2002

Residual stress by welding should be reduced because that decreases the reliability on strength of welded structure. The reason is that the total stiffness of structure decreases by non-linear behavior of weldment under external load. The release of residual stress by mechanical loading and unloading is often performed in the fabrication of box structure for steel bridge. The proper degree of loading and unloading is significant at release method of residual stress by mechanical loading because that degree is changed by material and geometric shape of welded structure. Therefore, the simulation model that could exactly analyze the release of residual stress by mechanical loading is to be necessary. This simulation model should be established on the based of variable and accurate measurement data. In this study, the non-linear behavior of weldments under external loading and unloading, such as the decrease and increase of structure stiffness, was investigated by monitoring of nominal stress and strain. Tensile loading and unloading test under variable load was performed and the proper degree of stress relaxation was measured by sectioning technique using strain gauge.

• Advances in materials Research
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• 제12권1호
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• pp.15-29
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• 2023

In this paper, fracture analysis of a continuously inhomogeneous arch structure with two longitudinal cracks is developed in terms of the time-dependent strain energy release rate. The arch under consideration exhibits non-linear creep behavior. The cross-section of the arch is a rectangle. The material is continuously inhomogeneous along the thickness of the cross-section. The arch is loaded by two bending moments applied at its end sections. The mechanical behavior of the material is described by using a non-linear stress-strain-time relationship. The two longitudinal cracks are located symmetrically with respect to the mid-span of the arch. Due to the symmetry, only half of the arch is considered. Time-dependent solutions to strain energy release rate are obtained by analyzing the balance of the energy. For verification, time-dependent solutions to the strain energy release rate are derived also by considering the time-dependent complementary strain energy. The evolution of the strain energy release rate with the time is analyzed. The effects of material inhomogeneity, locations of the two cracks along the thickness of the arch and the magnitude of the external loading on the time-dependent strain energy release rate are evaluated.

• Journal of Pharmaceutical Investigation
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• 제41권6호
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• pp.363-369
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• 2011

In this study, we demonstrated the release behavior of carvedilol with the content of polyvinylpyrrolidone K-30 (PVP K-30) and the effect of citric acid and fumaric acid as acidifiers on the release behavior of drug. In addition, it tries to inquire into the release behavior difference of the carvedilol according to the manufacturing method. The release behavior of the tablets was compared with Dilatrand$^{(R)}$ in the simulated gastric fluid (pH1.2). Differential scanning calorimeter (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FT-IR) were characterized for the physicochemical properties of the tablets. In case of mixing the carvedilol and PVP K-30, in case the ratio of the carvedilol and PVP K-30 was 1:5, the release behavior was the highest among. As well as the dissolution rate of tablets manufactured by lyophilization and rotary evaporator was higher than physical mixture. The dissolution rate of containing acidifiers was more improved. But, rather the excessive amount of the acidifier addition reduced the dissolution rate.

• KSBB Journal
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• 제5권4호
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• pp.377-382
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• 1990

The characteristics controlled drug release have been studied for biodegradable polymer matrix. Polymer matrix was prepared from glycerine, prednisolone and dextran. Mathematical analysis of the data showed that the release behavior actually conformed to the Higuchi's diffusion controlled model. The release time was increased as drug loading doses increased, whereas decreased as glycerine concentration increased. The release rate did not change by varying molecular weight of dextran.

• 보건행정학회지
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• 제11권3호
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• pp.121-150
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• 2001

This study was conducted to investigate provider's behavior change after releasing the information on the Cesarean section rate. Claims data filed at the National Health Insurance Corporation was used for this analysis and the focus of this study was the change of cesarean rate after the public disclosure of information. Average rates of the year 1999 and 2000 were compared, on the institutional basis, and range and coefficient of variation were estimated. For the last decade, Cesarean section rate has been increased dramatically. Clinical or demographic factors could not adequately explain the increase. Instead, nonclinical factors, such as financial incentive, physician's convenience, practice characteristics, etc., were more significant in explaining the increasing rate. Providers' behavior was significantly affected by the public release of information: after the release, average rate was decreased by 10.2%, and variations were also decreased. In particular, the extent of decrease was explained mainly by nonclinical factor rather than clinical ones. The results suggest that disseminating practice information to providers and consumers could contribute to reducing unnecessary medical service.