• Journal of Pharmaceutical Investigation
• /
• v.38 no.2
• /
• pp.99-104
• /
• 2008

PLGA micro/nano particles encapsulating ranitidine as a hydrophilic model drug were prepared by the double-emulsion solvent evaporation method. Surface morphology investigation by scanning electron microscope (SEM) showed that the emulsification by sonication could produce nanoparticles, whereas microparticles were prepared using high speed homogenizer. Moreover, while nanohalf-shell structure instead of spherical nanoparticle could be produced by adding poloxamer into oil phase (MC) with PLGA 504H, the addition of poloxamer didn't change particle shape in case of PLGA 502H. On the other hand, microparticle with poloxamer had more surface pores than those without poloxamer. The size and polydispersity (PDI) of particles were determined by particle size analyzer. Effective diameters of particles were in the range of $400{\sim}800\;nm$ and $1200{\sim}3300\;nm$ in case of nanoparticles and microparticles, respectively. Encapsulation efficiencies were in the range of $1.2{\sim}2.9%$. The addition of poloxamer produced the particles with higher encapsulation efficiency. In vitro release study in phosphate buffer (pH 7.4) at $37^{\circ}C$ showed common large initial burst release. However, the relative slower release profile could be observed in case of microparticles. Poloxamer addition increased the release rate, which was thought to be related to the increased surface area of particles.

• Applied Chemistry for Engineering
• /
• v.33 no.5
• /
• pp.482-487
• /
• 2022

In this study, the activity test and characterization were performed to evaluate the hydrogen sulfide removal characteristics using a V/TiO₂ catalyst at room temperature. The optimal vanadium loading was 10 wt%, and the durability was greater than 60 minutes at 60~80% relative humidity. The Brunauer-Emmett-Teller (BET) surface area and raman spectroscopy results confirmed that the structure of the vanadium site exposed to the surface was a dominant factor in catalyst activity. From Scanning Electron Microscope (SEM), Energy Dispersive Spectroscopy (EDS) and X-ray crystallography (XRD) analyses, it was found that sulfur can be accumulated on the catalyst surface, which results in a decrease in durability under catalytic activity tests. Therefore, it is judged that a combined process of catalytic oxidation and regeneration is needed.

• Journal of the Korean Society of Industry Convergence
• /
• v.1 no.1
• /
• pp.21-30
• /
• 1998

The purpose of this study is to clarify the floor temperature on the human body and to estimate thermal comfort zone in a heated room. In order to evaluate the effects of floor heating, a series of experiments were carried out using Korean subjects. The following experiments were conducted: 1) to obtain the effective radiation area and configuration factors of the person in the sitting posture on a floor to get the mean radiant temperature, 2) to measure contacted area of the person to the floor to calculate conduction heat rate, 3) to measure convective heat transfer coefficient of the body and 4) to know the thermal comfort zone of indoor environment heated by ON-DOL. Subjects were exposed to the following conditions: combinations of air temperature $20^{\circ}C$, $22.5^{\circ}C$, $25^{\circ}C$, and floor temperature $20^{\circ}C$, $22.5^{\circ}C$, $25^{\circ}C$, $27.5^{\circ}C$, $30^{\circ}C$, $32.5^{\circ}C$, $35^{\circ}C$, $37.5^{\circ}C$, $40^{\circ}C$ under still air and 50% relative humidity in the controllable artificial climate chamber. To evaluate the effect of heat conduction between the body and a floor modified mean skin temperature was defined. Weighting coefficient to calculate mean skin temperature were modified with the contacted area. The experiments revealed a positive correlation between the modified operative temperature and the modified mean skin temperature. The modified mean skin temperature can indicate the effect of heat conduction between body and a floor surface.

• 한국지구물리탐사학회:학술대회논문집
• /
• 2003.11a
• /
• pp.142-149
• /
• 2003

Blind hydraulic backfilling is a commonly used technique for subsidence control of the strata over unapproachable waterlogged underground excavations. In this investigation model studies on all the three variants of this technique, namely, hydro-pneumatic or air-assisted gravity backfilling, pumped-slurry backfilling and simple gravity backfilling, have been carried out in fully transparent models of the underground excavations. On examination of the filling process, it was revealed that in all the three cases, the basic process of filling occurs by sand transport along one or more meandering channels. The relative influence of sand, water and air flow rates on the area of filling from a single inlet point and the hydraulic pressure loss per unit length were studied in details. In hydro-pneumatic backfilling process, the air bubbles while moving upward through the meandering channels provide an additional buoyant force over and above the available hydraulic head. In this way the area of filling from a single borehole may be quite large even at small flow rates of water. During actual field implementation the injected air, if not released completely from the rise side holes, may cause troubles by way of creating potholes on the surface. The pumped-slurry technique has shown its capability of filling a relatively larger area at faster rate, especially when high-volume, low-pressure method was selected. But simple gravity filling was also found to be equally effective method as slurry pumping, especially when flow rates were high. In the second and third method discussed above, examination of variations of injection pressure was also done and its relation with physical phenomenon was also attempted. Some empirical relationships were also developed using multivariate regression with a view to help the practicing engineers.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.35 no.2
• /
• pp.170-177
• /
• 1999

In order to research the relationship between distribution of fish and the ocean environment in Southern Sea of Korea, echo survey and oceanographic observation were carried out from July 27 to 31 in 1998. The DSL(Depth Scattering Layer) and high density of fishes were appeared in northeastern Cheju Island and offshore of Karnak bay by color echo sounder. The relative Sa(area backscattering coefficient) in offshore of Karnak bay was 5,500 at 28KHz, 12,500 at 200KHz and Northeastern Cheju Island was 6,000 at 28KHz, 20,000 at 200KHz. During the acoustic survey period, Ocean environment of high density of fishes area were as the follows. The surface Northeastern Cheju Island were ranged 20~$26.5^{\circ}C,\;31.5~32.5\perthousand$ and that bottom were ranged 16~$20^{\circ}C,\;35.4~34\perthousand$. The shallow water area in offshore of Karnak bay were ranged 24~$26.5^{\circ}C,\;30.0~31.5\perthousand$

• Journal of Korea Water Resources Association
• /
• v.33 no.4
• /
• pp.427-435
• /
• 2000

It is often crucial to obtain a map of flood inundated area with more accurate and rapid manner. This study attempts to evaluate the potential of satellite synthetic aperture radar (SAR) data for mapping of flood inundated area in Imjin river basin. Multitemporal RADARSAT SAR data of three different dates were obtained at the time of flooding on August 4 and before and after the flooding. Once the data sets were geometrically corrected and preprocessed, the temporal characteristics of relative radar backscattering were analyzed. By comparing the radar backscattering of several surface features, it was clear that the flooded rice paddy showed the distinctive temporal pattern of radar response. Flooded rice paddy showed significantly lower radar signal while the normally growing rice paddy show high radar returns, which also could be easily interpreted from the color composite imagery. In addition to delineating the flooded rice fields, the multitemporal radar imagery also allow us to distinguish the afterward condition of once-flooded rice field.

• Journal of the Speleological Society of Korea
• /
• no.72
• /
• pp.19-30
• /
• 2006

The purpose of this study is to clarified the geology and geomorphic characteristics of the Hantan River Basin. In this area, some kind of landforms are developed such as pre-land forms, lava plateau, and present landforms etc. Some river terraces are peculiar features in the area. Some conclusions are as follows : The vicinity of the Hantan River is lava plateau formed from the volcanic activity. Some steptoes are located in the lava plateau. Baekeuiri formation means the river bed boulder beneath the lava formation. The development of drainage patterns are unstable and the bifurcation ratio, the ratio of mean length of the river are lower than the other rivers. The relative height of the terraces is about $5{\sim}25m$ and the terraces are alluvial terraces. In the Jiktang Fall area, bedrock is granite and basalt plateau covered the bedrock. In that point, the old erosion surface is relatively steeper than the horizontal-basalt plateau. Vertical columnar joints are developed and weathering materials creep on the valley wall. The cross section of the landform of the Kosukjung vicinities are somewhat different from the landforms of Jiktang Fall. The bedrock near the Kosukjung is granite that is the same with the Jiktang Fall. But the cross section shows a asymmetrical curve from each side.

• Journal of Digital Convergence
• /
• v.20 no.2
• /
• pp.317-323
• /
• 2022

This study aimed to qualitative analyze the cusp variation pattern of the mandibular second premolars using a three-dimensional virtual models, and to analyze the left-right bilateral symmetry with a quantitative analysis of the tooth surface area according to the cusp variation. 127 virtual mandibular second premolars were prepared and individual absolute/relative cusp area, total crown area and groove form were analyzed using RapidForm2004(INUS technology INC, Seoul, Korea). Independent t-test, Kruskal-Wallis test and chi-square were performed. As a result, the groove form showed high bilateral symmetry between the left and right sides. Based on the left side of groove form, the bilateral symmetry was 100.0% for the U pattern, and 73.7% for the H patterned, and 78.9% for the Y pattern(p<.001). The finding could be as a meaningful reference for manufacturing CAD/CAM dental prostheses, and it is expected that further studies will be conducted on more samples including the mandibular second premolar immediately after eruption.

• Journal of The Geomorphological Association of Korea
• /
• v.28 no.1
• /
• pp.83-99
• /
• 2021

Burn severity analysis using satellite imagery has high capabilities for research and management in inaccessible areas. We extracted the forest fire area of the DMZ (Demilitarized Zone) in the western Imjin Estuary which is restricted to access due to the confrontation between South and North Korea. Then we analyzed the forest fire severity and recoverability using atmospheric corrected Surface Reflectance Level-2 data collected from Landsat-8 OLI (Operational Land Imagery) / TIRS (Thermal Infrared Sensor). Normalized Burn Ratio (NBR), differenced NBR (dNBR), and Relative dNBR (RdNBR) were analyzed based on changes in the spectral pattern of satellite images to estimate burn severity area and intensity. Also, we evaluated the recoverability after a forest fire using a land cover map which is constructed from the NBR, dNBR, and RdNBR analyzed results. The results of dNBR and RdNBR analysis for the six years (during May 30, 2014 - May 30, 2020) showed that the intensity of monthly burn severity was affected by seasonal changes after the outbreak and the intensity of annual burn severity gradually decreased after the fire events. The regrowth of vegetation was detected in most of the affected areas for three years (until May 2020) after the forest fire reoccurred in May 2017. The monthly recoverability (from April 2014 to December 2015) of forests and grass fields was increased and decreased per month depending on the vegetation growth rate of each season. In the case of annual recoverability, the growth of forest and grass field was reset caused by the recurrence of a forest fire in 2017, then gradually recovered with grass fields from 2017 to 2020. We confirmed that remote sensing was effectively applied to research of the burn severity and recoverability in the DMZ. This study would also provide implications for the management and construction statistics database of the forest fire in the DMZ.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.1
• /
• pp.153-157
• /
• 2016

Background: In radiation therapy, estimation of surface doses is clinically important. This study aimed to obtain an analytical relationship to determine the skin surface dose, kerma and the depth of maximum dose, with energies of 6 and 18 megavoltage (MV). Materials and Methods: To obtain the dose on the surface of skin, using the relationship between dose and kerma and solving differential equations governing the two quantities, a general relationship of dose changes relative to the depth was obtained. By dosimetry all the standard square fields of $5cm{\times}5cm$ to $40cm{\times}40cm$, an equation similar to response to differential equations of the dose and kerma were fitted on the measurements for any field size and energy. Applying two conditions: a) equality of the area under dose distribution and kerma changes in versus depth in 6 and 18 MV, b) equality of the kerma and dose at $x=d_{max}$ and using these results, coefficients of the obtained analytical relationship were determined. By putting the depth of zero in the relation, amount of PDD and kerma on the surface of the skin, could be obtained. Results: Using the MATLAB software, an exponential binomial function with R-Square >0.9953 was determined for any field size and depth in two energy modes 6 and 18MV, the surface PDD and kerma was obtained and both of them increase due to the increase of the field, but they reduce due to increased energy and from the obtained relation, depth of maximum dose can be determined. Conclusions: Using this analytical formula, one can find the skin surface dose, kerma and thickness of the buildup region.