Journal of Pharmaceutical Investigation

  • 제38권2호
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  • Pages.99-104
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  • 2008
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  • 2093-5552(pISSN)
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  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
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DOI QR코드

DOI QR Code

이중 유제 방법으로 제조된 PLGA 미립자들과 반구체:특성과 라니티딘(ranitidine)의 방출 양상

PLGA particles and half-shells prepared by double emulsion method: characterization and release profiles of ranitidine

  • 남대식 (인제대학교 공과대학 나노공학부) ;
  • 김성철 (인제대학교 공과대학 나노공학부) ;
  • 강수용 (인제대학교 공과대학 나노공학부) ;
  • 오돈치멕문크자갈 (인제대학교 공과대학 나노공학부) ;
  • 심영기 (인제대학교 공과대학 나노공학부) ;
  • 이우경 (인제대학교 공과대학 나노공학부)
  • 발행 : 2008.04.21
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초록

PLGA micro/nano particles encapsulating ranitidine as a hydrophilic model drug were prepared by the double-emulsion solvent evaporation method. Surface morphology investigation by scanning electron microscope (SEM) showed that the emulsification by sonication could produce nanoparticles, whereas microparticles were prepared using high speed homogenizer. Moreover, while nanohalf-shell structure instead of spherical nanoparticle could be produced by adding poloxamer into oil phase (MC) with PLGA 504H, the addition of poloxamer didn't change particle shape in case of PLGA 502H. On the other hand, microparticle with poloxamer had more surface pores than those without poloxamer. The size and polydispersity (PDI) of particles were determined by particle size analyzer. Effective diameters of particles were in the range of $400{\sim}800\;nm$ and $1200{\sim}3300\;nm$ in case of nanoparticles and microparticles, respectively. Encapsulation efficiencies were in the range of $1.2{\sim}2.9%$. The addition of poloxamer produced the particles with higher encapsulation efficiency. In vitro release study in phosphate buffer (pH 7.4) at $37^{\circ}C$ showed common large initial burst release. However, the relative slower release profile could be observed in case of microparticles. Poloxamer addition increased the release rate, which was thought to be related to the increased surface area of particles.

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참고문헌

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