• Korean Journal of Poultry Science
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• v.46 no.4
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• pp.287-296
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• 2019

Avian sex determination system involves the male ZZ and female ZW chromosomes. However, very few studies are reported the expression, functional role and importance of genes on the W chromosome because of its small and highly heterochromatic genomic regions. Recent studies demonstrated that the W chromosome may have critical roles in physiology, sex determination and subsequent sexual differentiation in chickens. Therefore, gene annotation, including describing the expression and function of genes in the chicken W chromosome, is needed. In this study, we have searched the W chromosome of chickens and selected a total of 36 genes to evaluated their specific expression in the testis and ovary at various developmental stages such as embryonic day 6 (E6), hatch and adult. Interestingly, out of 36 genes in chicken W chromosome, we have found seven female-specific expression at E6.5 day, indicating that they are functionally related to female chicken gonadal differentiation. In addition, we have identified the stage specific gene expression from the sex specific genes. Furthermore, we analyzed the relative location of genes in the chicken W chromosome. Collectively, these results will contribute molecular insights into the sexual determination, differentiation and female development based on the W chromosome.

• Journal of the Korean Geotechnical Society
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• v.18 no.6
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• pp.153-160
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• 2002

A new system identification method based on tunnel deformation data is proposed to find the damage in the lining structure. For this, an inverse problem in which the deformation data and dead load of concrete lining are known a priori is introduced to estimate the degree and location of the damages. Models based on uniform reduction of stiffness and homogenized crack concept are individually employed to compare the applicability and relative advantages of the models. Numerical analyses are peformed for the idealized tunnel structure and the effect of white noise, common in most measurement data, is also included to better understand the suitability of the proposed models. As a result, model 1 based on uniform stiffness reduction method is shown to be relatively insensitive to the noise, while model 2 with the homogenized crack concept is proven to be easily applied to the field situation since the effect of stiffness reduction is rather small.

• Steel and Composite Structures
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• v.22 no.1
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• pp.113-139
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• 2016

The nonlinear seismic responses of steel buildings with perimeter moment resisting frames (PMRF) and interior gravity frames (IGF) are estimated, modeling the interior connections first as perfectly pinned (PPC), and then as partially restrained (PRC). Two 3D steel building models, twenty strong motions and three levels of the PRC rigidity, which are represented by the Richard Model and the Beam Line Theory, are considered. The RUAUMOKO Computer Program is used for the required time history nonlinear dynamic analysis. The responses can be significantly reduced when interior connections are considered as PRC, confirming what observed in experimental investigations. The reduction significantly varies with the strong motion, story, model, structural deformation, response parameter, and location of the structural element. The reduction is larger for global than for local response parameters; average reductions larger than 30% are observed for shears and displacements while they are about 20% for bending moments. The reduction is much larger for medium- than for low-rise buildings indicating a considerable influence of the structural complexity. It can be concluded that, the effect of the dissipated energy at PRC should not be neglected. Even for connections with relative small stiffness, which are usually idealized as PPC, the reduction can be significant. Thus, PRC can be used at IGF of steel buildings with PMRF to get more economical construction, to reduce the seismic response and to make steel building more seismic load tolerant. Much more research is needed to consider other aspects of the problem to reach more general conclusions.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.2971-2977
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• 2014

Background: Long non-coding RNAs (lncRNAs) have been recently observed in various human cancers. However, the role of lncRNAs in pancreatic duct adenocarcinoma (PDAC) remains unclarified. The aim of this study was to detect the expression of lncRNA MALAT1 in PDAC formalin-fixed, paraffin embedded (FFPE) tissues and to investigate the clinical significance of the MALAT1 level. Methods: The expression of MALAT1 was examined in 45 PDAC and 25 adjacent non-cancerous FFPE tissues, as well as in five PDAC cell lines and a normal pancreatic epithelium cell line HPDE6c-7, using qRT-PCR. The relationship between MALAT1 level and clinicopathological parameters of PDAC was analyzed with the Kaplan-Meier method and Cox proportional hazards model. Results: The relative level of MALAT1 was significantly higher in PDAC compared to the adjacent normal pancreatic tissues (p=0.009). When comparing the MALAT1 level in the cultured cell lines, remarkably higher expression of MALAT1 was found in aspc-1 PDAC cells compared with the immortal pancreatic duct epithelial cell line HPDE6c-7 (q=7.573, p<0.05). Furthermore, MALAT1 expression level showed significant correlation with tumor size (r=0.35, p=0.018), tumor stage (r=0.439, p=0.003) and depth of invasion (r=0.334, p=0.025). Kaplan-Meier analysis revealed that patients with higher MALAT1 expression had a poorer disease free survival (p=0.043). Additionally, multivariate analysis indicated that overexpression of MALAT1, as well as the tumor location and nerve invasion, was an independent predictor of disease-specific survival of PDAC. Conclusion: MALAT1 might be considered as a potential prognostic indicator and may be a target for diagnosis and gene therapy for PDAC.

• Journal of Advanced Marine Engineering and Technology
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• v.39 no.9
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• pp.959-966
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• 2015

In this paper, we propose an indoor visible light communication(VLC) localization using Walsh code which can identify overlapped signals transmitted from the different LED sources as each of orthogonal signal at a receiver and using Manchester code which can eliminate the flicker of LED light and maintain a constant brightness. The proposed system can estimate the relative position of the receiver by using Lambertian radiation properties and trilateration method that are applied to the location information of fixed LED sources and the received signals from them. In order to verify the feasibility of the proposed system, we carried out the simulation in an indoor space with $6{\times}6{\times}1.5m^3$ installed LED lamps of 16. The simulation result shows that the proposed method achieves an average positioning error of 0.0536 m and a maximum positioning error of 0.2977 m.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2171-2174
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• 2012

Background: Pancreatic cancer is a distressing disease with a miserable prospects and early recognition remains a challenge due to ubiquitous symptomatic presentation, deep anatomical location, and aggressive etiology. False positives and problems in distinguishing pancreatitis from adenocarcinoma limit the use of CA 19-9 as both disorders can present with similar symptoms and share radiographic physiognomies. This study aimed to assess the relative increase in accuracy of diagnosing the patients with chronic pancreatitis, benign neoplasm of pancreas and adenocarcinomas with CA 19-9, haptoglobin, and serum amyloid A in comparison to CA 19-9 alone. Materials and Methods: This hospital based case control study was carried out in the Departments of Medicine and Biochemistry of Manipal Teaching Hospital, Pokhara, Nepal, between $1^{st}$ January 2010 and $31^{st}$ December 2011. The variables assessed were age, gender, serum CA19-9, serum haptoglobulin, serum Amyloid A. The data were analyzed using Excel 2003, R 2.8.0 Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5.1 Windows Version. Results: Out of 197 cases of pancreatic disease, maximum number of assumed cases were of adenocarcinoma of pancreas (95). Number of males (59) were more than females (36) in assumed cases of adenocarcinoma of pancreas. The mean values of CA19-9 raised considerably in cases of chronic pancreatitis, benign neoplasm and adenocarcinoma of pancreas when compared to controls. The highest augmention in CA19-9 values were in cases of adenocarcinoma of pancreas. The p-value indicates that in cases of chronic pancreatitis, there was not significant increase in precision of diagnosis. Conclusions: These statistics established that haptoglobin and SAA are useful in discriminating cancer from benign conditions as well as healthy controls.

• Korean Journal of Cognitive Science
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• v.16 no.3
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• pp.175-188
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• 2005

Recently, Li, Brenner, Cornelissen and Kim (2002) reported that 2D shape perception during pursuit eye movement just reflected the retinal image, and this result implies that the visual system ignored the extra-retinal information. In reality, however, we usually do not experience the perceptual distottion of 2D shape during pursuit eye movement. One Possibility is that the visual system night exploit the fact that the relative location between objects on retinal image is constantly maintained even during pursuit eye movement. The present research examined this possibility. Interestingly, perceptual distortion of 2D shape was observed even in the presence of reference, however, the amount of distortion decreased compared to when the reference does not exist. The distance between the reference and the target affected the perceptual distortion. These results imply that reference information is used in 2D shape perception during pursuit eye movement but it cannot completely explain the stable and accurate representation of 2D shape perception during pursuit eye movement.

• Journal of Advanced Marine Engineering and Technology
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• v.40 no.6
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• pp.468-475
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• 2016

The purpose of this study is to investigate the acoustic problems of the conventional heat recovery ventilator and to suggest the methods of noise reduction from a heat recovery ventilator according to the installed location. The noise level, in this study, was measured and discussed as the parameters of size, wind volume and sound absorbing duct length for a heat recovery ventilator based on domestic and international related standards. It is found, as a result, that almost all of noise levels from the small and medium heat recovery ventilators without the sound absorbing duct in the anechoic chamber were higher than the noise standard value of 50 dB(A) regardless of the wind volume, and the noise levels went down when a sound absorbing duct was installed. In addition, the sound pressure level relative to frequency bands according to the length of sound absorbing duct was generally decreased, as the length of sound absorbing duct in the small and medium heat recovery ventilators was big, and the sound pressure level was generally increased, as the wind volume was great.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.3
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• pp.711-721
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• 2014

PPWS, a large number of which a main cable of a suspension bridge consists of, must be precisely erected at a target location under construction considering the differences among design conditions. The absolute sag is measured for several PPWSs, which are reference strands and the relative sag is surveyed from them to other PPWSs, which are divided into several groups. And the adjustment of PPWS length is performed to erect it at target configuration. When PPWS is being under erection in a real bridge site, the procedures are as follows; evaluate sag sensitivities according to sag variation factors, calculate an adjustment length of PPWS corresponding to them and adjust a sag of PPWS by controlling the calculated amount of PPWS length. In this study, the differential-related equations of sag sensitivity were proposed for support movement of PPWS. Before site demonstration study of a series of them, we established a catenary model system and accomplished verification tests of them. From test results, the validation of them was done.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.6 no.2
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• pp.13-22
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• 2011

Objectives : The purpose of this study is to find out the characteristics of intervertebral disc changes and relative factors of the spondylolisthesis patients in fifties by type of spondylolisthesis. Methods : We investigated 69 cases of patients who visited one Korean traditional medicine hospital and were diagnosed as spondylolisthesis on L-spine X-ray and L-spine magnetic resonance imaging(MRI). We selected 37 lytic spondylolisthesis patients and 32 degenerative spondylolisthesis patients. We analysed the relativity between the numbers of changed discs, types of changed disc, locations of nerve compression and types of spondylolisthesis. Results : 1. The number of changed discs increase in lytic type, but there is no statistically significant difference. 2. Bulging disc is the dominant type of disc change. There is no significant difference between two types. 3. Both foraminal type was shown dominantly in lytic spondylolisthesis, diffuse type in degenerative spondylolisthesis by the analysis of the location of the nerve compression. But the symptoms of patients and dermatome did not match in most of the cases. Conculsions : The direction of nerve compression is different while the disc changing aspects are similar in both types. In several spondylolisthesis patients in fifties, symptoms of patient are related to degeneration of vertebrae, not to the type of spondylolisthesis.