• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5073-5076
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• 2013

Objective: This study aimed to investigate whether the miR-198 expression level is related to clinicopathological factors and prognosis of esophageal cancer. Methods: MicroRNA was extracted from esophageal cancer patients who underwent surgery for assessment using the Taqman@ MicroRNA assay. The correlation between miR-198 expression and clinicopathological features was analyzed, and the significance of miR-198 as a prognostic factor and its relationship with survival was determined. Results: MicroRNA-198 (miR-198) expression was higher in patients with poor prognosis than those with good prognosis (P<0.05). Kaplan-Meier analysis results showed that the miR-198 expression level had a significant correlation with survival time (P=0.030) and that patients with a higher expression of miR-198 had a shorter survival time. Cox multi-factor model analysis showed that patient prognosis (P=0.014), tumor length (P=0.040) and expression (P=0.012), and survival time had a significant correlation; the corresponding risks were 7.268, 1.246, and 3.524, respectively. Conclusion: miR-198 overexpression is involved in the poor prognosis of esophageal cancer and can be used as a biomarker for selection of cases requiring especial attention.

• 한국산학기술학회논문지
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• 제17권2호
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• pp.112-122
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• 2016

모바일 게임에 대한 소비자들의 수요가 증가하면서 게임 기업들 간의 경쟁이 심화되고 있다. 보다 성공적인 마케팅을 위한 전략으로 많은 게임사에서는 크로스 프로모션을 적극 활용하고 있다. 모바일 게임의 크로스 프로모션 마케팅 전략은 기존 게임 인프라를 활용해 소비자에게 새로운 게임에 대한 경험을 제공하고 각 게임사가 보유한 사용자층을 활용할 수 있다는 측면에서 저비용, 고효율 마케팅 방식으로 손꼽힌다. 그러나 크로스 프로모션의 이러한 마케팅적 이점에도 불구하고 크로스 프로모션과 모바일 게임의 수용 관계를 밝히는 실증적 연구는 미비하다. 본 연구는 소비자들의 모바일 게임 수용태도에 미치는 크로스 프로모션의 영향 요인을 규명하고자 하였다. 이를 위해 기존 선행 연구를 바탕으로 소비자의 게임 수용태도에 영향요인들을 살펴보고 모바일 게임의 이미지 광고 및 크로스 프로모션 기획 및 개발에 대한 이론적, 실무적 함의를 제시한다.

• 한국경영과학회지
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• 제27권4호
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• pp.127-137
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• 2002

This study aims at developing and empirically testing a comprehensive model of organizational justice derived from the prior empirical studies on organizational justice. The study seeks to understand the antecedents to and the consequences are addressed. The first question is what characteristics of the HRM systems determine the levels of perceived distributive and procedural justice. Hypotheses are derived from the two prominent theoretical models, i.e., the self-interests model (SIM) and the group value model (GVM). Those factors include neutrality, consistency, accuracy. ethicality. credibility. and reciprocity in the processes of making HRM decisions. All nine factors suggested by the two models aye adopted for this study as major determinants of both distributive and procedural justice. The second question of this study is related to the moderating effects of individual differences on the relationship between the SIM and GVM variables and perceived distributive and procedural justice in organizational contexts. The final research question deals with the consequences of perceived organizational justice. specifically job - related altitudes and organizational commitment. Job-related attitudes in this study refer to job satisfaction, job motivation, and job involvement, i.e., the willingness to make contributions. identification with organization, and intent to stay. In examining the consequences of perceived organizational justice, the study focuses on the interaction effects of procedural and distributive justice on the above nine outcome variables. The results show that both SIM and GVM variables significantly influence distributive and procedural justice. However, hierarchical regression analyses reveal that the GVM variables except more influence has been focused on the consequences of perceived distributive justice with regard to outcomes provided by the organization.

• Biomolecules & Therapeutics
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• 제21권3호
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• pp.204-209
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• 2013

Osteoprotegerin (OPG) is a secreted glycoprotein and a member of the tumor necrosis factor receptor superfamily. It usually functions in bone remodeling, by inhibiting osteoclastogenesis through interaction with a receptor activator of the nuclear factor ${\kappa}B$ (RANKL). Transglutaminases-2 (Tgase-2) is a group of multifunctional enzymes that plays a role in cancer cell metastasis and bone formation. However, relationship between OPG and Tgase-2 is not studied. Therefore, we investigated the involvement of 12-O-Tetradecanoylphorbol 13-acetate in the expression of OPG in MG-63 osteosarcoma cells. Interleukin-$1{\beta}$ time-dependently induced OPG and Tgase-2 expression in cell lysates and media of the MG-63 cells by a Western blot. Additional 110 kda band was found in the media of MG-63 cells. 12-O-Tetradecanoylphorbol 13-acetate also induced OPG and Tgase-2 expression. However, an 110 kda band was not found in TPA-treated media of MG-63 cells. Cystamine, a Tgase-2 inhibitor, dose-dependently suppressed the expression of OPG in MG-63 cells. Gene silencing of Tgase-2 also significantly suppressed the expression of OPG in MG-63 cells. Next, we examined whether a band of 110 kda of OPG contains an isopeptide bond, an indication of Tgase-2 action, by monoclonal antibody specific for the isopeptide bond. However, we could not find the isopeptide bond at 110 kda but 77 kda, which is believed to be the band position of Tgase-2. This suggested that 110 kda is not the direct product of Tgase-2's action. All together, OPG and Tgase-2 is induced by IL-$1{\beta}$ or TPA in MG-63 cells and Tgase-2 is involved in OPG expression in MG-63 cells.

• Journal of Pharmaceutical Investigation
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• 제37권5호
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• pp.297-303
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• 2007

The purposes of this study were to clarify the involvement of P-glycoprotein (P-gp) in the efflux of levosulpiride in knockout mice that lack the mdr1a1b gene and to evaluate the relationship between the genetic polymorphisms in MDR1 gene (exon 21) and levosulpiride disposition in healthy Korean subjects. After oral administration ($10\;{\mu}g/g$) of levosulpiride to mdr1a/1b(-/-) and wild-type mice, plasma and brain samples were obtained at 45 min. We also investigated the genotype for MDR1 (exon 21) gene in humans using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. A single oral dose of 25 mg levosulpiride was administered to 58 healthy subjects, who were based on the MDR1 genotype for the G2677T SNP. Blood samples were taken up to 36 hr after dosing. The concentrations of levosulpiride in mouse plasma and brain were statistically significant difference between the two animal groups (P<0.05). In addition, the average brain-to-plasma concentration ratio (Kp) of levosulpiride was 3.4-fold (P<0.01) higher in the mdr1a/1b(-/-) mice compared with the wild-type mice. We also found that the values of $AUC_{0-{\infty}$, partial AUC ($AUC_{0-4h}$) and $C_{max}$ were significantly different between homozygous 2677TT subjects and the subjects with at least one wild-type allele (GG and GT subjects, P=0.012 for $AUC_{0-{\infty}$; P=0.008 for $AUC_{0-4h}$; P=0.038 for $C_{max}$). The results confirm that levosulpiride is a P-gp substrate in vivo, and clearly demonstrate the effect of SNP 2677G>T in exon 21 of the MDR1 gene on levosulpiride disposition.

• 한국의류학회지
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• 제39권2호
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• pp.233-246
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• 2015

Focus on Digital Fashion Image, the conceptual framework for the thesis is established from Virtuality in Digital Art. Formative characteristics and aesthetic characteristics were studied by classifying the Digital Fashion Image applied and expressed by digital media and technology. A detective research method was used for a case study. A literature study for case-by-case data was analyzed with focus on the works expressing fashion that utilized digital media and technology since the 2000s. Through this study, the Digital revolution has created the socio-cultural impact of a Virtual representation to implement technology and fashion culture that finds ways to take advantage of the image shown in a Digital Fashion Media by understanding Virtuality. The results are as follows. First, it was a re-formation of the fashion culture through the experience of virtuality with mental zone parameters between the media 'Mediation Code'. Reflect the reality of the virtual environment as represented by a cultural image of fashion brands and fashion that reset the team relationship and formed a Homo Ludens cultural code. Second, 'Interactive Exchange' acts on the exchange interaction between the method of digital technology, the human and the machine as well as the technical interoperability of network elements and techniques. This exchange is applied to fashion images that express emotion. Forming personalized fashion items and the user interactively storage that expresses the interactive exchange to forward the identity of the emotional fashion by a change in the message delivery system fashion. Third, the emphasis on intuitive artistic expression 'Synesthesia Immersion' induces a sense of immersion and excitement through the fusion of the interconnected. Enhance a visual image in fashion sensory representation and maximize a tactile and visual virtual reality involvement.

• Safety and Health at Work
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• 제5권2호
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• pp.60-65
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• 2014

Background: To elucidate the relationship between safety culture maturity and safety performance of a particular company. Methods: To identify the factors that contribute to a safety culture, a survey questionnaire was created based mainly on the studies of $Fern{\acute{a}}ndez-Mu{\tilde{n}}iz$ et al. The survey was randomly distributed to 1000 employees of two oil companies and realized a rate of valid answer of 51%. Minitab 16 software was used and diverse tests, including the descriptive statistical analysis, factor analysis, reliability analysis, mean analysis, and correlation, were used for the analysis of data. Ten factors were extracted using the analysis of factor to represent safety culture and safety performance. Results: The results of this study showed that the managers' commitment, training, incentives, communication, and employee involvement are the priority domains on which it is necessary to stress the effort of improvement, where they had all the descriptive average values lower than 3.0 at the level of Company B. Furthermore, the results also showed that the safety culture influences the safety performance of the company. Therefore, Company A with a good safety culture (the descriptive average values more than 4.0), is more successful than Company B in terms of accident rates. Conclusion: The comparison between the two petrochemical plants of the group Sonatrach confirms these results in which Company A, the managers of which are English and Norwegian, distinguishes itself by the maturity of their safety culture has significantly higher evaluations than the company B, who is constituted of Algerian staff, in terms of safety management practices and safety performance.

• 영재교육연구
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• 제18권3호
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• pp.613-634
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• 2008

본 연구는 영재성의 기초인 유아의 사고능력이 연령 별로 모의 양육태도와 어떤 연관이 있는 가를 알아보고자 하였다 연구대상은 5시에 소재한 유치원에 등원하는 4$\sim$6세 유아 401명과 어머니를 대상으로 하였다. 측정도구로는 영재성 평가검사로 활용되는 레이쌀 검사 시리즈에서 가장 난이도가 낮은 유아의 사고능력을 알아볼 수 있는 레이븐 CPM 검사와 부모의 양육태도에 관한 질문지를 사용하였다. 부모양육태도 검사는 지지표현, 합리적 설명, 성취압력, 간섭, 처벌, 감독, 과잉기대, 비일관성 등 8개 하위 영역으로 구성되어 있다. 연구결과는 먼저 부모의 양육태도는 연령대에 따라 다르게 영향을 미치는 것으로 나타났다. 4세 유아는 합리적 설명, 성취압력, 처벌, 감독 요인이 문제해결능력에 영향을 미치고 있음이 밝혀졌고, 5세는 지지표현과 감독이 중요한 요인으로 나타났다. 그리고 6세는 지지표현, 합리적 설명, 처벌, 과잉기대가 사고력 문제 해결에 영향을 미치는 것으로 나타났다. 양육태도 영역별 정적 혹은 부적 효과를 논의하였다. 이 결과는 부모가 자녀의 연령에 따라 양육태도를 변화시켜 대응하는 것이 사고력 발달에 효과적이 될 수 있음을 시사하는 것이다.

• 한국콘텐츠학회논문지
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• 제13권4호
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• pp.218-229
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• 2013

한국의 고령화로 증가한 노인인구가 행복한 노년의 삶을 사는데 필요한 요소 중의 하나로 사회활동의 참여가 있다. 다양한 사회활동의 하나 중 자원봉사활동은 사회적으로는 시민사회의 기반이 되는 역할을 하며 개인적으로 노인의 삶의 질을 향상시키는 효과가 있다. 본 연구는 한국 노인의 자원봉사활동 현황과 자원봉사활동 참여 요인을 분석하되 노인인구의 다양성을 고려하여 연령집단별로 분석하는 것을 목적으로 한다. 한국 고령화 연구 패널의 2차년도 자료에서 55세 이상의 노인을 예비노인(55세-65세), 전기노인(65세-74세), 후기노인(75세 이상)으로 분류하여 기술통계와 로지스틱 회귀분석으로 분석하였다. 분석 결과, 노인의 자원봉사활동 참여율은 매우 낮았으며, 노인의 사회적 관계가 노인이 자원봉사활동 참여에 중요한 역할을 하는 것으로 밝혀졌다. 또한 연령별 다양성을 고려해야 할 필요성도 확인되었다.

• 융합정보논문지
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• 제10권11호
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• pp.313-323
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• 2020

본 연구는 다문화가정 어머니의 자존감, 부모효능감이 자녀진로지원행동(지지, 간섭, 관여부족)에 미치는 영향을 살펴보고, 자존감과 자녀진로지원행동 관계에서 부모효능감의 매개효과를 확인하는 것을 목적으로 하였다. 이를 위해 7차년도 다문화청소년-학부모패널 데이터를 활용하였으며, 1,188명의 결혼이주여성의 데이터를 대상으로 기술통계, 상관분석, 회귀분석을 실시하였다. 분석결과, 다문화가정 어머니의 자녀진로지원행동에 영향을 미치는 요인으로는 자존감(β=.277), 부모효능감(β=.134)이 정적으로 유의미하였다. 또한 자존감과 자녀진로지원행동의 관계에서 부모효능감은 부분매개를 하는 것으로 나타났다. 이를 바탕으로 본 연구는 다문화가정 어머니의 부모효능감을 향상시키고 바람직한 자녀진로지도를 수행할 수 있도록 정책적, 실천적 방안을 제언하였다.