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http://dx.doi.org/10.7314/APJCP.2013.14.9.5073

Involvement of MicroRNA-198 Overexpression in the Poor Prognosis of Esophageal Cancer  

Qi, Bo (Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University)
Yao, Wen-Jian (Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University)
Zhao, Bao-Sheng (Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University)
Qin, Xiu-Guang (Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University)
Wang, Yi (Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University)
Wang, Wen-Ju (Gastroscopy Room, the First Affiliated Hospital of Xinxiang Medical University)
Wang, Tian-Yun (Department of Biochemistry and Molecular Biology, Xinxiang Medical University)
Liu, Shang-Guo (Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University)
Li, Han-Chen (Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.9, 2013 , pp. 5073-5076 More about this Journal
Abstract
Objective: This study aimed to investigate whether the miR-198 expression level is related to clinicopathological factors and prognosis of esophageal cancer. Methods: MicroRNA was extracted from esophageal cancer patients who underwent surgery for assessment using the Taqman@ MicroRNA assay. The correlation between miR-198 expression and clinicopathological features was analyzed, and the significance of miR-198 as a prognostic factor and its relationship with survival was determined. Results: MicroRNA-198 (miR-198) expression was higher in patients with poor prognosis than those with good prognosis (P<0.05). Kaplan-Meier analysis results showed that the miR-198 expression level had a significant correlation with survival time (P=0.030) and that patients with a higher expression of miR-198 had a shorter survival time. Cox multi-factor model analysis showed that patient prognosis (P=0.014), tumor length (P=0.040) and expression (P=0.012), and survival time had a significant correlation; the corresponding risks were 7.268, 1.246, and 3.524, respectively. Conclusion: miR-198 overexpression is involved in the poor prognosis of esophageal cancer and can be used as a biomarker for selection of cases requiring especial attention.
Keywords
Esophageal cancer; microRNA-198; prognosis;
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