• 한국정보통신학회논문지
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• 제20권12호
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• pp.2282-2288
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• 2016

보안키 생성기법으로 하드웨어 또는 소프트웨어 관련 생성기법들이 다양하게 제안되고 있다. 본 연구는 기존의 보안키 생성기법들을 분석하여, NAND 플래시 메모리의 Bad Block 정보를 이용하는 새로운 보안키인 NBSK(NAND Bad block based Secure Key)을 설계하고 이를 이용한 암호화기법을 제안한다. NAND 플래시 메모리에 존재하는 Bad Block은 생산중에 발생하기도 하고 사용 도중에 발생하기도 한다. 생산중 발생하는 초기 Bad Block 정보는 변하지 않으며, 사용도중 발생하는 Bad Block 정보는 주기적으로 변할 수 있다는 특성을 가지고 있다. 따라서 본 연구는 NAND 플래시 메모리 생산중에 발생하는 초기의 Bad Block 정보의 물리주소를 이용하여 보안키로 활용할 수 있도록 암호화키를 설계하고 이를 이용한 암호화 기법을 제안한다. 제안 기법을 이용하면 보안키의 생성과 분배의 단순성과 보안키의 인증성과 기밀성 등의 일반적인 보안 특성을 만족할 수 있다.

• Bulletin of the Korean Chemical Society
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• 제34권3호
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• pp.827-830
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• 2013

Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with $EC_{50}$ 3.05 and 2.87 ${\mu}g/mL$, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with $IC_{50}$ values of 3.18 and 5.22 ${\mu}M$, respectively.

• 정보보호학회논문지
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• 제12권5호
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• pp.53-61
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• 2002

이 논문에서는 B2B 시스템에서 사용할 수 있는 XML. 기반의 키 복구 설계에 대해 소개한다. 이 키 복구는 시스템 내에서 사용되는 전자서명과 암호화를 W3C(World Wide Web Consortium)에서 최근 정의하고 있는 XML 전자서명 (XML Digital Signature)과 XML 암호화(XML Encryption)를 사용한다. 서명이나 암호화한 결과 값이 XML 문서 형태로 구성되고 시스템 전반에 사용되는 메시지들이 또한 모두 XML 문서 형태로 구성됨으로 기존의 XML 응용 및 XML 기반의 전자상거래 플랫폼에 투명하게 접목이 가능하다. 또한, 키 복구 방식으로는 키 위탁방식을 사용하며 기업에서 사용할 수 있도록 설계되고 구현되었다. 이 키 복구는 회사 내의 키 복구 서버로부터의 키 복구는 물론, 거래가 있는 다른 회사의 키 복구 서버에 대해 그 거래에 해당하는 문서의 키 복구 요청도 가능한 것이 그 특징이다

• Journal of Ginseng Research
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• 제46권1호
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• pp.71-78
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• 2022

Ginseng is an international herb that has been used for thousands of years. Two species most commonly applied and investigated in the ginseng family are Asian ginseng and American ginseng. The number of randomized controlled clinical trials (RCTs) has conspicuously increased, driven by the rapid development of ginseng. However, the reporting of RCT items of ginseng is deficient because of different trial designs and reporting formats, which is a challenge for researchers who are looking for the data with high quality and reliability. Thus, this study focused on providing an extensive analysis of these two species and examined the quality of the RCTs, based on the Consolidated Standards of Reporting Trials (CONSORT) guideline. Ninety-one RCTs conducted from 1980 to 2019 that were related to Asian ginseng and American ginseng used singly met our inclusion criteria. We found that the reporting quality of the two species has improved during the past 40 years. Publication date and sample size were significantly associated with the reporting quality. Rigorous RCTs designed for the species of ginseng are warranted, which can shed light on product research and development of ginseng in the future.

• International Journal of Stem Cells
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• 제16권2호
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• pp.202-214
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• 2023

Background and Objectives: To investigate the role of exosomes from periodontal ligament cells (PDLCs) in bone marrow mesenchymal stem cell (BMSC) migration. Methods and Results: Human PDLCs were applied cyclic tension stretching. Exosomes were extracted from cultured PDLCs by ultracentrifugation, then characterized for their size, morphology and protein markers by NTA, TEM and western blotting. The process that PKH26-labeled exosomes taken up by BMSCs was assessed by confocal microscope. BMSC migration was examined by Transwell assay. Exosomes derived from PDLCs were identified. Cyclic tension stretch application on PDLCs can enhance the migration ability of BMSCs through exosomes. The exosomal miRNA expression profiles of unstretched and stretched PDLCs were tested by miRNA microarray. Four miRNAs (miR-4633-5p, miR-30c-5p, miR-371a-3p and let-7b-3p) were upregulated and six (miR-4689, miR-8485, miR-4655-3p, miR-4672, miR-3180-5p and miR-4476) were downregulated in the exosomes after stretching. Sixteen hub proteins were found in the miRNA-mRNA network. Gene Ontology and KEGG pathway analyses demonstrated that the target genes of differentially expressed exosomal miRNAs closely related to the PI3K pathway and vesicle transmission. Conclusions: The exosomes derived from cyclic tension-stretched PDLCs can promote the migration of BMSCs. Alternation of microRNA profiles provides a basis for further research on the regulatory function of the exosomal miRNAs of PDLCs during orthodontic tooth movement.

• 한국항행학회논문지
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• 제15권5호
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• pp.865-870
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• 2011

64-비트 블록 암호 MD-64는 WSN과 같은 환경에서 효율적으로 구현이 가능하도록 설계된 블록 암호이다. 본 논문에서는 MD-64의 전체 라운드에 대한 확장된 연관키 부메랑 공격을 제안한다. 본 논문에서 소개하는 공격은 MD-64에 대한 첫 번째 공격이며, $2^{45.5}$개의 연관키 선택 평문을 이용하여 $2^{95}$의 MD-64 암호화 연산을 수행하여 MD-64의 비밀키를 복구한다.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2009년도 춘계학술대회
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• pp.445-449
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• 2009

Nowadays ubiquitous sensor network (USN) has been considered as a key technique in all kinds of industrial area. The main purpose of this study is to search and analyze systems in real industrial fields based on USN. USN technique has been applied into various industrial fields such as ground/underground management system, visitor counter system, monitoring system, unmanned vehicles system and so on. The result of this study will be fruitful not only for researches but also for practices in industrial fields related to USN.

• BMB Reports
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• 제45권12호
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• pp.700-706
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• 2012

Obesity is a worldwide epidemic as well as being a major risk factor for diabetes, cardiovascular diseases and several types of cancers. Obesity is mainly due to the overgrowth of adipose tissue arising from an imbalance between energy intake and energy expenditure. Adipose tissue, primarily composed of adipocytes, plays a key role in maintaining whole body energy homeostasis. In view of the treatment of obesity and obesity-related diseases, it is critical to understand the detailed signal transduction mechanisms of adipogenic differentiation. Adipogenic differentiation is tightly regulated by many key signal cascades, including insulin signaling. These signal cascades generally transfer or amplify the signal by using serial tyrosine phosphorylations. Thus, protein tyrosine kinases and protein tyrosine phosphatases are closely related to adipogenic differentiation. Compared to protein tyrosine kinases, protein tyrosine phosphatases have received little attention in adipogenic differentiation. This review aims to highlight the involvement of protein tyrosine phosphatases in adipogenic differentiation and the possibility of protein tyrosine phosphatases as drugs to target obesity.

• Journal of Plant Biotechnology
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• 제42권1호
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• pp.1-5
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• 2015

The biological roles of glycogen synthase kinase 3 (GSK3) proteins have long been extensively explored in eukaryotic organisms including fungi, animals and plants. This gene family has evolutionary well conserved kinase domain and shares similar phosphorylation properties to their substrate proteins. However, their specific biological roles are surprisingly distinct in different organisms. GSK3s play key role in key regulating the cytoskeleton and metabolic processes in animal systems, but plant GSKs are involved in quite different processes, such as flower development, brassinosteroid signaling, abiotic stresses, and organogenesis. In particular, recent studies have reported the critical multiple functions of BIN2 and its related paralogues plant GSK3s during organogenesis via connecting hormonal or developmental programs. In this review, we outline the recent understanding in the versatile functions related in physiological and biochemical relevance, which are mediated by plant GSK3s in various cellular signaling.

• 보건행정학회지
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• 제28권3호
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• pp.257-262
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• 2018

This study reviews the advent of long-term care (LTC) hospitals and its key issues in Korea. For analysis, enforcement ordinances and enforcement rules related to LTC hospitals were reviewed. Official statistic data were used for quantitative analysis and Organization for Economic Cooperation and Development data were utilized for comparative analysis. Various references and expert interviews were conducted for status analysis. As of 2016, the number of LTC hospitals was 1,386 and the number of beds were 246,373. It showed the trend of increasing medical care costs and the cost of care at LTC hospitals increasing from 998.8 billion Korean won in 2008 to 4,745.6 billion Korean won in 2016, accounting for 7.3% of the total National Health Insurance expenditure. From the societal perspective, several issues were pointed out within the current health care system related to LTC hospitals: establishment of roles, concerns about the increase in medical expenses, and the quality of medical personnel.