• Title/Summary/Keyword: related-key

Search Result 4,020, Processing Time 0.039 seconds

Alpha-Ketoglutarate: Physiological Functions and Applications

  • Wu, Nan;Yang, Mingyao;Gaur, Uma;Xu, Huailiang;Yao, Yongfang;Li, Diyan
    • Biomolecules & Therapeutics
    • /
    • v.24 no.1
    • /
    • pp.1-8
    • /
    • 2016
  • Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles. AKG as a precursor of glutamate and glutamine is a central metabolic fuel for cells of the gastrointestinal tract as well. AKG can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in the skeletal muscles and can be used in clinical applications. In addition to these health benefits, a recent study has shown that AKG can extend the lifespan of adult Caenorhabditis elegans by inhibiting ATP synthase and TOR. AKG not only extends lifespan, but also delays age-related disease. In this review, we will summarize the advances in AKG research field, in the content of its physiological functions and applications.

esearch Trend Analysis Focused on Thesis Key Words: in the Fields of Korean Language and Literature, Korean Language Education, and Korean Language Education as a Foreign Language (학위논문 주제어 중심 연구동향 분석 -국어국문학, 국어교육학, 한국어교육학 분야를 중심으로-)

  • Kim, Eunsil;Kang, Seunghae
    • Journal of Korean language education
    • /
    • v.29 no.2
    • /
    • pp.25-48
    • /
    • 2018
  • The aim of this study was to analyze research trends in the fields of Korean Language and Literature, Korean Language Education, and Korean Language Education as a Foreign Language. To this end, key words were extracted from 29,470 academic theses published between 2000 and 2017. The results of the analysis are as follows. First, in the field of Korean Language and Literature, there is greater quantity in studies about Korean language than about literature, and starting from 2010, there was an increase in studies similar to those from the field of Korean Language Education as a Foreign Language. Next, in comparison to the other fields, the field of Korean Language Education has greater variance in its research theme-in particular, numerous studies related to the site of education. Finally, the field of Korean Language Education has the following trends: a) there are copious studies focused on Korean language learners in comparison to other fields, b) there are a greater number of studies focused on culture, and c) the key words change by time period which suggest that research demands transformed over time. Overall, a total of 64 highest frequency key words from the three academic fields were investigated. Of these, 22 were common key words and 42 were differential key words. In this way, it was possible to illuminate the identity of each field.

Wireless Synchronous Transfer of Power and Reverse Signals

  • Li, Yang;Li, Yumei;Feng, Shaojie;Yang, Qingxin;Dong, Weihao;Zhao, Jingtai;Xue, Ming
    • Journal of Power Electronics
    • /
    • v.19 no.3
    • /
    • pp.827-834
    • /
    • 2019
  • Wireless power transfer via coupled magnetic resonances has been a hot research topic in recent years. In addition, the number of related devices has also been increasing. However, reverse signals transfer is often required in addition to wireless power transfer. The structure of the circuit for a wireless power transfer system via coupled magnetic resonances is analyzed. The advantages and disadvantages of both parallel compensation and series compensation are listed. Then the compensation characteristics of the inductor, capacitor and resistor were studied and an appropriate compensation method was selected. The reverse signals can be transferred by controlling the compensation of the resistor. In addition, it can be demodulated by extracting the change of the primary current. A 3.3 MHz resonant frequency with a 100 kHz reverse signals transfer system platform was established in the laboratory. Experimental results demonstrate that wireless power and reverse signals can be transferred synchronously.

Glycine alleviated diquat-induced hepatic injury via inhibiting ferroptosis in weaned piglets

  • Hua, Hongwei;Xu, Xiao;Tian, Wei;Li, Pei;Zhu, Huiling;Wang, Wenjun;Liu, Yulan;Xiao, Kan
    • Animal Bioscience
    • /
    • v.35 no.6
    • /
    • pp.938-947
    • /
    • 2022
  • Objective: The beneficial effects of glycine were tested in piglets with diquat-induced hepatic injury. Methods: Thirty-two piglets were assigned by a 2×2 factorial experimental design including glycine supplementation and diquat challenge. After 3 weeks of feeding with a basic diet or a 1% glycine supplemented diet, piglets were challenged with diquat or saline. After 1 week later, the piglets were slaughtered and samples were collected. Results: Our results indicated that glycine alleviated diquat induced morphological hepatic injury, decreased the activities of plasma alanine aminotransferase, aspartate aminotransferase and glutamyl transpeptidase in the piglets under diquat challenge, and increased total antioxidant capacity and antioxidative enzyme activity significantly. Adding glycine enhanced the concentrations of hepatic adenosine triphosphate and adenosine diphosphate. Transmission electron microscope observation showed that diquat induced clear hepatocytes ferroptosis and its effect could be alleviated by glycine to a certain degree. Moreover, glycine significantly affected mRNA and protein expression of ferroptosis-related signals in the liver. Conclusion: These results demonstrated that glycine attenuated liver damage via inhibiting ferroptosis.

A Statistical Study on the Key Words in the Titles of Nursing Related Theses (학위논문의 주요어 분석 (간호학 및 간호학관련 학위논문을 중심으로 : 1960-1991. 8))

  • 고옥자;김상혜;김희걸;이금재;이영숙
    • Journal of Korean Academy of Nursing
    • /
    • v.24 no.1
    • /
    • pp.58-69
    • /
    • 1994
  • In order to see the development of Nursing related research activities in Korea over the last three decades, abstracts of almost all of the Master and Ph.D theses that appeared from 1961 up to August 1991 were collected. The number of theses was 2354, from which an index of key words has been constructed. Key words were defined as those terms in each thesis title that convey major objectives of the given thesis study and the important nursing concepts dealt with in the thesis. Although all the key words were picked from the thesis title only, full use was made of the abstracts in deciding the principal objectives and essential contents of the thesis studies and their important concepts as well. In total, 539 kinds of key words were identified from the 2354 titles, and the identified words were all found to be in the International Nursing Index. On an average each title has two key words. Which key words were most frequently used, how they have changed with time, what kind of concept is preferably dealt with by each graduate school, and the concepts to which a given key word is likely to be connected were examined. The results are summerized below : 1) For each decade the theses numbers were as follows : 54(2.3%) from the 60’s, 413(17.5%) from the 70’s, 1523(64.7%) from the 80’s, and 364(15.5%) from the 90’s. Master’s thesis contributed 96% (2252) of the papers and Ph. D’s theses filled the remaining 4%(102). 2) A total of 539 key words were used, averaging about 2 for each thesis. The most frequently used key words were ‘Nurse’, ‘Anxiety’, ‘Knowledge / Attitude /Practice’, ‘Stress /Stressor’, ‘Attitude’, ‘Job-Satisfaction’, ‘Mental Disorder’, ‘Operation’, ‘Elderly’, ‘Nursing Role’. 3) Each decades key words can be classified as : the 60’s : ‘Nursing Education’, ‘Pulmonary Tuberculosis’, ‘Mother-Child Health’, ‘Growth & Development’, ‘Public Facilities’, ‘Mental Disorder’ : the 70’s : ‘Nurse’, ‘Family Planning’, ‘Attitude’ / ‘Knowledge, Attitude / Practice’, ‘Curriculum in Nursing Education’, ‘Clinical Practice in Nursing’, ‘Analysis of the Work of the Nurse’, ‘Health Education of School’, : the 80’s : ‘Nurse’, ‘Anxiety’, ‘Stress /Stressor’, ‘Operation’, ‘Nursing Role’, ‘Job Satisfaction’ : the 90’s : ‘Nurse’, ‘Elderly’, ‘Family-Support’, ‘Stress /Stressor’, ‘Home Care’. Key word ‘Nurse’ appears continuously and most frequently through the years, which indicates that there has been active study of the characteristics of nurses and related fields. The concept ‘Anxiety’ has been studied steadly from the 80’s and it shows that interest in health and disease are increasing Which comes as a result of society changing to an industrial and informational community. 4) Looking into each graduate school’s study area key words ‘Anxiety’, ‘Nurse’, ‘Mental Disorder’, ‘Stress /Stressor’, ‘Operation’, ‘Attitude’, ‘Hemo-dialysis’, were studied in the regular graduate school : ‘Family Planning /Contraception’, ‘Knowledge / Attitude /Practice’, ‘Physical Health-State /Physical Health Examination’, ‘Nurse’, ‘Using Clinical Facilities’, ‘Health Education of School’, were studied in the Graduate School of Public Health’ ; ‘Nurse’, ‘Anxiety’, ‘Stress / Stressor’, ‘Job-Satisfaction’, ‘Clinical Practice Education’, ‘Nursing Education’, were studied in the Graduate School of Education : ‘Nurse’, ‘Job Satisfaction’, ‘Nursing Role’, ‘Administration - Employment /Employment Management’, ‘Leadership’, ‘Personnel Profile’, ‘Nursing Manpower / Changing Working Place’, were studied in the Graduate School of Public Administration. 5) The Connection between key words were : ‘Nurse Job Satisfaction’, ‘Stress / Stressor ⇔ Coping / Ajustment’, ‘Nurse ⇔ Nursing Role’, ‘Anxiety ⇔ Giving Information’, ‘Nurse ⇔ Stress / Stressor’, ‘Anxiety ⇔ Operation’, ‘Nurse ⇔ Burnout’, ‘Knowledge, Attitude, Practice ⇔ Family Planning’, ‘Nurse Administration ⇔ Employment’, ‘Anxiety Muscle ⇔ Relaxation Technic’, ‘Anxiety ⇔ Mental Disorder’. From the above it can be noted that many nursing concepts were handled in the thesis titles. But there were more than enough papers on the characteristics of the nurse. It is suggested that in depth research be made on ‘Nursing Accidents’, t-‘Ethics’, ‘Nurse - Patient Interactions’, ‘Spritual Care’, ‘Dying’, ‘Hospice’, ‘Resident Helper’ and that there should be in depth research relating to the physical and mental development of youth and in particular physical concepts like ‘Drug - Abuse’, ‘Child -Abuse and Teaching’.

  • PDF

Analysis of Published Papers and their Keywords in the Journal of Korean Academic Society of Nursing Education 2007 (2007년도 한국간호교육학회지 논문 분석)

  • Bang, Kyung-Sook;Lee, Sun-Ok;Park, Young-Im;Jun, Myung-Hee;Kim, Hyun-Sook;Son, Haeng-Mi;Kang, Jeong-Hee;Yu, Su-Jeong
    • The Journal of Korean Academic Society of Nursing Education
    • /
    • v.14 no.2
    • /
    • pp.244-251
    • /
    • 2008
  • Purpose: This research was aimed to explore the major subjects and research themes and to classify characteristics of the key words in the Journal of Korean Academic Society of Nursing Education 2007. Method: A total of 33 published papers during 2007 were analyzed with structured analysis forms. Result: Most of the research subjects were healthy people such as student nurses and RNs. The topics of education related research were categorized into 9 domains: educational methods, educational curriculum, study type & methods, knowledge level & contents, psychosocial variables related to knowledge & education, attitude, behavior, development & evaluation of educational programs, and effects of educational programs. The most common key words in this papers were concepts related to health risk factors and health promotion. Quantitative research was used about 70% overall, while experimental design was 18.2%. Conclusion: Most of the subjects were healthy people and the most common domain was health related concepts in the Journal of Korean Academic Society of Nursing Education. In addition, key words and topics were on nursing educational issues. It can be concluded that the Journal of Korean Academic Society of Nursing Education has published mainly education focused papers.

Association Between p53 Arg72Pro Polymorphism and the Risk of Human Papillomavirus-related Head and Neck Squamous Cell Carcinoma: A Meta-analysis

  • Xia, Ling-Yun;Zeng, Xian-Tao;Li, Cheng;Leng, Wei-Dong;Fan, Ming-Wen
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.14 no.10
    • /
    • pp.6127-6130
    • /
    • 2013
  • This study aimed to investigate the association between p53 Arg72Pro polymorphism and the risk of human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) by conducting meta-analysis. The PubMed database was searched for relevant studies until May 30, 2013. Relevant studies were selected and data were extracted by two independent authors. Overall, subgroup, and sensitivity analyses were then conducted using the Comprehensive Meta-Analysis v2.2 software. Wild-genotype ArgArg was considered as reference [odds ratio (OR) = 1.00]. Nine studies involving 1071 HNSCC cases were obtained. Meta-analysis results indicated no association between p53 Arg72Pro polymorphism and the risk of HPV-related HNSCC: for Pro/Pro vs. Arg/Arg, OR = 1.17, 95% confidence interval (CI) = 0.70-1.98; for Arg/Pro vs. Arg/Arg, OR = 1.25, 95% CI = 0.97-1.72; and for (Pro/Pro + Arg/Pro) vs. Arg/Arg, OR = 1.28, 95% CI = 0.95-1.70. These meta-analysis results were supported by subgroup and sensitivity analysis results. In conclusions, p53 Arg72Pro polymorphism is a potential marker of HP infection-related HNSCC rather than a susceptibility gene polymorphism.

Influences of Daily Life Posture Habits and Work-related Factors in Musculoskeletal Subjective Symptoms among Hospital Employees (병원 의료종사자의 생활습관자세와 업무특성이 근골격계 자각증상에 미치는 영향)

  • Park, Mijeong;Lee, Eun-young
    • Journal of muscle and joint health
    • /
    • v.23 no.2
    • /
    • pp.125-137
    • /
    • 2016
  • Purpose: The purpose of this study was to identify the influences of hospital employees' daily life posture habits and work-related factors upon musculoskeletal subjective symptoms. Methods: This study was a descriptive survey study. Data were collected using structured a self-report questionnaire between April 1 and May 31, 2015. One hundred and ninety two employees were recruited in three hospitals. The collected data were analyzed using descriptive statistics, ${\chi}^2$ test, t-test, and binomial logistic regression. Results: The habit of leaning on one side and the habit of bending the back in an improper posture are key postures based on lifestyle affecting musculoskeletal subjective symptoms in neck, shoulders, arms, waist, and legs. Labours accompanying repeated arm movements for a long time are key work-related risk factors affecting musculoskeletal subjective symptoms in arms. Conclusion: The results of this study confirmed that, to prevent musculoskeletal diseases, it is necessary to identify and mediate personal factors like daily life posture habits as well as work-related risk factors. They may be utilized as basic materials for education of musculoskeletal health promotion and development of life guidance programs.

Extracellular Proteome Profiling of Bacillus pumilus SCU11 Producing Alkaline Protease for Dehairing

  • Wang, Chao;Yu, Shiqiang;Song, Ting;He, Tingting;Shao, Huanhuan;Wang, Haiyan
    • Journal of Microbiology and Biotechnology
    • /
    • v.26 no.11
    • /
    • pp.1993-2005
    • /
    • 2016
  • Bacillus pumilus is one of the most characterized microorganisms that are used for high-level production of select industrial enzymes. A novel B. pumilus SCU11 strain possessing high alkaline protease activity was obtained in our previous work. The culture supernatant of this strain showed efficient dehairing capability with minimal collagen damage, indicating promising potential applications in the leather industry. In this study, the strain's extracellular proteome was identified by LC-MS/MS-based shotgun proteomic analysis, and their related secretory pathways were characterized by BLAST searches. A total of 513 proteins, including 100 actual secreted and 413 intracellular proteins, were detected in the extracellular proteome. The functions of these secreted proteins were elucidated and four complete secretory systems (Sec, Tat, Com, and ABC transporter) were proposed for B. pumilus. These data provide B. pumilus a comprehensive extracellular proteome profile, which is a valuable theoretical and applicative basis for future genetic modifications and development of industrial enzymes.

Identification and functional prediction of long non-coding RNAs related to skeletal muscle development in Duroc pigs

  • Ma, Lixia;Qin, Ming;Zhang, Yulun;Xue, Hui;Li, Shiyin;Chen, Wei;Zeng, Yongqing
    • Animal Bioscience
    • /
    • v.35 no.10
    • /
    • pp.1512-1523
    • /
    • 2022
  • Objective: The growth of pigs involves multiple regulatory mechanisms, and modern molecular breeding techniques can be used to understand the skeletal muscle growth and development to promote the selection process of pigs. This study aims to explore candidate lncRNAs and mRNAs related to skeletal muscle growth and development among Duroc pigs with different average daily gain (ADG). Methods: A total of 8 pigs were selected and divided into two groups: H group (high-ADG) and L group (low-ADG). And followed by whole transcriptome sequencing to identify differentially expressed (DE) lncRNAs and mRNAs. Results: In RNA-seq, 703 DE mRNAs (263 up-regulated and 440 down-regulated) and 74 DE lncRNAs (45 up-regulated and 29 down-regulated) were identified. In addition, 1,418 Transcription factors (TFs) were found. Compared with mRNAs, lncRNAs had fewer exons, shorter transcript length and open reading frame length. DE mRNAs and DE lncRNAs can form 417 lncRNA-mRNA pairs (antisense, cis and trans). DE mRNAs and target genes of lncRNAs were enriched in cellular processes, biological regulation, and regulation of biological processes. In addition, quantitative trait locus (QTL) analysis was used to detect the functions of DE mRNAs and lncRNAs, the most of DE mRNAs and target genes of lncRNAs were enriched in QTLs related to growth traits and skeletal muscle development. In single-nucleotide polymorphism/insertion-deletion (SNP/INDEL) analysis, 1,081,182 SNP and 131,721 INDEL were found, and transition was more than transversion. Over 60% of percentage were skipped exon events among alternative splicing events. Conclusion: The results showed that different ADG among Duroc pigs with the same diet maybe due to the DE mRNAs and DE lncRNAs related to skeletal muscle growth and development.