• Journal of Energy Engineering
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• v.11 no.4
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• pp.370-379
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• 2002

In the Korean electricity supply structure, the role of nuclear power generation is essential. But, the delaying of radioactive waste management program induces negative impact to the stable electricity supply. Despite the continuing endeavors of Korean Government and nuclear power industry, radioactive waste management program of Korea is experiencing a continuing setback. In this background, the study examined the past and current policy and recommends that; Long term safety assurance should be the prime objective of radioactive waste management; Siting process should be transparent and opened to the public with the involvement of safety regulatory authority; A new neutral organization which has no conflicts of interest with any other existing organizations should be established to coordinate and manage the R&D programs.

• Journal of Food Hygiene and Safety
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• v.13 no.3
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• pp.299-304
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• 1998

From 1993 to 1996, 1,500 cases of foodborne disease was reported annually in Korea. Salmonellosis were 55.1% of the reported bacterial fordborne disease cases. However, in general, it is estimated that the reported incidence of salmonellosis represents less than the real incidence. This study showed that salmonellosis estimates 177,000 cases (about 150 times of reported cases) costing 5.9 billion won in Korea. Only medical costs and productivity losses were included in the estimate of costs of the 177,000 cases estimated to occur in 1996. This estimates were considerably difference to U.S.A. in cases and costs, but not significantly difference in cases/population (%), expense/GDP (%). Understanding the social economic costs of foodborne disease will be endorsed risk assessment as a necessary method for evaluation and improving food safety regulatory programs in Korea.

• Journal of Microbiology and Biotechnology
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• v.3 no.3
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• pp.146-155
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• 1993

A DNA fragment from an alkali-tolerent Bacillus sp., conferring strong promoter activity, was subcloned into the promoter probe plasmid pPL703 and the nucleotide sequence of this promoter region was determined. The sequence analysis suggested that this highly efficient promoter region containing the complex clustered promoters comprised three kinds of promoters (P1, P2 and P3), which are transcribed by $\sigma^B (formerly \sigma^{37}), \sigma^E(formerly \sigma^{29}) and \sigma^A (formerly \sigma^{43})$ RNA polymerase holoenzymes which play major rules at the onset of endospore formation, during sporulation and at the vegetative phase of growth, respectively. S1 nuclease mapping experiments showed that all three promoters had staggered transcription initiation points. The results of chloramphenicol acetyltransferase assay after the subcloning experiments also indicated that the expression of these clustered promoters was correlated with the programs of growth and endospore development. Promoter P1, P2 and P3 were preceded by 75% AT, 79% AT and 81% AT regions, respectively, and a partial deletion of AT-rich region prevented transcription from promoter P1 in vivo. Two sets of 5 -AGTGTT-3 sequences and inverted repeat sequences located around the promoter P1 were speculated as the possible cis acting sites for the catabolite repression in B. subtilis. In vivo transcripts from these sequence regions may be able to form a secondary structure, however, the possibility that a regulatory protein induced by the excess amount of glucose could be bound to such a domain for crucial action remains to be determined.

• The Journal of the Korea Contents Association
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• v.18 no.10
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• pp.575-583
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• 2018

The purpose of this study is to examine Mediating effects of aging anxiety on the relationship between social activities and successful aging and Moderating effects of social support in relation to aging anxiety and successful aging. A total of 513 respondents participated in the questionnaire, 450 of which were used for the analysis. The analysis used mediating effect and regulatory effect test using regression analysis. The results showed that social activities lowered aging anxiety and helped to improve successful aging. Aging anxiety showed a mediating effect on the relationship between social activity and successful aging and confirmed the moderating effect of social support on the relationship between aging anxiety and successful aging. On the basis of this, the social activity providers diversify the social activity programs, reorganize the business system so that aging anxiety can be mitigated, and establish a mutual support system among the participants, so that successful aging through social activities will be more effective It is necessary to be managed so that.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.23 no.4
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• pp.109-124
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• 2012

The purpose of this study is to propose an approach to acquire research records effectively in context of government-funded research institutes via case studies and a questionnaire survey. For the case studies, a report from Joint Information Systems Committee JISC in UK, the University of Melbourne policy on the management of research data and records, a report from Canadian Association of Research Libraries(CARL) are analyzed. In addition, a survey questionnaire is conducted for forty nine government-funded research institutes and forty three responses out of 49 institutes are collected and analyzed. Based on the analyses on case studies and responses of the survey, an approach for research records management with four aspects is proposed: regulatory policy, best practices and manuals, professionals for research records, and outreach programs of individual reseach institutes for acquiring appropriate research records.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1011-1018
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• 2015

This study was conducted to investigate the plasma phosphoproteome and differential plasma phosphoproteins in cases of of Opisthorchis viverrini (OV)-related cholangiocarcinoma (CCA). Plasma phosphoproteomes from CCA patients (10) and non-CCA subjects (5 each for healthy subjects and OV infection) were investigated using gel-based and solution-based LC-MS/MS. Phosphoproteins in plasma samples were enriched and analyzed by LC-MS/MS. STRAP, PANTHER, iPath, and MeV programs were applied for the identification of their functions, signaling and metabolic pathways; and for the discrimination of potential biomarkers in CCA patients and non-CCA subjects, respectively. A total of 90 and 60 plasma phosphoproteins were identified by gel-based and solution-based LC-MS/MS, respectively. Most of the phosphoproteins were cytosol proteins which play roles in several cellular processes, signaling pathways, and metabolic pathways (STRAP, PANTHER, and iPath analysis). The absence of serine/arginine repetitive matrix protein 3 (A6NNA2), tubulin tyrosine ligase-like family, member 6, and biorientation of chromosomes in cell division protein 1-like (Q8NFC6) in plasma phosphoprotein were identified as potential biomarkers for the differentiation of healthy subjects from patients with CCA and OV infection. To differentiate CCA from OV infection, the absence of both serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform and coiled-coil domain-containing protein 126 precursor (Q96EE4) were then applied. A combination of 5 phosphoproteins may new alternative choices for CCA diagnosis.

• Journal of Animal Science and Technology
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• v.55 no.6
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• pp.515-520
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• 2013

Pyruvate kinase M2 (PKM2) is a key regulatory enzyme in the glycolytic pathway. It is one of four pyruvate kinase isoenzymes that widely differ in their occurrence according to tissue type. PKM2 is expressed in differentiated tissues, such as fat tissues, lung, as well as normal proliferating cells, embryonic cells, and tumor cells. The objective of this study was to investigate the association of single nucleotide polymorphisms (SNPs) in the PKM2 gene with meat quality traits in Berkshire pigs. We detected a SNP (g.34341 A>G) in the 3'UTR region of the PKM2 gene in 670 Berkshire pigs through DNA sequencing. Three genotypes, AA, AG, and GG, were found for this SNP, but based on an association analysis with meat quality traits, genotype AA was significantly associated with thicker back fat than genotype GG (p=0.027). Therefore, the g.34341 A>G polymorphism in the 3'UTR region of the porcine PKM2 gene could be applied in pig breeding programs to improve back fat thickness.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2013.04a
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• pp.589-595
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• 2013

A reactor vessel internals comprehensive vibration assessment program(RVI CVAP) of an advanced power reactor 1400(APR1400) is being verified on the integrity of RVI for the design life of the plant by performing the non-prototype category-2 type on the US Nuclear Regulatory Commission Guide(NRC RG) 1.20, for which consists of a vibration and stress analysis program, a limited vibration measurement program, an inspection program, and the correlation of these programs. The aim of this paper is to describe the plan for the vibration measurement, test and acceptance criteria portion, and documentation and results of the APR1400 RVI CVAP. We will conduct the limited vibration measurement program of the APR1400 RVI CVAP according to the measurement plan and the vibration measurement testing in this paper.

• Journal of Auto-vehicle Safety Association
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• v.11 no.4
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• pp.6-15
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• 2019

Since introducing the offset frontal impact test in EuroNCAP in 1997, the vehicle has been constantly changing according to its usage and purpose. As of 2019, many vehicles have been released to the public, which has led to a large structural mass difference between small, medium and large vehicles. Also, the geometry of the front of the vehicle is completely different for each vehicle and tends not to be perfectly aligned at frontal collisions. The difference in mass of each of these vehicles and less performing structures for offset crashes have led to dramatically worse outcome in a car to car offset frontal impact tests. Even though a decade later passenger cars have become much safer due to consumer test programs and regulatory requirements, the aggressiveness and compatibility that can cause damage to the opponent car in the event of car to car collision is not considered in the above-mentioned section, and therefore much improvement is needed. After many years of study to solve this problem, EuroNCAP has developed a new mode MPDB offset front test that considers the aggressiveness and compatibility that can affect the opponent cars that have collided. This paper introduces the development process of aggressiveness and compatibility evaluation method of MPDB in EuroNCAP which will be implemented from 2020. Several impact tests have been conducted at different test conditions to rate the vehicle structure performance only focused on aggressiveness and compatibility of MPDB.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.19 no.3
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• pp.322-333
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• 2012

Purpose: The purpose of this study was to evaluate the effects of a newly developed Introduction to Clinical Nursing (ICN) program on critical thinking skills, communication competence, self-efficacy, and clinical performance self-confidence in nursing students in their third year. Methods: One group pre-test and post-test design was used with three data collection time points (pre-test, post-test1 and post-test2). Participants were 74 third year nursing students approaching their first clinical practicum. The new program included (a) simulated clinical encounters regarding situations of assessing hospitalized patents and caring for patients with oxygenation needs, (b) objective structured clinical examination of skills, (c) lectures, and (e) field trips. Data were analyzed using paired t-tests. Results: After the ICN course, critical thinking skills(significant only between pretest and post-test2), communication competence, and clinical performance self-confidence improved significantly (p<.05). There was no improvement in the self-efficacy total score but there was significant improvement in the subscale, self-regulatory efficacy. Conclusions: The study results indicate that the ICN course may be effective in increasing critical thinking skills, communication competence, and clinical performance self-confidence in nursing students. However, the effect size was very small and modifications of this program should be considered to develop more cost-effective educational programs.