• Nuclear Engineering and Technology
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• 제54권11호
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• pp.3975-3984
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• 2022

Distributed control system architecture is adopted for I&C systems of Prototype Fast Breeder Reactor, where the geographically distributed control systems are connected to centralized servers & display stations via switched Ethernet networks. TCP/IP communication plays a significant role in the successful operations of this architecture. The communication tasks at control nodes are taken care by TCP/IP offload modules; local area switched network is realized using layer-2/3 switches, which are finally connected to network interfaces of centralized servers & display stations. Safety, security, reliability, and fault tolerance of control systems used for safety-related applications of nuclear power plants is ensured by indigenous design and qualification as per guidelines laid down by regulatory authorities. In the case of commercially available components, appropriate suitability analysis is required for getting the operation clearances from regulatory authorities. This paper details the proposed approach for the suitability analysis of TCP/IP communication nodes, including control systems at the field, network switches, and servers/display stations. Development of test platform using commercially available tools and diagnostics software engineered for control nodes/display stations are described. Each TCP link behavior with impaired packets and multiple traffic loads is described, followed by benchmarking of the network switch's routing characteristics and security features.

• 무역학회지
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• 제47권6호
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• pp.269-289
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• 2022

The COVID-19 pandemic has disrupted supply chains across the world. When the pandemic broke out, the disruptions were mainly due to the lockdowns imposed in various countries. The WTO has predicted that the pandemic might cause world trade to decline by 13 to 32 per cent in 2020. This paper will examine the implications of COVID-19 on digital trade, particularly the use of blockchain in the Asia Pacific. The Asia Pacific (particularly Singapore and Hong Kong) is a leader in the use of digital technologies. This paper will thus attempt to draw out lessons from the first movers for the rest of Asia. It will examine the bottlenecks in the application of this technology in the Asia Pacific countries, and the need for regulatory changes in the Asia-Pacific. It will trace the technology's barriers to adoption, both as regards interoperability, and regulatory framework. The advantages of blockchain technology in trade finance are clear; it can promote trade efficiency, mitigate risk and expand trade to other regions. However, earlier efforts to introduce digital technologies have failed. More collaborative efforts are required, so that networks can connect seamlessly on a single technology platform, and meet the demand for trade finance. The COVID-19 pandemic seems to have provided an enabling environment for the intensification of digital efforts, increasing their urgency; should these measures indeed successfully occur, they will improve the resiliency of supply chains across the region.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1477-1482
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• 2012

Squamous cell carcinoma and adenocarcinoma are the major histological types of non-small cell lung cancer. Because they differ on the basis of histopathological and clinical characteristics and their relationship with smoking, their etiologies may be different; for example, different tumor suppressor genes may be related to the genesis of each type. We used microarray data to construct three regulatory networks to identify potential genes related to lung adenocarcinoma and squamous cell carcinoma and investigated the similarity and specificity of them. In the network, some of the observed transcription factors and target genes had been previously proven to be related to lung adenocarcinoma and squamous cell carcinoma. We also found some new transcription factors and target genes related to SCC. The results demonstrated that regulatory network analysis is useful in connection analysis between lung adenocarcinoma and squamous cell carcinoma.

• Fisheries and Aquatic Sciences
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• 제26권6호
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• pp.406-422
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• 2023

Sarcopenia is an age-related, progressive skeletal muscle disorder involving the loss of muscle mass and strength. Previous studies have shown that γ-aminobutyric acid (GABA) from fermented oysters aids in regulatory T cells (Tregs) cell expansion and function by enhancing autophagy, and concomitantly mediate muscle regeneration by modulating muscle inflammation and satellite cell function. The fermentation process of oysters not only increases the GABA content but also enhances the content of branched amino acids and free amino acids that aid the level of protein absorption and muscle strength, mass, and repair. In this study, the effect of GABA-enriched fermented sarco oyster extract (FSO) on reduced muscle mass and functions via Treg modulation and enhanced autophagy in aged mice was investigated. Results showed that FSO enhanced the expression of autophagy markers (autophagy-related gene 5 [ATG5] and GABA receptor-associated protein [GABARAP]), forkhead box protein 3 (FoxP3) expression, and levels of anti-inflammatory cytokines (interleukin [IL]-10 and transforming growth factor [TGF]-β) secreted by Tregs while reducing pro-inflammatory cytokine levels (IL-17A and interferon [IFN]-γ). Furthermore, FSO increased the expression of IL-33 and its receptor IL-1 receptor-like 1 (ST2); well-known signaling pathways that increase amphiregulin (Areg) secretion and expression of myogenesis markers (myogenic factor 5, myoblast determination protein 1, and myogenin). Muscle mass and function were also enhanced via FSO. Overall, the current study suggests that FSO increased autophagy, which enhanced Treg accumulation and function, decreased muscle inflammation, and increased satellite cell function for muscle regeneration and therefore could decrease the loss of muscle mass and function with aging.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7645-7652
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• 2014

Neuroblastoma (NB), the most common extracranial solid tumor, accounts for 10% of childhood cancer. To date, scientists have gained quite a lot of knowledge about microRNAs (miRNAs) and their genes in NB. Discovering inner regulation networks, however, still presents problems. Our study was focused on determining differentially-expressed miRNAs, their target genes and transcription factors (TFs) which exert profound influence on the pathogenesis of NB. Here we constructed three regulatory networks: differentially-expressed, related and global. We compared and analyzed the differences between the three networks to distinguish key pathways and significant nodes. Certain pathways demonstrated specific features. The differentially-expressed network consists of already identified differentially-expressed genes, miRNAs and their host genes. With this network, we can clearly see how pathways of differentially expressed genes, differentially expressed miRNAs and TFs affect on the progression of NB. MYCN, for example, which is a mutated gene of NB, is targeted by hsa-miR-29a and hsa-miR-34a, and regulates another eight differentially-expressed miRNAs that target genes VEGFA, BCL2, REL2 and so on. Further related genes and miRNAs were obtained to construct the related network and it was observed that a miRNA and its target gene exhibit special features. Hsa-miR-34a, for example, targets gene MYC, which regulates hsa-miR-34a in turn. This forms a self-adaption association. TFs like MYC and PTEN having six types of adjacent nodes and other classes of TFs investigated really can help to demonstrate that TFs affect pathways through expressions of significant miRNAs involved in the pathogenesis of NB. The present study providing comprehensive data partially reveals the mechanism of NB and should facilitate future studies to gain more significant and related data results for NB.

• 디지털융복합연구
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• 제11권9호
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• pp.87-94
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• 2013

정보통신망상에 무분별하게 유통되는 각종 불법정보에 대한 기존의 법적규제는 정보통신서비스제공자의 형사적 책임과 민사적 책임을 중심으로 논의되고 있다. 하지만 본 논문에서는 정보통신망상의 불법정보 차단을 위한 경찰권행사의 대상으로서 경찰책임의 문제로 접근해보았다. 이러한 인식을 근거로 정보통신망상 불법정보의 신속한 차단을 위해 행위책임자에 대한 직접적 규제방식이 아닌 상태책임자인 정보통신서비스제공자에 대한 간접적 규제방식을 채택하고 있는 현행 정보통신망법 제44조의7 제2항의 문제점과 개선방안을 제시하고자 하였다.

• 한국산학기술학회논문지
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• 제12권7호
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• pp.3275-3279
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• 2011

유무선망 상호접속 서비스 제공을 통한 통화요금의 사업자별 배부가 서비스 설비원가에 의하여 많은 부분이 정의되는 점을 고려한다면 망 설비를 통하여 제공되는 서비스들의 통화량 기준에 의한 평가가 이루어져야 한다. 이러한 관점에서 이동통신망 설비를 음성, 데이터서비스를 위한 전용설비와 공통설비로 구분하고, 공통설비는 합리적 기준에 의한 서비스별 설비원가의 배부 방법의 도출이 필수적이다. 본 논문에서는 유럽 GSM 시스템에서 이용되고 있는 이동통신망 공통설비 원가 배부 방안 분석을 통하여 국내 CDMA 이동망의 공통설비 원가 배부를 위한 회선 음성 서비스와 패킷 데이터서비스간의 단일 통화량으로 계측하기 위한 서비스간 환산계수 방안을 도출하였다.

• Molecules and Cells
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• 제46권1호
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• pp.33-40
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• 2023

RNAs are versatile molecules that are primarily involved in gene regulation and can thus be widely used to advance the fields of therapeutics and diagnostics. In particular, circular RNAs which are highly stable, have emerged as strong candidates for use on next-generation therapeutic platforms. Endogenous circular RNAs control gene regulatory networks by interacting with other biomolecules or through translation into polypeptides. Circular RNAs exhibit cell-type specific expression patterns, which can be altered in tissues and body fluids depending on pathophysiological conditions. Circular RNAs that are aberrantly expressed in diseases can function as biomarkers or therapeutic targets. Moreover, exogenous circular RNAs synthesized in vitro can be introduced into cells as therapeutic molecules to modulate gene expression networks in vivo. Depending on the purpose, synthetic circular RNA sequences can either be identical to endogenous circular RNA sequences or artificially designed. In this review, we introduce the life cycle and known functions of intracellular circular RNAs. The current stage of endogenous circular RNAs as biomarkers and therapeutic targets is also described. Finally, approaches and considerations that are important for applying the available knowledge on endogenous circular RNAs to design exogenous circular RNAs for therapeutic purposes are presented.

• 전자공학회논문지
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• 제52권1호
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• pp.79-86
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• 2015

인지무선네트워크(Cognitive Radio Networks, CRNs)는 네트워크 환경을 인지하고 적응적으로 운용할 수 있는 지능형 무선 네트워킹을 제공하기 위한 기술로 인지되고 있다. CRN은 FCC(Federal Communications Commission)의 최근 정책으로 인해 비인가된 사용자가 네트워크의 주사용자를 방해하지 않는 한 유휴 스펙트럼을 활용할 수 있도록 허락하는 기술이다. 그러므로 CRNs의 보안 특성은 다른 네트워크와 달라야만 한다. 본 논문의 목적은 Tsai등의 위임기반 인증 프로토콜(TDAP)로부터 CRN상의 비인가된 사용자를 위한 보안의 특성을 추출함으로서 새로운 위임기반 인증 프로토콜(NDAP)을 제안하는데 있다. 먼저 TDAP에 대한 보안분석을 제시하고 비인가 사용자 인증을 위한 프로토콜 설계 목표를 설정한다. 그런 후 TDAP에 대한 보안 해결책과 CRNs를 위한 새로운 프로토콜로서 NDAP을 제안한다. 본 논문에서 제안한 NDAP은 CRNs과 다양한 융합응용의 보안 기반 구조로 활용될 수 있을 것이다.

• Reproductive and Developmental Biology
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• 제32권4호
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• pp.229-235
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• 2008

Silencing of Dicer1 by siRNA did not inhibit development up to the blastocyst stage, but decreased expression of selected transcription factors, including Oct-4, Sox2 and Nanog, suggesting that Dicer1 gene expression is associated with differentiation processes at the blastocyst stage (Cui et al., 2007). In order to get insights into genes which may be linked with microRNA system, we compared gene expression profiles in Gapdh and Dicer1 siRNA-microinjected blastocysts using the Applied Biosystem microarray technology. Our data showed that 397 and 737 out of 16354 genes were up- and down-regulated, respectively, following siRNA microinjection (p<0.05), including 24 up- and 28 down-regulated transcription factors. Identification of genes that are preferentially expressed at particular Dicer1 knock down embryos provides insights into the complex gene regulatory networks that drive differentiation processes in embryos at blastocyst stage.