• Asia Marketing Journal
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• 제17권1호
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• pp.123-148
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• 2015

Built on regulatory focus theory, this article develops a research model proposing the relationship between management controls (outcome, activity and capability), sales employees' prevention and promotion focus and their behavioral responses (feedback seeking from different sources and relationship investment). The model also suggests that salesperson perceived organizational fit (P-O fit) contributes by influencing the situational self-regulatory mechanism based on regulatory fit theory. To analyze the data, a structural equation model procedure using LISREL 8.5 was employed. To access the potential common method bias, the MV" marker method was applied using a scale theoretically unrelated to at least one scale in the analysis as the MV marker. The results showed that the greater the salesperson's perceived activity control system, the greater the extent of employee prevention focus. The findings also showed that output control and capability control system are positively related to the promotion focus of salespeople. Salespeople's prevention focus relates negatively to the relational investment and positively to organization feedback seeking. The results indicate that salespeople who have promotion focus exhibit the predicted positive influence on their relationship investment. A significant contribution of this research framework is suggesting salesperson regulatory focus as a mediator and its' effects on different types of sales-related behaviors. The author suggests that the motivational orientations of salespeople play key roles in shaping feedback seeking behaviors from different sources; broadly, that employees with a promotion focus will be more sensitive to customers' feedback, and employees with a prevention focus will seek more feedback from the organization. Furthermore, salespeople with a promotion focus will invest more resources to build relationships with customers than salespeople with a prevention focus. This research also explains the moderating role of person-organization fit on the effect of salespeople's regulatory focus and behavioral responses based on regulatory fit theory

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2015년도 춘계학술발표대회
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• pp.449-451
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• 2015

When cyber attacks are discovered in nuclear facilities, licensees are required to notify regulatory organizations for quick action. This also helps regulatory organizations to strengthen regulatory capabilities for cyber security. Currently the U.S. issued the final draft rule for Cyber Security Event Notifications. Domestic regulatory activities being at an early stage for cyber security need to implement law for Cyber Security Event Notifications. Since the current laws are focused on the aspect of safety, they are in need of more specific laws for cyber security.

• Journal of Radiation Protection and Research
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• 제26권3호
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• pp.255-263
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• 2001

An Orphan Sources Control program controlled by a web based information system in Korea has been developed to satisfy the national demand on a total management of and integrated radiation safety. There are, currently, three approaches going on to control and manage the orphan sources in Korea. First, Korean regulatory authority has been conducting scrutinizing investigation on and thoroughly monitoring the possession of unlicensed radioactive sources from the late 1990s. Second, the regulatory authority will fully operate an information system on radiation safety to effectively trace and monitor all radioactive sources in the country by the mid 2001. Finally, the regulatory authority strongly advises steel mill companies to closely scrutinize and inspect the scrap metals when they attempt to reutilize metals to prevent from being contaminated by uncontrolled sources through the scrap monitoring systems.

• Interdisciplinary Bio Central
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• 제1권1호
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• pp.4.1-4.7
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• 2009

Introduction: Histone modifications and DNA methylation are the major factors in epigenetic gene regulation. Especially, revealing how histone modifications are related to DNA methylation is one of the challenging problems in this field. In this paper, we address this issue and propose several plausible mechanisms for precise controlling of DNA methylation status at CpG islands. Materials and Methods: To establish the regulatory relationships, we used 38 histone modification types including H2A.Z and CTCF, and DNA methylation status at CpG islands across chromosome 6, 20, and 22 of human CD4+ T cell. We utilized Bayesian network to construct regulatory network. Results and Discussion: We found several meaningful relationships supported by previous studies. In addition, our results show that histone modifications can be clustered into several groups with different regulatory properties. Based on those findings we predicted the status of methylation level at CpG islands with high accuracy, and suggested core-regulatory network to control DNA methylation status.

• 초등상담연구
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• 제6권1호
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• pp.247-268
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• 2007

This thesis aims to examine the influences of self-regulatory group counseling on self-regulation and school life satisfaction of the higher grade students in Elementary school. To achieve this aim, the following research questions were posed: First, What kind of influence does the self-regulatory group counseling have on the self- regulation of the higher grade students in Elementary school. Second, What kind of influence does the self-regulatory group counseling have on school life satisfaction scale of the higher grade students in Elementary school. In order to verify these research questions, the self-regulation test and school life satisfaction scale were conducted to both the experimental group and control group in pre-test, next, self-regulatory group counseling was practiced to the experimental group. And finally, a post-test was given to both the experimental group and control group. For this study, 200 students from 6th-grader of S Elementary school located in Incheon were given the self-regulation test and chosen 50 students who received low marks. Then, 50 students were researched into the school life satisfaction scale and chosen 16 students who got average-below score again. It was two matching groups through consideration of their score of the school life satisfaction scale, 8 students were arranged to the experimental group and the rest to the control group. The Self-Regulatory Group Counseling program developed by Eun Hyuck-gi(1999). The program was based on the following three programs: "The development. of the Cognitive-Behavioral Counseling therapy and their reports" by Kim HyeSuk(1996), Group counseling" by Brigman and Early(1991) and the study on the improving program in human relation" by Park KyeongAe(1998). The Self-Regulatory Group Counseling program activity was conducted during 6 weeks. Each session was 60 minutes and it continued for 8 sessions. The data collected to find out a difference in self-regulation and the degree of school life satisfaction between the experimental and control groups were processed by means of SPSSWIN program, and the post-test between both the groups were comparatively analyzed through t-test, a mean difference test. The following conclusions were drawn from the results of this study. First, the self-regulatory group counseling program has obvious effect of improving the self-regulation of the higher grade students in Elementary school. Second, the self-regulatory group counseling program has obvious effect of improving the school life satisfaction of the higher grade students in Elementary school. Particularly, this study shows statistical significance in cognitive facts of the self-regulation and the degrees of satisfaction with general school life, teacher, friend and facilities. Since the self-regulatory group counseling program has positive effects on self-regulation and satisfaction with their school life, It is required to utilize the structured self-regulatory group counseling program in school more widely to help students.

• IMMUNE NETWORK
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• 제7권4호
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• pp.167-172
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• 2007

Various cell types that express regulatory function may influence the pathogenesis of most and perhaps all infections. Some regulatory cells are present at the time of infection whereas others are induced or activated in response to infection. The actual mechanisms by which different types of infections signal regulatory cell responses remain poorly understood. However a most likely mechanism is the creation of a microenvironment that permits the conversion of conventional T cells into cells with the same antigen specificity that have regulatory function. Some possible means by which this can occur are discussed. The relationship between regulatory cells and infections is complex especially with chronic situations. The outcome can either be of benefit to the host or damage the disease control process or in rare instances appears to be a component of a finely balanced relationship between the host and the infecting agent. Manipulating the regulatory cell responses to achieve a favorable outcome of infection remains an unfulfilled objective of therapeutic immunology.

• Parasites, Hosts and Diseases
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• 제50권1호
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• pp.29-35
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• 2012

The aim of the study is to characterize the phenotypes of $CD4^+$ $CD25^+$ T regulatory cells within the liver granulomas and association with both Foxp-3 gene expression and splenic cytokines. Naive C57BL/6 mice were intravenously injected with multiple doses of the soluble egg antigen (SEA) 7 days before cercarial infection. The immunized and infected control groups were sacrificed 8 and 16 weeks post-infection (PI). Histopathology, parasitological parameters, splenic phenotypes for T regulatory cells, the FOXP-3 expression in hepatic granuloma using real-time PCR, and the associated splenic cytokines were studied. Histopathological examination of the liver revealed remarkable increase in degenerated ova within hepatic granuloma which decreased in diameter at weeks 8 and 16 PI ($P$<0.01). The percentage of T regulatory cells ($CD4^+$ $CD25^+$) increased significantly ($P$<0.01) in the immunized group compared to the infected control at weeks 8 and 16 PI. The FOXP-3 expression in hepatic granulomas increased from 10 at week 8 to 30 fold at week 16 PI in the infected control group. However, its expression in the immunized group showed an increase from 30 at week 8 to 70 fold at week 16 PI. The splenic cytokine levels of pro-inflammatory cytokines, IFN-${\gamma}$, IL-4, and TNF-${\alpha}$, showed significant decreases ($P$<0.05) compared to the infected control group. In conclusion, the magnitude and phenotype of the egg-induced effects on T helper responses were found to be controlled by a parallel response within the T regulatory population which provides protection in worm parasite-induced immunopathology.

• 제어로봇시스템학회논문지
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• 제11권10호
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• pp.843-850
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• 2005

FBA(flux balance analysis) with Boolean rules for representing regulatory events has correctly predicted cellular behaviors, such as optimal flux distribution, maximal growth rate, metabolic by-product, and substrate concentration changes, with various environmental conditions. However, until now, since FBA has not taken into account a hierarchical regulatory network, it has limited the representation of the whole transcriptional regulation mechanism and interactions between specific regulatory proteins and genes. In this paper, in order to solve these problems, we describe the construction of hierarchical regulatory network with defined symbols and the introduction of a weight for representing interactions between symbols. Finally, the whole cellular behaviors with time were simulated through the linkage of a hierarchical regulatory network module and dynamic simulation module including FBA. The central metabolic network of E. coli was chosen as the basic model to identify our suggested modeling method.

• Nuclear Engineering and Technology
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• 제15권2호
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• pp.154-159
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• 1983

The principles and practices of national nuclear regulatory agencies around the world differ significantly. This paper outlines the philosophical approach to nuclear regulation of the Atomic Energy Control Board of Canada and attempts to explain the principles which have governed the Board's licensing and compliance programs during the past 37 years.

• Journal of Microbiology and Biotechnology
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• 제15권3호
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• pp.551-559
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• 2005

The recent rapid increase in genomic data related to many microorganisms and the development of computational tools to accurately analyze large amounts of data have enabled us to design several kinds of simulation approaches for the complex behaviors of cells. Among these approaches, dFBA (dynamic flux balance analysis), which utilizes FBA, differential equations, and regulatory events, has correctly predicted cellular behaviors under given environmental conditions. However, until now, dFBA has centered on substrate concentration, cell growth, and gene on/off, but a detailed hierarchical structure of a regulatory network has not been taken into account. The use of Boolean rules for regulatory events in dFBA has limited the representation of interactions between specific regulatory proteins and genes and the whole transcriptional regulation mechanism with environmental change. In this paper, we adopted the operon as the basic structure, constructed a hierarchical structure for a regulatory network with defined fundamental symbols, and introduced a weight between symbols in order to solve the above problems. Finally, the total control mechanism of regulatory elements (operons, genes, effectors, etc.) with time was simulated through the linkage of dFBA with regulatory network modeling. The lac operon, trp operon, and tna operon in the central metabolic network of E. coli were chosen as the basic models for control patterns. The suggested modeling method in this study can be adopted as a basic framework to describe other transcriptional regulations, and provide biologists and engineers with useful information on transcriptional regulation mechanisms under extracellular environmental change.