• BMB Reports
• /
• v.54 no.7
• /
• pp.356-367
• /
• 2021

Cell-based therapy is a promising approach in the field of regenerative medicine. As cells are formed into spheroids, their survival, functions, and engraftment in the transplanted site are significantly improved compared to single cell transplantation. To improve the therapeutic effect of cell spheroids even further, various biomaterials (e.g., nano- or microparticles, fibers, and hydrogels) have been developed for spheroid engineering. These biomaterials not only can control the overall spheroid formation (e.g., size, shape, aggregation speed, and degree of compaction), but also can regulate cell-to-cell and cell-to-matrix interactions in spheroids. Therefore, cell spheroids in synergy with biomaterials have recently emerged for cell-based regenerative therapy. Biomaterials-assisted spheroid engineering has been extensively studied for regeneration of bone or/and cartilage defects, critical limb ischemia, and myocardial infarction. Furthermore, it has been expanded to pancreas islets and hair follicle transplantation. This paper comprehensively reviews biomaterials-assisted spheroid engineering for regenerative therapy.

• BMB Reports
• /
• v.56 no.1
• /
• pp.10-14
• /
• 2023

Organoids derived from stem cells or organ-specific progenitors are self-organizable, self-renewable, and multicellular three-dimensional (3D) structures that can mimic the function and structure of the derived tissue. Due to such characteristics, organoids are attracting attention as an excellent ex vivo model for drug screening at the stage of drug development. In addition, since the applicability of organoids as therapeutics for tissue regeneration has been embossed, the development of various organoids-based regenerative medicine has been rapidly progressing, reaching the clinical trial stage. In this review, we give a general overview of organoids and describe current status and prospects of organoid-based regenerative medicine, focusing on organoid-based regenerative therapeutics currently under development including clinical trials.

• IE interfaces
• /
• v.11 no.3
• /
• pp.89-101
• /
• 1998

The randomness of the input variables in simulation experiments produce output responses which are also realizations of random variables. The random responses make necessary the use of statistical inferences to adequately describe the stochastic nature of the output. The analysis of the simulation output of non-terminating simulations is frequently complicated by the autocorrelation of the output data and the effect of the initial conditions that produces biased estimates. The regenerative method has been developed to deal with some of the problems created by the random nature of the simulation experiments. It provides a simple solution to some tactical problems and can produce valid statistical results. However, not all processes can he modeled using the regenerative method. Other processes modeled as regenerative may not return to a given demarcating state frequently enough to allow for adequate statistical analysis. This paper shows how the state transformation concept was successfully used in a queueing model and a job shop model. Although the first example can be analyzed using the regenerative method. it has the problem of too few recurrences under certain conditions. The second model has the problem of no recurrences. In both cases, the state transformation increase the frequency of the demarcating state. It was shown that time state transformations are regenerative and produce more cycles than the best typical discrete demarcating state in a given run length.

• Transactions of The Korea Fluid Power Systems Society
• /
• v.7 no.2
• /
• pp.7-12
• /
• 2010

In these days, the researches about hybrid and fuel cell electric vehicles are actively performed due to the environmental contamination and resource exhaust. Specially, the technology of regenerative braking, converting heat energy to electric energy, is one of the most effective technologies to improve fuel economy. This paper developed a regenerative braking control algorithm that is considered vehicle stability. The vehicle has a inline motor at front drive shaft and has a EHB(Electo-hydraulic Brake) system. The control logic and regenerative braking control algorithm are analyzed by MATLAB/Simulink. The vehicle model is carried out by CarSim and the driving simulation is performed by using co-simulation of CarSim and MATLAB/Simulink. From the simulation results, a regenerative braking control algorithm is verified to improve the vehicle stability as well as fuel economy.

• The Transactions of the Korean Institute of Power Electronics
• /
• v.13 no.3
• /
• pp.213-220
• /
• 2008

In this paper, the regenerative inverter system with voltage drop compensation mode is proposed. When the main rectifier is broken, the DC traction can not be supplied the power from the utility. Actually, the reserve rectifier is mounted in the substation to prevent this accident. In this paper, the voltage drop compensation mode is added to the regenerative inverter system in order to substitute the reserve rectifier. The proposed regenerative inverter system returns the regenerative energy from the DC line voltage to the utility. In addition, the inverter can be compensate the harmonics caused by the power conversion devices used in the DC traction system. We demonstrated the effectiveness of the proposed control algorithm by using computer simulation.

• Journal of Electrical Engineering and Technology
• /
• v.13 no.2
• /
• pp.800-811
• /
• 2018

This paper presents a regenerative braking control scheme for Switched Reluctance Machine (SRM) drive in Electric Vehicles (EVs). The main purpose is to maximize the recovered energy during battery charging by taking into account the nonlinear physical characteristics of the Switched Reluctance Machine. The proposed regenerative braking method employs the back-EMF in the generation process as a complicated position-dependent voltage source. The proposed maximum power recovery (MPR) operation of the regenerative braking is first based on the maximization of the extracted power from the machine and then the maximization of the power transferred to the battery. The maximum power extraction (MPE) from SRM is based on maximizing the energy conversion ratio by the calculation of the optimum PWM switching duty cycle, turn-on, and turn-off angles. By using the impedance matching theorem that allows the maximum power transfer (MPT) of the MPE, the proposed MPR is achieved. The parametric averaged value modeling of the machine phase currents in the chopping control mode is used for MPR realization. By following this model, a nonlinear equivalent input resistance is derived for the battery internal resistance matching. The effectiveness of the proposed regenerative braking method is demonstrated through simulation results and experimental implementation.

• BMB Reports
• /
• v.52 no.12
• /
• pp.718-727
• /
• 2019

Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell transplant. Functional NK cells may impact engraftment success of life-saving procedures such as bone marrow transplantation in human SCID patients. Therefore, in animal models, a T cell-/B cell-/NK cell+ environment provides a valuable tool for understanding the function of the innate immune system and for developing targeted NK therapies against human immune diseases. In this review, we focus on underlying mechanisms of human SCID, recent progress in the development of SCID animal models, and utilization of SCID pig model in biomedical sciences. Numerous physiologies in pig are comparable to those in human such as immune system, X-linked heritability, typical T-B+NK- cellular phenotype, and anatomy. Due to analogous features of pig to those of human, studies have found that immunodeficient pig is the most appropriate model for human SCID.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.20 no.7
• /
• pp.447-454
• /
• 2008

The regenerative evaporative cooler(REC) is to cool a stream of air using evaporative cooling effect without an increase in the humidity ratio. In the regenerative evaporative cooler, the air can be cooled down to a temperature lower than its inlet wet-bulb temperature. Besides the cooling performance, for practical application of the regenerative evaporative cooler, the compactness of the system is also a very important factor to be considered. In this respect, three different configurations, i.e., the flat plate type, the corrugated plate type, and the finned channel type are investigated and compared for the most compact configuration. The optimal structure of each configuration is obtained individually to minimize the volume for a given effectiveness within a limit of the pressure drop. Comparing the three optimal structures, the finned channel type is found to give the most compact structure among the considered configurations. The volume of the regenerative cooler can be reduced to 1/8 by adopting the finned channel type as compared to that of the flat plate type.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.18 no.5
• /
• pp.393-401
• /
• 2006

The regenerative evaporation water cooler is devised and analysed in this study. The regenerative evaporation water cooler is composed of a sensible heat exchanger to cool the incoming air, followed by a latent heat exchanger to cool the water evaporatively with the cooled air flowing out of the sensible heat exchanger. By linearizing psychrometric characteristics, the heat and mass transfer in the regenerative evaporation water cooler is analyzed theoretically. The results show that the water can be cooled down even lower than the wet-bulb temperature of the inlet air. When the inlet air is $32^{\circ}C$ and 20% in relative humidity, and the inlet temperature of the water is $20^{\circ}C$, the regenerative evaporation water cooler provides a larger cooling capacity than the conventional evaporation water cooler if the effectiveness of the latent heat exchanger is higher than 0.6 and that of the sensible heat exchanger is higher than 0.5.

• BMB Reports
• /
• v.52 no.11
• /
• pp.625-634
• /
• 2019

Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell transplant. Functional NK cells may impact engraftment success of life-saving procedures such as bone marrow transplantation in human SCID patients. Therefore, in animal models, a T cell-/B cell-/NK cell＋ environment provides a valuable tool for understanding the function of the innate immune system and for developing targeted NK therapies against human immune diseases. In this review, we focus on underlying mechanisms of human SCID, recent progress in the development of SCID animal models, and utilization of SCID pig model in biomedical sciences. Numerous physiologies in pig are comparable to those in human such as immune system, X-linked heritability, typical T-B＋NK- cellular phenotype, and anatomy. Due to analogous features of pig to those of human, studies have found that immunodeficient pig is the most appropriate model for human SCID.