• Clinical and Experimental Pediatrics
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• 제59권3호
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• pp.114-119
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• 2016

Purpose: This study aimed to assess the reference values and factors influencing blood lead levels among Korean adolescents. Methods: The study population consisted of 1,585 adolescents (801 males, 784 females; aged 10-19 years) who participated in the Korea National Health and Nutrition Examination Survey 2010-2013. We analyzed blood lead concentrations in relation to demographic/lifestyle characteristics for all participants. "Reference values" of blood lead levels were calculated as the upper limit of the 95% confidence interval of the 95th percentile. Results: The average "reference value" for blood lead concentrations among Korean adolescents was $2.25{\mu}g/dL$ ($2.49{\mu}g/dL$ for males, $2.07{\mu}g/dL$ for females), and the geometric mean of the blood lead concentrations was $1.34{\mu}g/dL$. Males had higher blood lead concentrations than females (male, $1.48{\mu}g/dL$; female, $1.19{\mu}g/dL$; P<0.001). Elementary school students had higher blood lead concentrations than junior and senior high school students ($1.44{\mu}g/dL$ vs. $1.31{\mu}g/dL$, P<0.001). Participants living in detached houses had higher blood lead concentrations than those living in apartments (P<0.001) and current smokers had higher concentrations than nonsmokers or participants with secondhand smoke exposure (P<0.05). Additionally, participants with excessive alcohol consumption had higher levels than non-drinkers (P<0.001). Conclusion: This study provides national reference data on blood lead concentrations stratified by demographic and lifestyle factors among Korean adolescents. Further studies are needed to elucidate the relationship between increased lead exposure and demographic factors including type of housing.

• Journal of the Korean Statistical Society
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• 제29권1호
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• pp.17-27
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• 2000

In this paper, we develop noninformative priors that are used for estimating the reliability of stress-strength system under the Burr-type X model. A class of priors is found by matching the coverage probabilities of one-sided Bayesian credible interval with the corresponding frequentist coverage probabilities. It turns out that the reference prior as well as the Jeffreys prior are the second order matching prior. The propriety of posterior under the noninformative priors is proved. The frequentist coverage probabilities are investigated for samll samples via simulation study.

• 한국산업정보학회논문지
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• 제4권4호
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• pp.47-52
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• 1999

본 논문에서는 Burr Type-X 분포하에서 stress-strength 의 신뢰도를 추정하는 데 사용되어지는 비정보적 사전분포들을 개발하는 것이다. 개발된 reference 사전분포가 first order matching 사전분포가 된다는 것이 밝혀졌으며, 또한 matching 사전분포하에서 사후분포의 타당성을 밝혔다. 소표본하에서, 고전적 포함확률들이 주여져 있다.

• 품질경영학회지
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• 제36권4호
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• pp.87-92
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• 2008

It is common to use CUSUM charts for detecting small level shifts in processes control, in which reference value(k) and decision interval(h) are the design parameters to be determined. To control process with autocorrelation, CUSUM charts could be applied to residuals obtained from fitting ARIMA models. However, constant level shifts in processes lead to varying mean shifts in residual processes and thus standard CUSUM charts may need to be modified. In this paper, we study the performance of CUSUM charts with various design parameters applied to autocorrelated processes, especially focussing on ARMA(1,1) models, and propose how they can be determined to get better performance in terms of the average run length.

• Structural Engineering and Mechanics
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• 제55권4호
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• pp.885-900
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• 2015

This paper introduces Romberg-Richardson's method as one of the numerical integration tools for computation of stress intensity factor in a pre-cracked specimen subjected to a complex stress field across the crack faces. Also, the computation of stress intensity factor for various stress fields using existing three methods: average stress over interval method, piecewise linear stress method, piecewise quadratic method are modified by using Richardson extrapolation method. The direct integration method is used as reference for constant and linear stress distribution across the crack faces while Gauss-Chebyshev method is used as reference for nonlinear distribution of stress across the crack faces in order to obtain the stress intensity factor. It is found that modified methods (average stress over intervals-Richardson method, piecewise linear stress-Richardson method, piecewise quadratic-Richardson method) yield more accurate results after a few numbers of iterations than those obtained using these methods in their original form. Romberg-Richardson's method is proven to be more efficient and accurate than Gauss-Chebyshev method for complex stress field.

• 대한치과보철학회지
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• 제37권4호
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• pp.516-530
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• 1999

The current clinical technique for occlusal vertical dimension recording is based on marking the skin reference points on the patient's face and measuring between these points using caliper-like device. And it is difficult to achieve reliable measurements by this technique because of movable soft tissue. The purpose of this study is to reveal the stability of skin reference points by comparing the relative movement between extra-oral skin reference points and intra-oral reference points using X-ray fluoroscope. 10 test subjects were divided into 2 groups : Group I (natural dentition) and Group II (denture-wearer whose vertical dimension was lost) and Group III consists of identical test subjects to Group II with their upper denture removed and record base inserted. Attaching the 3 mm diameter steel ball to nose tip, lower lip, chin and to existing denture (or record base), fluoroscopic examination and recording were taken during 2 jaw opening and closing movements. After subsequent digitization using personal computer, 1219 still pictures with 0.1 second interval were made. Using the 2 dimensional graphic software, measurements between reference points were executed. Dividing the entire jaw movement into 3 ranges (total, 1st half opening, 2nd half opening), rate of movement and relative movement between extra-oral and intra-oral reference points were calculated and statistically analyzed. The results of this study are as follows. 1 Within the same experimental group, no statistical difference was found in the stability of skin reference between lower lip point and chin point during total range of jaw opening and closing movement (p>.05) 2. In the first half range of jaw opening, statistical difference was found between Group I (natural dentition) and Group II (denture wearer) (p<.05) Group I has greater skin reference stability than Group II. 3. In the first half range of jaw opening, statistical difference was found between Group I and Group III (record base wearer) (p<.05). Group I has greater skin reference stability than Group III. 4. In the first half range of jaw opening, no statistical difference was found in the stability of skin reference between Group II and Group III (p>.05). 5. In the second half range of jaw opening, no statistical difference was found in the stability of skin reference between any experimental groups (p>.05). 6. In patients with their occlusal vertical dimension lost, employing other measuring references rather than skin is recommended because of low stability.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1998년도 하계종합학술대회논문집
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• pp.962-965
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• 1998

In this paper, single-phase PWM AC to AC converter that operates with unit powr factor and sinusidal input line currents is presented. The currentcontrol of this converter is based on the predicted current control method with fixed switching frequency and the line currents track to reference currents within sampling time interval.

• 한국산업정보학회:학술대회논문집
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• 한국산업정보학회 1999년도 춘계학술대회 발표논문집
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• pp.191-197
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• 1999

In this paper, we develop noninformative priors that are used for estimating the reliability of stress-strength system under the Burr-type X distribution. A class of priors is found by matching the coverage probabilities of one-sided Bayesian credible interval with the corresponding frequentist coverage probabilities. It turns out that the reference prior is a first order matching prior. The propriety of posterior under matching prior is provided. The frequentist coverage probabilities are given for small samples.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2007년도 하계종합학술대회 논문집
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• pp.21-22
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• 2007

The reference scheduler presented by IEEE 802.11e standard is inefficient because it polls all admitted stations in the same interval. It increases poll overheads and waste time. In this paper we proposed an efficient scheduling algorithm to improve the aggregate throughput and the number of admitted stations.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2006년도 추계학술대회
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• pp.80-86
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• 2006

Bioequivalence is a term in pharmacokinetics used to access the expected in vivo biological equivalence of two proprietary preparations of a drug. Bioequivalence studies are usually performed for generic drugs. Two pharmaceutical products are bioequivalent if they are pharmaceutically equivalent and their bioavailabilioes after administration in the same molar dose are similar. Bioequivalence is usually accessed by single dose in vivo studies in healthy volunteers and the reference product is usually the innovator product that is marketed. Regulatory definition of bioequivalence is based on the statistical analysis of thebioavailability of the reference and test product. In general, two products are evaluated as bioequivalent if the 90% confidence interval of the relative mean Cmaxand AUC of the test to reference product are within 80.00% to 125.00% in the fasting state. Key process in bioequivalence study is development and validation of bioanalytical method, determination of the drug concentration in the biosamples (usually plasma or serum) obtained from volunteers, calculation of the pharmacokinetic parameters and statistical analysis of the pharmacokinetic parameters. Although current guidelines and regulations do not require the bioequivalence studies to be done under good laboratory practice (CLP), the issues to perform the bioequivalence studies under GLP environment is emerged both from the regulatory and industry side. GLP perspectives of bioequivalence studiesare needed to be discussed in respect to achieve quality assurance in bioequivalence studies.